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NFIB nuclear factor I B [ Homo sapiens (human) ]

Gene ID: 4781, updated on 6-Sep-2017
Official Symbol
NFIBprovided by HGNC
Official Full Name
nuclear factor I Bprovided by HGNC
Primary source
HGNC:HGNC:7785
See related
Ensembl:ENSG00000147862 MIM:600728; Vega:OTTHUMG00000021027
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CTF; NF1-B; NFI-B; NFIB2; NFIB3; NF-I/B; NFI-RED; HMGIC/NFIB
Orthologs
Location:
9p23-p22.3
Exon count:
16
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 9 NC_000009.12 (14081843..14398983, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (14081842..14398982, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L3 pseudogene 11 Neighboring gene ATP synthase, H+ transporting, mitochondrial Fo complex subunit D pseudogene 3 Neighboring gene ribosomal protein L7a pseudogene 47 Neighboring gene transfer RNA-His (GTG) 1-6 Neighboring gene zinc finger DHHC-type containing 21 Neighboring gene cell division cycle associated 4 pseudogene 1

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study.
NHGRI GWA Catalog

Replication interactions

Interaction Pubs
Knockdown of NFI-B by shRNA enhances HIV-1 replication in peripheral blood mononuclear cells (PBMCs) and in Jurkat cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
Clara cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
DNA replication IEA
Inferred from Electronic Annotation
more info
 
Type I pneumocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
Type II pneumocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
anterior commissure morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
cell differentiation involved in salivary gland development IEA
Inferred from Electronic Annotation
more info
 
chondrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
commissural neuron axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
 
glial cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
hindbrain development IEA
Inferred from Electronic Annotation
more info
 
lung ciliated cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of epithelial cell proliferation involved in lung morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of mesenchymal cell proliferation involved in lung development ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of pri-miRNA transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
principal sensory nucleus of trigeminal nerve development ISS
Inferred from Sequence or Structural Similarity
more info
 
salivary gland cavitation IEA
Inferred from Electronic Annotation
more info
 
transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cerebellar mossy fiber ISS
Inferred from Sequence or Structural Similarity
more info
 
fibrillar center IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
nuclear factor 1 B-type
Names
CCAAT-box-binding transcription factor
TGGCA-binding protein
nuclear factor 1/B

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190737.1NP_001177666.1  nuclear factor 1 B-type isoform 1

    See identical proteins and their annotated locations for NP_001177666.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1).
    Source sequence(s)
    AI140312, AL136366, AL441963, BX648845
    Consensus CDS
    CCDS55291.1
    UniProtKB/Swiss-Prot
    O00712
    Related
    ENSP00000370340.1, OTTHUMP00000022769, ENST00000380953.5, OTTHUMT00000055472
    Conserved Domains (3) summary
    cl00055
    Location:69173
    MH1; N-terminal Mad Homology 1 (MH1) domain
    pfam00859
    Location:209493
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:947
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
  2. NM_001190738.1NP_001177667.1  nuclear factor 1 B-type isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences, one of which results in translation from an upstream start codon, compared to variant 1. The resulting protein (isoform 2) has a different and longer N-terminus and a shorter C-terminus when it is compared to isoform 1.
    Source sequence(s)
    AI140312, AK131233, AL136366, AL137017, AL441963
    Consensus CDS
    CCDS55292.1
    UniProtKB/Swiss-Prot
    O00712
    UniProtKB/TrEMBL
    A0A0A0MRX8
    Related
    ENSP00000370321.4, OTTHUMP00000280976, ENST00000380934.8, OTTHUMT00000487755
    Conserved Domains (3) summary
    cl00055
    Location:95199
    MH1; N-terminal Mad Homology 1 (MH1) domain
    pfam00859
    Location:235441
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:3773
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
  3. NM_001282787.1NP_001269716.1  nuclear factor 1 B-type isoform 4

    See identical proteins and their annotated locations for NP_001269716.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains a distinct 5' UTR, lacks an in-frame portion of the 5' coding region and contains an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (4) is shorter compared to isoform 1.
    Source sequence(s)
    AI140312, AL441963, BP372854, BX648416
    Consensus CDS
    CCDS65007.1
    UniProtKB/Swiss-Prot
    O00712
    Related
    ENSP00000442888.1, ENST00000543693.5
    Conserved Domains (1) summary
    pfam00859
    Location:1237
    CTF_NFI; CTF/NF-I family transcription modulation region
  4. NM_005596.3NP_005587.2  nuclear factor 1 B-type isoform 3

    See identical proteins and their annotated locations for NP_005587.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks alternate exons in the 3' end, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AI140312, AL441963, BC001283, BX648845, DA785516
    Consensus CDS
    CCDS6474.1
    UniProtKB/Swiss-Prot
    O00712
    UniProtKB/TrEMBL
    Q5VW28
    Related
    ENSP00000370346.3, OTTHUMP00000022765, ENST00000380959.7, OTTHUMT00000055468
    Conserved Domains (3) summary
    pfam00859
    Location:209415
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:1047
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:69173
    MH1; N-terminal Mad Homology 1 (MH1) domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p7 Primary Assembly

    Range
    14081843..14398983 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017014741.1XP_016870230.1  nuclear factor 1 B-type isoform X10

  2. XM_017014740.1XP_016870229.1  nuclear factor 1 B-type isoform X9

    UniProtKB/TrEMBL
    U3KQE8
    Related
    ENSP00000475813.2, OTTHUMP00000273258, ENST00000606230.2, OTTHUMT00000470132
  3. XM_005251468.4XP_005251525.1  nuclear factor 1 B-type isoform X3

    Conserved Domains (3) summary
    cl00055
    Location:65169
    MH1; N-terminal Mad Homology 1 (MH1) domain
    pfam00859
    Location:205494
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:443
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
  4. XM_017014739.1XP_016870228.1  nuclear factor 1 B-type isoform X8

  5. XM_006716773.2XP_006716836.1  nuclear factor 1 B-type isoform X2

    Conserved Domains (3) summary
    cl00055
    Location:69173
    MH1; N-terminal Mad Homology 1 (MH1) domain
    pfam00859
    Location:209497
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:947
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
  6. XM_005251470.2XP_005251527.1  nuclear factor 1 B-type isoform X7

    See identical proteins and their annotated locations for XP_005251527.1

    UniProtKB/TrEMBL
    Q5VW27
    Related
    ENSP00000380709.2, OTTHUMP00000022766, ENST00000397579.6, OTTHUMT00000055469
    Conserved Domains (3) summary
    cl00055
    Location:69173
    MH1; N-terminal Mad Homology 1 (MH1) domain
    pfam00859
    Location:209416
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:947
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
  7. XM_005251469.2XP_005251526.1  nuclear factor 1 B-type isoform X4

    See identical proteins and their annotated locations for XP_005251526.1

    UniProtKB/TrEMBL
    Q5VW30
    Related
    ENSP00000380705.3, OTTHUMP00000022768, ENST00000397575.7, OTTHUMT00000055471
    Conserved Domains (3) summary
    cl00055
    Location:69173
    MH1; N-terminal Mad Homology 1 (MH1) domain
    pfam00859
    Location:209489
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:947
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
  8. XM_006716775.2XP_006716838.1  nuclear factor 1 B-type isoform X6

    Conserved Domains (3) summary
    cl00055
    Location:69173
    MH1; N-terminal Mad Homology 1 (MH1) domain
    pfam00859
    Location:209470
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:947
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
  9. XM_006716774.2XP_006716837.1  nuclear factor 1 B-type isoform X5

    Related
    ENSP00000490588.1, OTTHUMP00000281662, ENST00000636432.1, OTTHUMT00000488970
    Conserved Domains (3) summary
    cl00055
    Location:69173
    MH1; N-terminal Mad Homology 1 (MH1) domain
    pfam00859
    Location:209502
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:947
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
  10. XM_005251467.2XP_005251524.1  nuclear factor 1 B-type isoform X1

    See identical proteins and their annotated locations for XP_005251524.1

    UniProtKB/TrEMBL
    Q5VW26
    Related
    ENSP00000380711.2, OTTHUMP00000022767, ENST00000397581.6, OTTHUMT00000055470
    Conserved Domains (3) summary
    cl00055
    Location:69173
    MH1; N-terminal Mad Homology 1 (MH1) domain
    pfam00859
    Location:209498
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:947
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
  11. XM_017014742.1XP_016870231.1  nuclear factor 1 B-type isoform X12

    UniProtKB/TrEMBL
    A0A1B0GWB8
    Related
    ENSP00000490864.1, OTTHUMP00000281659, ENST00000636735.1, OTTHUMT00000488968
  12. XM_005251471.3XP_005251528.1  nuclear factor 1 B-type isoform X11

    Conserved Domains (1) summary
    pfam00859
    Location:1246
    CTF_NFI; CTF/NF-I family transcription modulation region

RNA

  1. XR_001746309.1 RNA Sequence

  2. XR_001746308.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018920.2 Alternate CHM1_1.1

    Range
    14081962..14399030 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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