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NFKBIB NFKB inhibitor beta [ Homo sapiens (human) ]

Gene ID: 4793, updated on 5-Jul-2020

Summary

Official Symbol
NFKBIBprovided by HGNC
Official Full Name
NFKB inhibitor betaprovided by HGNC
Primary source
HGNC:HGNC:7798
See related
Ensembl:ENSG00000104825 MIM:604495
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IKBB; TRIP9
Summary
The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jul 2011]
Expression
Ubiquitous expression in testis (RPKM 8.2), bone marrow (RPKM 7.5) and 25 other tissues See more
Orthologs

Genomic context

See NFKBIB in Genome Data Viewer
Location:
19q13.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (38899503..38908894)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (39390340..39399534)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein L Neighboring gene Ras and Rab interactor like Neighboring gene sirtuin 2 Neighboring gene coiled-coil glutamate rich protein 2 Neighboring gene seryl-tRNA synthetase 2, mitochondrial Neighboring gene mitochondrial ribosomal protein S12

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The mRNA expression levels for alpha-tubulin, TRADD, IFN-gamma R2, GAS1, MADD, NF-kappaB, I-kappa B, 14-3-3 protein, APaf1, PARP, IGF-1 receptor, RB1, Rb2/p130, ARC, and caspase 6 are upregulated in human neuronal cells after treatment with HIV-1 gp120 PubMed
Tat tat The gene expression of NFKBIB is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells PubMed
tat I kappa B potently inhibits HIV-1 Tat-mediated transactivation of the HIV-1 LTR promoter PubMed
tat HIV-1 Tat induces the phosphorylation and degradation of IkappaB through a p56lck dependent mechanism, leading to the activation of NF-kappa B PubMed
Vpr vpr HIV-1 Vpr induces phosphorylation of IkappaB-beta at serine positions 177 and 181 PubMed
vpr Overexpression of NFKBIB is induced by HIV-1 Vpr in the transfected 293T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coactivator activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cellular response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasmic sequestering of NF-kappaB IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of nucleic acid-templated transcription IEA
Inferred from Electronic Annotation
more info
 
signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription, DNA-templated TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
NF-kappa-B inhibitor beta
Names
I-kappa-B-beta
NF-kappa-BIB
TR-interacting protein 9
TRIP-9
ikB-B
ikB-beta
ikappaBbeta
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
thyroid receptor-interacting protein 9

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029624.1 RefSeqGene

    Range
    5270..14190
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001243116.1NP_001230045.1  NF-kappa-B inhibitor beta isoform 2

    See identical proteins and their annotated locations for NP_001230045.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon compared to variant 1. This results in translation initiation from an in-frame downstream AUG, and a shorter isoform (2) compared to isoform 1.
    Source sequence(s)
    AI684894, BC015528, BI520169
    Consensus CDS
    CCDS74362.1
    UniProtKB/Swiss-Prot
    Q15653
    UniProtKB/TrEMBL
    G5E9C2
    Related
    ENSP00000375929.4, ENST00000392079.7
    Conserved Domains (3) summary
    cd00204
    Location:2175
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:125212
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:120151
    ANK; ANK repeat [structural motif]
  2. NM_001369699.1NP_001356628.1  NF-kappa-B inhibitor beta isoform 3

    Status: REVIEWED

    Source sequence(s)
    AB209784, AC011455
    Related
    ENSP00000459728.1, ENST00000572515.5
    Conserved Domains (3) summary
    PHA03095
    Location:203298
    PHA03095; ankyrin-like protein; Provisional
    COG0666
    Location:57148
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:206237
    ANK; ANK repeat [structural motif]
  3. NM_001369700.1NP_001356629.1  NF-kappa-B inhibitor beta isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC011455
    Conserved Domains (3) summary
    PHA03095
    Location:111206
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:114145
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:52142
    Ank_2; Ankyrin repeats (3 copies)
  4. NM_002503.5NP_002494.2  NF-kappa-B inhibitor beta isoform 1

    See identical proteins and their annotated locations for NP_002494.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes the longest isoform (1).
    Source sequence(s)
    AI684894, BC015528, DA633677
    Consensus CDS
    CCDS12524.1
    UniProtKB/Swiss-Prot
    Q15653
    Related
    ENSP00000312988.5, ENST00000313582.6
    Conserved Domains (4) summary
    COG0666
    Location:240299
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:88261
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:206237
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:52118
    Ank_2; Ankyrin repeats (3 copies)

RNA

  1. NR_040515.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate acceptor splice site at the second exon, and is alternatively spliced at the 3' end compared to variant 1. It is represented as non-coding due to the presence of an upstream ORF (with a strong Kozak signal) that is predicted to interfere with the translation of the downstream longer ORF; translation of the upstream ORF renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA044256, AB209784, AK057862, BX111397, DA633677
    Related
    ENST00000509705.3
  2. NR_161470.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011455

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    38899503..38908894
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723227.3XP_006723290.3  NF-kappa-B inhibitor beta isoform X2

  2. XM_006723226.2XP_006723289.2  NF-kappa-B inhibitor beta isoform X1

    Conserved Domains (3) summary
    cd00204
    Location:56229
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:179266
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:174205
    ANK; ANK repeat [structural motif]

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_014040929.1 Reference GRCh38.p13 PATCHES

    Range
    309338..318566
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001001716.1: Suppressed sequence

    Description
    NM_001001716.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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