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EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 [ Canis lupus familiaris (dog) ]

Gene ID: 478257, updated on 25-Jul-2026
Official Symbol
EIF2AK4provided by VGNC
Official Full Name
eukaryotic translation initiation factor 2 alpha kinase 4provided by VGNC
Primary source
VGNC:VGNC:40259
See related
RGD:12089236
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
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See EIF2AK4 in Genome Data Viewer
Location:
chromosome: 30
Exon count:
39
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 30 NC_051834.1 (7271731..7376532)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 30 NC_006612.4 (7199521..7302773)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 30 NC_049251.1 (7430444..7533631)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 30 NC_049290.1 (7195772..7298966)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 30 NC_049771.1 (7301246..7405146)

Chromosome 30 - NC_051834.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111093307 Neighboring gene U6 spliceosomal RNA Neighboring gene ETS translocation variant 5-like Neighboring gene signal recognition particle 14 Neighboring gene Bcl2 modifying factor

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables eukaryotic translation initiation factor 2alpha kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of translational initiation by eIF2 alpha phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
eIF-2-alpha kinase GCN2
XP_005638286.1
XP_005638288.1
XP_038297730.1
XP_038372356.1
XP_038372357.1
XP_038372358.1
XP_038435945.1
XP_038435946.1
XP_038435948.1
XP_038500219.1
XP_038500220.1
XP_038500221.1
XP_535431.3

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051834.1 Reference ROS_Cfam_1.0

    Range
    7271731..7376532
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038441802.1 → XP_038297730.1  eIF-2-alpha kinase GCN2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JY43
    Conserved Domains (6) summary
    smart00591
    Location:26 → 137
    RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
    PLN02972
    Location:1054 → 1487
    PLN02972; Histidyl-tRNA synthetase
    cd14012
    Location:299 → 538
    PK_eIF2AK_GCN2_rpt1; Pseudokinase domain, repeat 1, of eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2
    cd14046
    Location:583 → 1002
    STKc_EIF2AK4_GCN2_rpt2; Catalytic domain, repeat 2, of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2
    pfam15709
    Location:151 → 205
    DUF4670; Domain of unknown function (DUF4670)
    cl00266
    Location:1393 → 1637
    HGTP_anticodon; HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for ...

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049290.1 Alternate UMICH_Zoey_3.1

    Range
    7195772..7298966
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038516429.1 → XP_038372357.1  

  2. XM_038516430.1 → XP_038372358.1  

  3. XM_038516428.1 → XP_038372356.1  

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049771.1 Alternate UNSW_CanFamBas_1.0

    Range
    7301246..7405146
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038644292.1 → XP_038500220.1  

  2. XM_038644293.1 → XP_038500221.1  

  3. XM_038644291.1 → XP_038500219.1  

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049251.1 Alternate UU_Cfam_GSD_1.0

    Range
    7430444..7533631
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038580018.1 → XP_038435946.1  eIF-2-alpha kinase GCN2 isoform X9

    UniProtKB/TrEMBL
    A0A8C0JY43

  2. XM_038580020.1 → XP_038435948.1  eIF-2-alpha kinase GCN2 isoform X10

    UniProtKB/TrEMBL
    A0A8C0JY43

  3. XM_038580017.1 → XP_038435945.1  eIF-2-alpha kinase GCN2 isoform X8

    UniProtKB/TrEMBL
    A0A8C0JY43

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006612.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    7199521..7302773
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005638229.4 → XP_005638286.1  eIF-2-alpha kinase GCN2 isoform X12

    UniProtKB/TrEMBL
    A0A8C0JY43
    Conserved Domains (8) summary
    smart00220
    Location:539 → 953
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG0124
    Location:1004 → 1441
    HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
    cd14012
    Location:248 → 487
    PK_eIF2AK_GCN2_rpt1; Pseudokinase domain, repeat 1, of eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2
    cd14046
    Location:532 → 951
    STKc_EIF2AK4_GCN2_rpt2; Catalytic domain, repeat 2, of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2
    pfam00069
    Location:245 → 488
    Pkinase; Protein kinase domain
    pfam05773
    Location:18 → 121
    RWD; RWD domain
    cl00266
    Location:1346 → 1592
    HGTP_anticodon; HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for ...
    cl00268
    Location:1012 → 1336
    class_II_aaRS-like_core; Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches ...

  2. XM_005638231.4 → XP_005638288.1  eIF-2-alpha kinase GCN2 isoform X13

    UniProtKB/TrEMBL
    A0A8C0JY43
    Conserved Domains (7) summary
    smart00220
    Location:590 → 1004
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    PRK12292
    Location:1061 → 1465
    hisZ; ATP phosphoribosyltransferase regulatory subunit; Provisional
    cd14012
    Location:299 → 538
    PK_eIF2AK_GCN2_rpt1; Pseudokinase domain, repeat 1, of eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2
    cd14046
    Location:583 → 1002
    STKc_EIF2AK4_GCN2_rpt2; Catalytic domain, repeat 2, of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2
    pfam00069
    Location:296 → 539
    Pkinase; Protein kinase domain
    pfam05773
    Location:18 → 134
    RWD; RWD domain
    cl00268
    Location:1063 → 1387
    class_II_aaRS-like_core; Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches ...

  3. XM_535431.6 → XP_535431.3  eIF-2-alpha kinase GCN2 isoform X11

    UniProtKB/TrEMBL
    A0A8C0JY43
    Conserved Domains (8) summary
    smart00220
    Location:590 → 1004
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG0124
    Location:1055 → 1492
    HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
    cd14012
    Location:299 → 538
    PK_eIF2AK_GCN2_rpt1; Pseudokinase domain, repeat 1, of eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2
    cd14046
    Location:583 → 1002
    STKc_EIF2AK4_GCN2_rpt2; Catalytic domain, repeat 2, of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2
    pfam00069
    Location:296 → 539
    Pkinase; Protein kinase domain
    pfam05773
    Location:18 → 134
    RWD; RWD domain
    cl00266
    Location:1397 → 1643
    HGTP_anticodon; HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for ...
    cl00268
    Location:1063 → 1387
    class_II_aaRS-like_core; Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches ...
Nucleotide Protein
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