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CREBBP CREB binding protein [ Canis lupus familiaris (dog) ]

Gene ID: 479866, updated on 17-Aug-2024

Summary

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Official Symbol
CREBBPprovided by VGNC
Official Full Name
CREB binding proteinprovided by VGNC
Primary source
VGNC:VGNC:39601
See related
Ensembl:ENSCAFG00845001617
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 6
Exon count:
33
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 6 NC_051810.1 (37623705..37751833)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 6 NC_006588.4 (38739122..38865694)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 6 NC_049227.1 (37712371..37838937)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 6 NC_049266.1 (37408543..37535100)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 6 NC_049747.1 (37301774..37428236)

Chromosome 6 - NC_051810.1Genomic Context describing neighboring genes Neighboring gene U1 spliceosomal RNA Neighboring gene adenylate cyclase 9 Neighboring gene uncharacterized LOC119872337 Neighboring gene TNF receptor associated protein 1 Neighboring gene uncharacterized LOC119881518 Neighboring gene deoxyribonuclease 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of a prostaglandin-responsive element in the Na,K-ATPase beta 1 promoter that is regulated by cAMP and Ca2+. Evidence for an interactive role of cAMP regulatory element-binding protein and Sp1. Matlhagela K, et al. J Biol Chem, 2005 Jan 7. PMID 15485816

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables chromatin DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables histone acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transcription coactivator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of histone acetyltransferase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of transcription regulator complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
CREB-binding protein; LOW QUALITY PROTEIN: CREB-binding protein
Names
CREB binding protein (Rubinstein-Taybi syndrome)
XP_003434912.1
XP_038335248.1
XP_038335249.1
XP_038396497.1
XP_038396498.1
XP_038404514.1
XP_038460596.1
XP_038460597.1
XP_038523574.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051810.1 Reference ROS_Cfam_1.0

    Range
    37623705..37751833
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038667646.1 → XP_038523574.1  LOW QUALITY PROTEIN: CREB-binding protein isoform X1

    UniProtKB/TrEMBL
    A0A8C0YZ36, A0A8P0SXJ8
    Related
    ENSCAFP00845002277.1, ENSCAFT00845002858.1
    Conserved Domains (11) summary
    cd05495
    Location:1197 → 1304
    Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
    PHA03247
    Location:787 → 1128
    PHA03247; large tegument protein UL36; Provisional
    COG5076
    Location:1051 → 1303
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    cd02337
    Location:1815 → 1855
    ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
    cd15802
    Location:1316 → 1388
    RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
    cd15557
    Location:1390 → 1421
    PHD_CBP_p300; PHD finger found in CREB-binding protein (CBP) and histone acetyltransferase p300
    pfam09606
    Location:2070 → 2520
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam02172
    Location:694 → 774
    KIX; KIX domain
    pfam02135
    Location:470 → 537
    zf-TAZ; TAZ zinc finger
    pfam08214
    Location:1452 → 1759
    HAT_KAT11; Histone acetylation protein
    pfam09030
    Location:2144 → 2222
    Creb_binding; Creb binding

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049266.1 Alternate UMICH_Zoey_3.1

    Range
    37408543..37535100
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038479320.1 → XP_038335248.1  CREB-binding protein isoform X2

  2. XM_038479321.1 → XP_038335249.1  CREB-binding protein isoform X3

    Conserved Domains (11) summary
    cd05495
    Location:1031 → 1138
    Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
    PHA03247
    Location:621 → 962
    PHA03247; large tegument protein UL36; Provisional
    COG5076
    Location:885 → 1137
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    cd02337
    Location:1649 → 1689
    ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
    cd15802
    Location:1150 → 1222
    RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
    cd15557
    Location:1224 → 1255
    PHD_CBP_p300; PHD finger found in CREB-binding protein (CBP) and histone acetyltransferase p300
    pfam09606
    Location:1904 → 2354
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam02172
    Location:528 → 608
    KIX; KIX domain
    pfam02135
    Location:304 → 371
    zf-TAZ; TAZ zinc finger
    pfam08214
    Location:1286 → 1593
    HAT_KAT11; Histone acetylation protein
    pfam09030
    Location:1978 → 2056
    Creb_binding; Creb binding

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049747.1 Alternate UNSW_CanFamBas_1.0

    Range
    37301774..37428236
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038604668.1 → XP_038460596.1  CREB-binding protein isoform X4

  2. XM_038604669.1 → XP_038460597.1  CREB-binding protein isoform X5

    Conserved Domains (11) summary
    cd05495
    Location:1031 → 1138
    Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
    PHA03247
    Location:621 → 962
    PHA03247; large tegument protein UL36; Provisional
    COG5076
    Location:885 → 1137
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    cd02337
    Location:1649 → 1689
    ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
    cd15802
    Location:1150 → 1222
    RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
    cd15557
    Location:1224 → 1255
    PHD_CBP_p300; PHD finger found in CREB-binding protein (CBP) and histone acetyltransferase p300
    pfam09606
    Location:1904 → 2354
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam02172
    Location:528 → 608
    KIX; KIX domain
    pfam02135
    Location:304 → 371
    zf-TAZ; TAZ zinc finger
    pfam08214
    Location:1286 → 1593
    HAT_KAT11; Histone acetylation protein
    pfam09030
    Location:1978 → 2056
    Creb_binding; Creb binding

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049227.1 Alternate UU_Cfam_GSD_1.0

    Range
    37712371..37838937
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038540569.1 → XP_038396497.1  CREB-binding protein isoform X6

    UniProtKB/TrEMBL
    A0A8C0LST7, A0A8C0SS06, A0A8C0YZ36, A0A8P0NNM4, A0A8P0SXJ8

  2. XM_038540570.1 → XP_038396498.1  CREB-binding protein isoform X7

    UniProtKB/TrEMBL
    A0A8C0RBV5, A0A8C0YZ36, A0A8P0PET3, A0A8P0SXJ8
    Conserved Domains (11) summary
    cd05495
    Location:1031 → 1138
    Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
    PHA03247
    Location:621 → 962
    PHA03247; large tegument protein UL36; Provisional
    COG5076
    Location:885 → 1137
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    cd02337
    Location:1649 → 1689
    ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
    cd15802
    Location:1150 → 1222
    RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
    cd15557
    Location:1224 → 1255
    PHD_CBP_p300; PHD finger found in CREB-binding protein (CBP) and histone acetyltransferase p300
    pfam09606
    Location:1904 → 2354
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam02172
    Location:528 → 608
    KIX; KIX domain
    pfam02135
    Location:304 → 371
    zf-TAZ; TAZ zinc finger
    pfam08214
    Location:1286 → 1593
    HAT_KAT11; Histone acetylation protein
    pfam09030
    Location:1978 → 2056
    Creb_binding; Creb binding

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006588.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    38739122..38865694
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003434864.5 → XP_003434912.1  CREB-binding protein isoform X8

    UniProtKB/TrEMBL
    A0A8C0LST7, A0A8C0SS06, A0A8C0YZ36, A0A8P0NNM4, A0A8P0SXJ8
    Conserved Domains (10) summary
    cd05495
    Location:1090 → 1197
    Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
    cd02337
    Location:1708 → 1748
    ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
    cd15802
    Location:1209 → 1281
    RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
    cd15557
    Location:1283 → 1314
    PHD_CBP_p300; PHD finger found in CREB-binding protein (CBP) and histone acetyltransferase p300
    pfam02172
    Location:587 → 667
    KIX; KIX domain
    pfam02135
    Location:363 → 430
    zf-TAZ; TAZ zinc finger
    pfam08214
    Location:1345 → 1652
    HAT_KAT11; Histone acetylation protein
    pfam09030
    Location:2037 → 2115
    Creb_binding; Creb binding
    pfam09606
    Location:1963 → 2413
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl26464
    Location:680 → 1021
    Atrophin-1; Atrophin-1 family

  2. XM_038548586.1 → XP_038404514.1  CREB-binding protein isoform X9

    UniProtKB/TrEMBL
    A0A8C0RBV5, A0A8C0YZ36, A0A8P0PET3, A0A8P0SXJ8
    Conserved Domains (11) summary
    cd05495
    Location:1031 → 1138
    Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
    PHA03247
    Location:621 → 962
    PHA03247; large tegument protein UL36; Provisional
    COG5076
    Location:885 → 1137
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    cd02337
    Location:1649 → 1689
    ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
    cd15802
    Location:1150 → 1222
    RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
    cd15557
    Location:1224 → 1255
    PHD_CBP_p300; PHD finger found in CREB-binding protein (CBP) and histone acetyltransferase p300
    pfam09606
    Location:1904 → 2354
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam02172
    Location:528 → 608
    KIX; KIX domain
    pfam02135
    Location:304 → 371
    zf-TAZ; TAZ zinc finger
    pfam08214
    Location:1286 → 1593
    HAT_KAT11; Histone acetylation protein
    pfam09030
    Location:1978 → 2056
    Creb_binding; Creb binding
Nucleotide Protein
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