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NFYB nuclear transcription factor Y subunit beta [ Homo sapiens (human) ]

Gene ID: 4801, updated on 25-Jan-2024

Summary

Official Symbol
NFYBprovided by HGNC
Official Full Name
nuclear transcription factor Y subunit betaprovided by HGNC
Primary source
HGNC:HGNC:7805
See related
Ensembl:ENSG00000120837 MIM:189904; AllianceGenome:HGNC:7805
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HAP3; CBF-A; CBF-B; NF-YB
Summary
The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in prostate (RPKM 10.4), endometrium (RPKM 9.3) and 25 other tissues See more
Orthologs
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Genomic context

See NFYB in Genome Data Viewer
Location:
12q23.3
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (104117086..104138210, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (104078781..104099908, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (104510864..104531988, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene glycosyltransferase 8 domain containing 2 Neighboring gene phosphoglycerate mutase 1 (brain) pseudogene Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23711 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23714 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4784 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:104458005-104458174 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4785 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4786 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23722 Neighboring gene host cell factor C2 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23731 Neighboring gene RNA, 5S ribosomal pseudogene 370 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:104530547-104531140 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:104531141-104531732 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4789 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4790 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23735 Neighboring gene uncharacterized LOC105369947 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23741 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23744 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23747 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23754 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23756 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23757 Neighboring gene long intergenic non-protein coding RNA 2385

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Component Evidence Code Pubs
part_of CCAAT-binding factor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of CCAAT-binding factor complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of CCAAT-binding factor complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of RNA polymerase II transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-DNA complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
nuclear transcription factor Y subunit beta
Names
CAAT box DNA-binding protein subunit B
CCAAT-binding transcription factor subunit A
Transcription factor NF-Y, B subunit
nuclear transcription factor Y subunit B
nuclear transcription factor Y, beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001414518.1NP_001401447.1  nuclear transcription factor Y subunit beta isoform a

    Status: REVIEWED

    Source sequence(s)
    AC089983
    UniProtKB/TrEMBL
    F8VSL3
    Related
    ENSP00000448250.2, ENST00000551446.6
  2. NM_001414519.1NP_001401448.1  nuclear transcription factor Y subunit beta isoform a

    Status: REVIEWED

    Source sequence(s)
    AC089983
    UniProtKB/TrEMBL
    F8VSL3
  3. NM_001414520.1NP_001401449.1  nuclear transcription factor Y subunit beta isoform b

    Status: REVIEWED

    Source sequence(s)
    AC089983
    UniProtKB/Swiss-Prot
    A8K7B9, P25208, Q96IY8
  4. NM_001414521.1NP_001401450.1  nuclear transcription factor Y subunit beta isoform b

    Status: REVIEWED

    Source sequence(s)
    AC089983
    UniProtKB/Swiss-Prot
    A8K7B9, P25208, Q96IY8
    Related
    ENSP00000447486.1, ENST00000551727.5
  5. NM_001414522.1NP_001401451.1  nuclear transcription factor Y subunit beta isoform c

    Status: REVIEWED

    Source sequence(s)
    AC089983
  6. NM_001414523.1NP_001401452.1  nuclear transcription factor Y subunit beta isoform d

    Status: REVIEWED

    Source sequence(s)
    AC089983
  7. NM_001414524.1NP_001401453.1  nuclear transcription factor Y subunit beta isoform d

    Status: REVIEWED

    Source sequence(s)
    AC089983
  8. NM_001414525.1NP_001401454.1  nuclear transcription factor Y subunit beta isoform d

    Status: REVIEWED

    Source sequence(s)
    AC089983
  9. NM_001414526.1NP_001401455.1  nuclear transcription factor Y subunit beta isoform d

    Status: REVIEWED

    Source sequence(s)
    AC089983
  10. NM_001414527.1NP_001401456.1  nuclear transcription factor Y subunit beta isoform e

    Status: REVIEWED

    Source sequence(s)
    AC089983
  11. NM_001414528.1NP_001401457.1  nuclear transcription factor Y subunit beta isoform f

    Status: REVIEWED

    Source sequence(s)
    AC089983
  12. NM_001414529.1NP_001401458.1  nuclear transcription factor Y subunit beta isoform f

    Status: REVIEWED

    Source sequence(s)
    AC089983
  13. NM_001414530.1NP_001401459.1  nuclear transcription factor Y subunit beta isoform g

    Status: REVIEWED

    Source sequence(s)
    AC089983
  14. NM_001414531.1NP_001401460.1  nuclear transcription factor Y subunit beta isoform h

    Status: REVIEWED

    Source sequence(s)
    AC089983
  15. NM_001414532.1NP_001401461.1  nuclear transcription factor Y subunit beta isoform h

    Status: REVIEWED

    Source sequence(s)
    AC089983
  16. NM_006166.4NP_006157.1  nuclear transcription factor Y subunit beta isoform b

    See identical proteins and their annotated locations for NP_006157.1

    Status: REVIEWED

    Source sequence(s)
    AA479300, AL042186, AU151875, AW576189, BC005316, BF032637, BG776259, BQ420877, CD678671
    Consensus CDS
    CCDS9098.1
    UniProtKB/Swiss-Prot
    A8K7B9, P25208, Q96IY8
    Related
    ENSP00000240055.3, ENST00000240055.8
    Conserved Domains (1) summary
    pfam00808
    Location:57122
    CBFD_NFYB_HMF; Histone-like transcription factor (CBF/NF-Y) and archaeal histone

RNA

  1. NR_182773.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC089983
  2. NR_182774.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC089983

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    104117086..104138210 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005268910.5XP_005268967.1  nuclear transcription factor Y subunit beta isoform X1

    See identical proteins and their annotated locations for XP_005268967.1

    UniProtKB/TrEMBL
    F8VSL3
    Conserved Domains (1) summary
    pfam00808
    Location:58123
    CBFD_NFYB_HMF; Histone-like transcription factor (CBF/NF-Y) and archaeal histone
  2. XM_047428880.1XP_047284836.1  nuclear transcription factor Y subunit beta isoform X2

    UniProtKB/Swiss-Prot
    A8K7B9, P25208, Q96IY8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    104078781..104099908 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054372113.1XP_054228088.1  nuclear transcription factor Y subunit beta isoform X1

    UniProtKB/TrEMBL
    F8VSL3
  2. XM_054372114.1XP_054228089.1  nuclear transcription factor Y subunit beta isoform X2

    UniProtKB/Swiss-Prot
    A8K7B9, P25208, Q96IY8