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NFRKB nuclear factor related to kappaB binding protein [ Homo sapiens (human) ]

Gene ID: 4798, updated on 22-Sep-2022

Summary

Official Symbol
NFRKBprovided by HGNC
Official Full Name
nuclear factor related to kappaB binding proteinprovided by HGNC
Primary source
HGNC:HGNC:7802
See related
Ensembl:ENSG00000170322 MIM:164013; AllianceGenome:HGNC:7802
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
INO80G
Summary
Enables protease binding activity. Predicted to be involved in DNA recombination and DNA repair. Located in nucleoplasm. Colocalizes with Ino80 complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 11.1), ovary (RPKM 7.8) and 25 other tissues See more
Orthologs
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Genomic context

See NFRKB in Genome Data Viewer
Location:
11q24.3
Exon count:
27
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (129863636..129895578, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (129899341..129931605, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (129733531..129765473, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene transmembrane protein 45B Neighboring gene TMEM45B-NFRKB intergenic CAGE-defined mid-level expression enhancer Neighboring gene PR/SET domain 10 Neighboring gene Sharpr-MPRA regulatory region 3666 Neighboring gene PRDM10 divergent transcript

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp547B2013

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables protease binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of Ino80 complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
nuclear factor related to kappa-B-binding protein
Names
DNA-binding protein R kappa B
INO80 complex subunit G

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001143835.2NP_001137307.1  nuclear factor related to kappa-B-binding protein isoform 1

    See identical proteins and their annotated locations for NP_001137307.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (1).
    Source sequence(s)
    AP003327
    Consensus CDS
    CCDS44770.1
    UniProtKB/Swiss-Prot
    Q6P4R8, Q9H048
    UniProtKB/TrEMBL
    A0A024R3K9
    Related
    ENSP00000506850.1, ENST00000682444.1
    Conserved Domains (1) summary
    pfam14465
    Location:392476
    NFRKB_winged; NFRKB Winged Helix-like
  2. NM_006165.4NP_006156.2  nuclear factor related to kappa-B-binding protein isoform 2

    See identical proteins and their annotated locations for NP_006156.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter, differs in the 5' UTR and 5' coding region, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (2) has a longer N-terminus and includes an additional internal segment, compared to isoform 1.
    Source sequence(s)
    AL512730, AP003327, BC063280, BM975529, X80878
    Consensus CDS
    CCDS8483.1
    UniProtKB/Swiss-Prot
    Q6P4R8
    Related
    ENSP00000436926.1, ENST00000524794.5
    Conserved Domains (1) summary
    pfam14465
    Location:417501
    NFRKB_winged; NFRKB Winged Helix-like

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    129863636..129895578 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    129899341..129931605 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)