U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

KPNA1 karyopherin subunit alpha 1 [ Canis lupus familiaris (dog) ]

Gene ID: 478585, updated on 25-Jul-2026
Official Symbol
KPNA1provided by VGNC
Official Full Name
karyopherin subunit alpha 1provided by VGNC
Primary source
VGNC:VGNC:42500
See related
Ensembl:ENSCAFG00845023382 RGD:12344975
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See KPNA1 in Genome Data Viewer
Location:
chromosome: 33
Exon count:
17
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 33 NC_051837.1 (25796537..25867021, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 33 NC_006615.4 (25585686..25656082, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 33 NC_049254.1 (26194435..26265045, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 33 NC_049293.1 (25593501..25663791, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 33 NC_049774.1 (25636870..25707309, complement)

Chromosome 33 - NC_051837.1Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 162 member A Neighboring gene WD repeat domain 5B Neighboring gene uncharacterized LOC119867298 Neighboring gene poly(ADP-ribose) polymerase family member 9 Neighboring gene deltex E3 ubiquitin ligase 3L

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables nuclear import signal receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in NLS-bearing protein import into nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in postsynapse to nucleus signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
importin subunit alpha-5

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051837.1 Reference ROS_Cfam_1.0

    Range
    25796537..25867021 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038445131.1 → XP_038301059.1  importin subunit alpha-5

    UniProtKB/TrEMBL
    A0A8C0K030, A0A8I3PSN7, A0A8I3PVT7
    Related
    ENSCAFP00845032379.1, ENSCAFT00845041300.1
    Conserved Domains (2) summary
    COG5064
    Location:33 → 516
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:128 → 154
    ARM; armadillo repeat [structural motif]

  2. XM_038445134.1 → XP_038301062.1  importin subunit alpha-5

    UniProtKB/TrEMBL
    A0A8C0K030, A0A8I3PSN7, A0A8I3PVT7
    Conserved Domains (2) summary
    COG5064
    Location:33 → 516
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:128 → 154
    ARM; armadillo repeat [structural motif]

  3. XM_038445133.1 → XP_038301061.1  importin subunit alpha-5

    UniProtKB/TrEMBL
    A0A8C0K030, A0A8I3PSN7, A0A8I3PVT7
    Conserved Domains (2) summary
    COG5064
    Location:33 → 516
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:128 → 154
    ARM; armadillo repeat [structural motif]

  4. XM_038445135.1 → XP_038301063.1  importin subunit alpha-5

    UniProtKB/TrEMBL
    A0A8C0K030, A0A8I3PSN7, A0A8I3PVT7
    Conserved Domains (2) summary
    COG5064
    Location:33 → 516
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:128 → 154
    ARM; armadillo repeat [structural motif]

  5. XM_038445132.1 → XP_038301060.1  importin subunit alpha-5

    UniProtKB/TrEMBL
    A0A8C0K030, A0A8I3PSN7, A0A8I3PVT7
    Conserved Domains (2) summary
    COG5064
    Location:33 → 516
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:128 → 154
    ARM; armadillo repeat [structural motif]

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049293.1 Alternate UMICH_Zoey_3.1

    Range
    25593501..25663791 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038519384.1 → XP_038375312.1  

    Conserved Domains (2) summary
    COG5064
    Location:33 → 516
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:128 → 154
    ARM; armadillo repeat [structural motif]

  2. XM_038519387.1 → XP_038375315.1  

    Conserved Domains (2) summary
    COG5064
    Location:33 → 516
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:128 → 154
    ARM; armadillo repeat [structural motif]

  3. XM_038519386.1 → XP_038375314.1  

    Conserved Domains (2) summary
    COG5064
    Location:33 → 516
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:128 → 154
    ARM; armadillo repeat [structural motif]

  4. XM_038519388.1 → XP_038375316.1  

    Conserved Domains (2) summary
    COG5064
    Location:33 → 516
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:128 → 154
    ARM; armadillo repeat [structural motif]

  5. XM_038519385.1 → XP_038375313.1  

    Conserved Domains (2) summary
    COG5064
    Location:33 → 516
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:128 → 154
    ARM; armadillo repeat [structural motif]

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049774.1 Alternate UNSW_CanFamBas_1.0

    Range
    25636870..25707309 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038647399.1 → XP_038503327.1  

    Conserved Domains (2) summary
    COG5064
    Location:33 → 516
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:128 → 154
    ARM; armadillo repeat [structural motif]

  2. XM_038647402.1 → XP_038503330.1  

    Conserved Domains (2) summary
    COG5064
    Location:33 → 516
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:128 → 154
    ARM; armadillo repeat [structural motif]

  3. XM_038647401.1 → XP_038503329.1  

    Conserved Domains (2) summary
    COG5064
    Location:33 → 516
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:128 → 154
    ARM; armadillo repeat [structural motif]

  4. XM_038647403.1 → XP_038503331.1  

    Conserved Domains (2) summary
    COG5064
    Location:33 → 516
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:128 → 154
    ARM; armadillo repeat [structural motif]

  5. XM_038647400.1 → XP_038503328.1  

    Conserved Domains (2) summary
    COG5064
    Location:33 → 516
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:128 → 154
    ARM; armadillo repeat [structural motif]

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049254.1 Alternate UU_Cfam_GSD_1.0

    Range
    26194435..26265045 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038583011.1 → XP_038438939.1  importin subunit alpha-5

    UniProtKB/TrEMBL
    A0A8C0K030, A0A8I3PSN7, A0A8I3PVT7
    Conserved Domains (2) summary
    COG5064
    Location:33 → 516
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:128 → 154
    ARM; armadillo repeat [structural motif]

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006615.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    25585686..25656082 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_535761.7 → XP_535761.1  importin subunit alpha-5

    See identical proteins and their annotated locations for XP_535761.1

    UniProtKB/TrEMBL
    A0A8C0K030, A0A8I3PSN7, A0A8I3PVT7
    Conserved Domains (2) summary
    COG5064
    Location:33 → 516
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:128 → 154
    ARM; armadillo repeat [structural motif]

  2. XM_022414019.2 → XP_022269727.1  importin subunit alpha-5

    UniProtKB/TrEMBL
    A0A8C0K030, A0A8I3PSN7, A0A8I3PVT7
    Conserved Domains (2) summary
    COG5064
    Location:33 → 516
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:128 → 154
    ARM; armadillo repeat [structural motif]

  3. XM_038462295.1 → XP_038318223.1  importin subunit alpha-5

    UniProtKB/TrEMBL
    A0A8C0K030, A0A8I3PSN7, A0A8I3PVT7
    Conserved Domains (2) summary
    COG5064
    Location:33 → 516
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:128 → 154
    ARM; armadillo repeat [structural motif]

  4. XM_005639560.4 → XP_005639617.1  importin subunit alpha-5

    See identical proteins and their annotated locations for XP_005639617.1

    UniProtKB/TrEMBL
    A0A8C0K030, A0A8I3PSN7, A0A8I3PVT7
    Conserved Domains (2) summary
    COG5064
    Location:33 → 516
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:128 → 154
    ARM; armadillo repeat [structural motif]

  5. XM_038462294.1 → XP_038318222.1  importin subunit alpha-5

    UniProtKB/TrEMBL
    A0A8C0K030, A0A8I3PSN7, A0A8I3PVT7
    Conserved Domains (2) summary
    COG5064
    Location:33 → 516
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:128 → 154
    ARM; armadillo repeat [structural motif]
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials