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SLC12A6 solute carrier family 12 member 6 [ Canis lupus familiaris (dog) ]

Gene ID: 478239, updated on 25-Jul-2026
Official Symbol
SLC12A6provided by VGNC
Official Full Name
solute carrier family 12 member 6provided by VGNC
Primary source
VGNC:VGNC:46223
See related
Ensembl:ENSCAFG00845019004 RGD:12100875
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See SLC12A6 in Genome Data Viewer
Location:
chromosome: 30
Exon count:
26
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 30 NC_051834.1 (868821..957072)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 30 NC_006612.4 (817004..905364)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 30 NC_049251.1 (1043815..1131948)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 30 NC_049290.1 (817202..905323)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 30 NC_049771.1 (916172..1004333)

Chromosome 30 - NC_051834.1Genomic Context describing neighboring genes Neighboring gene NUT midline carcinoma family member 1 Neighboring gene NOP10 ribonucleoprotein Neighboring gene uncharacterized LOC119866855 Neighboring gene uncharacterized LOC119866854 Neighboring gene katanin regulatory subunit B1 like 1 Neighboring gene ER membrane protein complex subunit 4 Neighboring gene uncharacterized LOC102151917 Neighboring gene uncharacterized LOC119866856

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Comparison of K-Cl cotransport expression in high and low K dog erythrocytes. Ochiai H, et al. Exp Anim, 2006 Jan. PMID 16508213
  2. Light-activated BioID - an optically activated proximity labeling system to study protein-protein interactions. Shafraz O, et al. J Cell Sci, 2023 Oct 1. PMID 37756605, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables potassium:chloride symporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell volume homeostasis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in chloride ion homeostasis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in chloride transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in potassium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in potassium ion import across plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
solute carrier family 12 member 6
Names
K-Cl cotransporter 3
solute carrier family 12 (potassium/chloride transporters), member 6

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051834.1 Reference ROS_Cfam_1.0

    Range
    868821..957072
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038441820.1 → XP_038297748.1  solute carrier family 12 member 6 isoform X1

    UniProtKB/TrEMBL
    A0A8I3P9I5, A0A8I3PB47
    Related
    ENSCAFP00845026837.1, ENSCAFT00845034286.1
    Conserved Domains (1) summary
    TIGR00930
    Location:110 → 1151
    2a30; K-Cl cotransporter

  2. XM_038441822.1 → XP_038297750.1  solute carrier family 12 member 6 isoform X2

    UniProtKB/TrEMBL
    A0A8I3P4U1, A0A8I3PB47
    Related
    ENSCAFP00845026994.1, ENSCAFT00845034465.1
    Conserved Domains (1) summary
    TIGR00930
    Location:95 → 1136
    2a30; K-Cl cotransporter

  3. XM_038441821.1 → XP_038297749.1  solute carrier family 12 member 6 isoform X1

    UniProtKB/TrEMBL
    A0A8I3P9I5, A0A8I3PB47
    Conserved Domains (1) summary
    TIGR00930
    Location:110 → 1151
    2a30; K-Cl cotransporter

  4. XM_038441823.1 → XP_038297751.1  solute carrier family 12 member 6 isoform X3

    UniProtKB/TrEMBL
    A0A8I3PB47, A0A8I3S428
    Related
    ENSCAFP00845027096.1, ENSCAFT00845034587.1
    Conserved Domains (1) summary
    TIGR00930
    Location:61 → 1102
    2a30; K-Cl cotransporter

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049290.1 Alternate UMICH_Zoey_3.1

    Range
    817202..905323
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038516304.1 → XP_038372232.1  

    Conserved Domains (1) summary
    TIGR00930
    Location:110 → 1151
    2a30; K-Cl cotransporter

  2. XM_038516306.1 → XP_038372234.1  

    Conserved Domains (1) summary
    TIGR00930
    Location:95 → 1136
    2a30; K-Cl cotransporter

  3. XM_038516305.1 → XP_038372233.1  

    Conserved Domains (1) summary
    TIGR00930
    Location:110 → 1151
    2a30; K-Cl cotransporter

  4. XM_038516307.1 → XP_038372235.1  

    Conserved Domains (1) summary
    TIGR00930
    Location:61 → 1102
    2a30; K-Cl cotransporter

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049771.1 Alternate UNSW_CanFamBas_1.0

    Range
    916172..1004333
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038644155.1 → XP_038500083.1  

    Conserved Domains (1) summary
    TIGR00930
    Location:110 → 1151
    2a30; K-Cl cotransporter

  2. XM_038644154.1 → XP_038500082.1  

    Conserved Domains (1) summary
    TIGR00930
    Location:110 → 1151
    2a30; K-Cl cotransporter

  3. XM_038644156.1 → XP_038500084.1  

    Conserved Domains (1) summary
    TIGR00930
    Location:95 → 1136
    2a30; K-Cl cotransporter

  4. XM_038644157.1 → XP_038500085.1  

    Conserved Domains (1) summary
    TIGR00930
    Location:61 → 1102
    2a30; K-Cl cotransporter

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049251.1 Alternate UU_Cfam_GSD_1.0

    Range
    1043815..1131948
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038579902.1 → XP_038435830.1  solute carrier family 12 member 6 isoform X1

    UniProtKB/TrEMBL
    A0A8I3P9I5, A0A8I3PB47
    Conserved Domains (1) summary
    TIGR00930
    Location:110 → 1151
    2a30; K-Cl cotransporter

  2. XM_038579901.1 → XP_038435829.1  solute carrier family 12 member 6 isoform X1

    UniProtKB/TrEMBL
    A0A8I3P9I5, A0A8I3PB47
    Conserved Domains (1) summary
    TIGR00930
    Location:110 → 1151
    2a30; K-Cl cotransporter

  3. XM_038579903.1 → XP_038435831.1  solute carrier family 12 member 6 isoform X2

    UniProtKB/TrEMBL
    A0A8I3P4U1, A0A8I3PB47
    Conserved Domains (1) summary
    TIGR00930
    Location:95 → 1136
    2a30; K-Cl cotransporter

  4. XM_038579904.1 → XP_038435832.1  solute carrier family 12 member 6 isoform X3

    UniProtKB/TrEMBL
    A0A8I3PB47, A0A8I3S428
    Conserved Domains (1) summary
    TIGR00930
    Location:61 → 1102
    2a30; K-Cl cotransporter

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006612.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    817004..905364
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_014109414.3 → XP_013964889.1  solute carrier family 12 member 6 isoform X1

    UniProtKB/TrEMBL
    A0A8I3P9I5, A0A8I3PB47
    Conserved Domains (1) summary
    TIGR00930
    Location:110 → 1151
    2a30; K-Cl cotransporter

  2. XM_005638184.4 → XP_005638241.1  solute carrier family 12 member 6 isoform X2

    UniProtKB/TrEMBL
    A0A8I3P4U1, A0A8I3PB47
    Conserved Domains (1) summary
    TIGR00930
    Location:95 → 1136
    2a30; K-Cl cotransporter

  3. XM_005638183.4 → XP_005638240.1  solute carrier family 12 member 6 isoform X1

    UniProtKB/TrEMBL
    A0A8I3P9I5, A0A8I3PB47
    Conserved Domains (1) summary
    TIGR00930
    Location:110 → 1151
    2a30; K-Cl cotransporter

  4. XM_851514.6 → XP_856607.1  solute carrier family 12 member 6 isoform X3

    UniProtKB/TrEMBL
    A0A8I3PB47, A0A8I3S428
    Conserved Domains (1) summary
    TIGR00930
    Location:61 → 1102
    2a30; K-Cl cotransporter
Nucleotide Protein
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