MAP3K1 mitogen-activated protein kinase kinase kinase 1 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: MAP3K1provided by VGNC
Official Full Name: mitogen-activated protein kinase kinase kinase 1provided by VGNC
Primary source: VGNC:VGNC:42966
See related: Ensembl:ENSCAFG00845028679
Gene type: protein coding
RefSeq status: MODEL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 2

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	2	NC_051806.1 (44400091..44478773)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	2	NC_006584.4 (40979535..41058128)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	2	NC_049223.1 (43100342..43179022)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	2	NC_049262.1 (41477057..41555639)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	2	NC_049743.1 (42280433..42359075)
105	previous assembly	CanFam3.1 (GCF_000002285.3)	2	NC_006584.3 (43918210..43996817)

Chromosome 2 - NC_051806.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

REN28305 (e-PCR)
- UniSTS:353105

REN28309 (e-PCR)
- UniSTS:353109

ECD05748 (e-PCR)
- UniSTS:286810

REN28361 (e-PCR)
- UniSTS:353161

stSG625149 (e-PCR)
- UniSTS:456341

stSG625150 (e-PCR)
- UniSTS:456342

stSG625151 (e-PCR)
- UniSTS:456343

stSG625152 (e-PCR)
- UniSTS:456344

stSG625159 (e-PCR)
- UniSTS:456351

RH70595 (e-PCR)
- UniSTS:3757

ECD13328 (e-PCR)
- UniSTS:294358

MAP3K1_3196 (e-PCR)
- UniSTS:462331

Homology

Orthologs from Annotation Pipeline: 418 organisms have orthologs with human gene MAP3K1
Orthologs

General protein information

Go to the top of the page Help

Preferred Names: mitogen-activated protein kinase kinase kinase 1

XP_038325748.1

EC 2.7.11.25

XP_038386556.1

EC 2.7.11.25

XP_038450802.1

EC 2.7.11.25

XP_038514848.1

EC 2.7.11.25

XP_535240.4

EC 2.7.11.25

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051806.1 Reference ROS_Cfam_1.0

Range

44400091..44478773

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038658920.1 → XP_038514848.1 mitogen-activated protein kinase kinase kinase 1

UniProtKB/TrEMBL

A0A8C0LJE1, A0A8C0N237, A0A8I3PX84

Related

ENSCAFP00845039758.1, ENSCAFT00845050716.1

Conserved Domains (2) summary

cd06630
Location:1237 → 1504

STKc_MEKK1; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 1

cd16494
Location:440 → 495

RING-CH-C4HC3_ZSWM2; RING-CH finger, H2 subclass (C4HC3-type), found in zinc finger SWIM domain-containing protein 2 (ZSWIM2) and similar proteins

Alternate UMICH_Zoey_3.1

Genomic

NC_049262.1 Alternate UMICH_Zoey_3.1

Range

41477057..41555639

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038469820.1 → XP_038325748.1 mitogen-activated protein kinase kinase kinase 1

Conserved Domains (2) summary

cd06630
Location:1237 → 1504

STKc_MEKK1; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 1

cd16494
Location:440 → 495

RING-CH-C4HC3_ZSWM2; RING-CH finger, H2 subclass (C4HC3-type), found in zinc finger SWIM domain-containing protein 2 (ZSWIM2) and similar proteins

Alternate UNSW_CanFamBas_1.0

Genomic

NC_049743.1 Alternate UNSW_CanFamBas_1.0

Range

42280433..42359075

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038594874.1 → XP_038450802.1 mitogen-activated protein kinase kinase kinase 1

Conserved Domains (2) summary

cd06630
Location:1237 → 1504

STKc_MEKK1; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 1

cd16494
Location:440 → 495

RING-CH-C4HC3_ZSWM2; RING-CH finger, H2 subclass (C4HC3-type), found in zinc finger SWIM domain-containing protein 2 (ZSWIM2) and similar proteins

Alternate UU_Cfam_GSD_1.0

Genomic

NC_049223.1 Alternate UU_Cfam_GSD_1.0

Range

43100342..43179022

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038530628.1 → XP_038386556.1 mitogen-activated protein kinase kinase kinase 1

Conserved Domains (2) summary

cd06630
Location:1237 → 1504

STKc_MEKK1; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 1

cd16494
Location:440 → 495

RING-CH-C4HC3_ZSWM2; RING-CH finger, H2 subclass (C4HC3-type), found in zinc finger SWIM domain-containing protein 2 (ZSWIM2) and similar proteins

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

NC_006584.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

Range

40979535..41058128

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_535240.7 → XP_535240.4 mitogen-activated protein kinase kinase kinase 1

UniProtKB/TrEMBL

A0A8C0LJE1, A0A8C0N237, A0A8I3PX84

Conserved Domains (2) summary

cd06630
Location:1237 → 1504

STKc_MEKK1; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 1

cd16494
Location:440 → 495

RING-CH-C4HC3_ZSWM2; RING-CH finger, H2 subclass (C4HC3-type), found in zinc finger SWIM domain-containing protein 2 (ZSWIM2) and similar proteins