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SLC12A1 solute carrier family 12 member 1 [ Canis lupus familiaris (dog) ]

Gene ID: 478292, updated on 25-Jul-2026
Official Symbol
SLC12A1provided by VGNC
Official Full Name
solute carrier family 12 member 1provided by VGNC
Primary source
VGNC:VGNC:46218
See related
Ensembl:ENSCAFG00845019364 RGD:12118648
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
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See SLC12A1 in Genome Data Viewer
Location:
chromosome: 30
Exon count:
28
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 30 NC_051834.1 (14593665..14682546)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 30 NC_006612.4 (14381456..14470305)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 30 NC_049251.1 (14743702..14832801)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 30 NC_049290.1 (14516360..14605436)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 30 NC_049771.1 (14631905..14720735)

Chromosome 30 - NC_051834.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 24 member 5 Neighboring gene myelin expression factor 2 Neighboring gene cortexin 2 Neighboring gene uncharacterized LOC119866886 Neighboring gene uncharacterized LOC111093270 Neighboring gene uncharacterized LOC106558052 Neighboring gene deoxyuridine triphosphatase

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Rare independent mutations in renal salt handling genes contribute to blood pressure variation. Ji W, et al. Nat Genet, 2008 May. PMID 18391953, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables sodium:potassium:chloride symporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell volume homeostasis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in chloride ion homeostasis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in chloride transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in potassium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in potassium ion import across plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in sodium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
solute carrier family 12 member 1
Names
solute carrier family 12 (sodium/potassium/chloride transporters), member 1

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051834.1 Reference ROS_Cfam_1.0

    Range
    14593665..14682546
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038442270.1 → XP_038298198.1  solute carrier family 12 member 1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0R5L6
    Conserved Domains (1) summary
    TIGR00930
    Location:104 → 1100
    2a30; K-Cl cotransporter

  2. XM_038442271.1 → XP_038298199.1  solute carrier family 12 member 1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0R5L6, A0A8I3P5F9
    Related
    ENSCAFP00845027258.1, ENSCAFT00845034800.1
    Conserved Domains (1) summary
    TIGR00930
    Location:104 → 1100
    2a30; K-Cl cotransporter

  3. XM_038442272.1 → XP_038298200.1  solute carrier family 12 member 1 isoform X3

    UniProtKB/TrEMBL
    A0A8C0R5L6, A0A8I3P0K3
    Related
    ENSCAFP00845027448.1, ENSCAFT00845035058.1
    Conserved Domains (1) summary
    TIGR00930
    Location:104 → 1100
    2a30; K-Cl cotransporter

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049290.1 Alternate UMICH_Zoey_3.1

    Range
    14516360..14605436
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038516714.1 → XP_038372642.1  

    Conserved Domains (1) summary
    TIGR00930
    Location:104 → 1100
    2a30; K-Cl cotransporter

  2. XM_038516715.1 → XP_038372643.1  

    Conserved Domains (1) summary
    TIGR00930
    Location:104 → 1100
    2a30; K-Cl cotransporter

  3. XM_038516716.1 → XP_038372644.1  

    Conserved Domains (1) summary
    TIGR00930
    Location:104 → 1100
    2a30; K-Cl cotransporter

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049771.1 Alternate UNSW_CanFamBas_1.0

    Range
    14631905..14720735
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038644646.1 → XP_038500574.1  

    Conserved Domains (1) summary
    TIGR00930
    Location:104 → 1100
    2a30; K-Cl cotransporter

  2. XM_038644647.1 → XP_038500575.1  

    Conserved Domains (1) summary
    TIGR00930
    Location:104 → 1100
    2a30; K-Cl cotransporter

  3. XM_038644648.1 → XP_038500576.1  

    Conserved Domains (1) summary
    TIGR00930
    Location:104 → 1100
    2a30; K-Cl cotransporter

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049251.1 Alternate UU_Cfam_GSD_1.0

    Range
    14743702..14832801
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038580355.1 → XP_038436283.1  solute carrier family 12 member 1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0R5L6
    Conserved Domains (1) summary
    TIGR00930
    Location:104 → 1100
    2a30; K-Cl cotransporter

  2. XM_038580356.1 → XP_038436284.1  solute carrier family 12 member 1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0R5L6, A0A8I3P5F9
    Conserved Domains (1) summary
    TIGR00930
    Location:104 → 1100
    2a30; K-Cl cotransporter

  3. XM_038580357.1 → XP_038436285.1  solute carrier family 12 member 1 isoform X3

    UniProtKB/TrEMBL
    A0A8C0R5L6, A0A8I3P0K3
    Conserved Domains (1) summary
    TIGR00930
    Location:104 → 1100
    2a30; K-Cl cotransporter

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006612.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    14381456..14470305
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005638388.4 → XP_005638445.1  solute carrier family 12 member 1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0R5L6
    Conserved Domains (3) summary
    TIGR00930
    Location:104 → 1100
    2a30; K-Cl cotransporter
    pfam03522
    Location:695 → 1100
    SLC12; Solute carrier family 12
    pfam08403
    Location:90 → 156
    AA_permease_N; Amino acid permease N-terminal

  2. XM_014109428.3 → XP_013964903.1  solute carrier family 12 member 1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0R5L6
    Conserved Domains (3) summary
    TIGR00930
    Location:104 → 1100
    2a30; K-Cl cotransporter
    pfam03522
    Location:695 → 1100
    SLC12; Solute carrier family 12
    pfam08403
    Location:90 → 156
    AA_permease_N; Amino acid permease N-terminal

  3. XM_535467.7 → XP_535467.2  solute carrier family 12 member 1 isoform X3

    UniProtKB/TrEMBL
    A0A8C0R5L6
    Conserved Domains (3) summary
    TIGR00930
    Location:104 → 1100
    2a30; K-Cl cotransporter
    pfam03522
    Location:695 → 1100
    SLC12; Solute carrier family 12
    pfam08403
    Location:90 → 156
    AA_permease_N; Amino acid permease N-terminal
Nucleotide Protein
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