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NFIB nuclear factor I B [ Homo sapiens (human) ]

Gene ID: 4781, updated on 25-Nov-2025
Official Symbol
NFIBprovided by HGNC
Official Full Name
nuclear factor I Bprovided by HGNC
Primary source
HGNC:HGNC:7785
See related
Ensembl:ENSG00000147862 MIM:600728; AllianceGenome:HGNC:7785
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CTF; MACID; NF1-B; NFI-B; NFIB2; NFIB3; NF-I/B; NFI-RED; HMGIC/NFIB
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and transcription regulator inhibitor activity. Involved in brain development and regulation of DNA-templated transcription. Located in fibrillar center and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Ubiquitous expression in fat (RPKM 8.5), brain (RPKM 6.3) and 24 other tissues See more
Orthologs
mouse all
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Try the new Gene table
Try the new Transcript table
See NFIB in Genome Data Viewer
Location:
9p23-p22.3
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (14081843..14532077, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (14091330..14541744, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (14081842..14532075, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L3 pseudogene 11 Neighboring gene ATP synthase peripheral stalk subunit d pseudogene 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:14204487-14204986 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:14238163-14238924 Neighboring gene ribosomal protein L7a pseudogene 47 Neighboring gene Sharpr-MPRA regulatory region 8618 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:14273817-14274417 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:14274418-14275017 Neighboring gene Sharpr-MPRA regulatory region 4176 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19774 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:14348801-14349300 Neighboring gene NFIB antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:14355781-14356280 Neighboring gene Sharpr-MPRA regulatory region 5074 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:14395820-14396037 Neighboring gene tRNA-His (anticodon GTG) 1-6 Neighboring gene Sharpr-MPRA regulatory region 8525 Neighboring gene uncharacterized LOC124902121 Neighboring gene uncharacterized LOC124902120 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:14547038-14547640 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:14597299-14597830 Neighboring gene zDHHC palmitoyltransferase 21 Neighboring gene cell division cycle associated 4 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19775 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19776 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:14693435-14693935 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:14721879-14722818 Neighboring gene cerberus 1, DAN family BMP antagonist

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Effect of the NFIB rs28379954 T>C polymorphism on CYP2D6-catalyzed metabolism of solanidine. Smith RL, et al. Clin Transl Sci, 2024 Feb. PMID 38385986, Free PMC Article
  2. Genetic Variant of NFIB is Associated With the Metastasis of Osteosarcoma in Chinese Population. Xu L, et al. Technol Cancer Res Treat, 2019 Jan 1. PMID 31522615, Free PMC Article
  3. Nuclear factor I/B promotes colorectal cancer cell proliferation, epithelial-mesenchymal transition and 5-fluorouracil resistance. Liu Z, et al. Cancer Sci, 2019 Jan. PMID 30320939, Free PMC Article
  4. The expanding spectrum of NFIB-associated phenotypes in a diverse patient population-A report of two new patients. Barrus K, et al. Am J Med Genet A, 2020 Dec. PMID 32902921
  5. Pathogenic nonsense variant in NFIB in another patient with dysmorphism, Autism Spectrum Disorder, agenesis of the corpus callosum, and intellectual disability. Rao ACA, et al. Eur J Med Genet, 2020 Dec. PMID 33130023

See all (127) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Effect of the NFIB rs28379954 T>C polymorphism on CYP2D6-catalyzed metabolism of solanidine.
    Title: Effect of the NFIB rs28379954 T>C polymorphism on CYP2D6-catalyzed metabolism of solanidine.
  2. CircIFFO1 suppresses tumor growth and metastasis of cutaneous squamous cell carcinoma by targeting the miR-424-5p/NFIB axis.
    Title: CircIFFO1 suppresses tumor growth and metastasis of cutaneous squamous cell carcinoma by targeting the miR-424-5p/NFIB axis.
  3. NFIB facilitates replication licensing by acting as a genome organizer.
    Title: NFIB facilitates replication licensing by acting as a genome organizer.
  4. Marked intrafamilial variability of clinical and neuroimaging manifestations in NFIB-related developmental disorder.
    Title: Marked intrafamilial variability of clinical and neuroimaging manifestations in NFIB-related developmental disorder.
  5. Transcriptional regulation of NDUFA4L2 by NFIB induces sorafenib resistance by decreasing reactive oxygen species in hepatocellular carcinoma.
    Title: Transcriptional regulation of NDUFA4L2 by NFIB induces sorafenib resistance by decreasing reactive oxygen species in hepatocellular carcinoma.
  6. Knockdown of circ-PIP5K1A overcomes resistance to cisplatin in ovarian cancer by miR-942-5p/NFIB axis.
    Title: Knockdown of circ-PIP5K1A overcomes resistance to cisplatin in ovarian cancer by miR-942-5p/NFIB axis.
  7. Impact of NFIB and CYP1A variants on clozapine serum concentration-A retrospective naturalistic cohort study on 526 patients with known smoking habits.
    Title: Impact of NFIB and CYP1A variants on clozapine serum concentration-A retrospective naturalistic cohort study on 526 patients with known smoking habits.
  8. Exosomal miR-626 promotes the malignant behavior of oral cancer cells by targeting NFIB.
    Title: Exosomal miR-626 promotes the malignant behavior of oral cancer cells by targeting NFIB.
  9. The Polymorphic Nuclear Factor NFIB Regulates Hepatic CYP2D6 Expression and Influences Risperidone Metabolism in Psychiatric Patients.
    Title: The Polymorphic Nuclear Factor NFIB Regulates Hepatic CYP2D6 Expression and Influences Risperidone Metabolism in Psychiatric Patients.
  10. Transcriptional Regulation of RIP2 Gene by NFIB Is Associated with Cellular Immune and Inflammatory Response to APEC Infection.
    Title: Transcriptional Regulation of RIP2 Gene by NFIB Is Associated with Cellular Immune and Inflammatory Response to APEC Infection.
Submit: New GeneRIF Correction See all GeneRIFs (72)

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Macrocephaly, acquired, with impaired intellectual development
MedGen: C4748993 OMIM: 618286 GeneReviews: Not available
Compare labs

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2024-12-10)

ClinGen Genome Curation Page
Haploinsufficency

Sufficient evidence for dosage pathogenicity (Last evaluated 2024-12-10)

ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study.
EBI GWAS Catalog

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Replication interactions

Interaction Pubs
Knockdown of NFI-B by shRNA enhances HIV-1 replication in peripheral blood mononuclear cells (PBMCs) and in Jurkat cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription regulator inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in anterior commissure morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in anterior commissure morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in brain development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell differentiation involved in salivary gland development IEA
Inferred from Electronic Annotation
more info
  
involved_in cell proliferation in forebrain IEA
Inferred from Electronic Annotation
more info
  
involved_in chondrocyte differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in chondrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in club cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in club cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in commissural neuron axon guidance IEA
Inferred from Electronic Annotation
more info
  
involved_in commissural neuron axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within exit from mitosis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within forebrain development IEA
Inferred from Electronic Annotation
more info
  
involved_in gene expression IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within generation of neurons IEA
Inferred from Electronic Annotation
more info
  
involved_in glial cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in glial cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within glial cell fate specification IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within glial cell proliferation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within hindbrain development IEA
Inferred from Electronic Annotation
more info
  
involved_in lung ciliated cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in lung ciliated cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within lung development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of epithelial cell proliferation involved in lung morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of epithelial cell proliferation involved in lung morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of mesenchymal cell proliferation involved in lung development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of mesenchymal cell proliferation involved in lung development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of miRNA transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within neural precursor cell proliferation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neurogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neuron fate specification IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in principal sensory nucleus of trigeminal nerve development IEA
Inferred from Electronic Annotation
more info
  
involved_in principal sensory nucleus of trigeminal nerve development ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within regeneration IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to bacterium IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to wounding IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within retina development in camera-type eye IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within salivary gland cavitation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within tissue homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in type I pneumocyte differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in type I pneumocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in type II pneumocyte differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in type II pneumocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cerebellar mossy fiber IEA
Inferred from Electronic Annotation
more info
  
located_in cerebellar mossy fiber ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in chromatin ISA
Inferred from Sequence Alignment
more info
  
located_in fibrillar center IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
nuclear factor 1 B-type
Names
CCAAT-box-binding transcription factor
TGGCA-binding protein
nuclear factor 1/B

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190737.2 → NP_001177666.1  nuclear factor 1 B-type isoform 1

    See identical proteins and their annotated locations for NP_001177666.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AI140312, AL136366, AL441963, BX648845
    Consensus CDS
    CCDS55291.1
    UniProtKB/TrEMBL
    A0A1B0GWJ4
    Related
    ENSP00000370340.1, ENST00000380953.6
    Conserved Domains (3) summary
    cl00055
    Location:69 → 173
    MH1; N-terminal Mad Homology 1 (MH1) domain
    pfam00859
    Location:209 → 493
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:9 → 47
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

  2. NM_001190738.2 → NP_001177667.1  nuclear factor 1 B-type isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences, one of which results in translation from an upstream start codon, compared to variant 1. The resulting protein (isoform 2) has a different and longer N-terminus and a shorter C-terminus when it is compared to isoform 1.
    Source sequence(s)
    AK131233, AL136366, AL137017, AL441963
    Consensus CDS
    CCDS55292.1
    UniProtKB/TrEMBL
    A0A0A0MRX8, A0A1B0GWJ4
    Related
    ENSP00000370321.4, ENST00000380934.8
    Conserved Domains (3) summary
    cl00055
    Location:95 → 199
    MH1; N-terminal Mad Homology 1 (MH1) domain
    pfam00859
    Location:235 → 441
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:37 → 73
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

  3. NM_001282787.2 → NP_001269716.1  nuclear factor 1 B-type isoform 4

    See identical proteins and their annotated locations for NP_001269716.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains a distinct 5' UTR, lacks an in-frame portion of the 5' coding region and contains an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (4) is shorter compared to isoform 1.
    Source sequence(s)
    AI140312, AL441963, BP372854, BX648416
    Consensus CDS
    CCDS65007.1
    UniProtKB/Swiss-Prot
    O00712
    Related
    ENSP00000442888.1, ENST00000543693.5
    Conserved Domains (1) summary
    pfam00859
    Location:1 → 237
    CTF_NFI; CTF/NF-I family transcription modulation region

  4. NM_001369458.1 → NP_001356387.1  nuclear factor 1 B-type isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) encodes the longest isoform (5).
    Source sequence(s)
    AL136366, AL159169, AL441963
    UniProtKB/TrEMBL
    A0A1B0GWI9
    Conserved Domains (3) summary
    pfam00859
    Location:231 → 520
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:32 → 69
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:91 → 195
    MH1; N-terminal Mad Homology 1 (MH1) domain

  5. NM_001369459.1 → NP_001356388.1  nuclear factor 1 B-type isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL159169, AL441963
    UniProtKB/TrEMBL
    A0A1B0GWI9
    Conserved Domains (3) summary
    pfam00859
    Location:231 → 511
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:32 → 69
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:91 → 195
    MH1; N-terminal Mad Homology 1 (MH1) domain

  6. NM_001369460.1 → NP_001356389.1  nuclear factor 1 B-type isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963
    Consensus CDS
    CCDS94389.1
    UniProtKB/TrEMBL
    A0A1B0GWI9, A0A2R8Y7V8
    Related
    ENSP00000496424.1, ENST00000646622.1
    Conserved Domains (3) summary
    pfam00859
    Location:205 → 494
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:4 → 43
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:65 → 169
    MH1; N-terminal Mad Homology 1 (MH1) domain

  7. NM_001369461.1 → NP_001356390.1  nuclear factor 1 B-type isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963
    Consensus CDS
    CCDS94386.1
    UniProtKB/TrEMBL
    A0A1B0GWI9, Q5VW30
    Related
    ENSP00000380705.3, ENST00000397575.7
    Conserved Domains (3) summary
    pfam00859
    Location:209 → 489
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:10 → 47
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:69 → 173
    MH1; N-terminal Mad Homology 1 (MH1) domain

  8. NM_001369462.1 → NP_001356391.1  nuclear factor 1 B-type isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL159169, AL441963
    UniProtKB/TrEMBL
    A0A1B0GWI9
    Conserved Domains (4) summary
    pfam00859
    Location:231 → 438
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:32 → 69
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:91 → 195
    MH1; N-terminal Mad Homology 1 (MH1) domain
    cl30265
    Location:407 → 497
    PRK09579; multidrug efflux protein; Reviewed

  9. NM_001369463.1 → NP_001356392.1  nuclear factor 1 B-type isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963
    UniProtKB/TrEMBL
    A0A1B0GWJ4
    Conserved Domains (3) summary
    pfam00859
    Location:205 → 466
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:4 → 43
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:65 → 169
    MH1; N-terminal Mad Homology 1 (MH1) domain

  10. NM_001369464.1 → NP_001356393.1  nuclear factor 1 B-type isoform 11

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963
    Consensus CDS
    CCDS94385.1
    UniProtKB/TrEMBL
    A0A1B0GWI9, Q5VW27
    Related
    ENSP00000380709.2, ENST00000397579.6
    Conserved Domains (4) summary
    pfam00859
    Location:209 → 416
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:10 → 47
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:69 → 173
    MH1; N-terminal Mad Homology 1 (MH1) domain
    cl30265
    Location:385 → 475
    PRK09579; multidrug efflux protein; Reviewed

  11. NM_001369465.1 → NP_001356394.1  nuclear factor 1 B-type isoform 12

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963
    UniProtKB/TrEMBL
    A0A1B0GWJ4
    Conserved Domains (3) summary
    pfam00859
    Location:200 → 484
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:1 → 38
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:60 → 164
    MH1; N-terminal Mad Homology 1 (MH1) domain

  12. NM_001369466.1 → NP_001356395.1  nuclear factor 1 B-type isoform 13

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963
    UniProtKB/TrEMBL
    A0A1B0GWI9
    Related
    ENSP00000490945.1, ENST00000635877.1
    Conserved Domains (4) summary
    pfam00859
    Location:205 → 412
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:4 → 43
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:65 → 169
    MH1; N-terminal Mad Homology 1 (MH1) domain
    cl30265
    Location:381 → 471
    PRK09579; multidrug efflux protein; Reviewed

  13. NM_001369467.1 → NP_001356396.1  nuclear factor 1 B-type isoform 14

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963
    Consensus CDS
    CCDS94384.1
    UniProtKB/TrEMBL
    A0A1B0GU97, A0A1B0GWI9
    Related
    ENSP00000490020.1, ENST00000637640.1
    Conserved Domains (4) summary
    PRK15127
    Location:376 → 466
    PRK15127; multidrug efflux RND transporter permease subunit AcrB
    pfam10524
    Location:2 → 38
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:60 → 164
    MH1; N-terminal Mad Homology 1 (MH1) domain
    pfam00859
    Location:200 → 407
    CTF_NFI; CTF/NF-I family transcription modulation region

  14. NM_001369468.1 → NP_001356397.1  nuclear factor 1 B-type isoform 15

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL159169, AL441963
    UniProtKB/TrEMBL
    A0A1B0GWJ4
    Conserved Domains (3) summary
    pfam00859
    Location:231 → 437
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:32 → 69
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:91 → 195
    MH1; N-terminal Mad Homology 1 (MH1) domain

  15. NM_001369469.1 → NP_001356398.1  nuclear factor 1 B-type isoform 16

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963
    UniProtKB/TrEMBL
    A0A1B0GWI9
    Conserved Domains (3) summary
    pfam00859
    Location:161 → 368
    CTF_NFI; CTF/NF-I family transcription modulation region
    cl00055
    Location:21 → 125
    MH1; N-terminal Mad Homology 1 (MH1) domain
    cl30265
    Location:337 → 427
    PRK09579; multidrug efflux protein; Reviewed

  16. NM_001369470.1 → NP_001356399.1  nuclear factor 1 B-type isoform 17

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963
    Consensus CDS
    CCDS94390.1
    UniProtKB/TrEMBL
    A0A1B0GVN4
    Related
    ENSP00000490588.1, ENST00000636432.1
    Conserved Domains (3) summary
    pfam10524
    Location:3 → 43
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:64 → 116
    MH1; N-terminal Mad Homology 1 (MH1) domain
    pfam00859
    Location:130 → 419
    CTF_NFI; CTF/NF-I family transcription modulation region

  17. NM_001369471.1 → NP_001356400.1  nuclear factor 1 B-type isoform 18

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963
    UniProtKB/TrEMBL
    A0A1B0GWJ4
    Related
    ENSP00000547643.1, ENST00000877584.1
    Conserved Domains (3) summary
    pfam00859
    Location:209 → 414
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:10 → 47
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:69 → 173
    MH1; N-terminal Mad Homology 1 (MH1) domain

  18. NM_001369472.1 → NP_001356401.1  nuclear factor 1 B-type isoform 19

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963
    Consensus CDS
    CCDS94388.1
    UniProtKB/TrEMBL
    A0A1B0GWJ4, U3KQE8
    Related
    ENSP00000475813.2, ENST00000606230.2
    Conserved Domains (3) summary
    pfam00859
    Location:205 → 411
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:4 → 43
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:65 → 169
    MH1; N-terminal Mad Homology 1 (MH1) domain

  19. NM_001369473.1 → NP_001356402.1  nuclear factor 1 B-type isoform 20

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963
    UniProtKB/TrEMBL
    A0A1B0GWJ4
    Conserved Domains (3) summary
    pfam00859
    Location:205 → 410
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:4 → 43
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:65 → 169
    MH1; N-terminal Mad Homology 1 (MH1) domain

  20. NM_001369474.1 → NP_001356403.1  nuclear factor 1 B-type isoform 21

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963
    UniProtKB/TrEMBL
    A0A1B0GWJ4
    Conserved Domains (3) summary
    pfam00859
    Location:204 → 409
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:6 → 42
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:64 → 168
    MH1; N-terminal Mad Homology 1 (MH1) domain

  21. NM_001369475.1 → NP_001356404.1  nuclear factor 1 B-type isoform 22

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963
    UniProtKB/TrEMBL
    A0A1B0GWI9
    Conserved Domains (4) summary
    pfam00859
    Location:134 → 341
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:10 → 47
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:68 → 120
    MH1; N-terminal Mad Homology 1 (MH1) domain
    cl30265
    Location:310 → 400
    PRK09579; multidrug efflux protein; Reviewed

  22. NM_001369476.1 → NP_001356405.1  nuclear factor 1 B-type isoform 23

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963
    Consensus CDS
    CCDS94383.1
    UniProtKB/TrEMBL
    A0A1B0GW37, A0A1B0GWJ4
    Related
    ENSP00000490762.1, ENST00000636057.1
    Conserved Domains (3) summary
    pfam10524
    Location:2 → 38
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:60 → 164
    MH1; N-terminal Mad Homology 1 (MH1) domain
    pfam00859
    Location:200 → 406
    CTF_NFI; CTF/NF-I family transcription modulation region

  23. NM_001369477.1 → NP_001356406.1  nuclear factor 1 B-type isoform 24

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963
    UniProtKB/TrEMBL
    A0A1B0GWJ4
    Conserved Domains (3) summary
    pfam00859
    Location:191 → 396
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:10 → 47
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:69 → 173
    MH1; N-terminal Mad Homology 1 (MH1) domain

  24. NM_001369478.1 → NP_001356407.1  nuclear factor 1 B-type isoform 25

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963
    Conserved Domains (3) summary
    pfam00859
    Location:130 → 336
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:4 → 43
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:64 → 116
    MH1; N-terminal Mad Homology 1 (MH1) domain

  25. NM_001369479.1 → NP_001356408.1  nuclear factor 1 B-type isoform 26

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963
    Consensus CDS
    CCDS94382.1
    UniProtKB/TrEMBL
    A0A1B0GWB8
    Related
    ENSP00000490864.1, ENST00000636735.1
    Conserved Domains (2) summary
    pfam00859
    Location:30 → 237
    CTF_NFI; CTF/NF-I family transcription modulation region
    cl30265
    Location:206 → 296
    PRK09579; multidrug efflux protein; Reviewed

  26. NM_001369480.1 → NP_001356409.1  nuclear factor 1 B-type isoform 27

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963
    Conserved Domains (1) summary
    pfam00859
    Location:30 → 236
    CTF_NFI; CTF/NF-I family transcription modulation region

  27. NM_001369481.1 → NP_001356410.1  nuclear factor 1 B-type isoform 28

    Status: VALIDATED

    Source sequence(s)
    AL136366
    Consensus CDS
    CCDS94387.1
    UniProtKB/TrEMBL
    A0A0S2Z4H3, Q5W0Y9
    Related
    ENSP00000370308.3, ENST00000380921.3
    Conserved Domains (2) summary
    pfam10524
    Location:10 → 47
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:69 → 173
    MH1; N-terminal Mad Homology 1 (MH1) domain

  28. NM_001429577.1 → NP_001416506.1  nuclear factor 1 B-type isoform 29

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963
    UniProtKB/TrEMBL
    A0A1B0GWI9, Q5VW26
    Related
    ENSP00000380711.2, ENST00000397581.7

  29. NM_005596.3 → NP_005587.2  nuclear factor 1 B-type isoform 3

    See identical proteins and their annotated locations for NP_005587.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks alternate exons in the 3' end, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AI140312, AL441963, BC001283, BX648845, DA785516
    Consensus CDS
    CCDS6474.1
    UniProtKB/Swiss-Prot
    G3V1P1, H7BYE8, O00166, O00712, Q12858, Q5VW29, Q63HM5, Q6ZNF9, Q96J45
    UniProtKB/TrEMBL
    A0A1B0GWJ4, Q5VW28
    Related
    ENSP00000370346.3, ENST00000380959.7
    Conserved Domains (3) summary
    pfam00859
    Location:209 → 415
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:10 → 47
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:69 → 173
    MH1; N-terminal Mad Homology 1 (MH1) domain

RNA

  1. NR_161382.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963

  2. NR_161383.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963

  3. NR_161384.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963

  4. NR_161385.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL441963

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    14081843..14532077 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    14091330..14541744 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O00712.2 GenPept UniProtKB/Swiss-Prot:O00712

Gene LinkOut

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