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C6 complement C6 [ Canis lupus familiaris (dog) ]

Gene ID: 479348, updated on 1-May-2025
Official Symbol
C6provided by VGNC
Official Full Name
complement C6provided by VGNC
Primary source
VGNC:VGNC:38598
See related
Ensembl:ENSCAFG00845002251 RGD:12066315
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Location:
chromosome: 4
Exon count:
24
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 4 NC_051808.1 (68735676..68831218)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 4 NC_006586.4 (67906727..68001886)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 4 NC_049225.1 (69147692..69242660)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 4 NC_049264.1 (68496658..68591527)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 4 NC_049745.1 (68608273..68703504)

Chromosome 4 - NC_051808.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111095728 Neighboring gene phosphatidylinositol specific phospholipase C X domain containing 3 Neighboring gene 40S ribosomal protein S4-like Neighboring gene beta-arrestin-2-like Neighboring gene beta-arrestin-2-like Neighboring gene uncharacterized LOC102154943 Neighboring gene maestro heat like repeat family member 2B Neighboring gene uncharacterized LOC102154572

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of membrane attack complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
complement component C6

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051808.1 Reference ROS_Cfam_1.0

    Range
    68735676..68831218
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038663821.1 → XP_038519749.1  complement component C6

    UniProtKB/TrEMBL
    A0A8I3MFG0, A0A8I3MIG2
    Conserved Domains (6) summary
    PHA02831
    Location:646 → 766
    PHA02831; EEV host range protein; Provisional
    smart00057
    Location:770 → 841
    FIMAC; factor I membrane attack complex
    smart00209
    Location:570 → 614
    TSP1; Thrombospondin type 1 repeats
    cd00112
    Location:142 → 173
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam01823
    Location:296 → 516
    MACPF; MAC/Perforin domain
    cl15278
    Location:85 → 133
    TSP_1; Thrombospondin type 1 domain

  2. XM_038663824.1 → XP_038519752.1  complement component C6

    UniProtKB/TrEMBL
    A0A8I3MFG0, A0A8I3MIG2
    Related
    ENSCAFP00845003179.1, ENSCAFT00845003979.1
    Conserved Domains (6) summary
    PHA02831
    Location:646 → 766
    PHA02831; EEV host range protein; Provisional
    smart00057
    Location:770 → 841
    FIMAC; factor I membrane attack complex
    smart00209
    Location:570 → 614
    TSP1; Thrombospondin type 1 repeats
    cd00112
    Location:142 → 173
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam01823
    Location:296 → 516
    MACPF; MAC/Perforin domain
    cl15278
    Location:85 → 133
    TSP_1; Thrombospondin type 1 domain

  3. XM_038663826.1 → XP_038519754.1  complement component C6

    UniProtKB/TrEMBL
    A0A8I3MFG0, A0A8I3MIG2
    Conserved Domains (6) summary
    PHA02831
    Location:646 → 766
    PHA02831; EEV host range protein; Provisional
    smart00057
    Location:770 → 841
    FIMAC; factor I membrane attack complex
    smart00209
    Location:570 → 614
    TSP1; Thrombospondin type 1 repeats
    cd00112
    Location:142 → 173
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam01823
    Location:296 → 516
    MACPF; MAC/Perforin domain
    cl15278
    Location:85 → 133
    TSP_1; Thrombospondin type 1 domain

  4. XM_038663820.1 → XP_038519748.1  complement component C6

    UniProtKB/TrEMBL
    A0A8I3MFG0, A0A8I3MIG2
    Related
    ENSCAFP00845003146.1, ENSCAFT00845003945.1
    Conserved Domains (6) summary
    PHA02831
    Location:646 → 766
    PHA02831; EEV host range protein; Provisional
    smart00057
    Location:770 → 841
    FIMAC; factor I membrane attack complex
    smart00209
    Location:570 → 614
    TSP1; Thrombospondin type 1 repeats
    cd00112
    Location:142 → 173
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam01823
    Location:296 → 516
    MACPF; MAC/Perforin domain
    cl15278
    Location:85 → 133
    TSP_1; Thrombospondin type 1 domain

  5. XM_038663825.1 → XP_038519753.1  complement component C6

    UniProtKB/TrEMBL
    A0A8I3MFG0, A0A8I3MIG2
    Conserved Domains (6) summary
    PHA02831
    Location:646 → 766
    PHA02831; EEV host range protein; Provisional
    smart00057
    Location:770 → 841
    FIMAC; factor I membrane attack complex
    smart00209
    Location:570 → 614
    TSP1; Thrombospondin type 1 repeats
    cd00112
    Location:142 → 173
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam01823
    Location:296 → 516
    MACPF; MAC/Perforin domain
    cl15278
    Location:85 → 133
    TSP_1; Thrombospondin type 1 domain

  6. XM_038663823.1 → XP_038519751.1  complement component C6

    UniProtKB/TrEMBL
    A0A8I3MFG0, A0A8I3MIG2
    Conserved Domains (6) summary
    PHA02831
    Location:646 → 766
    PHA02831; EEV host range protein; Provisional
    smart00057
    Location:770 → 841
    FIMAC; factor I membrane attack complex
    smart00209
    Location:570 → 614
    TSP1; Thrombospondin type 1 repeats
    cd00112
    Location:142 → 173
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam01823
    Location:296 → 516
    MACPF; MAC/Perforin domain
    cl15278
    Location:85 → 133
    TSP_1; Thrombospondin type 1 domain

  7. XM_038663827.1 → XP_038519755.1  complement component C6

    UniProtKB/TrEMBL
    A0A8I3MFG0, A0A8I3MIG2
    Related
    ENSCAFP00845003192.1, ENSCAFT00845003995.1
    Conserved Domains (6) summary
    PHA02831
    Location:646 → 766
    PHA02831; EEV host range protein; Provisional
    smart00057
    Location:770 → 841
    FIMAC; factor I membrane attack complex
    smart00209
    Location:570 → 614
    TSP1; Thrombospondin type 1 repeats
    cd00112
    Location:142 → 173
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam01823
    Location:296 → 516
    MACPF; MAC/Perforin domain
    cl15278
    Location:85 → 133
    TSP_1; Thrombospondin type 1 domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049264.1 Alternate UMICH_Zoey_3.1

    Range
    68496658..68591527
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038474106.1 → XP_038330034.1  complement component C6

  2. XM_038474108.1 → XP_038330036.1  complement component C6

  3. XM_038474110.1 → XP_038330038.1  complement component C6

  4. XM_038474105.1 → XP_038330033.1  complement component C6

  5. XM_038474109.1 → XP_038330037.1  complement component C6

  6. XM_038474107.1 → XP_038330035.1  complement component C6

  7. XM_038474111.1 → XP_038330039.1  complement component C6

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049745.1 Alternate UNSW_CanFamBas_1.0

    Range
    68608273..68703504
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038599504.1 → XP_038455432.1  complement component C6

  2. XM_038599506.1 → XP_038455434.1  complement component C6

  3. XM_038599508.1 → XP_038455436.1  complement component C6

  4. XM_038599503.1 → XP_038455431.1  complement component C6

  5. XM_038599507.1 → XP_038455435.1  complement component C6

  6. XM_038599505.1 → XP_038455433.1  complement component C6

  7. XM_038599509.1 → XP_038455437.1  complement component C6

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049225.1 Alternate UU_Cfam_GSD_1.0

    Range
    69147692..69242660
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038535214.1 → XP_038391142.1  complement component C6

    UniProtKB/TrEMBL
    A0A8C0SCV7, A0A8I3MFG0

  2. XM_038535216.1 → XP_038391144.1  complement component C6

    UniProtKB/TrEMBL
    A0A8C0SCV7, A0A8I3MFG0

  3. XM_038535217.1 → XP_038391145.1  complement component C6

    UniProtKB/TrEMBL
    A0A8C0SCV7, A0A8I3MFG0

  4. XM_038535213.1 → XP_038391141.1  complement component C6

    UniProtKB/TrEMBL
    A0A8C0SCV7, A0A8I3MFG0

  5. XM_038535215.1 → XP_038391143.1  complement component C6

    UniProtKB/TrEMBL
    A0A8C0SCV7, A0A8I3MFG0

  6. XM_038535218.1 → XP_038391146.1  complement component C6

    UniProtKB/TrEMBL
    A0A8C0SCV7, A0A8I3MFG0

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006586.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    67906727..68001886
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038499120.1 → XP_038355048.1  complement component C6

    UniProtKB/TrEMBL
    A0A8P0PRM6, A0A8P0T891
    Conserved Domains (6) summary
    PHA02831
    Location:646 → 766
    PHA02831; EEV host range protein; Provisional
    smart00057
    Location:770 → 841
    FIMAC; factor I membrane attack complex
    smart00209
    Location:570 → 614
    TSP1; Thrombospondin type 1 repeats
    cd00112
    Location:142 → 173
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam01823
    Location:296 → 516
    MACPF; MAC/Perforin domain
    cl15278
    Location:85 → 133
    TSP_1; Thrombospondin type 1 domain

  2. XM_022417885.2 → XP_022273593.1  complement component C6

    UniProtKB/TrEMBL
    A0A8P0PRM6, A0A8P0T891
    Conserved Domains (6) summary
    PHA02831
    Location:646 → 766
    PHA02831; EEV host range protein; Provisional
    smart00057
    Location:770 → 841
    FIMAC; factor I membrane attack complex
    smart00209
    Location:570 → 614
    TSP1; Thrombospondin type 1 repeats
    cd00112
    Location:142 → 173
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam01823
    Location:296 → 516
    MACPF; MAC/Perforin domain
    cl15278
    Location:85 → 133
    TSP_1; Thrombospondin type 1 domain

  3. XM_022417887.2 → XP_022273595.1  complement component C6

    UniProtKB/TrEMBL
    A0A8P0PRM6, A0A8P0T891
    Conserved Domains (6) summary
    PHA02831
    Location:646 → 766
    PHA02831; EEV host range protein; Provisional
    smart00057
    Location:770 → 841
    FIMAC; factor I membrane attack complex
    smart00209
    Location:570 → 614
    TSP1; Thrombospondin type 1 repeats
    cd00112
    Location:142 → 173
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam01823
    Location:296 → 516
    MACPF; MAC/Perforin domain
    cl15278
    Location:85 → 133
    TSP_1; Thrombospondin type 1 domain

  4. XM_022417882.2 → XP_022273590.1  complement component C6

    UniProtKB/TrEMBL
    A0A8P0PRM6, A0A8P0T891
    Conserved Domains (6) summary
    PHA02831
    Location:646 → 766
    PHA02831; EEV host range protein; Provisional
    smart00057
    Location:770 → 841
    FIMAC; factor I membrane attack complex
    smart00209
    Location:570 → 614
    TSP1; Thrombospondin type 1 repeats
    cd00112
    Location:142 → 173
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam01823
    Location:296 → 516
    MACPF; MAC/Perforin domain
    cl15278
    Location:85 → 133
    TSP_1; Thrombospondin type 1 domain

  5. XM_022417886.2 → XP_022273594.1  complement component C6

    UniProtKB/TrEMBL
    A0A8P0PRM6, A0A8P0T891
    Conserved Domains (6) summary
    PHA02831
    Location:646 → 766
    PHA02831; EEV host range protein; Provisional
    smart00057
    Location:770 → 841
    FIMAC; factor I membrane attack complex
    smart00209
    Location:570 → 614
    TSP1; Thrombospondin type 1 repeats
    cd00112
    Location:142 → 173
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam01823
    Location:296 → 516
    MACPF; MAC/Perforin domain
    cl15278
    Location:85 → 133
    TSP_1; Thrombospondin type 1 domain

  6. XM_022417884.2 → XP_022273592.1  complement component C6

    UniProtKB/TrEMBL
    A0A8P0PRM6, A0A8P0T891
    Conserved Domains (6) summary
    PHA02831
    Location:646 → 766
    PHA02831; EEV host range protein; Provisional
    smart00057
    Location:770 → 841
    FIMAC; factor I membrane attack complex
    smart00209
    Location:570 → 614
    TSP1; Thrombospondin type 1 repeats
    cd00112
    Location:142 → 173
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam01823
    Location:296 → 516
    MACPF; MAC/Perforin domain
    cl15278
    Location:85 → 133
    TSP_1; Thrombospondin type 1 domain

  7. XM_536488.7 → XP_536488.2  complement component C6

    See identical proteins and their annotated locations for XP_536488.2

    UniProtKB/TrEMBL
    A0A8P0PRM6, A0A8P0T891
    Conserved Domains (6) summary
    PHA02831
    Location:646 → 766
    PHA02831; EEV host range protein; Provisional
    smart00057
    Location:770 → 841
    FIMAC; factor I membrane attack complex
    smart00209
    Location:570 → 614
    TSP1; Thrombospondin type 1 repeats
    cd00112
    Location:142 → 173
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam01823
    Location:296 → 516
    MACPF; MAC/Perforin domain
    cl15278
    Location:85 → 133
    TSP_1; Thrombospondin type 1 domain
Nucleotide Protein
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