Sign in to NCBI
Format

Send to:

Choose Destination

NFIB nuclear factor I B [ Homo sapiens (human) ]

Gene ID: 4781, updated on 5-Apr-2020

Summary

Go to the top of the page Help
Official Symbol
NFIBprovided by HGNC
Official Full Name
nuclear factor I Bprovided by HGNC
Primary source
HGNC:HGNC:7785
See related
Ensembl:ENSG00000147862 MIM:600728
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CTF; MACID; NF1-B; NFI-B; NFIB2; NFIB3; NF-I/B; NFI-RED; HMGIC/NFIB
Expression
Ubiquitous expression in fat (RPKM 8.5), brain (RPKM 6.3) and 24 other tissues See more
Orthologs
mouse all

Genomic context

Go to the top of the page Help
See NFIB in Genome Data Viewer
Location:
9p23-p22.3
Exon count:
22
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (14081843..14532077, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (14081842..14398982, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L3 pseudogene 11 Neighboring gene ATP synthase peripheral stalk subunit d pseudogene 3 Neighboring gene ribosomal protein L7a pseudogene 47 Neighboring gene tRNA-His (anticodon GTG) 1-6 Neighboring gene zinc finger DHHC-type palmitoyltransferase 21 Neighboring gene cell division cycle associated 4 pseudogene 1 Neighboring gene cerberus 1, DAN family BMP antagonist

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Genetic Variant of NFIB is Associated With the Metastasis of Osteosarcoma in Chinese Population. Xu L, et al. Technol Cancer Res Treat, 2019 Jan 1. PMID 31522615, Free PMC Article
  2. Nuclear factor I/B promotes colorectal cancer cell proliferation, epithelial-mesenchymal transition and 5-fluorouracil resistance. Liu Z, et al. Cancer Sci, 2019 Jan. PMID 30320939, Free PMC Article
  3. Nuclear Factor I/B: A Master Regulator of Cell Differentiation with Paradoxical Roles in Cancer. Becker-Santos DD, et al. EBioMedicine, 2017 Aug. PMID 28596133, Free PMC Article
  4. Developmental transcription factor NFIB is a putative target of oncofetal miRNAs and is associated with tumour aggressiveness in lung adenocarcinoma. Becker-Santos DD, et al. J Pathol, 2016 Oct. PMID 27357447
  5. Nuclear factor one B (NFIB) encodes a subtype-specific tumour suppressor in glioblastoma. Stringer BW, et al. Oncotarget, 2016 May 17. PMID 27083054, Free PMC Article

See all (75) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The knockdown of calpain 1, NFIB, or both increased GBM cell migration and up-regulated the pro-migratory factors fatty acid-binding protein 7 (FABP7) and Ras homolog family member A (RHOA).
    Title: A positive feedback loop involving nuclear factor IB and calpain 1 suppresses glioblastoma cell migration.
  2. The SNP rs7034162 was associated with metastasis of OS in the Chinese population. It functions as a risk factor in the incidence of metastasis possibly via downregulation of NFIB.
    Title: Genetic Variant of <i>NFIB</i> is Associated With the Metastasis of Osteosarcoma in Chinese Population.
  3. NFIB promotes cell survival by directly suppressing p21 transcription in TP53-mutated triple-negative breast cancer cells.
    Title: NFIB promotes cell survival by directly suppressing p21 transcription in TP53-mutated triple-negative breast cancer.
  4. High NFIB expression correlates with lymph node metastasis and poor differentiation in tumors of patients with esophagogastric junction adenocarcinoma (EJA) predicting poor outcome.
    Title: Prognostic significance of NFIA and NFIB in esophageal squamous carcinoma and esophagogastric junction adenocarcinoma.
  5. Breast adenoid cystic carcinomas probably constitute a convergent phenotype, whereby activation of MYB and MYBL1 and their downstream targets can be driven by the MYB-NFIB fusion gene, MYBL1 rearrangements, MYB amplification, or other yet to be identified mechanisms.
    Title: MYBL1 rearrangements and MYB amplification in breast adenoid cystic carcinomas lacking the MYB-NFIB fusion gene.
  6. This study confirmed the association of SNP rs1324183 in MPDZ-NF1B with keratoconus and revealed the association of this SNP with keratoconus severity and corneal parameters. It is thus a putative genetic marker for monitoring the progression of keratoconus to a severe form and facilitating early intervention.
    Title: Analysis of multiple genetic loci reveals <i>MPDZ-NF1B</i> rs1324183 as a putative genetic marker for keratoconus.
  7. Haploinsufficiency of NFIB causes ID with macrocephaly.
    Title: NFIB Haploinsufficiency Is Associated with Intellectual Disability and Macrocephaly.
  8. Nuclear factor I/B (NFIB) is overexpressed in colorectal cancer (CRC) tissues.
    Title: Nuclear factor I/B promotes colorectal cancer cell proliferation, epithelial-mesenchymal transition and 5-fluorouracil resistance.
  9. Salivary gland ACC cases expressing the MYB-NFIB chimeric gene showed significantly higher blood vessels density compared to non-expressing cases, and suggested that higher VEGF production capability in the former cases may be the cause. The findings also suggested that MYB-NFIB chimeric gene expression may be related to the onset age of ACC.
    Title: Study of MYB-NFIB chimeric gene expression, tumor angiogenesis, and proliferation in adenoid cystic carcinoma of salivary gland.
  10. High NF1B expression is associated with cell growth, aggressiveness, metastasis in gastric cancer.
    Title: NFIB promotes cell growth, aggressiveness, metastasis and EMT of gastric cancer through the Akt/Stat3 signaling pathway.
Submit: New GeneRIF Correction See all GeneRIFs (46)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
MACROCEPHALY, ACQUIRED, WITH IMPAIRED INTELLECTUAL DEVELOPMENT
MedGen: C4748993 OMIM: 618286 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study.
NHGRI GWA Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

Go to the top of the page Help

Replication interactions

Interaction Pubs
Knockdown of NFI-B by shRNA enhances HIV-1 replication in peripheral blood mononuclear cells (PBMCs) and in Jurkat cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
 PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
Clara cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
DNA replication IEA
Inferred from Electronic Annotation
more info
  
anterior commissure morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
brain development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
cell differentiation involved in salivary gland development IEA
Inferred from Electronic Annotation
more info
  
chondrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
commissural neuron axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
  
glial cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
hindbrain development IEA
Inferred from Electronic Annotation
more info
  
lung ciliated cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
negative regulation of epithelial cell proliferation involved in lung morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
negative regulation of mesenchymal cell proliferation involved in lung development ISS
Inferred from Sequence or Structural Similarity
more info
  
negative regulation of pri-miRNA transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
 PubMed 
principal sensory nucleus of trigeminal nerve development ISS
Inferred from Sequence or Structural Similarity
more info
  
response to bacterium IEA
Inferred from Electronic Annotation
more info
  
salivary gland cavitation IEA
Inferred from Electronic Annotation
more info
  
type I pneumocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
type II pneumocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
cerebellar mossy fiber ISS
Inferred from Sequence or Structural Similarity
more info
  
fibrillar center IDA
Inferred from Direct Assay
more info
  
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
  
nucleoplasm IDA
Inferred from Direct Assay
more info
  
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
nuclear factor 1 B-type
Names
CCAAT-box-binding transcription factor
TGGCA-binding protein
nuclear factor 1/B

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190737.2 → NP_001177666.1  nuclear factor 1 B-type isoform 1

    See identical proteins and their annotated locations for NP_001177666.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AI140312, AL136366, AL441963, BX648845
    Consensus CDS
    CCDS55291.1
    UniProtKB/Swiss-Prot
    O00712
    Related
    ENSP00000370340.1, ENST00000380953.6
    Conserved Domains (3) summary
    cl00055
    Location:69 → 173
    MH1; N-terminal Mad Homology 1 (MH1) domain
    pfam00859
    Location:209 → 493
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:9 → 47
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

  2. NM_001190738.1 → NP_001177667.1  nuclear factor 1 B-type isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences, one of which results in translation from an upstream start codon, compared to variant 1. The resulting protein (isoform 2) has a different and longer N-terminus and a shorter C-terminus when it is compared to isoform 1.
    Source sequence(s)
    AI140312, AK131233, AL136366, AL137017, AL441963
    Consensus CDS
    CCDS55292.1
    UniProtKB/Swiss-Prot
    O00712
    UniProtKB/TrEMBL
    A0A0A0MRX8
    Related
    ENSP00000370321.4, ENST00000380934.8
    Conserved Domains (3) summary
    cl00055
    Location:95 → 199
    MH1; N-terminal Mad Homology 1 (MH1) domain
    pfam00859
    Location:235 → 441
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:37 → 73
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

  3. NM_001282787.1 → NP_001269716.1  nuclear factor 1 B-type isoform 4

    See identical proteins and their annotated locations for NP_001269716.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains a distinct 5' UTR, lacks an in-frame portion of the 5' coding region and contains an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (4) is shorter compared to isoform 1.
    Source sequence(s)
    AI140312, AL441963, BP372854, BX648416
    Consensus CDS
    CCDS65007.1
    UniProtKB/Swiss-Prot
    O00712
    Related
    ENSP00000442888.1, ENST00000543693.5
    Conserved Domains (1) summary
    pfam00859
    Location:1 → 237
    CTF_NFI; CTF/NF-I family transcription modulation region

  4. NM_001369458.1 → NP_001356387.1  nuclear factor 1 B-type isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) encodes the longest isoform (5).
    Source sequence(s)
    AL136366, AL159169, AL441963
    Conserved Domains (3) summary
    pfam00859
    Location:231 → 520
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:32 → 69
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:91 → 195
    MH1; N-terminal Mad Homology 1 (MH1) domain

  5. NM_001369459.1 → NP_001356388.1  nuclear factor 1 B-type isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL159169, AL441963
    Conserved Domains (3) summary
    pfam00859
    Location:231 → 511
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:32 → 69
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:91 → 195
    MH1; N-terminal Mad Homology 1 (MH1) domain

  6. NM_001369460.1 → NP_001356389.1  nuclear factor 1 B-type isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963
    Related
    ENSP00000496424.1, ENST00000646622.1
    Conserved Domains (3) summary
    pfam00859
    Location:205 → 494
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:4 → 43
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:65 → 169
    MH1; N-terminal Mad Homology 1 (MH1) domain

  7. NM_001369461.1 → NP_001356390.1  nuclear factor 1 B-type isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963
    Related
    ENSP00000380705.3, ENST00000397575.7
    Conserved Domains (3) summary
    pfam00859
    Location:209 → 489
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:10 → 47
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:69 → 173
    MH1; N-terminal Mad Homology 1 (MH1) domain

  8. NM_001369462.1 → NP_001356391.1  nuclear factor 1 B-type isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL159169, AL441963
    Conserved Domains (4) summary
    pfam00859
    Location:231 → 438
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:32 → 69
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:91 → 195
    MH1; N-terminal Mad Homology 1 (MH1) domain
    cl30265
    Location:407 → 497
    PRK09579; multidrug efflux protein; Reviewed

  9. NM_001369463.1 → NP_001356392.1  nuclear factor 1 B-type isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963
    Conserved Domains (3) summary
    pfam00859
    Location:205 → 466
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:4 → 43
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:65 → 169
    MH1; N-terminal Mad Homology 1 (MH1) domain

  10. NM_001369464.1 → NP_001356393.1  nuclear factor 1 B-type isoform 11

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963
    Related
    ENSP00000380709.2, ENST00000397579.6
    Conserved Domains (4) summary
    pfam00859
    Location:209 → 416
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:10 → 47
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:69 → 173
    MH1; N-terminal Mad Homology 1 (MH1) domain
    cl30265
    Location:385 → 475
    PRK09579; multidrug efflux protein; Reviewed

  11. NM_001369465.1 → NP_001356394.1  nuclear factor 1 B-type isoform 12

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963
    Conserved Domains (3) summary
    pfam00859
    Location:200 → 484
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:1 → 38
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:60 → 164
    MH1; N-terminal Mad Homology 1 (MH1) domain

  12. NM_001369466.1 → NP_001356395.1  nuclear factor 1 B-type isoform 13

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963
    Related
    ENSP00000490945.1, ENST00000635877.1
    Conserved Domains (4) summary
    pfam00859
    Location:205 → 412
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:4 → 43
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:65 → 169
    MH1; N-terminal Mad Homology 1 (MH1) domain
    cl30265
    Location:381 → 471
    PRK09579; multidrug efflux protein; Reviewed

  13. NM_001369467.1 → NP_001356396.1  nuclear factor 1 B-type isoform 14

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963
    Related
    ENSP00000490020.1, ENST00000637640.1
    Conserved Domains (4) summary
    pfam00859
    Location:200 → 407
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:1 → 38
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:60 → 164
    MH1; N-terminal Mad Homology 1 (MH1) domain
    cl30265
    Location:376 → 466
    PRK09579; multidrug efflux protein; Reviewed

  14. NM_001369468.1 → NP_001356397.1  nuclear factor 1 B-type isoform 15

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL159169, AL441963
    Conserved Domains (3) summary
    pfam00859
    Location:231 → 437
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:32 → 69
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:91 → 195
    MH1; N-terminal Mad Homology 1 (MH1) domain

  15. NM_001369469.1 → NP_001356398.1  nuclear factor 1 B-type isoform 16

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963
    Conserved Domains (3) summary
    pfam00859
    Location:161 → 368
    CTF_NFI; CTF/NF-I family transcription modulation region
    cl00055
    Location:21 → 125
    MH1; N-terminal Mad Homology 1 (MH1) domain
    cl30265
    Location:337 → 427
    PRK09579; multidrug efflux protein; Reviewed

  16. NM_001369470.1 → NP_001356399.1  nuclear factor 1 B-type isoform 17

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963
    Related
    ENSP00000490588.1, ENST00000636432.1
    Conserved Domains (3) summary
    pfam00859
    Location:130 → 423
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:4 → 43
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:64 → 116
    MH1; N-terminal Mad Homology 1 (MH1) domain

  17. NM_001369471.1 → NP_001356400.1  nuclear factor 1 B-type isoform 18

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963
    Conserved Domains (3) summary
    pfam00859
    Location:209 → 414
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:10 → 47
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:69 → 173
    MH1; N-terminal Mad Homology 1 (MH1) domain

  18. NM_001369472.1 → NP_001356401.1  nuclear factor 1 B-type isoform 19

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963
    Related
    ENSP00000475813.2, ENST00000606230.2
    Conserved Domains (3) summary
    pfam00859
    Location:205 → 411
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:4 → 43
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:65 → 169
    MH1; N-terminal Mad Homology 1 (MH1) domain

  19. NM_001369473.1 → NP_001356402.1  nuclear factor 1 B-type isoform 20

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963
    Conserved Domains (3) summary
    pfam00859
    Location:205 → 410
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:4 → 43
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:65 → 169
    MH1; N-terminal Mad Homology 1 (MH1) domain

  20. NM_001369474.1 → NP_001356403.1  nuclear factor 1 B-type isoform 21

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963
    Conserved Domains (3) summary
    pfam00859
    Location:204 → 409
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:6 → 42
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:64 → 168
    MH1; N-terminal Mad Homology 1 (MH1) domain

  21. NM_001369475.1 → NP_001356404.1  nuclear factor 1 B-type isoform 22

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963
    Conserved Domains (4) summary
    pfam00859
    Location:134 → 341
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:10 → 47
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:68 → 120
    MH1; N-terminal Mad Homology 1 (MH1) domain
    cl30265
    Location:310 → 400
    PRK09579; multidrug efflux protein; Reviewed

  22. NM_001369476.1 → NP_001356405.1  nuclear factor 1 B-type isoform 23

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963
    Related
    ENSP00000490762.1, ENST00000636057.1
    Conserved Domains (3) summary
    pfam00859
    Location:200 → 406
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:1 → 38
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:60 → 164
    MH1; N-terminal Mad Homology 1 (MH1) domain

  23. NM_001369477.1 → NP_001356406.1  nuclear factor 1 B-type isoform 24

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963
    Conserved Domains (3) summary
    pfam00859
    Location:191 → 396
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:10 → 47
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:69 → 173
    MH1; N-terminal Mad Homology 1 (MH1) domain

  24. NM_001369478.1 → NP_001356407.1  nuclear factor 1 B-type isoform 25

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963
    Conserved Domains (3) summary
    pfam00859
    Location:130 → 336
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:4 → 43
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:64 → 116
    MH1; N-terminal Mad Homology 1 (MH1) domain

  25. NM_001369479.1 → NP_001356408.1  nuclear factor 1 B-type isoform 26

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963
    Related
    ENSP00000490864.1, ENST00000636735.1
    Conserved Domains (2) summary
    pfam00859
    Location:30 → 237
    CTF_NFI; CTF/NF-I family transcription modulation region
    cl30265
    Location:206 → 296
    PRK09579; multidrug efflux protein; Reviewed

  26. NM_001369480.1 → NP_001356409.1  nuclear factor 1 B-type isoform 27

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963
    Conserved Domains (1) summary
    pfam00859
    Location:30 → 236
    CTF_NFI; CTF/NF-I family transcription modulation region

  27. NM_001369481.1 → NP_001356410.1  nuclear factor 1 B-type isoform 28

    Status: VALIDATED

    Source sequence(s)
    AL136366
    Related
    ENSP00000370308.3, ENST00000380921.3
    Conserved Domains (2) summary
    pfam10524
    Location:10 → 47
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:69 → 173
    MH1; N-terminal Mad Homology 1 (MH1) domain

  28. NM_005596.3 → NP_005587.2  nuclear factor 1 B-type isoform 3

    See identical proteins and their annotated locations for NP_005587.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks alternate exons in the 3' end, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AI140312, AL441963, BC001283, BX648845, DA785516
    Consensus CDS
    CCDS6474.1
    UniProtKB/Swiss-Prot
    O00712
    UniProtKB/TrEMBL
    Q5VW28
    Related
    ENSP00000370346.3, ENST00000380959.7
    Conserved Domains (3) summary
    pfam00859
    Location:209 → 415
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:10 → 47
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:69 → 173
    MH1; N-terminal Mad Homology 1 (MH1) domain

RNA

  1. NR_161382.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963

  2. NR_161383.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963

  3. NR_161384.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL136366, AL441963

  4. NR_161385.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL441963

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    14081843..14532077 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006716773.3 → XP_006716836.1  nuclear factor 1 B-type isoform X2

    Conserved Domains (3) summary
    cl00055
    Location:69 → 173
    MH1; N-terminal Mad Homology 1 (MH1) domain
    pfam00859
    Location:209 → 497
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:9 → 47
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

  2. XM_006716775.3 → XP_006716838.1  nuclear factor 1 B-type isoform X6

    Conserved Domains (3) summary
    cl00055
    Location:69 → 173
    MH1; N-terminal Mad Homology 1 (MH1) domain
    pfam00859
    Location:209 → 470
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:9 → 47
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

  3. XM_006716774.3 → XP_006716837.1  nuclear factor 1 B-type isoform X5

    Conserved Domains (3) summary
    cl00055
    Location:69 → 173
    MH1; N-terminal Mad Homology 1 (MH1) domain
    pfam00859
    Location:209 → 502
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:9 → 47
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

  4. XM_005251467.3 → XP_005251524.1  nuclear factor 1 B-type isoform X1

    See identical proteins and their annotated locations for XP_005251524.1

    UniProtKB/TrEMBL
    Q5VW26
    Related
    ENSP00000380711.2, ENST00000397581.6
    Conserved Domains (3) summary
    cl00055
    Location:69 → 173
    MH1; N-terminal Mad Homology 1 (MH1) domain
    pfam00859
    Location:209 → 498
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:9 → 47
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

  5. XM_005251471.3 → XP_005251528.1  nuclear factor 1 B-type isoform X12

    Conserved Domains (1) summary
    pfam00859
    Location:1 → 246
    CTF_NFI; CTF/NF-I family transcription modulation region

RNA

  1. XR_001746309.2 RNA Sequence

  2. XR_001746308.2 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O00712.2 GenPept UniProtKB/Swiss-Prot:O00712

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous
You are here: NCBI > Genes & Expression > Gene
Support Center