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FLCN folliculin [ Canis lupus familiaris (dog) ]

Gene ID: 479529, updated on 1-Mar-2025
Official Symbol
FLCNprovided by VGNC
Official Full Name
folliculinprovided by VGNC
Primary source
VGNC:VGNC:101442
See related
RGD:12080575
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
BHD
Orthologs
human mouse all
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See FLCN in Genome Data Viewer
Location:
chromosome: 5
Exon count:
17
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 5 NC_051809.1 (42284487..42304049)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 5 NC_006587.4 (42316328..42335442)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 5 NC_049226.1 (42391398..42410513)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 5 NC_049265.1 (42251943..42271053)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 5 NC_049746.1 (42199268..42218373)

Chromosome 5 - NC_051809.1Genomic Context describing neighboring genes Neighboring gene RNA-binding protein EWS-like Neighboring gene COP9 signalosome subunit 3 Neighboring gene S-formylglutathione hydrolase-like Neighboring gene phospholipase D family member 6 Neighboring gene myosin phosphatase Rho interacting protein

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Loss of heterozygosity at the FLCN locus in early renal cystic lesions in dogs with renal cystadenocarcinoma and nodular dermatofibrosis. Bønsdorff TB, et al. Mamm Genome, 2009 May. PMID 19387735
  2. Second hits in the FLCN gene in a hereditary renal cancer syndrome in dogs. Bønsdorff TB, et al. Mamm Genome, 2008 Feb. PMID 18219524
  3. A mutation in the canine BHD gene is associated with hereditary multifocal renal cystadenocarcinoma and nodular dermatofibrosis in the German Shepherd dog. Lingaas F, et al. Hum Mol Genet, 2003 Dec 1. PMID 14532326
  4. Rab35-GEFs, DENND1A and folliculin differentially regulate podocalyxin trafficking in two- and three-dimensional epithelial cell cultures. Kinoshita R, et al. J Biol Chem, 2020 Mar 13. PMID 31992598, Free PMC Article
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rab35-GEFs, DENND1A and folliculin differentially regulate podocalyxin trafficking in two- and three-dimensional epithelial cell cultures.
    Title: Rab35-GEFs, DENND1A and folliculin differentially regulate podocalyxin trafficking in two- and three-dimensional epithelial cell cultures.
  2. Loss of heterozygosity/function of the FLCN gene contribute to renal cystadenocarcinoma and nodular dermatofibrosis.
    Title: Loss of heterozygosity at the FLCN locus in early renal cystic lesions in dogs with renal cystadenocarcinoma and nodular dermatofibrosis.
  3. The skin tumors of renal cystadenocarcinoma and nodular dermatofibrosis -affected dogs may be caused by haploinsufficiency of the FLCN gene product.
    Title: Second hits in the FLCN gene in a hereditary renal cancer syndrome in dogs.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of TORC1 signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
folliculin
NP_001121083.1
XP_038520037.1
XP_038520038.1
XP_038520039.1
XP_038520040.1
XP_038520041.1
XP_038520042.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127611.1 → NP_001121083.1  folliculin

    See identical proteins and their annotated locations for NP_001121083.1

    Status: PROVISIONAL

    Source sequence(s)
    EF632108
    UniProtKB/TrEMBL
    A0A8C0LBW2, A0A8P0TAE5, B1NLQ8
    Conserved Domains (2) summary
    pfam11704
    Location:106 → 265
    Folliculin; Vesicle coat protein involved in Golgi to plasma membrane transport
    pfam16692
    Location:345 → 566
    Folliculin_C; Folliculin C-terminal domain

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051809.1 Reference ROS_Cfam_1.0

    Range
    42284487..42304049
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038664112.1 → XP_038520040.1  folliculin isoform X1

    UniProtKB/TrEMBL
    A0A8C0LBW2, A0A8P0TAE5, B1NLQ8
    Conserved Domains (2) summary
    pfam11704
    Location:106 → 265
    Folliculin; Vesicle coat protein involved in Golgi to plasma membrane transport
    pfam16692
    Location:345 → 566
    Folliculin_C; Folliculin C-terminal domain

  2. XM_038664110.1 → XP_038520038.1  folliculin isoform X1

    UniProtKB/TrEMBL
    A0A8C0LBW2, A0A8P0TAE5, B1NLQ8
    Conserved Domains (2) summary
    pfam11704
    Location:106 → 265
    Folliculin; Vesicle coat protein involved in Golgi to plasma membrane transport
    pfam16692
    Location:345 → 566
    Folliculin_C; Folliculin C-terminal domain

  3. XM_038664109.1 → XP_038520037.1  folliculin isoform X1

    UniProtKB/TrEMBL
    A0A8C0LBW2, A0A8P0TAE5, B1NLQ8
    Conserved Domains (2) summary
    pfam11704
    Location:106 → 265
    Folliculin; Vesicle coat protein involved in Golgi to plasma membrane transport
    pfam16692
    Location:345 → 566
    Folliculin_C; Folliculin C-terminal domain

  4. XM_038664113.1 → XP_038520041.1  folliculin isoform X1

    UniProtKB/TrEMBL
    A0A8C0LBW2, A0A8P0TAE5, B1NLQ8
    Conserved Domains (2) summary
    pfam11704
    Location:106 → 265
    Folliculin; Vesicle coat protein involved in Golgi to plasma membrane transport
    pfam16692
    Location:345 → 566
    Folliculin_C; Folliculin C-terminal domain

  5. XM_038664114.1 → XP_038520042.1  folliculin isoform X1

    UniProtKB/TrEMBL
    A0A8C0LBW2, A0A8P0TAE5, B1NLQ8
    Conserved Domains (2) summary
    pfam11704
    Location:106 → 265
    Folliculin; Vesicle coat protein involved in Golgi to plasma membrane transport
    pfam16692
    Location:345 → 566
    Folliculin_C; Folliculin C-terminal domain

  6. XM_038664111.1 → XP_038520039.1  folliculin isoform X1

    UniProtKB/TrEMBL
    A0A8C0LBW2, A0A8P0TAE5, B1NLQ8
    Conserved Domains (2) summary
    pfam11704
    Location:106 → 265
    Folliculin; Vesicle coat protein involved in Golgi to plasma membrane transport
    pfam16692
    Location:345 → 566
    Folliculin_C; Folliculin C-terminal domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049265.1 Alternate UMICH_Zoey_3.1

    Range
    42251943..42271053
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049746.1 Alternate UNSW_CanFamBas_1.0

    Range
    42199268..42218373
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049226.1 Alternate UU_Cfam_GSD_1.0

    Range
    42391398..42410513
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006587.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    42316328..42335442
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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