U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

RUFY2 RUN and FYVE domain containing 2 [ Canis lupus familiaris (dog) ]

Gene ID: 479228, updated on 25-Jul-2026
Official Symbol
RUFY2provided by VGNC
Official Full Name
RUN and FYVE domain containing 2provided by VGNC
Primary source
VGNC:VGNC:45804
See related
Ensembl:ENSCAFG00845002043 RGD:12256206
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See RUFY2 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
20
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 4 NC_051808.1 (19840339..19892528, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 4 NC_006586.4 (19702525..19754450, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 4 NC_049225.1 (20287888..20339883, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 4 NC_049264.1 (19722465..19774279, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 4 NC_049745.1 (19944610..19996602, complement)

Chromosome 4 - NC_051808.1Genomic Context describing neighboring genes Neighboring gene phenazine biosynthesis like protein domain containing Neighboring gene heterogeneous nuclear ribonucleoprotein H3 Neighboring gene DNA replication helicase/nuclease 2 Neighboring gene small Cajal body-specific RNA 18 Neighboring gene solute carrier family 25 member 16

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
RUN and FYVE domain-containing protein 2

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051808.1 Reference ROS_Cfam_1.0

    Range
    19840339..19892528 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038662738.1 → XP_038518666.1  RUN and FYVE domain-containing protein 2 isoform X6

    UniProtKB/TrEMBL
    A0A8C0R897, A0A8I3MF76
    Related
    ENSCAFP00845002929.1, ENSCAFT00845003685.1
    Conserved Domains (3) summary
    TIGR02168
    Location:222 → 506
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd15759
    Location:534 → 604
    FYVE_RUFY2; FYVE domain found in RUN and FYVE domain-containing protein 2 (RUFY2) and similar proteins
    pfam02759
    Location:45 → 166
    RUN; RUN domain

  2. XM_038662734.1 → XP_038518662.1  RUN and FYVE domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0LR57
    Conserved Domains (3) summary
    TIGR02168
    Location:257 → 559
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd15759
    Location:587 → 657
    FYVE_RUFY2; FYVE domain found in RUN and FYVE domain-containing protein 2 (RUFY2) and similar proteins
    pfam02759
    Location:99 → 220
    RUN; RUN domain

  3. XM_038662739.1 → XP_038518667.1  RUN and FYVE domain-containing protein 2 isoform X7

    UniProtKB/TrEMBL
    A0A8C0LR57
    Conserved Domains (3) summary
    COG1196
    Location:269 → 475
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd15759
    Location:473 → 543
    FYVE_RUFY2; FYVE domain found in RUN and FYVE domain-containing protein 2 (RUFY2) and similar proteins
    pfam02759
    Location:99 → 220
    RUN; RUN domain

  4. XM_038662736.1 → XP_038518664.1  RUN and FYVE domain-containing protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A8C0LR57
    Conserved Domains (3) summary
    TIGR02168
    Location:276 → 560
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl28890
    Location:588 → 632
    FYVE_like_SF; FYVE domain like superfamily
    pfam02759
    Location:99 → 220
    RUN; RUN domain

  5. XM_038662733.1 → XP_038518661.1  RUN and FYVE domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LR57
    Conserved Domains (3) summary
    TIGR02168
    Location:276 → 560
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd15759
    Location:588 → 658
    FYVE_RUFY2; FYVE domain found in RUN and FYVE domain-containing protein 2 (RUFY2) and similar proteins
    pfam02759
    Location:99 → 220
    RUN; RUN domain

  6. XM_038662737.1 → XP_038518665.1  RUN and FYVE domain-containing protein 2 isoform X5

    UniProtKB/TrEMBL
    A0A8C0R897
    Conserved Domains (3) summary
    TIGR02168
    Location:244 → 528
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd15759
    Location:556 → 626
    FYVE_RUFY2; FYVE domain found in RUN and FYVE domain-containing protein 2 (RUFY2) and similar proteins
    pfam02759
    Location:67 → 188
    RUN; RUN domain

  7. XM_038662735.1 → XP_038518663.1  RUN and FYVE domain-containing protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0LQR5, A0A8I3MI06
    Related
    ENSCAFP00845002962.1, ENSCAFT00845003729.1
    Conserved Domains (3) summary
    TIGR02168
    Location:257 → 541
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd15759
    Location:569 → 639
    FYVE_RUFY2; FYVE domain found in RUN and FYVE domain-containing protein 2 (RUFY2) and similar proteins
    pfam02759
    Location:80 → 201
    RUN; RUN domain

  8. XM_038662741.1 → XP_038518669.1  RUN and FYVE domain-containing protein 2 isoform X9

    UniProtKB/TrEMBL
    A0A8I3MI43
    Conserved Domains (2) summary
    COG1196
    Location:269 → 456
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam02759
    Location:99 → 220
    RUN; RUN domain

  9. XM_038662740.1 → XP_038518668.1  RUN and FYVE domain-containing protein 2 isoform X8

    UniProtKB/TrEMBL
    A0A8I3MI43
    Related
    ENSCAFP00845003010.1, ENSCAFT00845003785.1
    Conserved Domains (2) summary
    COG1196
    Location:264 → 468
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam02759
    Location:99 → 220
    RUN; RUN domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049264.1 Alternate UMICH_Zoey_3.1

    Range
    19722465..19774279 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038473069.1 → XP_038328997.1  

    Conserved Domains (3) summary
    TIGR02168
    Location:222 → 506
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd15759
    Location:534 → 604
    FYVE_RUFY2; FYVE domain found in RUN and FYVE domain-containing protein 2 (RUFY2) and similar proteins
    pfam02759
    Location:45 → 166
    RUN; RUN domain

  2. XM_038473066.1 → XP_038328994.1  

  3. XM_038473070.1 → XP_038328998.1  

  4. XM_038473068.1 → XP_038328996.1  

  5. XM_038473065.1 → XP_038328993.1  

  6. XM_038473067.1 → XP_038328995.1  

    Conserved Domains (3) summary
    TIGR02168
    Location:257 → 541
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd15759
    Location:569 → 639
    FYVE_RUFY2; FYVE domain found in RUN and FYVE domain-containing protein 2 (RUFY2) and similar proteins
    pfam02759
    Location:80 → 201
    RUN; RUN domain

  7. XM_038473072.1 → XP_038329000.1  

  8. XM_038473071.1 → XP_038328999.1  

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049745.1 Alternate UNSW_CanFamBas_1.0

    Range
    19944610..19996602 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038598435.1 → XP_038454363.1  

    Conserved Domains (3) summary
    TIGR02168
    Location:222 → 506
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd15759
    Location:534 → 604
    FYVE_RUFY2; FYVE domain found in RUN and FYVE domain-containing protein 2 (RUFY2) and similar proteins
    pfam02759
    Location:45 → 166
    RUN; RUN domain

  2. XM_038598431.1 → XP_038454359.1  

  3. XM_038598436.1 → XP_038454364.1  

  4. XM_038598433.1 → XP_038454361.1  

  5. XM_038598430.1 → XP_038454358.1  

  6. XM_038598434.1 → XP_038454362.1  

    Conserved Domains (3) summary
    TIGR02168
    Location:244 → 528
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd15759
    Location:556 → 626
    FYVE_RUFY2; FYVE domain found in RUN and FYVE domain-containing protein 2 (RUFY2) and similar proteins
    pfam02759
    Location:67 → 188
    RUN; RUN domain

  7. XM_038598432.1 → XP_038454360.1  

    Conserved Domains (3) summary
    TIGR02168
    Location:257 → 541
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd15759
    Location:569 → 639
    FYVE_RUFY2; FYVE domain found in RUN and FYVE domain-containing protein 2 (RUFY2) and similar proteins
    pfam02759
    Location:80 → 201
    RUN; RUN domain

  8. XM_038598438.1 → XP_038454366.1  

  9. XM_038598437.1 → XP_038454365.1  

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049225.1 Alternate UU_Cfam_GSD_1.0

    Range
    20287888..20339883 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038534116.1 → XP_038390044.1  RUN and FYVE domain-containing protein 2 isoform X6

    UniProtKB/TrEMBL
    A0A8C0R897, A0A8I3MF76
    Conserved Domains (3) summary
    TIGR02168
    Location:222 → 506
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd15759
    Location:534 → 604
    FYVE_RUFY2; FYVE domain found in RUN and FYVE domain-containing protein 2 (RUFY2) and similar proteins
    pfam02759
    Location:45 → 166
    RUN; RUN domain

  2. XM_038534112.1 → XP_038390040.1  RUN and FYVE domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0LR57

  3. XM_038534117.1 → XP_038390045.1  RUN and FYVE domain-containing protein 2 isoform X7

    UniProtKB/TrEMBL
    A0A8C0LR57

  4. XM_038534114.1 → XP_038390042.1  RUN and FYVE domain-containing protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A8C0LR57

  5. XM_038534111.1 → XP_038390039.1  RUN and FYVE domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LR57

  6. XM_038534115.1 → XP_038390043.1  RUN and FYVE domain-containing protein 2 isoform X5

    UniProtKB/TrEMBL
    A0A8C0R897
    Conserved Domains (3) summary
    TIGR02168
    Location:244 → 528
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd15759
    Location:556 → 626
    FYVE_RUFY2; FYVE domain found in RUN and FYVE domain-containing protein 2 (RUFY2) and similar proteins
    pfam02759
    Location:67 → 188
    RUN; RUN domain

  7. XM_038534113.1 → XP_038390041.1  RUN and FYVE domain-containing protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0LQR5, A0A8I3MI06
    Conserved Domains (3) summary
    TIGR02168
    Location:257 → 541
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd15759
    Location:569 → 639
    FYVE_RUFY2; FYVE domain found in RUN and FYVE domain-containing protein 2 (RUFY2) and similar proteins
    pfam02759
    Location:80 → 201
    RUN; RUN domain

  8. XM_038534119.1 → XP_038390047.1  RUN and FYVE domain-containing protein 2 isoform X9

    UniProtKB/TrEMBL
    A0A8I3MI43

  9. XM_038534118.1 → XP_038390046.1  RUN and FYVE domain-containing protein 2 isoform X8

    UniProtKB/TrEMBL
    A0A8I3MI43

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006586.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    19702525..19754450 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_014112850.3 → XP_013968325.1  RUN and FYVE domain-containing protein 2 isoform X6

    UniProtKB/TrEMBL
    A0A8C0R897, A0A8I3MF76
    Conserved Domains (3) summary
    TIGR02168
    Location:222 → 506
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd15759
    Location:534 → 604
    FYVE_RUFY2; FYVE domain found in RUN and FYVE domain-containing protein 2 (RUFY2) and similar proteins
    pfam02759
    Location:45 → 166
    RUN; RUN domain

  2. XM_038489860.1 → XP_038345788.1  RUN and FYVE domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0LR57
    Conserved Domains (3) summary
    TIGR02168
    Location:257 → 559
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd15759
    Location:587 → 657
    FYVE_RUFY2; FYVE domain found in RUN and FYVE domain-containing protein 2 (RUFY2) and similar proteins
    pfam02759
    Location:99 → 220
    RUN; RUN domain

  3. XM_038489899.1 → XP_038345827.1  RUN and FYVE domain-containing protein 2 isoform X7

    UniProtKB/TrEMBL
    A0A8C0LR57
    Conserved Domains (3) summary
    COG1196
    Location:269 → 475
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd15759
    Location:473 → 543
    FYVE_RUFY2; FYVE domain found in RUN and FYVE domain-containing protein 2 (RUFY2) and similar proteins
    pfam02759
    Location:99 → 220
    RUN; RUN domain

  4. XM_038489875.1 → XP_038345803.1  RUN and FYVE domain-containing protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A8C0LR57
    Conserved Domains (3) summary
    TIGR02168
    Location:276 → 560
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl28890
    Location:588 → 632
    FYVE_like_SF; FYVE domain like superfamily
    pfam02759
    Location:99 → 220
    RUN; RUN domain

  5. XM_038489849.1 → XP_038345777.1  RUN and FYVE domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LR57
    Conserved Domains (3) summary
    TIGR02168
    Location:276 → 560
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd15759
    Location:588 → 658
    FYVE_RUFY2; FYVE domain found in RUN and FYVE domain-containing protein 2 (RUFY2) and similar proteins
    pfam02759
    Location:99 → 220
    RUN; RUN domain

  6. XM_005618950.4 → XP_005619007.2  RUN and FYVE domain-containing protein 2 isoform X5

    UniProtKB/TrEMBL
    A0A8C0R897
    Conserved Domains (3) summary
    TIGR02168
    Location:244 → 528
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd15759
    Location:556 → 626
    FYVE_RUFY2; FYVE domain found in RUN and FYVE domain-containing protein 2 (RUFY2) and similar proteins
    pfam02759
    Location:67 → 188
    RUN; RUN domain

  7. XM_014112847.2 → XP_013968322.1  RUN and FYVE domain-containing protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0LQR5, A0A8I3MI06
    Conserved Domains (3) summary
    TIGR02168
    Location:257 → 541
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd15759
    Location:569 → 639
    FYVE_RUFY2; FYVE domain found in RUN and FYVE domain-containing protein 2 (RUFY2) and similar proteins
    pfam02759
    Location:80 → 201
    RUN; RUN domain

  8. XM_038489910.1 → XP_038345838.1  RUN and FYVE domain-containing protein 2 isoform X9

    UniProtKB/TrEMBL
    A0A8I3MI43
    Conserved Domains (2) summary
    COG1196
    Location:269 → 456
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam02759
    Location:99 → 220
    RUN; RUN domain

  9. XM_038489907.1 → XP_038345835.1  RUN and FYVE domain-containing protein 2 isoform X8

    UniProtKB/TrEMBL
    A0A8I3MI43
    Conserved Domains (2) summary
    COG1196
    Location:264 → 468
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam02759
    Location:99 → 220
    RUN; RUN domain
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials