U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

COL3A1 collagen type III alpha 1 chain [ Canis lupus familiaris (dog) ]

Gene ID: 478835, updated on 1-Mar-2025

Summary

Go to the top of the page Help
Official Symbol
COL3A1provided by VGNC
Official Full Name
collagen type III alpha 1 chainprovided by VGNC
Primary source
VGNC:VGNC:39472
See related
Ensembl:ENSCAFG00845019819 RGD:12186118
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
PIIINP
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See COL3A1 in Genome Data Viewer
Location:
chromosome: 36
Exon count:
51
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 36 NC_051840.1 (30718700..30756283)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 36 NC_006618.4 (30394214..30431773)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 36 NC_049257.1 (30884313..30921873)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 36 NC_049296.1 (30779325..30816837)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 36 NC_049777.1 (30715289..30752838)

Chromosome 36 - NC_051840.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102156907 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC119867862 Neighboring gene collagen type V alpha 2 chain Neighboring gene uncharacterized LOC119867861

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Serum concentrations of PIIINP aminopeptide in dogs with liver fibrosis. Glińska-Suchocka K, et al. Pol J Vet Sci, 2016. PMID 27487511
  2. Associations between N-terminal procollagen type III, fibrosis and echocardiographic indices in dogs that died due to myxomatous mitral valve disease. Hezzell MJ, et al. J Vet Cardiol, 2014 Dec. PMID 25292459
  3. Association of Circulating Tissue Inhibitor of Metalloproteinases-1 and Procollagen Type III Aminoterminal Peptide Levels With Incident Heart Failure and Chronic Kidney Disease. Lieb W, et al. J Am Heart Assoc, 2019 Apr 2. PMID 30890055, Free PMC Article
  4. Genetic basis of cranial cruciate ligament rupture (CCLR) in dogs. Baird AE, et al. Connect Tissue Res, 2014 Aug. PMID 24684544
  5. Immunohistochemical analysis of collagen types I, III, IV and alpha-actin in the urethra of sexually intact and ovariectomized beagles. Augsburger HR, et al. Int Urogynecol J Pelvic Floor Dysfunct, 2007 Sep. PMID 17206491

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The blood levels of procollagen Type III-N-terminal peptide (PIIINP) in dogs who died of myxomatous mitral valve disease were associated with echocardiographic indices of heart dysfunction.
    Title: Associations between N-terminal procollagen type III, fibrosis and echocardiographic indices in dogs that died due to myxomatous mitral valve disease.
  2. procollagen type III aminoterminal peptide levels were not related to the risk of CKD or congestive heart failure.
    Title: Association of Circulating Tissue Inhibitor of Metalloproteinases-1 and Procollagen Type III Aminoterminal Peptide Levels With Incident Heart Failure and Chronic Kidney Disease.
  3. PIIINP serum concentration tests may be a promising non-invasive diagnostic technique that could be used in veterinary hepatology to assess the degree of liver fibrosis.
    Title: Serum concentrations of PIIINP aminopeptide in dogs with liver fibrosis.
  4. identified SNPs in key genes involved in ligament strength, stability and extracellular matrix formation (COL5A1, COL5A2, COL1A1, COL3A1, COL11A1, COL24A1, FBN1, LOX, LTBP2) which were significantly associated with CCLR susceptibility
    Title: Genetic basis of cranial cruciate ligament rupture (CCLR) in dogs.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables extracellular matrix structural constituent IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
collagen alpha-1(III) chain
Names
collagen alpha 1 type III
collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant)

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051840.1 Reference ROS_Cfam_1.0

    Range
    30718700..30756283
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038447284.1 → XP_038303212.1  collagen alpha-1(III) chain isoform X1

    UniProtKB/TrEMBL
    A0A8C0K6A5, A0A8C0MYN9, A0A8I3P6Q4
    Related
    ENSCAFP00845027401.1, ENSCAFT00845034992.1
    Conserved Domains (4) summary
    PRK07764
    Location:355 → 508
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    pfam00093
    Location:32 → 88
    VWC; von Willebrand factor type C domain
    pfam01391
    Location:633 → 689
    Collagen; Collagen triple helix repeat (20 copies)
    pfam01410
    Location:1231 → 1464
    COLFI; Fibrillar collagen C-terminal domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049296.1 Alternate UMICH_Zoey_3.1

    Range
    30779325..30816837
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038521358.1 → XP_038377286.1  collagen alpha-1(III) chain isoform X2

    Conserved Domains (4) summary
    PRK07764
    Location:355 → 508
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    pfam00093
    Location:32 → 88
    VWC; von Willebrand factor type C domain
    pfam01391
    Location:633 → 689
    Collagen; Collagen triple helix repeat (20 copies)
    pfam01410
    Location:1231 → 1464
    COLFI; Fibrillar collagen C-terminal domain

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049777.1 Alternate UNSW_CanFamBas_1.0

    Range
    30715289..30752838
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038649487.1 → XP_038505415.1  collagen alpha-1(III) chain isoform X1

    Conserved Domains (4) summary
    PRK07764
    Location:355 → 508
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    pfam00093
    Location:32 → 88
    VWC; von Willebrand factor type C domain
    pfam01391
    Location:633 → 689
    Collagen; Collagen triple helix repeat (20 copies)
    pfam01410
    Location:1231 → 1464
    COLFI; Fibrillar collagen C-terminal domain

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049257.1 Alternate UU_Cfam_GSD_1.0

    Range
    30884313..30921873
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038585075.1 → XP_038441003.1  collagen alpha-1(III) chain isoform X1

    UniProtKB/TrEMBL
    A0A8C0K6A5, A0A8C0MYN9, A0A8I3P6Q4
    Conserved Domains (4) summary
    PRK07764
    Location:355 → 508
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    pfam00093
    Location:32 → 88
    VWC; von Willebrand factor type C domain
    pfam01391
    Location:633 → 689
    Collagen; Collagen triple helix repeat (20 copies)
    pfam01410
    Location:1231 → 1464
    COLFI; Fibrillar collagen C-terminal domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006618.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    30394214..30431773
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_845916.6 → XP_851009.1  collagen alpha-1(III) chain isoform X1

    UniProtKB/TrEMBL
    A0A8C0K6A5, A0A8C0MYN9, A0A8I3P6Q4
    Conserved Domains (4) summary
    PRK07764
    Location:355 → 508
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    pfam00093
    Location:32 → 88
    VWC; von Willebrand factor type C domain
    pfam01391
    Location:633 → 689
    Collagen; Collagen triple helix repeat (20 copies)
    pfam01410
    Location:1231 → 1464
    COLFI; Fibrillar collagen C-terminal domain
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.