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F11R F11 receptor [ Canis lupus familiaris (dog) ]

Gene ID: 478974, updated on 25-Jul-2026
Official Symbol
F11Rprovided by VGNC
Official Full Name
F11 receptorprovided by VGNC
Primary source
VGNC:VGNC:56143
See related
Ensembl:ENSCAFG00845030092 RGD:12337791
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
JAM-A
Orthologs
all
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Try the new Transcripts and proteins table
See F11R in Genome Data Viewer
Location:
chromosome: 38
Exon count:
11
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 38 NC_051842.1 (21549642..21573725)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 38 NC_006620.4 (21506583..21530426)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 38 NC_049259.1 (22261259..22285444)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 38 NC_049298.1 (21437767..21461771)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 38 NC_049779.1 (21851653..21875546)

Chromosome 38 - NC_051842.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119868069 Neighboring gene thiosulfate sulfurtransferase like domain containing 1 Neighboring gene uncharacterized LOC119868070 Neighboring gene uncharacterized LOC119868020

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. JAM-A interacts with α3β1 integrin and tetraspanins CD151 and CD9 to regulate collective cell migration of polarized epithelial cells. Thölmann S, et al. Cell Mol Life Sci, 2022 Jan 24. PMID 35067832, Free PMC Article
  2. Claudins and JAM-A coordinately regulate tight junction formation and epithelial polarity. Otani T, et al. J Cell Biol, 2019 Oct 7. PMID 31467165, Free PMC Article
  3. Junctional adhesion molecule-a participates in the formation of apico-basal polarity through different domains. Rehder D, et al. Exp Cell Res, 2006 Oct 15. PMID 16919624
  4. Interplay between Extracellular Matrix Stiffness and JAM-A Regulates Mechanical Load on ZO-1 and Tight Junction Assembly. Haas AJ, et al. Cell Rep, 2020 Jul 21. PMID 32697990, Free PMC Article
  5. JAM-A regulates cortical dynein localization through Cdc42 to control planar spindle orientation during mitosis. Tuncay H, et al. Nat Commun, 2015 Aug 26. PMID 26306570, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. JAM-A interacts with alpha3beta1 integrin and tetraspanins CD151 and CD9 to regulate collective cell migration of polarized epithelial cells.
    Title: JAM-A interacts with α3β1 integrin and tetraspanins CD151 and CD9 to regulate collective cell migration of polarized epithelial cells.
  2. Interplay between Extracellular Matrix Stiffness and JAM-A Regulates Mechanical Load on ZO-1 and Tight Junction Assembly.
    Title: Interplay between Extracellular Matrix Stiffness and JAM-A Regulates Mechanical Load on ZO-1 and Tight Junction Assembly.
  3. The results demonstrate that claudins and JAM-A coordinately regulateTight junctions formation and epithelial polarity.
    Title: Claudins and JAM-A coordinately regulate tight junction formation and epithelial polarity.
  4. In the present study, organspecific expression of the tight junction proteins, claudin, occludin, junction adhesion molecule A and zona occludens 1 was examined in the canine duodenum, lung, liver and kidney.
    Title: Expression of claudins, occludin, junction adhesion molecule A and zona occludens 1 in canine organs.
  5. JAM-A regulates the planar orientation of the mitotic spindle during epithelial morphogenesis. It triggers transient activation of Cdc42 and PI3K, generates a gradient of PtdIns(3,4,5)P3 at the cortex and regulates the formation of the actin cytoskeleton.
    Title: JAM-A regulates cortical dynein localization through Cdc42 to control planar spindle orientation during mitosis.
  6. Findings suggest an important role for JAM-A in the development of apico-basal polarity in epithelial cells and identify regions in JAM-A which are critical for this role
    Title: Junctional adhesion molecule-a participates in the formation of apico-basal polarity through different domains.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by RefSeq

Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in establishment of endothelial intestinal barrier IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intestinal absorption IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of membrane permeability IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in bicellular tight junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
junctional adhesion molecule A
Names
Junctional adhesion molecule A

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051842.1 Reference ROS_Cfam_1.0

    Range
    21549642..21573725
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038448653.1 → XP_038304581.1  junctional adhesion molecule A

    UniProtKB/TrEMBL
    A0A8C0QSZ5, A0A8I3Q8K2
    Related
    ENSCAFP00845041923.1, ENSCAFT00845053366.1
    Conserved Domains (3) summary
    cd00096
    Location:36 → 40
    Ig; Ig strand A' [structural motif]
    cd20950
    Location:134 → 230
    IgI_2_JAM1; Second Ig-like domain of Junctional adhesion molecule-1 (JAM1); a member of the I-set of IgSF domains
    cl11960
    Location:30 → 128
    Ig; Immunoglobulin domain

RNA

  1. XR_005308951.1 RNA Sequence

    Related
    ENSCAFT00845053403.1

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049298.1 Alternate UMICH_Zoey_3.1

    Range
    21437767..21461771
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038522539.1 → XP_038378467.1  

    Conserved Domains (3) summary
    cd00096
    Location:36 → 40
    Ig; Ig strand A' [structural motif]
    cd20950
    Location:134 → 230
    IgI_2_JAM1; Second Ig-like domain of Junctional adhesion molecule-1 (JAM1); a member of the I-set of IgSF domains
    cl11960
    Location:30 → 128
    Ig; Immunoglobulin domain

RNA

  1. XR_005351826.1 RNA Sequence

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049779.1 Alternate UNSW_CanFamBas_1.0

    Range
    21851653..21875546
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038650739.1 → XP_038506667.1  

    Conserved Domains (3) summary
    cd00096
    Location:36 → 40
    Ig; Ig strand A' [structural motif]
    cd20950
    Location:134 → 230
    IgI_2_JAM1; Second Ig-like domain of Junctional adhesion molecule-1 (JAM1); a member of the I-set of IgSF domains
    cl11960
    Location:30 → 128
    Ig; Immunoglobulin domain

RNA

  1. XR_005419579.1 RNA Sequence

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049259.1 Alternate UU_Cfam_GSD_1.0

    Range
    22261259..22285444
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038586319.1 → XP_038442247.1  junctional adhesion molecule A

    UniProtKB/TrEMBL
    A0A8C0QSZ5, A0A8I3Q8K2
    Conserved Domains (3) summary
    cd00096
    Location:36 → 40
    Ig; Ig strand A' [structural motif]
    cd20950
    Location:134 → 230
    IgI_2_JAM1; Second Ig-like domain of Junctional adhesion molecule-1 (JAM1); a member of the I-set of IgSF domains
    cl11960
    Location:30 → 128
    Ig; Immunoglobulin domain

RNA

  1. XR_005385818.1 RNA Sequence

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006620.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    21506583..21530426
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038464138.1 → XP_038320066.1  junctional adhesion molecule A

    UniProtKB/TrEMBL
    A0A8C0QSZ5, A0A8I3Q8K2
    Conserved Domains (3) summary
    cd00096
    Location:36 → 40
    Ig; Ig strand A' [structural motif]
    cd20950
    Location:134 → 230
    IgI_2_JAM1; Second Ig-like domain of Junctional adhesion molecule-1 (JAM1); a member of the I-set of IgSF domains
    cl11960
    Location:30 → 128
    Ig; Immunoglobulin domain

RNA

  1. XR_005318769.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version

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