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NFRKB nuclear factor related to kappaB binding protein [ Homo sapiens (human) ]

Gene ID: 4798, updated on 11-Jul-2019

Summary

Official Symbol
NFRKBprovided by HGNC
Official Full Name
nuclear factor related to kappaB binding proteinprovided by HGNC
Primary source
HGNC:HGNC:7802
See related
Ensembl:ENSG00000170322 MIM:164013
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
INO80G
Expression
Ubiquitous expression in testis (RPKM 11.1), ovary (RPKM 7.8) and 25 other tissues See more
Orthologs

Genomic context

See NFRKB in Genome Data Viewer
Location:
11q24.3
Exon count:
32
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (129863636..129895596, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (129733670..129765490, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene transmembrane protein 45B Neighboring gene TMEM45B-NFRKB intergenic CAGE-defined mid-level expression enhancer Neighboring gene PR/SET domain 10 Neighboring gene long intergenic non-protein coding RNA 167 Neighboring gene elongin B pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • DNA Damage Recognition in GG-NER, organism-specific biosystem (from REACTOME)
    DNA Damage Recognition in GG-NER, organism-specific biosystemIn global genome nucleotide excision repair (GG-NER), the DNA damage is recognized by two protein complexes. The first complex consists of XPC, RAD23A or RAD23B, and CETN2. This complex probes the DN...
  • DNA Repair, organism-specific biosystem (from REACTOME)
    DNA Repair, organism-specific biosystemDNA repair is a phenomenal multi-enzyme, multi-pathway system required to ensure the integrity of the cellular genome. Living organisms are constantly exposed to harmful metabolic by-products, enviro...
  • Deubiquitination, organism-specific biosystem (from REACTOME)
    Deubiquitination, organism-specific biosystemUbiquitination, the modification of proteins by the covalent attachment of ubiquitin (Ub), is a key regulatory mechanism for many many cellular processes, including protein degradation by the 26S pro...
  • Global Genome Nucleotide Excision Repair (GG-NER), organism-specific biosystem (from REACTOME)
    Global Genome Nucleotide Excision Repair (GG-NER), organism-specific biosystemThe DNA damage in GG-NER is recognized by the joint action of two protein complexes. The first complex is composed of XPC, RAD23A or RAD23B and CETN2. The second complex, known as the UV-DDB complex,...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Nucleotide Excision Repair, organism-specific biosystem (from REACTOME)
    Nucleotide Excision Repair, organism-specific biosystemNucleotide excision repair (NER) was first described in the model organism E. coli in the early 1960s as a process whereby bulky base damage is enzymatically removed from DNA, facilitating the recove...
  • Overview of nanoparticle effects, organism-specific biosystem (from WikiPathways)
    Overview of nanoparticle effects, organism-specific biosystemThis pathway is giving a summary of currently known nanoparticle effects on cells and organisms. Although there is currently no nanoparticle specific effect known, there is a cascade of effects trigg...
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • UCH proteinases, organism-specific biosystem (from REACTOME)
    UCH proteinases, organism-specific biosystemDUBs of the Ub C-terminal Hydrolase (UCH) family are thiol proteases that have an N-terminal catalytic domain sometimes followed by C-terminal extensions that mediate protein-protein interactions. Hu...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp547B2013

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
protease binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA recombination IEA
Inferred from Electronic Annotation
more info
 
DNA repair IEA
Inferred from Electronic Annotation
more info
 
inflammatory response TAS
Traceable Author Statement
more info
PubMed 
protein deubiquitination TAS
Traceable Author Statement
more info
 
transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with Ino80 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Ino80 complex IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with Ino80 complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
nuclear factor related to kappa-B-binding protein
Names
DNA-binding protein R kappa B
INO80 complex subunit G

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001143835.2NP_001137307.1  nuclear factor related to kappa-B-binding protein isoform 1

    See identical proteins and their annotated locations for NP_001137307.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (1).
    Source sequence(s)
    AP003327
    Consensus CDS
    CCDS44770.1
    UniProtKB/Swiss-Prot
    Q6P4R8
    UniProtKB/TrEMBL
    A0A024R3K9
    Related
    ENSP00000400476.2, ENST00000446488.7
    Conserved Domains (1) summary
    pfam14465
    Location:392476
    NFRKB_winged; NFRKB Winged Helix-like
  2. NM_006165.3NP_006156.2  nuclear factor related to kappa-B-binding protein isoform 2

    See identical proteins and their annotated locations for NP_006156.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter, differs in the 5' UTR and 5' coding region, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (2) has a longer N-terminus and includes an additional internal segment, compared to isoform 1.
    Source sequence(s)
    AL512730, BC063280, BM975529, X80878
    Consensus CDS
    CCDS8483.1
    UniProtKB/Swiss-Prot
    Q6P4R8
    Related
    ENSP00000436926.1, ENST00000524794.5
    Conserved Domains (1) summary
    pfam14465
    Location:417501
    NFRKB_winged; NFRKB Winged Helix-like

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    129863636..129895596 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017798.1XP_016873287.1  nuclear factor related to kappa-B-binding protein isoform X9

  2. XM_017017797.2XP_016873286.1  nuclear factor related to kappa-B-binding protein isoform X8

  3. XM_017017793.2XP_016873282.1  nuclear factor related to kappa-B-binding protein isoform X1

  4. XM_017017799.1XP_016873288.1  nuclear factor related to kappa-B-binding protein isoform X10

  5. XM_011542851.2XP_011541153.1  nuclear factor related to kappa-B-binding protein isoform X4

    See identical proteins and their annotated locations for XP_011541153.1

    UniProtKB/Swiss-Prot
    Q6P4R8
    Conserved Domains (1) summary
    pfam14465
    Location:417501
    NFRKB_winged; NFRKB Winged Helix-like
  6. XM_017017795.2XP_016873284.1  nuclear factor related to kappa-B-binding protein isoform X5

    Conserved Domains (1) summary
    pfam14465
    Location:415499
    NFRKB_winged; NFRKB Winged Helix-like
  7. XM_011542850.3XP_011541152.1  nuclear factor related to kappa-B-binding protein isoform X2

    Conserved Domains (1) summary
    pfam14465
    Location:427511
    NFRKB_winged; NFRKB Winged Helix-like
  8. XM_005271567.3XP_005271624.1  nuclear factor related to kappa-B-binding protein isoform X6

    See identical proteins and their annotated locations for XP_005271624.1

    Conserved Domains (1) summary
    pfam14465
    Location:404488
    NFRKB_winged; NFRKB Winged Helix-like
  9. XM_017017796.1XP_016873285.1  nuclear factor related to kappa-B-binding protein isoform X7

    UniProtKB/Swiss-Prot
    Q6P4R8
    UniProtKB/TrEMBL
    A0A024R3K9
    Conserved Domains (1) summary
    pfam14465
    Location:392476
    NFRKB_winged; NFRKB Winged Helix-like
  10. XM_005271568.3XP_005271625.1  nuclear factor related to kappa-B-binding protein isoform X6

    See identical proteins and their annotated locations for XP_005271625.1

    Conserved Domains (1) summary
    pfam14465
    Location:404488
    NFRKB_winged; NFRKB Winged Helix-like
  11. XM_017017800.2XP_016873289.1  nuclear factor related to kappa-B-binding protein isoform X10

  12. XM_011542852.2XP_011541154.1  nuclear factor related to kappa-B-binding protein isoform X4

    See identical proteins and their annotated locations for XP_011541154.1

    UniProtKB/Swiss-Prot
    Q6P4R8
    Conserved Domains (1) summary
    pfam14465
    Location:417501
    NFRKB_winged; NFRKB Winged Helix-like
  13. XM_017017794.2XP_016873283.1  nuclear factor related to kappa-B-binding protein isoform X3

  14. XM_024448526.1XP_024304294.1  nuclear factor related to kappa-B-binding protein isoform X11

    Conserved Domains (1) summary
    cl26464
    Location:158367
    Atrophin-1; Atrophin-1 family
  15. XM_017017801.2XP_016873290.1  nuclear factor related to kappa-B-binding protein isoform X11

    Conserved Domains (1) summary
    cl26464
    Location:158367
    Atrophin-1; Atrophin-1 family
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