U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SLC25A12 solute carrier family 25 member 12 [ Canis lupus familiaris (dog) ]

Gene ID: 478798, updated on 25-Jul-2026
Official Symbol
SLC25A12provided by VGNC
Official Full Name
solute carrier family 25 member 12provided by VGNC
Primary source
VGNC:VGNC:46292
See related
Ensembl:ENSCAFG00845028165 RGD:12278777
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See SLC25A12 in Genome Data Viewer
Location:
chromosome: 36
Exon count:
21
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 36 NC_051840.1 (16305983..16511922, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 36 NC_006618.4 (16195022..16399770, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 36 NC_049257.1 (16496286..16703375, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 36 NC_049296.1 (16393768..16599876, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 36 NC_049777.1 (16393468..16600256, complement)

Chromosome 36 - NC_051840.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111094279 Neighboring gene dynein cytoplasmic 1 intermediate chain 2 Neighboring gene ATP synthase membrane subunit DAPIT, mitochondrial-like Neighboring gene general transcription factor IIF subunit 2-like Neighboring gene histone acetyltransferase 1 Neighboring gene U6 spliceosomal RNA Neighboring gene methionyl aminopeptidase type 1D, mitochondrial Neighboring gene distal-less homeobox 1

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A Mutation in the Mitochondrial Aspartate/Glutamate Carrier Leads to a More Oxidizing Intramitochondrial Environment and an Inflammatory Myopathy in Dutch Shepherd Dogs. Shelton GD, et al. J Neuromuscul Dis, 2019. PMID 31594244, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Description of a SLC25A12 variant resulting in an inflammatory myopathy in Dutch Shepherd dogs.
    Title: A Mutation in the Mitochondrial Aspartate/Glutamate Carrier Leads to a More Oxidizing Intramitochondrial Environment and an Inflammatory Myopathy in Dutch Shepherd Dogs.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables L-aspartate transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables L-glutamate transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in L-glutamate transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in aspartate transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in malate-aspartate shuttle IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
calcium-binding mitochondrial carrier protein Aralar1
Names
solute carrier family 25 (mitochondrial carrier, Aralar), member 12

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051840.1 Reference ROS_Cfam_1.0

    Range
    16305983..16511922 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038447061.1 → XP_038302989.1  calcium-binding mitochondrial carrier protein Aralar1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0JPG4, A0A8I3Q392
    Related
    ENSCAFP00845039151.1, ENSCAFT00845049924.1
    Conserved Domains (4) summary
    cd15900
    Location:93 → 117
    EFh_MICU; EF-hand motif [structural motif]
    cl28896
    Location:93 → 162
    EFh_MICU; EF-hand, calcium binding motif, found in mitochondrial calcium uptake proteins MICU1, MICU2, MICU3, and similar proteins
    pfam00153
    Location:516 → 611
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:17 → 82
    EF-hand_7; EF-hand domain pair

  2. XM_038447060.1 → XP_038302988.1  calcium-binding mitochondrial carrier protein Aralar1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JPF1, A0A8C0JPG4
    Conserved Domains (4) summary
    cd15900
    Location:102 → 126
    EFh_MICU; EF-hand motif [structural motif]
    cl28896
    Location:102 → 171
    EFh_MICU; EF-hand, calcium binding motif, found in mitochondrial calcium uptake proteins MICU1, MICU2, MICU3, and similar proteins
    pfam00153
    Location:525 → 620
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:26 → 91
    EF-hand_7; EF-hand domain pair

  3. XM_038447062.1 → XP_038302990.1  calcium-binding mitochondrial carrier protein Aralar1 isoform X3

    UniProtKB/TrEMBL
    A0A8C0JPG4, A0A8C0QUI0
    Conserved Domains (4) summary
    cd15900
    Location:91 → 115
    EFh_MICU; EF-hand motif [structural motif]
    cl28896
    Location:91 → 160
    EFh_MICU; EF-hand, calcium binding motif, found in mitochondrial calcium uptake proteins MICU1, MICU2, MICU3, and similar proteins
    pfam00153
    Location:514 → 609
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:15 → 80
    EF-hand_7; EF-hand domain pair

  4. XM_038447063.1 → XP_038302991.1  calcium-binding mitochondrial carrier protein Aralar1 isoform X4

    UniProtKB/TrEMBL
    A0A8C0JPG4, A0A8I3PZY8
    Related
    ENSCAFP00845038979.1, ENSCAFT00845049702.1
    Conserved Domains (1) summary
    pfam00153
    Location:423 → 518
    Mito_carr; Mitochondrial carrier protein

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049296.1 Alternate UMICH_Zoey_3.1

    Range
    16393768..16599876 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038521140.1 → XP_038377068.1  

    Conserved Domains (4) summary
    cd15900
    Location:93 → 117
    EFh_MICU; EF-hand motif [structural motif]
    cl28896
    Location:93 → 162
    EFh_MICU; EF-hand, calcium binding motif, found in mitochondrial calcium uptake proteins MICU1, MICU2, MICU3, and similar proteins
    pfam00153
    Location:516 → 611
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:17 → 82
    EF-hand_7; EF-hand domain pair

  2. XM_038521139.1 → XP_038377067.1  

    Conserved Domains (4) summary
    cd15900
    Location:102 → 126
    EFh_MICU; EF-hand motif [structural motif]
    cl28896
    Location:102 → 171
    EFh_MICU; EF-hand, calcium binding motif, found in mitochondrial calcium uptake proteins MICU1, MICU2, MICU3, and similar proteins
    pfam00153
    Location:525 → 620
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:26 → 91
    EF-hand_7; EF-hand domain pair

  3. XM_038521141.1 → XP_038377069.1  

    Conserved Domains (4) summary
    cd15900
    Location:91 → 115
    EFh_MICU; EF-hand motif [structural motif]
    cl28896
    Location:91 → 160
    EFh_MICU; EF-hand, calcium binding motif, found in mitochondrial calcium uptake proteins MICU1, MICU2, MICU3, and similar proteins
    pfam00153
    Location:514 → 609
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:15 → 80
    EF-hand_7; EF-hand domain pair

  4. XM_038521142.1 → XP_038377070.1  

    Conserved Domains (1) summary
    pfam00153
    Location:423 → 518
    Mito_carr; Mitochondrial carrier protein

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049777.1 Alternate UNSW_CanFamBas_1.0

    Range
    16393468..16600256 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038649256.1 → XP_038505184.1  

    Conserved Domains (4) summary
    cd15900
    Location:93 → 117
    EFh_MICU; EF-hand motif [structural motif]
    cl28896
    Location:93 → 162
    EFh_MICU; EF-hand, calcium binding motif, found in mitochondrial calcium uptake proteins MICU1, MICU2, MICU3, and similar proteins
    pfam00153
    Location:516 → 611
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:17 → 82
    EF-hand_7; EF-hand domain pair

  2. XM_038649255.1 → XP_038505183.1  

    Conserved Domains (4) summary
    cd15900
    Location:102 → 126
    EFh_MICU; EF-hand motif [structural motif]
    cl28896
    Location:102 → 171
    EFh_MICU; EF-hand, calcium binding motif, found in mitochondrial calcium uptake proteins MICU1, MICU2, MICU3, and similar proteins
    pfam00153
    Location:525 → 620
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:26 → 91
    EF-hand_7; EF-hand domain pair

  3. XM_038649257.1 → XP_038505185.1  

    Conserved Domains (4) summary
    cd15900
    Location:91 → 115
    EFh_MICU; EF-hand motif [structural motif]
    cl28896
    Location:91 → 160
    EFh_MICU; EF-hand, calcium binding motif, found in mitochondrial calcium uptake proteins MICU1, MICU2, MICU3, and similar proteins
    pfam00153
    Location:514 → 609
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:15 → 80
    EF-hand_7; EF-hand domain pair

  4. XM_038649258.1 → XP_038505186.1  

    Conserved Domains (1) summary
    pfam00153
    Location:423 → 518
    Mito_carr; Mitochondrial carrier protein

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049257.1 Alternate UU_Cfam_GSD_1.0

    Range
    16496286..16703375 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038584841.1 → XP_038440769.1  calcium-binding mitochondrial carrier protein Aralar1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0JPG4, A0A8I3Q392
    Conserved Domains (4) summary
    cd15900
    Location:93 → 117
    EFh_MICU; EF-hand motif [structural motif]
    cl28896
    Location:93 → 162
    EFh_MICU; EF-hand, calcium binding motif, found in mitochondrial calcium uptake proteins MICU1, MICU2, MICU3, and similar proteins
    pfam00153
    Location:516 → 611
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:17 → 82
    EF-hand_7; EF-hand domain pair

  2. XM_038584840.1 → XP_038440768.1  calcium-binding mitochondrial carrier protein Aralar1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JPF1, A0A8C0JPG4
    Conserved Domains (4) summary
    cd15900
    Location:102 → 126
    EFh_MICU; EF-hand motif [structural motif]
    cl28896
    Location:102 → 171
    EFh_MICU; EF-hand, calcium binding motif, found in mitochondrial calcium uptake proteins MICU1, MICU2, MICU3, and similar proteins
    pfam00153
    Location:525 → 620
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:26 → 91
    EF-hand_7; EF-hand domain pair

  3. XM_038584842.1 → XP_038440770.1  calcium-binding mitochondrial carrier protein Aralar1 isoform X3

    UniProtKB/TrEMBL
    A0A8C0JPG4, A0A8C0QUI0
    Conserved Domains (4) summary
    cd15900
    Location:91 → 115
    EFh_MICU; EF-hand motif [structural motif]
    cl28896
    Location:91 → 160
    EFh_MICU; EF-hand, calcium binding motif, found in mitochondrial calcium uptake proteins MICU1, MICU2, MICU3, and similar proteins
    pfam00153
    Location:514 → 609
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:15 → 80
    EF-hand_7; EF-hand domain pair

  4. XM_038584843.1 → XP_038440771.1  calcium-binding mitochondrial carrier protein Aralar1 isoform X4

    UniProtKB/TrEMBL
    A0A8C0JPG4, A0A8I3PZY8
    Conserved Domains (1) summary
    pfam00153
    Location:423 → 518
    Mito_carr; Mitochondrial carrier protein

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006618.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    16195022..16399770 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005640312.4 → XP_005640369.1  calcium-binding mitochondrial carrier protein Aralar1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0JPG4, A0A8I3Q392
    Conserved Domains (4) summary
    cd15900
    Location:93 → 117
    EFh_MICU; EF-hand motif [structural motif]
    cl28896
    Location:93 → 162
    EFh_MICU; EF-hand, calcium binding motif, found in mitochondrial calcium uptake proteins MICU1, MICU2, MICU3, and similar proteins
    pfam00153
    Location:516 → 611
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:17 → 82
    EF-hand_7; EF-hand domain pair

  2. XM_022414765.1 → XP_022270473.1  calcium-binding mitochondrial carrier protein Aralar1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JPF1, A0A8C0JPG4
    Conserved Domains (4) summary
    cd15900
    Location:102 → 126
    EFh_MICU; EF-hand motif [structural motif]
    cl28896
    Location:102 → 171
    EFh_MICU; EF-hand, calcium binding motif, found in mitochondrial calcium uptake proteins MICU1, MICU2, MICU3, and similar proteins
    pfam00153
    Location:525 → 620
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:26 → 91
    EF-hand_7; EF-hand domain pair

  3. XM_535962.5 → XP_535962.2  calcium-binding mitochondrial carrier protein Aralar1 isoform X3

    UniProtKB/TrEMBL
    A0A8C0JPG4, A0A8C0QUI0
    Conserved Domains (4) summary
    cd15900
    Location:91 → 115
    EFh_MICU; EF-hand motif [structural motif]
    cl28896
    Location:91 → 160
    EFh_MICU; EF-hand, calcium binding motif, found in mitochondrial calcium uptake proteins MICU1, MICU2, MICU3, and similar proteins
    pfam00153
    Location:514 → 609
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:15 → 80
    EF-hand_7; EF-hand domain pair

  4. XM_005640313.2 → XP_005640370.1  calcium-binding mitochondrial carrier protein Aralar1 isoform X4

    UniProtKB/TrEMBL
    A0A8C0JPG4, A0A8I3PZY8
    Conserved Domains (1) summary
    pfam00153
    Location:423 → 518
    Mito_carr; Mitochondrial carrier protein
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Miscellaneous