ABAT 4-aminobutyrate aminotransferase [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: ABATprovided by VGNC
Official Full Name: 4-aminobutyrate aminotransferaseprovided by VGNC
Primary source: VGNC:VGNC:37421
See related: Ensembl:ENSCAFG00000019030
Gene type: protein coding
RefSeq status: MODEL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all

Genomic context

Location:: chromosome: 6

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
105	current	CanFam3.1 (GCF_000002285.3)	6	NC_006588.3 (33385779..33471348, complement)

Chromosome 6 - NC_006588.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_006588.3 Chromosome 6 Reference CanFam3.1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

direct involvement of ABAT in pathways affecting lower esophageal sphincter (LES) control in gastro esophageal reflux disease
Title: 4-aminobutyrate aminotransferase (ABAT): genetic and pharmacological evidence for an involvement in gastro esophageal reflux disease.

Submit: New GeneRIF Correction

Variation

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Genotypes

See SNP Geneview Report

Pathways from BioSystems

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Alanine, aspartate and glutamate metabolism, organism-specific biosystem (from KEGG)
Alanine, aspartate and glutamate metabolism, organism-specific biosystem
Alanine, aspartate and glutamate metabolism
Alanine, aspartate and glutamate metabolism, conserved biosystem (from KEGG)
Alanine, aspartate and glutamate metabolism, conserved biosystem
Alanine, aspartate and glutamate metabolism
Butanoate metabolism, organism-specific biosystem (from KEGG)
Butanoate metabolism, organism-specific biosystem
Butanoate metabolism
Butanoate metabolism, conserved biosystem (from KEGG)
Butanoate metabolism, conserved biosystem
Butanoate metabolism
Degradation of GABA, organism-specific biosystem (from REACTOME)
Degradation of GABA, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GABA (gamma-Aminobutyrate) shunt, organism-specific biosystem (from KEGG)
GABA (gamma-Aminobutyrate) shunt, organism-specific biosystemPathway module; Nucleotide and amino acid metabolism; Other amino acid metabolism
GABA (gamma-Aminobutyrate) shunt, conserved biosystem (from KEGG)
GABA (gamma-Aminobutyrate) shunt, conserved biosystemPathway module; Nucleotide and amino acid metabolism; Other amino acid metabolism
GABA synthesis, release, reuptake and degradation, organism-specific biosystem (from REACTOME)
GABA synthesis, release, reuptake and degradation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GABAergic synapse, organism-specific biosystem (from KEGG)
GABAergic synapse, organism-specific biosystemGamma aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the mammalian central nervous system (CNS). When released in the synaptic cleft, GABA binds to three major classes o...
GABAergic synapse, conserved biosystem (from KEGG)
GABAergic synapse, conserved biosystemGamma aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the mammalian central nervous system (CNS). When released in the synaptic cleft, GABA binds to three major classes o...
Metabolic pathways, organism-specific biosystem (from KEGG)
Metabolic pathways, organism-specific biosystem
Metabolic pathways
Neuronal System, organism-specific biosystem (from REACTOME)
Neuronal System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Neurotransmitter Release Cycle, organism-specific biosystem (from REACTOME)
Neurotransmitter Release Cycle, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Propanoate metabolism, organism-specific biosystem (from KEGG)
Propanoate metabolism, organism-specific biosystem
Propanoate metabolism
Propanoate metabolism, conserved biosystem (from KEGG)
Propanoate metabolism, conserved biosystem
Propanoate metabolism
Transmission across Chemical Synapses, organism-specific biosystem (from REACTOME)
Transmission across Chemical Synapses, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Valine, leucine and isoleucine degradation, organism-specific biosystem (from KEGG)
Valine, leucine and isoleucine degradation, organism-specific biosystem
Valine, leucine and isoleucine degradation
Valine, leucine and isoleucine degradation, conserved biosystem (from KEGG)
Valine, leucine and isoleucine degradation, conserved biosystem
Valine, leucine and isoleucine degradation
beta-Alanine metabolism, organism-specific biosystem (from KEGG)
beta-Alanine metabolism, organism-specific biosystem
beta-Alanine metabolism
beta-Alanine metabolism, conserved biosystem (from KEGG)
beta-Alanine metabolism, conserved biosystem
beta-Alanine metabolism

General gene information

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Homology

Homologs of the ABAT gene: The ABAT gene is conserved in human, chimpanzee, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, and frog.
Orthologs from Annotation Pipeline: 247 organisms have orthologs with human gene ABAT
The Hierarchical Catalog of Orthologs

General protein information

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Preferred Names: 4-aminobutyrate aminotransferase, mitochondrial

XP_005621619.1

EC 2.6.1.19

EC 2.6.1.22

XP_022275790.1

EC 2.6.1.19

EC 2.6.1.22

XP_851424.2

EC 2.6.1.19

EC 2.6.1.22

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference CanFam3.1 Primary Assembly

Genomic

NC_006588.3 Reference CanFam3.1 Primary Assembly

Range

33385779..33471348 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_846331.5 → XP_851424.2 4-aminobutyrate aminotransferase, mitochondrial

See identical proteins and their annotated locations for XP_851424.2

UniProtKB/TrEMBL

E2R776

Related

ENSCAFP00000028090.3, ENSCAFT00000030230.3

Conserved Domains (1) summary

TIGR00699
Location:34 → 496

GABAtrns_euk; 4-aminobutyrate aminotransferase, eukaryotic type
XM_005621562.3 → XP_005621619.1 4-aminobutyrate aminotransferase, mitochondrial

See identical proteins and their annotated locations for XP_005621619.1

UniProtKB/TrEMBL

E2R776

Conserved Domains (1) summary

TIGR00699
Location:34 → 496

GABAtrns_euk; 4-aminobutyrate aminotransferase, eukaryotic type
XM_022420082.1 → XP_022275790.1 4-aminobutyrate aminotransferase, mitochondrial

Conserved Domains (1) summary

TIGR00699
Location:34 → 496

GABAtrns_euk; 4-aminobutyrate aminotransferase, eukaryotic type