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NFIB nuclear factor I B [ Homo sapiens (human) ]

Gene ID: 4781, updated on 22-Jan-2023

Summary

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Official Symbol
NFIBprovided by HGNC
Official Full Name
nuclear factor I Bprovided by HGNC
Primary source
HGNC:HGNC:7785
See related
Ensembl:ENSG00000147862 MIM:600728; AllianceGenome:HGNC:7785
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CTF; MACID; NF1-B; NFI-B; NFIB2; NFIB3; NF-I/B; NFI-RED; HMGIC/NFIB
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and transcription regulator inhibitor activity. Involved in brain development; negative regulation of DNA binding activity; and regulation of transcription by RNA polymerase II. Located in fibrillar center and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in fat (RPKM 8.5), brain (RPKM 6.3) and 24 other tissues See more
Orthologs
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Genomic context

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See NFIB in Genome Data Viewer
Location:
9p23-p22.3
Exon count:
22
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (14081843..14532077, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (14091330..14541744, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (14081842..14532075, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L3 pseudogene 11 Neighboring gene ATP synthase peripheral stalk subunit d pseudogene 3 Neighboring gene ribosomal protein L7a pseudogene 47 Neighboring gene Sharpr-MPRA regulatory region 8618 Neighboring gene Sharpr-MPRA regulatory region 4176 Neighboring gene NFIB antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 5074 Neighboring gene tRNA-His (anticodon GTG) 1-6 Neighboring gene Sharpr-MPRA regulatory region 8525 Neighboring gene uncharacterized LOC124902121 Neighboring gene uncharacterized LOC124902120 Neighboring gene zinc finger DHHC-type palmitoyltransferase 21 Neighboring gene cell division cycle associated 4 pseudogene 1 Neighboring gene cerberus 1, DAN family BMP antagonist

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Impact of NFIB and CYP1A variants on clozapine serum concentration-A retrospective naturalistic cohort study on 526 patients with known smoking habits. Lenk HÇ, et al. Clin Transl Sci, 2023 Jan. PMID 36152308, Free PMC Article
  2. The Polymorphic Nuclear Factor NFIB Regulates Hepatic CYP2D6 Expression and Influences Risperidone Metabolism in Psychiatric Patients. Lenk HÇ, et al. Clin Pharmacol Ther, 2022 May. PMID 35253216, Free PMC Article
  3. CircNFIB inhibits tumor growth and metastasis through suppressing MEK1/ERK signaling in intrahepatic cholangiocarcinoma. Du J, et al. Mol Cancer, 2022 Jan 17. PMID 35039066, Free PMC Article
  4. Serum nuclear factor IB as a novel and noninvasive indicator in the diagnosis of secondary hyperparathyroidism. Yu J, et al. J Clin Lab Anal, 2021 Jun. PMID 33991027, Free PMC Article
  5. NFIB induces functional astrocytes from human pluripotent stem cell-derived neural precursor cells mimicking in vivo astrogliogenesis. Yeon GB, et al. J Cell Physiol, 2021 Nov. PMID 33949692

See all (114) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Impact of NFIB and CYP1A variants on clozapine serum concentration-A retrospective naturalistic cohort study on 526 patients with known smoking habits.
    Title: Impact of NFIB and CYP1A variants on clozapine serum concentration-A retrospective naturalistic cohort study on 526 patients with known smoking habits.
  2. Exosomal miR-626 promotes the malignant behavior of oral cancer cells by targeting NFIB.
    Title: Exosomal miR-626 promotes the malignant behavior of oral cancer cells by targeting NFIB.
  3. The Polymorphic Nuclear Factor NFIB Regulates Hepatic CYP2D6 Expression and Influences Risperidone Metabolism in Psychiatric Patients.
    Title: The Polymorphic Nuclear Factor NFIB Regulates Hepatic CYP2D6 Expression and Influences Risperidone Metabolism in Psychiatric Patients.
  4. Transcriptional Regulation of RIP2 Gene by NFIB Is Associated with Cellular Immune and Inflammatory Response to APEC Infection.
    Title: Transcriptional Regulation of <i>RIP2</i> Gene by NFIB Is Associated with Cellular Immune and Inflammatory Response to APEC Infection.
  5. CircNFIB inhibits tumor growth and metastasis through suppressing MEK1/ERK signaling in intrahepatic cholangiocarcinoma.
    Title: CircNFIB inhibits tumor growth and metastasis through suppressing MEK1/ERK signaling in intrahepatic cholangiocarcinoma.
  6. Evaluating the association between MPDZ-NF1B rs1324183 and keratoconus in an independent northwestern Chinese population.
    Title: Evaluating the association between MPDZ-NF1B rs1324183 and keratoconus in an independent northwestern Chinese population.
  7. Circ_0069718 promotes the progression of breast cancer by up-regulating NFIB through sequestering miR-590-5p.
    Title: Circ_0069718 promotes the progression of breast cancer by up-regulating NFIB through sequestering miR-590-5p.
  8. Long noncoding RNA small nucleolar RNA host gene 12/microRNA-138-5p/nuclear factor I/B regulates neuronal apoptosis, inflammatory response, and oxidative stress in Parkinson's disease.
    Title: Long noncoding RNA small nucleolar RNA host gene 12/microRNA-138-5p/nuclear factor I/B regulates neuronal apoptosis, inflammatory response, and oxidative stress in Parkinson's disease.
  9. Nuclear Factor IA Is Down-regulated in Muscle-invasive and High-grade Bladder Cancers.
    Title: Nuclear Factor IA Is Down-regulated in Muscle-invasive and High-grade Bladder Cancers.
  10. LncRNA PCAT1 enhances cell proliferation, migration and invasion by miR-508-3p/NFIB axis in diffuse large B-cell lymphoma.
    Title: LncRNA PCAT1 enhances cell proliferation, migration and invasion by miR-508-3p/NFIB axis in diffuse large B-cell lymphoma.
Submit: New GeneRIF Correction See all GeneRIFs (67)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Macrocephaly, acquired, with impaired intellectual development
MedGen: C4748993 OMIM: 618286 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of NFI-B by shRNA enhances HIV-1 replication in peripheral blood mononuclear cells (PBMCs) and in Jurkat cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in anterior commissure morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in brain development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell differentiation involved in salivary gland development IEA
Inferred from Electronic Annotation
more info
  
involved_in chondrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in club cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in commissural neuron axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glandular epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in glial cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in hindbrain development IEA
Inferred from Electronic Annotation
more info
  
involved_in lung ciliated cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of epithelial cell proliferation involved in lung morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of mesenchymal cell proliferation involved in lung development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of miRNA transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of stem cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in principal sensory nucleus of trigeminal nerve development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in response to bacterium IEA
Inferred from Electronic Annotation
more info
  
involved_in salivary gland cavitation IEA
Inferred from Electronic Annotation
more info
  
involved_in stem cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in type I pneumocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in type II pneumocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cerebellar mossy fiber ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in chromatin ISA
Inferred from Sequence Alignment
more info
  
located_in fibrillar center IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
nuclear factor 1 B-type
Names
CCAAT-box-binding transcription factor
TGGCA-binding protein
nuclear factor 1/B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190737.2 → NP_001177666.1  nuclear factor 1 B-type isoform 1

    See identical proteins and their annotated locations for NP_001177666.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AI140312, AL136366, AL441963, BX648845
    Consensus CDS
    CCDS55291.1
    UniProtKB/Swiss-Prot
    O00712
    Related
    ENSP00000370340.1, ENST00000380953.6
    Conserved Domains (3) summary
    cl00055
    Location:69 → 173
    MH1; N-terminal Mad Homology 1 (MH1) domain
    pfam00859
    Location:209 → 493
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:9 → 47
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

  2. NM_001190738.2 → NP_001177667.1  nuclear factor 1 B-type isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences, one of which results in translation from an upstream start codon, compared to variant 1. The resulting protein (isoform 2) has a different and longer N-terminus and a shorter C-terminus when it is compared to isoform 1.
    Source sequence(s)
    AK131233, AL136366, AL137017, AL441963
    Consensus CDS
    CCDS55292.1
    UniProtKB/Swiss-Prot
    O00712
    UniProtKB/TrEMBL
    A0A0A0MRX8
    Related
    ENSP00000370321.4, ENST00000380934.8
    Conserved Domains (3) summary
    cl00055
    Location:95 → 199
    MH1; N-terminal Mad Homology 1 (MH1) domain
    pfam00859
    Location:235 → 441
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:37 → 73
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

  3. NM_001282787.2 → NP_001269716.1  nuclear factor 1 B-type isoform 4

    See identical proteins and their annotated locations for NP_001269716.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains a distinct 5' UTR, lacks an in-frame portion of the 5' coding region and contains an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (4) is shorter compared to isoform 1.
    Source sequence(s)
    AI140312, AL441963, BP372854, BX648416
    Consensus CDS
    CCDS65007.1
    UniProtKB/Swiss-Prot
    O00712
    Related
    ENSP00000442888.1, ENST00000543693.5
    Conserved Domains (1) summary
    pfam00859
    Location:1 → 237
    CTF_NFI; CTF/NF-I family transcription modulation region

  4. NM_001369458.1 → NP_001356387.1  nuclear factor 1 B-type isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) encodes the longest isoform (5).
    Source sequence(s)
    AL136366, AL159169, AL441963
    Conserved Domains (3) summary
    pfam00859
    Location:231 → 520
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:32 → 69
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:91 → 195
    MH1; N-terminal Mad Homology 1 (MH1) domain

  5. NM_001369459.1 → NP_001356388.1  nuclear factor 1 B-type isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL159169, AL441963
    Conserved Domains (3) summary
    pfam00859
    Location:231 → 511
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:32 → 69
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:91 → 195
    MH1; N-terminal Mad Homology 1 (MH1) domain

  6. NM_001369460.1 → NP_001356389.1  nuclear factor 1 B-type isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963
    Consensus CDS
    CCDS94389.1
    UniProtKB/TrEMBL
    A0A2R8Y7V8
    Related
    ENSP00000496424.1, ENST00000646622.1
    Conserved Domains (3) summary
    pfam00859
    Location:205 → 494
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:4 → 43
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:65 → 169
    MH1; N-terminal Mad Homology 1 (MH1) domain

  7. NM_001369461.1 → NP_001356390.1  nuclear factor 1 B-type isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963
    Consensus CDS
    CCDS94386.1
    UniProtKB/TrEMBL
    Q5VW30
    Related
    ENSP00000380705.3, ENST00000397575.7
    Conserved Domains (3) summary
    pfam00859
    Location:209 → 489
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:10 → 47
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:69 → 173
    MH1; N-terminal Mad Homology 1 (MH1) domain

  8. NM_001369462.1 → NP_001356391.1  nuclear factor 1 B-type isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL159169, AL441963
    Conserved Domains (4) summary
    pfam00859
    Location:231 → 438
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:32 → 69
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:91 → 195
    MH1; N-terminal Mad Homology 1 (MH1) domain
    cl30265
    Location:407 → 497
    PRK09579; multidrug efflux protein; Reviewed

  9. NM_001369463.1 → NP_001356392.1  nuclear factor 1 B-type isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963
    Conserved Domains (3) summary
    pfam00859
    Location:205 → 466
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:4 → 43
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:65 → 169
    MH1; N-terminal Mad Homology 1 (MH1) domain

  10. NM_001369464.1 → NP_001356393.1  nuclear factor 1 B-type isoform 11

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963
    Consensus CDS
    CCDS94385.1
    UniProtKB/TrEMBL
    Q5VW27
    Related
    ENSP00000380709.2, ENST00000397579.6
    Conserved Domains (4) summary
    pfam00859
    Location:209 → 416
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:10 → 47
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:69 → 173
    MH1; N-terminal Mad Homology 1 (MH1) domain
    cl30265
    Location:385 → 475
    PRK09579; multidrug efflux protein; Reviewed

  11. NM_001369465.1 → NP_001356394.1  nuclear factor 1 B-type isoform 12

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963
    Conserved Domains (3) summary
    pfam00859
    Location:200 → 484
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:1 → 38
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:60 → 164
    MH1; N-terminal Mad Homology 1 (MH1) domain

  12. NM_001369466.1 → NP_001356395.1  nuclear factor 1 B-type isoform 13

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963
    Related
    ENSP00000490945.1, ENST00000635877.1
    Conserved Domains (4) summary
    pfam00859
    Location:205 → 412
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:4 → 43
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:65 → 169
    MH1; N-terminal Mad Homology 1 (MH1) domain
    cl30265
    Location:381 → 471
    PRK09579; multidrug efflux protein; Reviewed

  13. NM_001369467.1 → NP_001356396.1  nuclear factor 1 B-type isoform 14

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963
    Consensus CDS
    CCDS94384.1
    UniProtKB/TrEMBL
    A0A1B0GU97
    Related
    ENSP00000490020.1, ENST00000637640.1
    Conserved Domains (4) summary
    PRK15127
    Location:376 → 466
    PRK15127; multidrug efflux RND transporter permease subunit AcrB
    pfam10524
    Location:2 → 38
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:60 → 164
    MH1; N-terminal Mad Homology 1 (MH1) domain
    pfam00859
    Location:200 → 407
    CTF_NFI; CTF/NF-I family transcription modulation region

  14. NM_001369468.1 → NP_001356397.1  nuclear factor 1 B-type isoform 15

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL159169, AL441963
    Conserved Domains (3) summary
    pfam00859
    Location:231 → 437
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:32 → 69
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:91 → 195
    MH1; N-terminal Mad Homology 1 (MH1) domain

  15. NM_001369469.1 → NP_001356398.1  nuclear factor 1 B-type isoform 16

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963
    Conserved Domains (3) summary
    pfam00859
    Location:161 → 368
    CTF_NFI; CTF/NF-I family transcription modulation region
    cl00055
    Location:21 → 125
    MH1; N-terminal Mad Homology 1 (MH1) domain
    cl30265
    Location:337 → 427
    PRK09579; multidrug efflux protein; Reviewed

  16. NM_001369470.1 → NP_001356399.1  nuclear factor 1 B-type isoform 17

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963
    Consensus CDS
    CCDS94390.1
    UniProtKB/TrEMBL
    A0A1B0GVN4
    Related
    ENSP00000490588.1, ENST00000636432.1
    Conserved Domains (3) summary
    pfam10524
    Location:3 → 43
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:64 → 116
    MH1; N-terminal Mad Homology 1 (MH1) domain
    pfam00859
    Location:130 → 419
    CTF_NFI; CTF/NF-I family transcription modulation region

  17. NM_001369471.1 → NP_001356400.1  nuclear factor 1 B-type isoform 18

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963
    Conserved Domains (3) summary
    pfam00859
    Location:209 → 414
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:10 → 47
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:69 → 173
    MH1; N-terminal Mad Homology 1 (MH1) domain

  18. NM_001369472.1 → NP_001356401.1  nuclear factor 1 B-type isoform 19

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963
    Consensus CDS
    CCDS94388.1
    UniProtKB/TrEMBL
    U3KQE8
    Related
    ENSP00000475813.2, ENST00000606230.2
    Conserved Domains (3) summary
    pfam00859
    Location:205 → 411
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:4 → 43
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:65 → 169
    MH1; N-terminal Mad Homology 1 (MH1) domain

  19. NM_001369473.1 → NP_001356402.1  nuclear factor 1 B-type isoform 20

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963
    Conserved Domains (3) summary
    pfam00859
    Location:205 → 410
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:4 → 43
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:65 → 169
    MH1; N-terminal Mad Homology 1 (MH1) domain

  20. NM_001369474.1 → NP_001356403.1  nuclear factor 1 B-type isoform 21

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963
    Conserved Domains (3) summary
    pfam00859
    Location:204 → 409
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:6 → 42
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:64 → 168
    MH1; N-terminal Mad Homology 1 (MH1) domain

  21. NM_001369475.1 → NP_001356404.1  nuclear factor 1 B-type isoform 22

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963
    Conserved Domains (4) summary
    pfam00859
    Location:134 → 341
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:10 → 47
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:68 → 120
    MH1; N-terminal Mad Homology 1 (MH1) domain
    cl30265
    Location:310 → 400
    PRK09579; multidrug efflux protein; Reviewed

  22. NM_001369476.1 → NP_001356405.1  nuclear factor 1 B-type isoform 23

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963
    Consensus CDS
    CCDS94383.1
    UniProtKB/TrEMBL
    A0A1B0GW37
    Related
    ENSP00000490762.1, ENST00000636057.1
    Conserved Domains (3) summary
    pfam10524
    Location:2 → 38
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:60 → 164
    MH1; N-terminal Mad Homology 1 (MH1) domain
    pfam00859
    Location:200 → 406
    CTF_NFI; CTF/NF-I family transcription modulation region

  23. NM_001369477.1 → NP_001356406.1  nuclear factor 1 B-type isoform 24

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963
    Conserved Domains (3) summary
    pfam00859
    Location:191 → 396
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:10 → 47
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:69 → 173
    MH1; N-terminal Mad Homology 1 (MH1) domain

  24. NM_001369478.1 → NP_001356407.1  nuclear factor 1 B-type isoform 25

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963
    Conserved Domains (3) summary
    pfam00859
    Location:130 → 336
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:4 → 43
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:64 → 116
    MH1; N-terminal Mad Homology 1 (MH1) domain

  25. NM_001369479.1 → NP_001356408.1  nuclear factor 1 B-type isoform 26

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963
    Consensus CDS
    CCDS94382.1
    UniProtKB/TrEMBL
    A0A1B0GWB8
    Related
    ENSP00000490864.1, ENST00000636735.1
    Conserved Domains (2) summary
    pfam00859
    Location:30 → 237
    CTF_NFI; CTF/NF-I family transcription modulation region
    cl30265
    Location:206 → 296
    PRK09579; multidrug efflux protein; Reviewed

  26. NM_001369480.1 → NP_001356409.1  nuclear factor 1 B-type isoform 27

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963
    Conserved Domains (1) summary
    pfam00859
    Location:30 → 236
    CTF_NFI; CTF/NF-I family transcription modulation region

  27. NM_001369481.1 → NP_001356410.1  nuclear factor 1 B-type isoform 28

    Status: VALIDATED

    Source sequence(s)
    AL136366
    Consensus CDS
    CCDS94387.1
    UniProtKB/TrEMBL
    Q5W0Y9
    Related
    ENSP00000370308.3, ENST00000380921.3
    Conserved Domains (2) summary
    pfam10524
    Location:10 → 47
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:69 → 173
    MH1; N-terminal Mad Homology 1 (MH1) domain

  28. NM_005596.3 → NP_005587.2  nuclear factor 1 B-type isoform 3

    See identical proteins and their annotated locations for NP_005587.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks alternate exons in the 3' end, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AI140312, AL441963, BC001283, BX648845, DA785516
    Consensus CDS
    CCDS6474.1
    UniProtKB/Swiss-Prot
    O00712, Q96J45
    UniProtKB/TrEMBL
    Q5VW28
    Related
    ENSP00000370346.3, ENST00000380959.7
    Conserved Domains (3) summary
    pfam00859
    Location:209 → 415
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:10 → 47
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:69 → 173
    MH1; N-terminal Mad Homology 1 (MH1) domain

RNA

  1. NR_161382.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963

  2. NR_161383.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963

  3. NR_161384.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963

  4. NR_161385.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL441963

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    14081843..14532077 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    14091330..14541744 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O00712.2 GenPept UniProtKB/Swiss-Prot:O00712

Gene LinkOut

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