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NFKB1 nuclear factor kappa B subunit 1 [ Homo sapiens (human) ]

Gene ID: 4790, updated on 24-Nov-2020

Summary

Official Symbol
NFKB1provided by HGNC
Official Full Name
nuclear factor kappa B subunit 1provided by HGNC
Primary source
HGNC:HGNC:7794
See related
Ensembl:ENSG00000109320 MIM:164011
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KBF1; EBP-1; NF-kB; CVID12; NF-kB1; NFKB-p50; NFkappaB; NF-kappaB; NFKB-p105; NF-kappa-B1; NF-kappabeta
Summary
This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. NFKB is a critical regulator of the immediate-early response to viral infection. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed. [provided by RefSeq, Aug 2020]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Expression
Ubiquitous expression in bone marrow (RPKM 27.7), appendix (RPKM 20.3) and 25 other tissues See more
Orthologs

Genomic context

See NFKB1 in Genome Data Viewer
Location:
4q24
Exon count:
27
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (102501266..102617302)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (103422486..103538459)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 728, pseudogene Neighboring gene uncharacterized LOC105377621 Neighboring gene zinc finger protein 705A pseudogene Neighboring gene uncharacterized LOC105377347 Neighboring gene mannosidase beta Neighboring gene ribosomal protein L21 pseudogene 49 Neighboring gene leucine rich repeat containing 37 member A15, pseudogene Neighboring gene keratin 8 pseudogene 46

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
GeneReviews: Not available
Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis.
GeneReviews: Not available
Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population.
GeneReviews: Not available
Genome-wide association study of treatment refractory schizophrenia in Han Chinese.
GeneReviews: Not available
Genome-wide contribution of genotype by environment interaction to variation of diabetes-related traits.
GeneReviews: Not available
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
GeneReviews: Not available
Immunodeficiency, common variable, 12
MedGen: C4225277 OMIM: 616576 GeneReviews: Not available
Compare labs

HIV-1 interactions

Replication interactions

Interaction Pubs
Monocyte derived dendritic cells from HIV-infected clinical samples downregulate NFKB1 (NK-kB) expression PubMed
Knockdown of nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (NFKB1; p50/p105) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed
Knockdown of nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (NFKB1; p50/p105) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Asp asp Analysis of point mutations in the USF1 and NF-kappaB sites in the cis-acting elements of ASP promoter region shows that USF1 and NF-kappaB are required for ASP activity PubMed
Envelope surface glycoprotein gp120 env The binding of soluble HIV-1 gp120 to TLR2 or TLR4 results in upregulation of the TNF-alpha and IL-8 production through NF-kappaB activation PubMed
env HIV-1 gp120 and methamphetamine synergistically induce release of IL-6 through the NF-kappaB pathway in astrocytes PubMed
env HIV-1 gp120-mediated increases in IL-8 production in astrocytes are mediated through the NF-KapaB pathway PubMed
env HIV-1 gp120 induces a time-dependent IL-6 upregulation by translocating NF-kappaB1 from cytoplasm to nucleus in human astrocyte cells PubMed
env HIV-1 gp120-mediated downregulation of P-gp is attenuated by SN50 (a nuclear factor-KappaB [NF-KappaB] inhibitor), suggesting involvement of NF-KappaB signaling in P-gp regulation in primary cultures of human fetal astrocytes PubMed
env HIV-1 gp120 activates NF-kappaB by inducing phosphorylation of IkappaBalpha in human astrocyte cells PubMed
env HIV-1 gp120-mediated upregulation of CCL5 expression requires the NF-kappaB pathway in astrocytes PubMed
env Inhibition of NRF2 by siRNA results in increased NOX2, NFkappaB (p65/p50), TNF-alpha, and MMP-9 proteins in astrocytes exposed to HIV-1 gp120 PubMed
env Increased neurotoxicity mediated by cocaine and gp120 involves signaling pathways including c-jun N-terminal kinase (JNK), p38, extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinases (MAPK), and nuclear factor (NF)-kappaB PubMed
env PC-PLC is an upstream regulator of HIV-1 gp120-mediated NF-kappaB activation in human monocyte-derived macrophages PubMed
env NF-kappaB and JNK signaling are involved in gp120-induced multidrug resistance protein 1 (Mrp1) regulation during an HIV-1 associated inflammatory response PubMed
env Treatment of human hepatic stellate cells with gp120 significantly increases secretion and gene expression of CCL2, metalloprotease-1 and interleukin-6. Gp120 also induces activation of Akt, NF-kappaB, and p38(MAPK) PubMed
env HIV-1 gp120 induces NF-kappaB activation and increases p21(cip1/waf1) and p27(kip1) protein levels in human mesangial cells PubMed
env The mRNA expression levels for alpha-tubulin, TRADD, IFN-gamma R2, GAS1, MADD, NF-kappaB, I-kappa B, 14-3-3 protein, APaf1, PARP, IGF-1 receptor, RB1, Rb2/p130, ARC, and caspase 6 are upregulated in human neuronal cells after treatment with HIV-1 gp120 PubMed
env HIV-1 gp120/CD4 interaction-induced NF-kappaB activation stimulates the hyperphosphorylation of IkappaB-alpha by IkappaB kinases (IKKs) PubMed
env HIV-1 envelope protein gp120 is able to induce COX-2 mRNA and protein in human neuroblastoma cell lines that express CXCR4 and CCR5 but not CD4; gp120 induces COX-2 promoter transcription through NF-kappaB and activating protein-1 (AP-1) sites PubMed
env CD4-p56Lck interaction is required for HIV-1 gp120-induced nuclear translocation of NF-kappaB in HeLa cells PubMed
env The protein tyrosine kinase p56lck plays an active role in transmitting an HIV-1 gp120-mediated signal that increases the oxidative state of cells and as a consequence amplifies TNF-mediated NF-kappa B DNA binding PubMed
env In CD4-positive Jurkat cells, gp120 enhances TNF-induced NF-kappa B activation PubMed
env Binding of heat-inactivated HIV-1 (iHIV-1) or HIV-1 gp120 to infected resting PBMCs is sufficient to activate NF-kappa B and AP-1, to induce cell surface expression of CD25, and to commit cells to produce virus PubMed
env HIV-1 gp120 and anti-CD4 antibodies induce a specific, significant decrease in the binding activity of NF-AT, NF-kappa B and AP-1, which leads to an inhibition of IL-2 production and cell proliferation PubMed
Envelope transmembrane glycoprotein gp41 env HIV-1 Env gp41 activates NK-kB (NFKB1) in human brain microvascular endothelial cells PubMed
env The HIV-1 gp41 cytoplasmic domain-induced NFkappaB activation requires TAK1, RelA, and NEMO proteins PubMed
env The cytoplasmic domain (residues 704-773) of HIV-1 gp41 induces NFkappaB activation. Deletion of a 12 amino-acid sequence (762CLFSYHRLRDLL) in gp41 leads to a dramatic loss of the NFkappaB activation and tyrosine 766 is particularly important PubMed
Nef nef HIV-1 Nef modulates NFKB1 activation PubMed
nef The (PxxP) regions that interact with SH3 domain-containing cellular kinases as well as two acidic C-terminal residues (E154/E155) are critical for Nef-mediated enhancement of NF-kappaB activity PubMed
nef HIV-1 and SIVcpz Nef proteins enhance TNF-alpha, IKK-beta, and RelA/p65-induced NF-kappaB activation in 293T cells PubMed
nef HIV-1 Nef activates nuclear transcription factor NF-kappaB in human monocyte/macrophages, promonoctyes, and dendritic cells, and to a lesser extent in immature dendritic cells PubMed
nef Knockdown of the p50 and p65 subunits of NF-kappaB by siRNA shows significant reduction of CCL5 levels, suggesting that NF-kappaB is involved in Nef-mediated upregulation of CCL5 PubMed
nef Stimulation of T cells by mitogens or antibodies to the T-cell receptor (TCR)-CD3 complex results in the downregulation of transcriptional factors NF-kappa B and AP-1 in cells expressing HIV-1 Nef PubMed
nef The interaction of HIV-1 Nef with TRAF2, TRAF5, and TRAF6 proteins activates NF-kappaB, leading to the degradation of IkappaB-alpha and the increased phosphorylation of IKK-alpha and IKK-beta in monocyte-derived macrophages PubMed
nef HIV-1 Nef upregulates TLR2 expression via NF-kappaB activation in THP-1 cells PubMed
nef Both the myristoylation site and the acidic cluster in HIV-1 Nef are required for the activation of NF-kappaB, which induces upregulation of TNFalpha and IL6 expression PubMed
nef HIV-1 Nef immunocomplexes analyzed by mass spectrometry reveal that NFKB-p105 is a Nef-binding protein in Jurkat cells PubMed
nef Nef-mediated activation of NF-kappaB in macrophages induces secretion of the acute-phase protein ferritin, which is necessary and sufficient for Nef-dependent B cell changes PubMed
nef HIV-1 Nef suppresses immunoglobulin class-switch DNA recombination by inducing IkappaBalpha and SOCS proteins, which block CD154, IL-4 and IL-10 cytokine signaling via NF-kappaB and STAT transcription factors PubMed
nef HIV-1 Nef inhibits the induction of HIV-1- and interleukin 2-directed gene expression, and the effect on HIV-1 transcription depends on an intact NF-kappa B-binding site PubMed
nef HIV-1 Nef expression in Drosophila inhibits NF-kappa-B activation PubMed
nef HIV-1 Nef inhibits the induction of NF-kappa B DNA-binding activity by T-cell mitogens, however Nef does not affect the DNA-binding activity of other transcription factors implicated in HIV-1 regulation, including SP-1, USF, URS, and NF-AT PubMed
Tat tat HIV-1 Tat decreases NFKB1 (NF-kB) activation in Leishmania-infected macrophages PubMed
tat HIV-1 Tat activates NFkappaB, causing the induction of CD95 ligand, CD69, iNOS, MCP-1, IL-2, IL-6, IL-8, IL-10, TNF-alpha, VCAM-1, ICAM-1, E-selectin, and MMP-9, as well as monocyte adhesion, cellular activation and angiogenesis PubMed
tat Human microglia cells treated with HIV-1 clade C Tat show more significant upregulation of IL-6 and TNF-alpha, and higher NF-kappaB activation as compared to clade B Tat-treated cells PubMed
tat HIV-1 Tat upregulates the expression of platelet-derived growth factor subunit B homodimer through activation of the PDGFR-B/MEK/NF-kappaB pathway in human brain microvascular pericytes PubMed
tat HIV-1 Tat-mediated transcriptional activation of the HIV-1 LTR promoter requires NFkappaB binding sites in the promoter and involves the activation of NFkappaB by Tat PubMed
tat HIV-1 Tat-mediated upregulation of CCL5 involves JAK2/3, AKT2/3, p38delta, NF-kappaB (p65/p50), C/EBP alpha/gamma, and AP-1 proteins PubMed
tat HIV-1 Tat enhances the NFkappaB activity by inhibiting IkappaB-alpha binding to p65 RelA PubMed
tat Exogenous Nef and TNF-alpha synergistically activate NF-kappaB and AP-1 resulting in enhancing HIV-1 Tat transactivation of the LTR and viral replication in both chronically infected promonocytic cells and acutely infected primary macrophages PubMed
tat HIV-1 Tat recruits P/CAF to the integrated HIV-1 LTR promoter causing the acetylation of histones, which in turn leads to the recruitment the p65 subunit of NFkappaB to the promoter PubMed
tat HIV-1 Tat induces the acetylation of the NFkappaB p50 subunit as well as the p50/p65 complex by p300, causing an increase in NFkappaB DNA binding activity and in the rate of transcription PubMed
tat Extracellular HIV-1 Tat upregulates the expression of human beta-defensin 2 (hBD-2) via JNK/NF-KappaB/AP-1-dependent pathways in human B cells PubMed
tat The transcription factors NF-KappaB and NF-AT contribute to the Tat-induced activation of the HERV-K (HML-2) gag RNA transcripts in Jurkat T cells and in primary lymphocytes PubMed
tat HIV-1 Tat enhances the NFkappaB activity and promotes the transcriptional activation of MIP-1alpha by interacting with IkappaB-alpha and p65 RelA PubMed
tat MiR-217 regulates HIV-1 Tat-induced activation of NF-kappaB and inactivation of AMPK in MAGI cells PubMed
tat Inhibition of human telomerase reverse transcriptase (hTERT) results in the upregulation of HIV-1 Tat-induced overexpression of intercellular adhesion molecule-1 (ICAM1) via the nuclear factor-kappaB-regulated mechanism PubMed
tat Acetylation-deficient cyclin T1 mutant dominantly suppresses NF-kappaB-mediated activation of the interleukin-8 promoter but continues to synergize with the HIV Tat protein to transactivate the HIV long terminal repeat PubMed
tat Herpes virus saimiri-StpC synergizes with Tat during transcriptional activation of the HIV-1 LTR. This transcriptional synergy between StpC and Tat requires Lck and NF-kappaB consensus binding sequences PubMed
tat Specific C/EBP and NF-kappaB transcription factor binding elements within the IL-1beta promoter are involved in Tat regulation of IL-1beta production PubMed
tat Treatment of astrocytes with cell-permeable superoxide dismutase (SOD) leads to a decrease in Tat-induced ROS generation and NF-kappaB activation PubMed
tat Glutamic acids at positions 92, 94, and 96 or lysine's at positions 88, 89, and 90 in the second encoding Tat exon are critical for the activation of NF-kappaB PubMed
tat HIV-1 Tat binds the deacetylase domain (amino acids 341-512) of SIRT1 and inhibits SIRT1 deacetylase activity, which results in the induction of NF-kappaB hyperacetylation PubMed
tat HIV-1 Tat-mediated upregulation of MMP-9 in human astrocytes results from NF-kappaB activation pathway PubMed
tat PPARalpha and PPARgamma over-expression prevent Tat-induced binding activity and transactivation of nuclear factor-kappaB PubMed
tat NFKB1 is downregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells PubMed
tat HIV-1 Tat in combination with IFN-gamma and TNF-alpha increases CXCL10 mRNA and protein in human astrocytes through the activation of the p38, Jnk, and Akt signaling pathways and their downstream transcription factors, NF-kappaB and STAT-1alpha PubMed
tat NFAT-1 negatively regulates HIV-1 Tat-mediated transactivation of the HIV-1 LTR by competing with NFkappaB for its binding to the LTR, thereby blocking the interaction of NFkappaB with Tat PubMed
tat HIV-1 Tat activates NFkappaB through the cellular interferon-inducible, double-stranded RNA dependent protein kinase, PKR PubMed
tat Activation of NFkappaB by HIV-1 Tat leads to a reduction in adenylyl cyclase activity and an inhibition of cAMP synthesis PubMed
tat Activation of NFkappaB by HIV-1 Tat is inhibited by Nitric Oxide PubMed
tat HIV-1 Tat-induced SOCS3 expression inhibits antiviral IFN-beta signaling to enhance HIV-1 replication in macrophages in a NF-kappaB-dependent manner PubMed
tat Recombinant CD40L synergizes with HIV-1 Tat to increase TNF-alpha release from primary human monocytes and microglia in an NF-kappaB-dependent manner. This synergism is attributed to a Tat-mediated up-regulation of CD40 PubMed
tat In HIV-1 Tat-expressing and HIV-infected astrocytes, endothelin-1 (ET-1) is significantly elevated through NF-kappaB (NF-kappaB)-responsive sites in the ET-1 promoter PubMed
tat NFkappaB tethers the p160 nuclear receptor co-activator GRIP1 to the HIV-1 LTR promoter, thereby regulating the full activation of this promoter by HIV-1 Tat PubMed
tat HIV-1 Tat has been shown to bind NFkappaB in vitro in gel shift, GST-pull down and affinity matrix assays PubMed
tat p56-lck plays a critical role in the activation of NFkappaB by HIV-1 Tat PubMed
tat HIV-1 Tat enhances tumor necrosis factor-induced activation of NFkappaB by downregulating manganese-dependent superoxide dismutase (MnSOD) PubMed
Vpr vpr HIV-1 Vpr activates NFKB1 dependent upon amino acids A30, A59, H71, R73, S79, and R80 in Vpr in HeLa cells transfected with an NF-kB luciferase reporter plasmid PubMed
vpr HIV-1 Vpr activates NFKB1 in HeLa cells transfected with an NF-kB luciferase reporter plasmid, which leads to G2 cell cycle arrest PubMed
vpr Upregulation of IL-6, IL-10, TNFalpha, and gamma interferon is linked to HIV-1 Vpr activation of NF-kappa B PubMed
vpr TNF secreted by HIV-1-infected cells (which may be attributed to Vpr) enhances NFKB1 (NK-kappa-B) activity in bystander cells AND induces replication of HIV-1 (reactivation) in a model of latently infected cells (J-Lat 10.6 cells) PubMed
vpr HIV-1 Vpr induced upregulation CXCL8 (IL8) involves PI3K/Akt mediated activation of NFKB1 (NF-kappa-B) in astrocytes PubMed
vpr HIV-1 Vpr induced upregulation of IL6 involves PI3K/Akt mediated activation of NFKB1 (NF-kappa-B) in astrocytes PubMed
vpr HIV-1 Vpr-mediated upregulation of CXCL8 (IL8) involves NFKB1 (NF-kappa-B) PubMed
vpr HIV-1 Vpr-mediated upregulation of IL6 involves NFKB1 (NF-kappa-B) PubMed
vpr HIV-1 and SIVcpz Vpr proteins inhibit NF-kappaB, but the opposite is observed for SIVgsn/mus/mon Vpr proteins PubMed
vpr HIV-1 Vpr regulates NF-kappa B, activating it in certain circumstances while suppressing it in others PubMed
vpr The ability of HIV-1 Vpr to activate NF-kappaB or activator protein 1-dependent luciferase expression requires TAK1, TRAF6, or TAB3 in cells PubMed
vpr HIV-1 Vpr-induced upregulation of CCL5 requires p50 and p65 subunits of NF-kappaB, p38delta MAPK, Akt-2 and Akt-3, and AP-1 transcription factor in HIV-1 Vpr transfected astrocytes PubMed
vpr HIV-1 Vpr interacts with RelB to promote the Vpr-mediated activation of NF-kappaB reporter gene and to enhance the transactivation of HIV LTR PubMed
vpr HIV-1 Vpr inhibits the NFkappaB signaling pathway in TNF-alpha treated cells and abolishes the phosphorylation of NFkappaB p65 subunit in response to such treatment PubMed
vpr HIV-1 Vpr-induced IL-6 production depends on the activation of NFkappaB and the involvement of C/EBP-beta, TLR4, and MyD88 PubMed
vpr Recruitment of PARP-1 by HIV-1 Vpr-glucocorticoid receptor (GR) complex prevents its nuclear localization, which is necessary for Vpr to suppress NF-kappaB PubMed
vpr HIV-1 Vpr activation of NF-kappa B regulated promoters is linked to Vpr regulation of IL-12, CD44, Toll-like receptor 4, indolamine 2,3-dioxygenase, macrophage receptor with collagenous structure, and thrombospondin 1 PubMed
vpr HIV-1 Vpr potentiates the trans-activation, but not the trans-repression, properties of the glucocorticoid receptor on NF-kappa B-regulated simple promoters PubMed
vpr HIV-1 Vpr increases IL-8 expression and IL-8 promoter activity by activating transcription factors NF-kappa B and NF-IL-6 and also increases transcription of NF-kappa B and NF-IL-6 enhancer containing viral promoters PubMed
vpr NF-kappa B contributes to HIV-1 transactivation by HIV-1 Vpr but is not completely responsible for this effect PubMed
vpr Data suggests that p300, through its interactions with NF-kappa B, basal transcriptional components, and Cdks, is modulated by HIV-1 Vpr and regulates HIV replication PubMed
vpr Vpr suppresses expression of IL-2, IL-10, IL-12, TNFalpha and IL-4, all of which are NF-kappa B-dependent PubMed
vpr Regulation of apoptosis by HIV-1 Vpr is linked to Vpr suppression of NF-kappa B activity via the induction of I kappa B and is mapped to the first alpha-helical domain (amino acids 17-34) of Vpr PubMed
Vpu vpu HIV-1 Vpu modulates NFKB1 activation PubMed
vpu HIV-1 Vpu inhibits NF-kappa B activation by interfering with beta-TrCP-mediated degradation of IkappaB-alpha PubMed
vpu Most HIV-1 and primate lentiviral Vpu proteins inhibit IKK-beta-induced NF-kappaB activation except HIV-1 group N Vpu proteins PubMed
vpu HIV-1 Vpu inhibits endogenous expression BST2-induced NF-kappaB activity in cells, and the inhibition requires the beta-TrCP binding motif (residues 51-56; DSGxxS) in Vpu PubMed
vpu NF-kappaB-mediated enhancement of the IFN-beta promoter activity is inhibited by HIV-1 Vpu PubMed
vpu HIV-1 Vpu interferes with beta-TrCP to inhibit TNF-alpha-induced activation of NFkappaB PubMed
capsid gag HIV-1 CA mutants N74D and P90A fail to bind to CPSF6 and cyclophilins (Nup358 and CypA), respectively, and trigger innate sensors, leading to nuclear translocation of NFkappaB and IRF3, production of type 1 IFN and induction of an antiviral state PubMed
nucleocapsid gag NFKB1 (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) is downregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells PubMed
gag HIV-1 Nucleocapsid has been shown to bind to the HIV-1 LTR promoter and enhance NF-kappaB, Sp1, and TFIIB-induced HIV-1 LTR-directed RNA transcription PubMed
retropepsin gag-pol HIV-1 protease can cleave p105 into a p45 maturation product and increases levels of active nuclear NF-kappa B complex PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC54151, DKFZp686C01211

Gene Ontology Provided by GOA

Process Evidence Code Pubs
Fc-epsilon receptor signaling pathway TAS
Traceable Author Statement
more info
 
T cell receptor signaling pathway TAS
Traceable Author Statement
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cellular response to angiotensin IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to dsRNA IEA
Inferred from Electronic Annotation
more info
 
cellular response to interleukin-1 IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to interleukin-6 IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to nicotine IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to tumor necrosis factor IEA
Inferred from Electronic Annotation
more info
 
inflammatory response TAS
Traceable Author Statement
more info
PubMed 
interleukin-1-mediated signaling pathway TAS
Traceable Author Statement
more info
 
membrane protein intracellular domain proteolysis TAS
Traceable Author Statement
more info
 
negative regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
negative regulation of calcidiol 1-monooxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cellular protein metabolic process IC
Inferred by Curator
more info
PubMed 
negative regulation of cholesterol transport IC
Inferred by Curator
more info
PubMed 
negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interleukin-12 production IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IC
Inferred by Curator
more info
PubMed 
negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of vitamin D biosynthetic process IC
Inferred by Curator
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
positive regulation of NF-kappaB transcription factor activity TAS
Traceable Author Statement
more info
 
positive regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of hyaluronan biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of lipid storage IC
Inferred by Curator
more info
PubMed 
positive regulation of macrophage derived foam cell differentiation IC
Inferred by Curator
more info
PubMed 
positive regulation of miRNA metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of type I interferon production TAS
Traceable Author Statement
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to muscle stretch IEA
Inferred from Electronic Annotation
more info
 
stimulatory C-type lectin receptor signaling pathway TAS
Traceable Author Statement
more info
 
stress-activated MAPK cascade TAS
Traceable Author Statement
more info
 
transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
I-kappaB/NF-kappaB complex TAS
Traceable Author Statement
more info
PubMed 
chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromatin ISA
Inferred from Sequence Alignment
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IGI
Inferred from Genetic Interaction
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IGI
Inferred from Genetic Interaction
more info
PubMed 
secretory granule lumen TAS
Traceable Author Statement
more info
 
specific granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
nuclear factor NF-kappa-B p105 subunit
Names
DNA-binding factor KBF1
nuclear factor NF-kappa-B p50 subunit
nuclear factor kappa-B DNA binding subunit
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050628.1 RefSeqGene

    Range
    5031..120974
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1316

mRNA and Protein(s)

  1. NM_001165412.2NP_001158884.1  nuclear factor NF-kappa-B p105 subunit isoform 2 proprotein

    See identical proteins and their annotated locations for NP_001158884.1

    Status: REVIEWED

    Source sequence(s)
    AF213884, AI076882, BC051765, M58603
    Consensus CDS
    CCDS54783.1
    UniProtKB/Swiss-Prot
    P19838
    UniProtKB/TrEMBL
    A0A024RDJ4
    Related
    ENSP00000378297.4, ENST00000394820.8
    Conserved Domains (7) summary
    cd07935
    Location:42243
    RHD-n_NFkB1; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1)
    cd00204
    Location:576705
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd01177
    Location:250351
    IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
    cd08797
    Location:815890
    Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105
    sd00045
    Location:542579
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:525612
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:685733
    Ank_4; Ankyrin repeats (many copies)
  2. NM_001319226.2NP_001306155.1  nuclear factor NF-kappa-B p105 subunit isoform 2 proprotein

    Status: REVIEWED

    Source sequence(s)
    AF213884, AI076882, BC051765, DB151710, M58603
    Consensus CDS
    CCDS54783.1
    UniProtKB/Swiss-Prot
    P19838
    UniProtKB/TrEMBL
    A0A024RDJ4
    Related
    ENSP00000424790.1, ENST00000505458.5
    Conserved Domains (7) summary
    cd07935
    Location:42243
    RHD-n_NFkB1; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1)
    cd00204
    Location:576705
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd01177
    Location:250351
    IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
    cd08797
    Location:815890
    Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105
    sd00045
    Location:542579
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:525612
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:685733
    Ank_4; Ankyrin repeats (many copies)
  3. NM_001382625.1NP_001369554.1  nuclear factor NF-kappa-B p105 subunit isoform 1

    Status: REVIEWED

    Source sequence(s)
    AF213884
    Conserved Domains (7) summary
    cd07935
    Location:43244
    RHD-n_NFkB1; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1)
    COG0666
    Location:500706
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd01177
    Location:251352
    IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
    cd08797
    Location:816891
    Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105
    sd00045
    Location:543580
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:587681
    Ank_2; Ankyrin repeats (3 copies)
    cl39094
    Location:690733
    Ank_2; Ankyrin repeats (3 copies)
  4. NM_001382626.1NP_001369555.1  nuclear factor NF-kappa-B p105 subunit isoform 1

    Status: REVIEWED

    Source sequence(s)
    AF213884
    Conserved Domains (7) summary
    cd07935
    Location:43244
    RHD-n_NFkB1; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1)
    COG0666
    Location:500706
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd01177
    Location:251352
    IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
    cd08797
    Location:816891
    Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105
    sd00045
    Location:543580
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:587681
    Ank_2; Ankyrin repeats (3 copies)
    cl39094
    Location:690733
    Ank_2; Ankyrin repeats (3 copies)
  5. NM_001382627.1NP_001369556.1  nuclear factor NF-kappa-B p105 subunit isoform 2 proprotein

    Status: REVIEWED

    Source sequence(s)
    AF213884
  6. NM_001382628.1NP_001369557.1  nuclear factor NF-kappa-B p105 subunit isoform 3

    Status: REVIEWED

    Source sequence(s)
    AF213884
    Related
    ENSP00000469340.1, ENST00000600343.5
  7. NM_003998.4NP_003989.2  nuclear factor NF-kappa-B p105 subunit isoform 1

    See identical proteins and their annotated locations for NP_003989.2

    Status: REVIEWED

    Source sequence(s)
    AF213884, AI076882, BC051765
    Consensus CDS
    CCDS3657.1
    UniProtKB/Swiss-Prot
    P19838
    Related
    ENSP00000226574.4, ENST00000226574.9
    Conserved Domains (7) summary
    cd07935
    Location:43244
    RHD-n_NFkB1; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1)
    COG0666
    Location:500706
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd01177
    Location:251352
    IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
    cd08797
    Location:816891
    Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105
    sd00045
    Location:543580
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:587681
    Ank_2; Ankyrin repeats (3 copies)
    cl39094
    Location:690733
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    102501266..102617302
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024454069.1XP_024309837.1  nuclear factor NF-kappa-B p105 subunit isoform X4

    Conserved Domains (7) summary
    cd00204
    Location:532661
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd01177
    Location:206307
    IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
    cd08797
    Location:771846
    Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105
    sd00045
    Location:498535
    ANK; ANK repeat [structural motif]
    cl08275
    Location:51199
    RHD-n; N-terminal sub-domain of the Rel homology domain (RHD)
    pfam12796
    Location:481568
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:641689
    Ank_4; Ankyrin repeats (many copies)
  2. XM_024454068.1XP_024309836.1  nuclear factor NF-kappa-B p105 subunit isoform X3

    Conserved Domains (7) summary
    cd07935
    Location:43244
    RHD-n_NFkB1; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1)
    COG0666
    Location:500706
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd01177
    Location:251352
    IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
    cd08797
    Location:816891
    Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105
    sd00045
    Location:543580
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:587681
    Ank_2; Ankyrin repeats (3 copies)
    cl39094
    Location:690733
    Ank_2; Ankyrin repeats (3 copies)
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