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SMG1 SMG1 nonsense mediated mRNA decay associated PI3K related kinase [ Canis lupus familiaris (dog) ]

Gene ID: 479832, updated on 25-Jul-2026
Official Symbol
SMG1provided by VGNC
Official Full Name
SMG1 nonsense mediated mRNA decay associated PI3K related kinaseprovided by VGNC
Primary source
VGNC:VGNC:46554
See related
Ensembl:ENSCAFG00845006073 RGD:12191434
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
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Try the new Transcripts and proteins table
See SMG1 in Genome Data Viewer
Location:
chromosome: 6
Exon count:
64
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 6 NC_051810.1 (26358423..26466667)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 6 NC_006588.4 (27565146..27672295)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 6 NC_049227.1 (26442823..26550125)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 6 NC_049266.1 (26158691..26265646)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 6 NC_049747.1 (26054208..26161313)

Chromosome 6 - NC_051810.1Genomic Context describing neighboring genes Neighboring gene C-type lectin domain containing 19A Neighboring gene uncharacterized LOC111096499 Neighboring gene uncharacterized LOC111096292 Neighboring gene ARL6 interacting reticulophagy regulator 1 Neighboring gene ribosomal protein S15a

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
serine/threonine-protein kinase SMG1
Names
SMG1 homolog, phosphatidylinositol 3-kinase-related kinase
smg-1 homolog, phosphatidylinositol 3-kinase-related kinase
XP_038334948.1
XP_038334949.1
XP_038334950.1
XP_038334951.1
XP_038396177.1
XP_038396178.1
XP_038396179.1
XP_038396180.1
XP_038401965.1
XP_038401969.1
XP_038401975.1
XP_038401979.1
XP_038460275.1
XP_038460276.1
XP_038460277.1
XP_038460278.1
XP_038524985.1
XP_038524986.1
XP_038524987.1
XP_038524988.1

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051810.1 Reference ROS_Cfam_1.0

    Range
    26358423..26466667
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038669059.1 → XP_038524987.1  serine/threonine-protein kinase SMG1 isoform X3

    UniProtKB/TrEMBL
    A0A8C0LCD9
    Conserved Domains (4) summary
    cd05170
    Location:2119 → 2424
    PIKKc_SMG1; Catalytic domain of Suppressor of Morphogenetic effect on Genitalia-1
    pfam02260
    Location:3628 → 3657
    FATC; FATC domain
    pfam15785
    Location:630 → 1240
    SMG1; Serine/threonine-protein kinase smg-1
    pfam17229
    Location:31 → 139
    DUF5303; Region of unknown function (DUF5303)

  2. XM_038669057.1 → XP_038524985.1  serine/threonine-protein kinase SMG1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LCD9, A0A8I3N269
    Related
    ENSCAFP00845008650.1, ENSCAFT00845011087.1
    Conserved Domains (4) summary
    cd05170
    Location:2119 → 2424
    PIKKc_SMG1; Catalytic domain of Suppressor of Morphogenetic effect on Genitalia-1
    pfam02260
    Location:3629 → 3658
    FATC; FATC domain
    pfam15785
    Location:630 → 1240
    SMG1; Serine/threonine-protein kinase smg-1
    pfam17229
    Location:31 → 139
    DUF5303; Region of unknown function (DUF5303)

  3. XM_038669058.1 → XP_038524986.1  serine/threonine-protein kinase SMG1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0LCD9
    Conserved Domains (4) summary
    cd05170
    Location:2118 → 2423
    PIKKc_SMG1; Catalytic domain of Suppressor of Morphogenetic effect on Genitalia-1
    pfam02260
    Location:3628 → 3657
    FATC; FATC domain
    pfam15785
    Location:629 → 1239
    SMG1; Serine/threonine-protein kinase smg-1
    pfam17229
    Location:31 → 139
    DUF5303; Region of unknown function (DUF5303)

  4. XM_038669060.1 → XP_038524988.1  serine/threonine-protein kinase SMG1 isoform X4

    UniProtKB/TrEMBL
    A0A8C0LCD9, A0A8I3MXW5
    Related
    ENSCAFP00845008441.1, ENSCAFT00845010815.1
    Conserved Domains (4) summary
    cd05170
    Location:2094 → 2399
    PIKKc_SMG1; Catalytic domain of Suppressor of Morphogenetic effect on Genitalia-1
    pfam02260
    Location:3604 → 3633
    FATC; FATC domain
    pfam15785
    Location:605 → 1215
    SMG1; Serine/threonine-protein kinase smg-1
    pfam17229
    Location:6 → 114
    DUF5303; Region of unknown function (DUF5303)

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049266.1 Alternate UMICH_Zoey_3.1

    Range
    26158691..26265646
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038479022.1 → XP_038334950.1  

    Conserved Domains (4) summary
    cd05170
    Location:2119 → 2424
    PIKKc_SMG1; Catalytic domain of Suppressor of Morphogenetic effect on Genitalia-1
    pfam02260
    Location:3628 → 3657
    FATC; FATC domain
    pfam15785
    Location:630 → 1240
    SMG1; Serine/threonine-protein kinase smg-1
    pfam17229
    Location:31 → 139
    DUF5303; Region of unknown function (DUF5303)

  2. XM_038479020.1 → XP_038334948.1  

    Conserved Domains (4) summary
    cd05170
    Location:2119 → 2424
    PIKKc_SMG1; Catalytic domain of Suppressor of Morphogenetic effect on Genitalia-1
    pfam02260
    Location:3629 → 3658
    FATC; FATC domain
    pfam15785
    Location:630 → 1240
    SMG1; Serine/threonine-protein kinase smg-1
    pfam17229
    Location:31 → 139
    DUF5303; Region of unknown function (DUF5303)

  3. XM_038479021.1 → XP_038334949.1  

    Conserved Domains (4) summary
    cd05170
    Location:2118 → 2423
    PIKKc_SMG1; Catalytic domain of Suppressor of Morphogenetic effect on Genitalia-1
    pfam02260
    Location:3628 → 3657
    FATC; FATC domain
    pfam15785
    Location:629 → 1239
    SMG1; Serine/threonine-protein kinase smg-1
    pfam17229
    Location:31 → 139
    DUF5303; Region of unknown function (DUF5303)

  4. XM_038479023.1 → XP_038334951.1  

    Conserved Domains (4) summary
    cd05170
    Location:2094 → 2399
    PIKKc_SMG1; Catalytic domain of Suppressor of Morphogenetic effect on Genitalia-1
    pfam02260
    Location:3604 → 3633
    FATC; FATC domain
    pfam15785
    Location:605 → 1215
    SMG1; Serine/threonine-protein kinase smg-1
    pfam17229
    Location:6 → 114
    DUF5303; Region of unknown function (DUF5303)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049747.1 Alternate UNSW_CanFamBas_1.0

    Range
    26054208..26161313
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038604349.1 → XP_038460277.1  

    Conserved Domains (4) summary
    cd05170
    Location:2119 → 2424
    PIKKc_SMG1; Catalytic domain of Suppressor of Morphogenetic effect on Genitalia-1
    pfam02260
    Location:3628 → 3657
    FATC; FATC domain
    pfam15785
    Location:630 → 1240
    SMG1; Serine/threonine-protein kinase smg-1
    pfam17229
    Location:31 → 139
    DUF5303; Region of unknown function (DUF5303)

  2. XM_038604347.1 → XP_038460275.1  

    Conserved Domains (4) summary
    cd05170
    Location:2119 → 2424
    PIKKc_SMG1; Catalytic domain of Suppressor of Morphogenetic effect on Genitalia-1
    pfam02260
    Location:3629 → 3658
    FATC; FATC domain
    pfam15785
    Location:630 → 1240
    SMG1; Serine/threonine-protein kinase smg-1
    pfam17229
    Location:31 → 139
    DUF5303; Region of unknown function (DUF5303)

  3. XM_038604348.1 → XP_038460276.1  

    Conserved Domains (4) summary
    cd05170
    Location:2118 → 2423
    PIKKc_SMG1; Catalytic domain of Suppressor of Morphogenetic effect on Genitalia-1
    pfam02260
    Location:3628 → 3657
    FATC; FATC domain
    pfam15785
    Location:629 → 1239
    SMG1; Serine/threonine-protein kinase smg-1
    pfam17229
    Location:31 → 139
    DUF5303; Region of unknown function (DUF5303)

  4. XM_038604350.1 → XP_038460278.1  

    Conserved Domains (4) summary
    cd05170
    Location:2094 → 2399
    PIKKc_SMG1; Catalytic domain of Suppressor of Morphogenetic effect on Genitalia-1
    pfam02260
    Location:3604 → 3633
    FATC; FATC domain
    pfam15785
    Location:605 → 1215
    SMG1; Serine/threonine-protein kinase smg-1
    pfam17229
    Location:6 → 114
    DUF5303; Region of unknown function (DUF5303)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049227.1 Alternate UU_Cfam_GSD_1.0

    Range
    26442823..26550125
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038540251.1 → XP_038396179.1  serine/threonine-protein kinase SMG1 isoform X3

    UniProtKB/TrEMBL
    A0A8C0LCD9
    Conserved Domains (4) summary
    cd05170
    Location:2119 → 2424
    PIKKc_SMG1; Catalytic domain of Suppressor of Morphogenetic effect on Genitalia-1
    pfam02260
    Location:3628 → 3657
    FATC; FATC domain
    pfam15785
    Location:630 → 1240
    SMG1; Serine/threonine-protein kinase smg-1
    pfam17229
    Location:31 → 139
    DUF5303; Region of unknown function (DUF5303)

  2. XM_038540249.1 → XP_038396177.1  serine/threonine-protein kinase SMG1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LCD9, A0A8I3N269
    Conserved Domains (4) summary
    cd05170
    Location:2119 → 2424
    PIKKc_SMG1; Catalytic domain of Suppressor of Morphogenetic effect on Genitalia-1
    pfam02260
    Location:3629 → 3658
    FATC; FATC domain
    pfam15785
    Location:630 → 1240
    SMG1; Serine/threonine-protein kinase smg-1
    pfam17229
    Location:31 → 139
    DUF5303; Region of unknown function (DUF5303)

  3. XM_038540250.1 → XP_038396178.1  serine/threonine-protein kinase SMG1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0LCD9
    Conserved Domains (4) summary
    cd05170
    Location:2118 → 2423
    PIKKc_SMG1; Catalytic domain of Suppressor of Morphogenetic effect on Genitalia-1
    pfam02260
    Location:3628 → 3657
    FATC; FATC domain
    pfam15785
    Location:629 → 1239
    SMG1; Serine/threonine-protein kinase smg-1
    pfam17229
    Location:31 → 139
    DUF5303; Region of unknown function (DUF5303)

  4. XM_038540252.1 → XP_038396180.1  serine/threonine-protein kinase SMG1 isoform X4

    UniProtKB/TrEMBL
    A0A8C0LCD9, A0A8I3MXW5
    Conserved Domains (4) summary
    cd05170
    Location:2094 → 2399
    PIKKc_SMG1; Catalytic domain of Suppressor of Morphogenetic effect on Genitalia-1
    pfam02260
    Location:3604 → 3633
    FATC; FATC domain
    pfam15785
    Location:605 → 1215
    SMG1; Serine/threonine-protein kinase smg-1
    pfam17229
    Location:6 → 114
    DUF5303; Region of unknown function (DUF5303)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006588.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    27565146..27672295
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038546047.1 → XP_038401975.1  serine/threonine-protein kinase SMG1 isoform X3

    UniProtKB/TrEMBL
    A0A8C0LCD9
    Conserved Domains (4) summary
    cd05170
    Location:2119 → 2424
    PIKKc_SMG1; Catalytic domain of Suppressor of Morphogenetic effect on Genitalia-1
    pfam02260
    Location:3628 → 3657
    FATC; FATC domain
    pfam15785
    Location:630 → 1240
    SMG1; Serine/threonine-protein kinase smg-1
    pfam17229
    Location:31 → 139
    DUF5303; Region of unknown function (DUF5303)

  2. XM_038546037.1 → XP_038401965.1  serine/threonine-protein kinase SMG1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LCD9, A0A8I3N269
    Conserved Domains (4) summary
    cd05170
    Location:2119 → 2424
    PIKKc_SMG1; Catalytic domain of Suppressor of Morphogenetic effect on Genitalia-1
    pfam02260
    Location:3629 → 3658
    FATC; FATC domain
    pfam15785
    Location:630 → 1240
    SMG1; Serine/threonine-protein kinase smg-1
    pfam17229
    Location:31 → 139
    DUF5303; Region of unknown function (DUF5303)

  3. XM_038546041.1 → XP_038401969.1  serine/threonine-protein kinase SMG1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0LCD9
    Conserved Domains (4) summary
    cd05170
    Location:2118 → 2423
    PIKKc_SMG1; Catalytic domain of Suppressor of Morphogenetic effect on Genitalia-1
    pfam02260
    Location:3628 → 3657
    FATC; FATC domain
    pfam15785
    Location:629 → 1239
    SMG1; Serine/threonine-protein kinase smg-1
    pfam17229
    Location:31 → 139
    DUF5303; Region of unknown function (DUF5303)

  4. XM_038546051.1 → XP_038401979.1  serine/threonine-protein kinase SMG1 isoform X4

    UniProtKB/TrEMBL
    A0A8C0LCD9, A0A8I3MXW5
    Conserved Domains (4) summary
    cd05170
    Location:2094 → 2399
    PIKKc_SMG1; Catalytic domain of Suppressor of Morphogenetic effect on Genitalia-1
    pfam02260
    Location:3604 → 3633
    FATC; FATC domain
    pfam15785
    Location:605 → 1215
    SMG1; Serine/threonine-protein kinase smg-1
    pfam17229
    Location:6 → 114
    DUF5303; Region of unknown function (DUF5303)
Nucleotide Protein
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