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ALOX12 arachidonate 12-lipoxygenase, 12S type [ Canis lupus familiaris (dog) ]

Gene ID: 479476, updated on 1-Mar-2025
Official Symbol
ALOX12provided by VGNC
Official Full Name
arachidonate 12-lipoxygenase, 12S typeprovided by VGNC
Primary source
VGNC:VGNC:49900
See related
Ensembl:ENSCAFG00845017004 RGD:12179236
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
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Location:
chromosome: 5
Exon count:
14
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 5 NC_051809.1 (32131142..32143103)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 5 NC_006587.4 (32164885..32176845)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 5 NC_049226.1 (32232935..32244895)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 5 NC_049265.1 (32097211..32109170)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 5 NC_049746.1 (32056686..32068416)

Chromosome 5 - NC_051809.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC106558811 Neighboring gene polyunsaturated fatty acid (12S)/(13S)-lipoxygenase, epidermal-type-like Neighboring gene uncharacterized LOC111095870 Neighboring gene chromosome 5 C17orf49 homolog Neighboring gene ribonuclease K

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables arachidonate 12(S)-lipoxygenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables arachidonate 15-lipoxygenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables linoleate 13S-lipoxygenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in linoleic acid metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in lipid oxidation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in sarcolemma IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
arachidonate 12-lipoxygenase, 12S-type; polyunsaturated fatty acid lipoxygenase ALOX12
XP_038331353.1
XP_038392522.1
XP_038456715.1
XP_038521249.1
XP_536613.2

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051809.1 Reference ROS_Cfam_1.0

    Range
    32131142..32143103
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038665321.1 → XP_038521249.1  polyunsaturated fatty acid lipoxygenase ALOX12

    UniProtKB/TrEMBL
    A0A8C0KCN8, A0A8I3S2E8
    Related
    ENSCAFP00845023621.1, ENSCAFT00845030117.1
    Conserved Domains (2) summary
    pfam00305
    Location:221 → 654
    Lipoxygenase
    cl00011
    Location:2 → 111
    PLAT; PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and ...

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049265.1 Alternate UMICH_Zoey_3.1

    Range
    32097211..32109170
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038475425.1 → XP_038331353.1  polyunsaturated fatty acid lipoxygenase ALOX12

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049746.1 Alternate UNSW_CanFamBas_1.0

    Range
    32056686..32068416
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038600787.1 → XP_038456715.1  polyunsaturated fatty acid lipoxygenase ALOX12

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049226.1 Alternate UU_Cfam_GSD_1.0

    Range
    32232935..32244895
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038536594.1 → XP_038392522.1  polyunsaturated fatty acid lipoxygenase ALOX12

    UniProtKB/TrEMBL
    A0A8C0K9S4, A0A8C0KCN8, A0A8C0MY34, A0A8P0NHJ0

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006587.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    32164885..32176845
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_536613.7 → XP_536613.2  polyunsaturated fatty acid lipoxygenase ALOX12

    UniProtKB/TrEMBL
    A0A8C0K9S4, A0A8C0KCN8, A0A8C0MY34, A0A8P0NHJ0
    Conserved Domains (2) summary
    cl00011
    Location:2 → 111
    PLAT; PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and ...
    cl27717
    Location:221 → 654
    Lipoxygenase; Lipoxygenase
Nucleotide Protein
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