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SCN1A sodium voltage-gated channel alpha subunit 1 [ Canis lupus familiaris (dog) ]

Gene ID: 478775, updated on 22-Jan-2024

Summary

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Official Symbol
SCN1Aprovided by VGNC
Official Full Name
sodium voltage-gated channel alpha subunit 1provided by VGNC
Primary source
VGNC:VGNC:45915
See related
Ensembl:ENSCAFG00845017165
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
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Genomic context

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Location:
chromosome: 36
Exon count:
29
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 36 NC_051840.1 (11240396..11380203, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 36 NC_006618.4 (11250750..11390861, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 36 NC_049257.1 (11407225..11547338, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 36 NC_049296.1 (11322130..11462589, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 36 NC_049777.1 (11294554..11434591, complement)

Chromosome 36 - NC_051840.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC111094186 Neighboring gene tetratricopeptide repeat domain 21B Neighboring gene protein CEBPZOS-like Neighboring gene uncharacterized LOC119867819 Neighboring gene sodium voltage-gated channel alpha subunit 9 Neighboring gene uncharacterized LOC119867818 Neighboring gene uncharacterized LOC102153897

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables voltage-gated sodium channel activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in membrane depolarization during action potential IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neuronal action potential IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of voltage-gated sodium channel complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
sodium channel protein type 1 subunit alpha; LOW QUALITY PROTEIN: sodium channel protein type 1 subunit alpha
Names
sodium channel voltage-gated type I alpha
sodium channel, voltage-gated, type I, alpha polypeptide
sodium channel, voltage-gated, type I, alpha subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051840.1 Reference ROS_Cfam_1.0

    Range
    11240396..11380203 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038446942.1 → XP_038302870.1  sodium channel protein type 1 subunit alpha isoform X3

    UniProtKB/TrEMBL
    A0A8I3PAU3, A0A8P0NYS6
    Conserved Domains (5) summary
    cd13433
    Location:1456 → 1508
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1189 → 1464
    Ion_trans; Ion transport protein
    pfam06512
    Location:978 → 1185
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:510 → 690
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1780 → 1827
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  2. XM_038446941.1 → XP_038302869.1  sodium channel protein type 1 subunit alpha isoform X2

    UniProtKB/TrEMBL
    A0A8I3PAU3, A0A8P0NYS6
    Conserved Domains (5) summary
    cd13433
    Location:1473 → 1525
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1206 → 1481
    Ion_trans; Ion transport protein
    pfam06512
    Location:995 → 1202
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:510 → 707
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1797 → 1844
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  3. XM_038446937.1 → XP_038302865.1  sodium channel protein type 1 subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A8C0Z6V2, A0A8P0SG87
    Conserved Domains (5) summary
    cd13433
    Location:1484 → 1536
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1217 → 1492
    Ion_trans; Ion transport protein
    pfam06512
    Location:1006 → 1213
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:510 → 718
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1808 → 1855
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  4. XM_038446938.1 → XP_038302866.1  sodium channel protein type 1 subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A8C0Z6V2, A0A8P0SG87
    Related
    ENSCAFP00845023846.1, ENSCAFT00845030408.1
    Conserved Domains (5) summary
    cd13433
    Location:1484 → 1536
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1217 → 1492
    Ion_trans; Ion transport protein
    pfam06512
    Location:1006 → 1213
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:510 → 718
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1808 → 1855
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  5. XM_038446940.1 → XP_038302868.1  sodium channel protein type 1 subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A8C0Z6V2, A0A8P0SG87
    Conserved Domains (5) summary
    cd13433
    Location:1484 → 1536
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1217 → 1492
    Ion_trans; Ion transport protein
    pfam06512
    Location:1006 → 1213
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:510 → 718
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1808 → 1855
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  6. XM_038446939.1 → XP_038302867.1  sodium channel protein type 1 subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A8C0Z6V2, A0A8P0SG87
    Conserved Domains (5) summary
    cd13433
    Location:1484 → 1536
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1217 → 1492
    Ion_trans; Ion transport protein
    pfam06512
    Location:1006 → 1213
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:510 → 718
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1808 → 1855
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049296.1 Alternate UMICH_Zoey_3.1

    Range
    11322130..11462589 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038521014.1 → XP_038376942.1  LOW QUALITY PROTEIN: sodium channel protein type 1 subunit alpha isoform X1

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049777.1 Alternate UNSW_CanFamBas_1.0

    Range
    11294554..11434591 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038649131.1 → XP_038505059.1  sodium channel protein type 1 subunit alpha isoform X3

    Conserved Domains (5) summary
    cd13433
    Location:1456 → 1508
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1189 → 1464
    Ion_trans; Ion transport protein
    pfam06512
    Location:978 → 1185
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:510 → 690
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1780 → 1827
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  2. XM_038649126.1 → XP_038505054.1  sodium channel protein type 1 subunit alpha isoform X1

    Conserved Domains (5) summary
    cd13433
    Location:1484 → 1536
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1217 → 1492
    Ion_trans; Ion transport protein
    pfam06512
    Location:1006 → 1213
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:510 → 718
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1808 → 1855
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  3. XM_038649127.1 → XP_038505055.1  sodium channel protein type 1 subunit alpha isoform X1

    Conserved Domains (5) summary
    cd13433
    Location:1484 → 1536
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1217 → 1492
    Ion_trans; Ion transport protein
    pfam06512
    Location:1006 → 1213
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:510 → 718
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1808 → 1855
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  4. XM_038649129.1 → XP_038505057.1  sodium channel protein type 1 subunit alpha isoform X1

    Conserved Domains (5) summary
    cd13433
    Location:1484 → 1536
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1217 → 1492
    Ion_trans; Ion transport protein
    pfam06512
    Location:1006 → 1213
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:510 → 718
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1808 → 1855
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  5. XM_038649128.1 → XP_038505056.1  sodium channel protein type 1 subunit alpha isoform X1

    Conserved Domains (5) summary
    cd13433
    Location:1484 → 1536
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1217 → 1492
    Ion_trans; Ion transport protein
    pfam06512
    Location:1006 → 1213
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:510 → 718
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1808 → 1855
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  6. XM_038649130.1 → XP_038505058.1  sodium channel protein type 1 subunit alpha isoform X2

    Conserved Domains (5) summary
    cd13433
    Location:1473 → 1525
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1206 → 1481
    Ion_trans; Ion transport protein
    pfam06512
    Location:995 → 1202
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:510 → 707
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1797 → 1844
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049257.1 Alternate UU_Cfam_GSD_1.0

    Range
    11407225..11547338 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038584708.1 → XP_038440636.1  sodium channel protein type 1 subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A8C0Z6V2, A0A8P0SG87
    Conserved Domains (5) summary
    cd13433
    Location:1484 → 1536
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1217 → 1492
    Ion_trans; Ion transport protein
    pfam06512
    Location:1006 → 1213
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:510 → 718
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1808 → 1855
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  2. XM_038584710.1 → XP_038440638.1  sodium channel protein type 1 subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A8C0Z6V2, A0A8P0SG87
    Conserved Domains (5) summary
    cd13433
    Location:1484 → 1536
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1217 → 1492
    Ion_trans; Ion transport protein
    pfam06512
    Location:1006 → 1213
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:510 → 718
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1808 → 1855
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  3. XM_038584709.1 → XP_038440637.1  sodium channel protein type 1 subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A8C0Z6V2, A0A8P0SG87
    Conserved Domains (5) summary
    cd13433
    Location:1484 → 1536
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1217 → 1492
    Ion_trans; Ion transport protein
    pfam06512
    Location:1006 → 1213
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:510 → 718
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1808 → 1855
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  4. XM_038584712.1 → XP_038440640.1  sodium channel protein type 1 subunit alpha isoform X3

    UniProtKB/TrEMBL
    A0A8I3PAU3, A0A8P0NYS6
    Conserved Domains (5) summary
    cd13433
    Location:1456 → 1508
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1189 → 1464
    Ion_trans; Ion transport protein
    pfam06512
    Location:978 → 1185
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:510 → 690
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1780 → 1827
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  5. XM_038584711.1 → XP_038440639.1  sodium channel protein type 1 subunit alpha isoform X2

    UniProtKB/TrEMBL
    A0A8I3PAU3, A0A8P0NYS6
    Conserved Domains (5) summary
    cd13433
    Location:1473 → 1525
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1206 → 1481
    Ion_trans; Ion transport protein
    pfam06512
    Location:995 → 1202
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:510 → 707
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1797 → 1844
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  6. XM_038584707.1 → XP_038440635.1  sodium channel protein type 1 subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A8C0Z6V2, A0A8P0SG87
    Conserved Domains (5) summary
    cd13433
    Location:1484 → 1536
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1217 → 1492
    Ion_trans; Ion transport protein
    pfam06512
    Location:1006 → 1213
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:510 → 718
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1808 → 1855
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006618.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    11250750..11390861 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_014110715.3 → XP_013966190.1  sodium channel protein type 1 subunit alpha isoform X3

    UniProtKB/TrEMBL
    A0A8I3PAU3, A0A8P0NYS6
    Conserved Domains (5) summary
    cd13433
    Location:1456 → 1508
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1189 → 1464
    Ion_trans; Ion transport protein
    pfam06512
    Location:978 → 1185
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:510 → 690
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1780 → 1827
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  2. XM_535941.7 → XP_535941.2  sodium channel protein type 1 subunit alpha isoform X1

    See identical proteins and their annotated locations for XP_535941.2

    UniProtKB/TrEMBL
    A0A8C0Z6V2, A0A8P0SG87
    Conserved Domains (5) summary
    cd13433
    Location:1484 → 1536
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1217 → 1492
    Ion_trans; Ion transport protein
    pfam06512
    Location:1006 → 1213
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:510 → 718
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1808 → 1855
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  3. XM_014110711.3 → XP_013966186.1  sodium channel protein type 1 subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A8C0Z6V2, A0A8P0SG87
    Conserved Domains (5) summary
    cd13433
    Location:1484 → 1536
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1217 → 1492
    Ion_trans; Ion transport protein
    pfam06512
    Location:1006 → 1213
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:510 → 718
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1808 → 1855
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  4. XM_005640264.4 → XP_005640321.1  sodium channel protein type 1 subunit alpha isoform X1

    See identical proteins and their annotated locations for XP_005640321.1

    UniProtKB/TrEMBL
    A0A8C0Z6V2, A0A8P0SG87
    Conserved Domains (5) summary
    cd13433
    Location:1484 → 1536
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1217 → 1492
    Ion_trans; Ion transport protein
    pfam06512
    Location:1006 → 1213
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:510 → 718
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1808 → 1855
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  5. XM_038463446.1 → XP_038319374.1  sodium channel protein type 1 subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A8C0Z6V2, A0A8P0SG87
    Conserved Domains (5) summary
    cd13433
    Location:1484 → 1536
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1217 → 1492
    Ion_trans; Ion transport protein
    pfam06512
    Location:1006 → 1213
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:510 → 718
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1808 → 1855
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  6. XM_014110714.3 → XP_013966189.1  sodium channel protein type 1 subunit alpha isoform X2

    UniProtKB/TrEMBL
    A0A8I3PAU3, A0A8P0NYS6
    Conserved Domains (5) summary
    cd13433
    Location:1473 → 1525
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1206 → 1481
    Ion_trans; Ion transport protein
    pfam06512
    Location:995 → 1202
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:510 → 707
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1797 → 1844
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
Nucleotide Protein
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