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NFIB nuclear factor I B [ Homo sapiens (human) ]

Gene ID: 4781, updated on 12-Aug-2018

Summary

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Official Symbol
NFIBprovided by HGNC
Official Full Name
nuclear factor I Bprovided by HGNC
Primary source
HGNC:HGNC:7785
See related
Ensembl:ENSG00000147862 MIM:600728; Vega:OTTHUMG00000021027
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CTF; NF1-B; NFI-B; NFIB2; NFIB3; NF-I/B; NFI-RED; HMGIC/NFIB
Expression
Ubiquitous expression in fat (RPKM 8.5), brain (RPKM 6.3) and 24 other tissues See more
Orthologs
mouse all

Genomic context

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See NFIB in Genome Data Viewer
Location:
9p23-p22.3
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 9 NC_000009.12 (14081843..14398983, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (14081842..14398982, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L3 pseudogene 11 Neighboring gene ATP synthase peripheral stalk subunit d pseudogene 3 Neighboring gene ribosomal protein L7a pseudogene 47 Neighboring gene transfer RNA-His (GTG) 1-6 Neighboring gene zinc finger DHHC-type containing 21 Neighboring gene cell division cycle associated 4 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

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Related articles in PubMed

  1. Nuclear Factor I/B: A Master Regulator of Cell Differentiation with Paradoxical Roles in Cancer. Becker-Santos DD, et al. EBioMedicine, 2017 Aug. PMID 28596133, Free PMC Article
  2. Developmental transcription factor NFIB is a putative target of oncofetal miRNAs and is associated with tumour aggressiveness in lung adenocarcinoma. Becker-Santos DD, et al. J Pathol, 2016 Oct. PMID 27357447
  3. Nuclear factor one B (NFIB) encodes a subtype-specific tumour suppressor in glioblastoma. Stringer BW, et al. Oncotarget, 2016 May 17. PMID 27083054, Free PMC Article
  4. Prognostic role of nuclear factor/IB and bone remodeling proteins in metastatic giant cell tumor of bone: A retrospective study. Quattrini I, et al. J Orthop Res, 2015 Aug. PMID 25764026
  5. HIV-1 induced nuclear factor I-B (NF-IB) expression negatively regulates HIV-1 replication through interaction with the long terminal repeat region. Vemula SV, et al. Viruses, 2015 Feb 5. PMID 25664610, Free PMC Article

See all (61) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  1. Both cases harbored the MYB-NFIB gene fusion as demonstrated by FISH and RNA-sequencing
    Title: Genetic Characterization of Adenoid Cystic Carcinoma of the Minor Salivary Glands: A Potential Familial Occurrence in First-Degree Relatives.
  2. Studied role of miR-30d in tumor invasiveness and migration in non-small lung cancer (NSCLC). Found miR-30d suppressed cell migration and invasion by directly targeting nuclear factor I B (NFIB) in NSCLC.
    Title: Non-small cell lung cancer: miR-30d suppresses tumor invasion and migration by directly targeting NFIB.
  3. NFIB-associated gene rearrangement is a frequent genetic event in vulvar adenoid cystic carcinomas. Chromosome translocations involving NFIB but with an intact MYB indicate the presence of novel oncogenic mechanisms for the development of adenoid cystic carcinomas of the vulva.
    Title: Frequent NFIB-associated Gene Rearrangement in Adenoid Cystic Carcinoma of the Vulva.
  4. Study highlighted the paradoxical involvement of NFIB in both the inhibition and promotion of tumor development as well as progression in different malignancies; especially between different tumor subtypes within a single organ system, such as in lung, brain and skin,which corroborates its diverse and distinct roles in specific tissues and cell types. [review]
    Title: Nuclear Factor I/B: A Master Regulator of Cell Differentiation with Paradoxical Roles in Cancer.
  5. Expression of the MYB-NFIB fusion oncogene in mammary tissue resulted in hyperplastic glands that developed into adenocarcinoma.
    Title: The impact of the MYB-NFIB fusion proto-oncogene in vivo.
  6. we report that the transcription factor NFIB is associated with significantly improved survival in glioblastoma
    Title: Nuclear factor one B (NFIB) encodes a subtype-specific tumour suppressor in glioblastoma.
  7. A trend toward superior PFS was noted with the MYB/NFIB rearrangement, although this was not statistically significant. NGS revealed three tumors with 4q12 amplification, producing increased copies of axitinib-targeted genes PDGFR/KDR/KIT.
    Title: A phase II study of axitinib (AG-013736) in patients with incurable adenoid cystic carcinoma.
  8. High NFIB levels are associated with expansive growth of a poorly differentiated and almost exclusively E-cadherin (CDH1)-negative invasive tumor cell population.
    Title: Transcription Factor NFIB Is a Driver of Small Cell Lung Cancer Progression in Mice and Marks Metastatic Disease in Patients.
  9. Studies indicate the role of nuclear factor one (NFIs) as epigenetic regulators in cancer.
    Title: Nuclear factor one transcription factors as epigenetic regulators in cancer.
  10. low expression of NFIB was significantly associated with biologically more aggressive subtypes and, ultimately, poorer survival in lung adenocarcinoma patients
    Title: Developmental transcription factor NFIB is a putative target of oncofetal miRNAs and is associated with tumour aggressiveness in lung adenocarcinoma.
Submit: New GeneRIF Correction See all GeneRIFs (36)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

Description
APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study.
NHGRI GWA Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of NFI-B by shRNA enhances HIV-1 replication in peripheral blood mononuclear cells (PBMCs) and in Jurkat cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
 PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific NAS
Non-traceable Author Statement
more info
 PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
Clara cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
DNA replication IEA
Inferred from Electronic Annotation
more info
  
anterior commissure morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
cell differentiation involved in salivary gland development IEA
Inferred from Electronic Annotation
more info
  
chondrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
commissural neuron axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
  
glial cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
hindbrain development IEA
Inferred from Electronic Annotation
more info
  
lung ciliated cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
negative regulation of epithelial cell proliferation involved in lung morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
negative regulation of mesenchymal cell proliferation involved in lung development ISS
Inferred from Sequence or Structural Similarity
more info
  
negative regulation of pri-miRNA transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
principal sensory nucleus of trigeminal nerve development ISS
Inferred from Sequence or Structural Similarity
more info
  
salivary gland cavitation IEA
Inferred from Electronic Annotation
more info
  
transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
type I pneumocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
type II pneumocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
cerebellar mossy fiber ISS
Inferred from Sequence or Structural Similarity
more info
  
fibrillar center IDA
Inferred from Direct Assay
more info
  
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
nuclear factor 1 B-type
Names
CCAAT-box-binding transcription factor
TGGCA-binding protein
nuclear factor 1/B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190737.1 → NP_001177666.1  nuclear factor 1 B-type isoform 1

    See identical proteins and their annotated locations for NP_001177666.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1).
    Source sequence(s)
    AI140312, AL136366, AL441963, BX648845
    Consensus CDS
    CCDS55291.1
    UniProtKB/Swiss-Prot
    O00712
    Related
    ENSP00000370340.1, OTTHUMP00000022769, ENST00000380953.5, OTTHUMT00000055472
    Conserved Domains (3) summary
    cl00055
    Location:69 → 173
    MH1; N-terminal Mad Homology 1 (MH1) domain
    pfam00859
    Location:209 → 493
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:9 → 47
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

  2. NM_001190738.1 → NP_001177667.1  nuclear factor 1 B-type isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences, one of which results in translation from an upstream start codon, compared to variant 1. The resulting protein (isoform 2) has a different and longer N-terminus and a shorter C-terminus when it is compared to isoform 1.
    Source sequence(s)
    AI140312, AK131233, AL136366, AL137017, AL441963
    Consensus CDS
    CCDS55292.1
    UniProtKB/Swiss-Prot
    O00712
    UniProtKB/TrEMBL
    A0A0A0MRX8
    Related
    ENSP00000370321.4, OTTHUMP00000280976, ENST00000380934.8, OTTHUMT00000487755
    Conserved Domains (3) summary
    cl00055
    Location:95 → 199
    MH1; N-terminal Mad Homology 1 (MH1) domain
    pfam00859
    Location:235 → 441
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:37 → 73
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

  3. NM_001282787.1 → NP_001269716.1  nuclear factor 1 B-type isoform 4

    See identical proteins and their annotated locations for NP_001269716.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains a distinct 5' UTR, lacks an in-frame portion of the 5' coding region and contains an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (4) is shorter compared to isoform 1.
    Source sequence(s)
    AI140312, AL441963, BP372854, BX648416
    Consensus CDS
    CCDS65007.1
    UniProtKB/Swiss-Prot
    O00712
    Related
    ENSP00000442888.1, ENST00000543693.5
    Conserved Domains (1) summary
    pfam00859
    Location:1 → 237
    CTF_NFI; CTF/NF-I family transcription modulation region

  4. NM_005596.3 → NP_005587.2  nuclear factor 1 B-type isoform 3

    See identical proteins and their annotated locations for NP_005587.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks alternate exons in the 3' end, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AI140312, AL441963, BC001283, BX648845, DA785516
    Consensus CDS
    CCDS6474.1
    UniProtKB/Swiss-Prot
    O00712
    UniProtKB/TrEMBL
    Q5VW28
    Related
    ENSP00000370346.3, OTTHUMP00000022765, ENST00000380959.7, OTTHUMT00000055468
    Conserved Domains (3) summary
    pfam00859
    Location:209 → 415
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:10 → 47
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:69 → 173
    MH1; N-terminal Mad Homology 1 (MH1) domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p12 Primary Assembly

    Range
    14081843..14398983 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024447555.1 → XP_024303323.1  nuclear factor 1 B-type isoform X7

    Conserved Domains (3) summary
    pfam00859
    Location:205 → 466
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:4 → 43
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:65 → 169
    MH1; N-terminal Mad Homology 1 (MH1) domain

  2. XM_017014741.1 → XP_016870230.1  nuclear factor 1 B-type isoform X11

  3. XM_005251468.5 → XP_005251525.1  nuclear factor 1 B-type isoform X3

    Related
    ENSP00000496424.1, ENST00000646622.1
    Conserved Domains (3) summary
    cl00055
    Location:65 → 169
    MH1; N-terminal Mad Homology 1 (MH1) domain
    pfam00859
    Location:205 → 494
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:4 → 43
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

  4. XM_017014740.1 → XP_016870229.1  nuclear factor 1 B-type isoform X10

    UniProtKB/TrEMBL
    U3KQE8
    Related
    ENSP00000475813.2, OTTHUMP00000273258, ENST00000606230.2, OTTHUMT00000470132

  5. XM_017014739.2 → XP_016870228.1  nuclear factor 1 B-type isoform X9

  6. XM_006716773.3 → XP_006716836.1  nuclear factor 1 B-type isoform X2

    Conserved Domains (3) summary
    cl00055
    Location:69 → 173
    MH1; N-terminal Mad Homology 1 (MH1) domain
    pfam00859
    Location:209 → 497
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:9 → 47
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

  7. XM_005251470.3 → XP_005251527.1  nuclear factor 1 B-type isoform X8

    See identical proteins and their annotated locations for XP_005251527.1

    UniProtKB/TrEMBL
    Q5VW27
    Related
    ENSP00000380709.2, OTTHUMP00000022766, ENST00000397579.6
    Conserved Domains (3) summary
    cl00055
    Location:69 → 173
    MH1; N-terminal Mad Homology 1 (MH1) domain
    pfam00859
    Location:209 → 416
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:9 → 47
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

  8. XM_005251469.3 → XP_005251526.1  nuclear factor 1 B-type isoform X4

    See identical proteins and their annotated locations for XP_005251526.1

    UniProtKB/TrEMBL
    Q5VW30
    Related
    ENSP00000380705.3, OTTHUMP00000022768, ENST00000397575.7
    Conserved Domains (3) summary
    cl00055
    Location:69 → 173
    MH1; N-terminal Mad Homology 1 (MH1) domain
    pfam00859
    Location:209 → 489
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:9 → 47
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

  9. XM_006716775.3 → XP_006716838.1  nuclear factor 1 B-type isoform X6

    Conserved Domains (3) summary
    cl00055
    Location:69 → 173
    MH1; N-terminal Mad Homology 1 (MH1) domain
    pfam00859
    Location:209 → 470
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:9 → 47
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

  10. XM_006716774.3 → XP_006716837.1  nuclear factor 1 B-type isoform X5

    Related
    ENSP00000490588.1, OTTHUMP00000281662, ENST00000636432.1
    Conserved Domains (3) summary
    cl00055
    Location:69 → 173
    MH1; N-terminal Mad Homology 1 (MH1) domain
    pfam00859
    Location:209 → 502
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:9 → 47
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

  11. XM_005251467.3 → XP_005251524.1  nuclear factor 1 B-type isoform X1

    See identical proteins and their annotated locations for XP_005251524.1

    UniProtKB/TrEMBL
    Q5VW26
    Related
    ENSP00000380711.2, OTTHUMP00000022767, ENST00000397581.6
    Conserved Domains (3) summary
    cl00055
    Location:69 → 173
    MH1; N-terminal Mad Homology 1 (MH1) domain
    pfam00859
    Location:209 → 498
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:9 → 47
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

  12. XM_017014742.1 → XP_016870231.1  nuclear factor 1 B-type isoform X13

    UniProtKB/TrEMBL
    A0A1B0GWB8
    Related
    ENSP00000490864.1, OTTHUMP00000281659, ENST00000636735.1, OTTHUMT00000488968

  13. XM_005251471.3 → XP_005251528.1  nuclear factor 1 B-type isoform X12

    Conserved Domains (1) summary
    pfam00859
    Location:1 → 246
    CTF_NFI; CTF/NF-I family transcription modulation region

RNA

  1. XR_001746309.2 RNA Sequence

  2. XR_001746308.2 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O00712.2 GenPept UniProtKB/Swiss-Prot:O00712

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