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NFE2L2 NFE2 like bZIP transcription factor 2 [ Homo sapiens (human) ]

Gene ID: 4780, updated on 8-Oct-2024

Summary

Official Symbol
NFE2L2provided by HGNC
Official Full Name
NFE2 like bZIP transcription factor 2provided by HGNC
Primary source
HGNC:HGNC:7782
See related
Ensembl:ENSG00000116044 MIM:600492; AllianceGenome:HGNC:7782
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NRF2; HEBP1; Nrf-2; IMDDHH
Summary
This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been characterized for this gene. [provided by RefSeq, Sep 2015]
Expression
Ubiquitous expression in esophagus (RPKM 93.8), thyroid (RPKM 52.1) and 24 other tissues See more
Orthologs
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Genomic context

See NFE2L2 in Genome Data Viewer
Location:
2q31.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (177230303..177264727, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (177712539..177746971, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (178095031..178129455, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:178077489-178078160 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12143 Neighboring gene microRNA 4444-1 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 Neighboring gene DnaJ heat shock protein family (Hsp40) member C19 pseudogene 5 Neighboring gene Sharpr-MPRA regulatory region 4724 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:178127429-178128628 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12145 Neighboring gene microRNA 3128 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16796 Neighboring gene Putative uncharacterized protein FLJ44553 Neighboring gene microRNA 6512 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:178202734-178203933 Neighboring gene H3 histone pseudogene 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 significantly upregulates Nrf2 in human astrocytes and is associated with increased levels of key antioxidant defensive enzymes Hemoxygenase (HO-1) and NAD(P)H dehydrogenase quinone1 (Nqo1) PubMed
env Inhibition of NRF2 by siRNA results in increased NOX2, NFkappaB (p65/p50), TNF-alpha, and MMP-9 proteins in astrocytes exposed to HIV-1 gp120 PubMed
Tat tat HIV-1 Tat activates NFE2L2 (Nrf2) protein levels in SH-SY5Y cells PubMed
tat HIV-1 Tat upregulates NFE2L2 (Nrf2) protein levels in SH-SY5Y cells PubMed
tat HIV-1 Tat-induced reactive oxygen species production and down-regulation of glutathione levels in TZM-bl cells are reversed through tanshinone II A-induced upregulation of NRF2 expression PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables molecular condensate scaffold activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription cis-regulatory region binding TAS
Traceable Author Statement
more info
PubMed 
enables transcription coregulator binding IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in PERK-mediated unfolded protein response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in PERK-mediated unfolded protein response TAS
Traceable Author Statement
more info
PubMed 
involved_in aflatoxin catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cell redox homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to angiotensin IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to copper ion IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to fluid shear stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to glucose starvation IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to hydrogen peroxide IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular response to hydrogen peroxide IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to laminar fluid shear stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to methionine IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to oxidative stress ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to oxidative stress NAS
Non-traceable Author Statement
more info
PubMed 
involved_in cellular response to oxidative stress TAS
Traceable Author Statement
more info
PubMed 
involved_in cellular response to tumor necrosis factor IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in endoplasmic reticulum unfolded protein response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in integrated stress response signaling NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of cardiac muscle cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cellular response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of endothelial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of ferroptosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of hematopoietic stem cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of vascular associated smooth muscle cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of D-glucose import IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of ERAD pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of blood coagulation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of blood vessel endothelial cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of glutathione biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of neuron projection development IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of reactive oxygen species metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of ubiquitin-dependent protein catabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in proteasomal ubiquitin-independent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in reactive oxygen species metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cellular response to oxidative stress EXP
Inferred from Experiment
more info
PubMed 
involved_in regulation of embryonic development IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of innate immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of removal of superoxide radicals IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
PubMed 
involved_in response to ischemia IEA
Inferred from Electronic Annotation
more info
 
involved_in response to oxidative stress IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 
part_of RNA polymerase II transcription regulator complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
 
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of mediator complex EXP
Inferred from Experiment
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 
part_of protein-DNA complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
nuclear factor erythroid 2-related factor 2
Names
nuclear factor erythroid-derived 2-like 2
nuclear factor, erythroid 2 like 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145412.3NP_001138884.1  nuclear factor erythroid 2-related factor 2 isoform 2

    See identical proteins and their annotated locations for NP_001138884.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR and uses a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 2, 4 and 5 encode the same protein.
    Source sequence(s)
    AW471118, BC011558, DB133391, DC314553
    Consensus CDS
    CCDS46457.1
    UniProtKB/TrEMBL
    B4DNB0, B7ZA33
    Related
    ENSP00000380253.4, ENST00000397063.9
    Conserved Domains (2) summary
    cd14720
    Location:478545
    bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
    pfam06886
    Location:2558
    TPX2; Targeting protein for Xklp2 (TPX2)
  2. NM_001145413.3NP_001138885.1  nuclear factor erythroid 2-related factor 2 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The resulting isoform (3) has a shorter N-terminus and is missing an internal segment, compared to isoform 1.
    Source sequence(s)
    AW471118, BC011558, DB133391, DC314553
    Consensus CDS
    CCDS46458.1
    UniProtKB/TrEMBL
    B4DNB0, B7ZA33
    Related
    ENSP00000411575.2, ENST00000446151.6
    Conserved Domains (2) summary
    cd14720
    Location:471538
    bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
    cd22249
    Location:2763
    UDM1_RNF168_RNF169-like; UDM1 (ubiquitin-dependent DSB recruitment module 1) found in RING finger proteins RNF168, RNF169 and similar proteins
  3. NM_001313900.1NP_001300829.1  nuclear factor erythroid 2-related factor 2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) represents use of an alternate promoter and 5' UTR and uses a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 2, 4 and 5 encode the same protein.
    Source sequence(s)
    AC079305, AK311688, AW471118
    Consensus CDS
    CCDS46457.1
    UniProtKB/TrEMBL
    B4DNB0, B7ZA33
    Related
    ENSP00000412191.2, ENST00000421929.6
    Conserved Domains (2) summary
    cd14720
    Location:478545
    bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
    pfam06886
    Location:2558
    TPX2; Targeting protein for Xklp2 (TPX2)
  4. NM_001313901.1NP_001300830.1  nuclear factor erythroid 2-related factor 2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) represents use of an alternate promoter and 5' UTR and uses a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 2, 4 and 5 encode the same protein.
    Source sequence(s)
    AC079305, AK311395, AW471118
    Consensus CDS
    CCDS46457.1
    UniProtKB/TrEMBL
    B4DNB0, B7ZA33
    Related
    ENSP00000400073.2, ENST00000448782.6
    Conserved Domains (2) summary
    cd14720
    Location:478545
    bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
    pfam06886
    Location:2558
    TPX2; Targeting protein for Xklp2 (TPX2)
  5. NM_001313902.2NP_001300831.1  nuclear factor erythroid 2-related factor 2 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. The resulting isoform (4) is shorter compared to isoform 1.
    Source sequence(s)
    AC079305, BI910808
    Consensus CDS
    CCDS92903.1
    UniProtKB/TrEMBL
    A0A8V8TN14, A0A8V8TN85
    Related
    ENSP00000514280.1, ENST00000699300.1
    Conserved Domains (2) summary
    cd14720
    Location:464531
    bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
    pfam06886
    Location:4174
    TPX2; Targeting protein for Xklp2 (TPX2)
  6. NM_001313903.2NP_001300832.1  nuclear factor erythroid 2-related factor 2 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The resulting isoform (5) is shorter compared to isoform 1.
    Source sequence(s)
    AC079305, BP228042
    Consensus CDS
    CCDS92904.1
    UniProtKB/TrEMBL
    A0A8V8TPA8, E2I973
    Related
    ENSP00000514217.1, ENST00000699223.1
    Conserved Domains (1) summary
    cd14720
    Location:421488
    bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
  7. NM_001313904.1NP_001300833.1  nuclear factor erythroid 2-related factor 2 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) represents use of an alternate promoter and 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The resulting isoform (6) is shorter compared to isoform 1.
    Source sequence(s)
    AC079305, AV702059, AW471118
    UniProtKB/TrEMBL
    B7ZA33
    Conserved Domains (1) summary
    cd14720
    Location:394461
    bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
  8. NM_006164.5NP_006155.2  nuclear factor erythroid 2-related factor 2 isoform 1

    See identical proteins and their annotated locations for NP_006155.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    BC011558, DA438735
    Consensus CDS
    CCDS42782.1
    UniProtKB/Swiss-Prot
    B2RBU2, B4E338, E9PGJ7, Q16236, Q53RW6, Q59HH2, Q96F71
    UniProtKB/TrEMBL
    E2I973
    Related
    ENSP00000380252.3, ENST00000397062.8
    Conserved Domains (2) summary
    cd14720
    Location:494561
    bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
    pfam06886
    Location:4074
    TPX2; Targeting protein for Xklp2 (TPX2)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    177230303..177264727 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    177712539..177746971 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)