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PIK3C2G phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma [ Canis lupus familiaris (dog) ]

Gene ID: 477681, updated on 1-Mar-2025
Official Symbol
PIK3C2Gprovided by VGNC
Official Full Name
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gammaprovided by VGNC
Primary source
VGNC:VGNC:44553
See related
Ensembl:ENSCAFG00845018749 RGD:12362438
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Location:
chromosome: 27
Exon count:
38
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 27 NC_051831.1 (28777707..29148879, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 27 NC_006609.4 (17634256..18004900)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 27 NC_049248.1 (17346838..17712725)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 27 NC_049287.1 (28624760..28982990, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 27 NC_049768.1 (28617093..28982011, complement)

Chromosome 27 - NC_051831.1Genomic Context describing neighboring genes Neighboring gene capping actin protein of muscle Z-line subunit alpha 3 Neighboring gene phospholipase C zeta 1 Neighboring gene small ubiquitin-related modifier 1-like Neighboring gene uncharacterized LOC111092748 Neighboring gene tetraspanin-2-like Neighboring gene uncharacterized LOC111092747 Neighboring gene RERG like Neighboring gene importin subunit alpha-1-like

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol-3-phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of phosphatidylinositol 3-kinase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
Names
phosphoinositide-3-kinase, class 2, gamma polypeptide
XP_013964221.1
XP_038294793.1
XP_038294794.1
XP_038294796.1
XP_038294797.1
XP_038294798.1
XP_038294799.1
XP_038315785.1
XP_038315786.1
XP_038315787.1
XP_038315788.1
XP_038315789.1
XP_038369458.1
XP_038369459.1
XP_038369460.1
XP_038369461.1
XP_038369462.1
XP_038369463.1
XP_038432859.1
XP_038432860.1
XP_038432861.1
XP_038432862.1
XP_038432863.1
XP_038432864.1
XP_038497270.1
XP_038497271.1
XP_038497272.1
XP_038497273.1
XP_038497274.1
XP_038497275.1

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051831.1 Reference ROS_Cfam_1.0

    Range
    28777707..29148879 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038438868.1 → XP_038294796.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X1

    UniProtKB/TrEMBL
    A0A8C0PKN7
    Related
    ENSCAFP00845026126.1, ENSCAFT00845033378.1
    Conserved Domains (5) summary
    cd06896
    Location:1248 → 1348
    PX_PI3K_C2_gamma; The phosphoinositide binding Phox Homology Domain of the Gamma Isoform of Class II Phosphoinositide 3-Kinases
    cd04012
    Location:520 → 675
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd05177
    Location:867 → 1219
    PI3Kc_C2_gamma; Catalytic domain of Class II Phosphoinositide 3-kinase gamma
    cl00271
    Location:692 → 860
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...
    cl14603
    Location:1374 → 1483
    C2; C2 domain

  2. XM_038438866.1 → XP_038294794.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X1

    UniProtKB/TrEMBL
    A0A8C0PKN7
    Conserved Domains (5) summary
    cd06896
    Location:1248 → 1348
    PX_PI3K_C2_gamma; The phosphoinositide binding Phox Homology Domain of the Gamma Isoform of Class II Phosphoinositide 3-Kinases
    cd04012
    Location:520 → 675
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd05177
    Location:867 → 1219
    PI3Kc_C2_gamma; Catalytic domain of Class II Phosphoinositide 3-kinase gamma
    cl00271
    Location:692 → 860
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...
    cl14603
    Location:1374 → 1483
    C2; C2 domain

  3. XM_038438869.1 → XP_038294797.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X2

    UniProtKB/TrEMBL
    A0A8C0PKN7, A0A8I3NWP1
    Related
    ENSCAFP00845025950.1, ENSCAFT00845033150.1
    Conserved Domains (5) summary
    cd06896
    Location:1248 → 1348
    PX_PI3K_C2_gamma; The phosphoinositide binding Phox Homology Domain of the Gamma Isoform of Class II Phosphoinositide 3-Kinases
    cd04012
    Location:520 → 675
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd05177
    Location:867 → 1219
    PI3Kc_C2_gamma; Catalytic domain of Class II Phosphoinositide 3-kinase gamma
    cl00271
    Location:692 → 860
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...
    cl14603
    Location:1373 → 1482
    C2; C2 domain

  4. XM_038438865.1 → XP_038294793.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X1

    UniProtKB/TrEMBL
    A0A8C0PKN7
    Conserved Domains (5) summary
    cd06896
    Location:1248 → 1348
    PX_PI3K_C2_gamma; The phosphoinositide binding Phox Homology Domain of the Gamma Isoform of Class II Phosphoinositide 3-Kinases
    cd04012
    Location:520 → 675
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd05177
    Location:867 → 1219
    PI3Kc_C2_gamma; Catalytic domain of Class II Phosphoinositide 3-kinase gamma
    cl00271
    Location:692 → 860
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...
    cl14603
    Location:1374 → 1483
    C2; C2 domain

  5. XM_038438871.1 → XP_038294799.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X4

    UniProtKB/TrEMBL
    A0A8C0PKN7
    Conserved Domains (4) summary
    cd04012
    Location:520 → 675
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cl00271
    Location:692 → 860
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...
    cl02484
    Location:285 → 367
    PI3K_rbd; PI3-kinase family, ras-binding domain
    cl21453
    Location:867 → 1197
    PKc_like; Protein Kinases, catalytic domain

  6. XM_038438870.1 → XP_038294798.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X3

    UniProtKB/TrEMBL
    A0A8C0PKN7
    Conserved Domains (3) summary
    cd04012
    Location:520 → 675
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cl00271
    Location:692 → 860
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...
    cl21453
    Location:867 → 1200
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_005303119.1 RNA Sequence

  2. XR_005303118.1 RNA Sequence

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049287.1 Alternate UMICH_Zoey_3.1

    Range
    28624760..28982990 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038513532.1 → XP_038369460.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X1

  2. XM_038513531.1 → XP_038369459.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X1

  3. XM_038513533.1 → XP_038369461.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X2

  4. XM_038513530.1 → XP_038369458.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X1

  5. XM_038513535.1 → XP_038369463.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X4

  6. XM_038513534.1 → XP_038369462.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X3

RNA

  1. XR_005346230.1 RNA Sequence

  2. XR_005346229.1 RNA Sequence

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049768.1 Alternate UNSW_CanFamBas_1.0

    Range
    28617093..28982011 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038641344.1 → XP_038497272.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X1

  2. XM_038641343.1 → XP_038497271.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X1

  3. XM_038641345.1 → XP_038497273.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X2

  4. XM_038641342.1 → XP_038497270.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X1

  5. XM_038641347.1 → XP_038497275.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X4

  6. XM_038641346.1 → XP_038497274.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X3

RNA

  1. XR_005413745.1 RNA Sequence

  2. XR_005413743.1 RNA Sequence

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049248.1 Alternate UU_Cfam_GSD_1.0

    Range
    17346838..17712725
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038576933.1 → XP_038432861.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X1

    UniProtKB/TrEMBL
    A0A8C0TFH2

  2. XM_038576932.1 → XP_038432860.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X1

    UniProtKB/TrEMBL
    A0A8C0TFH2

  3. XM_038576936.1 → XP_038432864.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X4

    UniProtKB/TrEMBL
    A0A8C0TFH2

  4. XM_038576935.1 → XP_038432863.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X3

    UniProtKB/TrEMBL
    A0A8C0TFH2

  5. XM_038576931.1 → XP_038432859.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X1

    UniProtKB/TrEMBL
    A0A8C0TFH2

  6. XM_038576934.1 → XP_038432862.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X2

    UniProtKB/TrEMBL
    A0A8C0PKN7, A0A8C0TFH2

RNA

  1. XR_005379904.1 RNA Sequence

  2. XR_005379905.1 RNA Sequence

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006609.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    17634256..18004900
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_014108746.3 → XP_013964221.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X1

    UniProtKB/TrEMBL
    A0A8C0PKN7, A0A8C0TFH2
    Conserved Domains (5) summary
    cd06896
    Location:1248 → 1348
    PX_PI3K_C2_gamma; The phosphoinositide binding Phox Homology Domain of the Gamma Isoform of Class II Phosphoinositide 3-Kinases
    cd04012
    Location:520 → 675
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd05177
    Location:867 → 1219
    PI3Kc_C2_gamma; Catalytic domain of Class II Phosphoinositide 3-kinase gamma
    cl00271
    Location:692 → 860
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...
    cl14603
    Location:1374 → 1483
    C2; C2 domain

  2. XM_038459858.1 → XP_038315786.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X1

    UniProtKB/TrEMBL
    A0A8C0PKN7, A0A8C0TFH2
    Conserved Domains (5) summary
    cd06896
    Location:1248 → 1348
    PX_PI3K_C2_gamma; The phosphoinositide binding Phox Homology Domain of the Gamma Isoform of Class II Phosphoinositide 3-Kinases
    cd04012
    Location:520 → 675
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd05177
    Location:867 → 1219
    PI3Kc_C2_gamma; Catalytic domain of Class II Phosphoinositide 3-kinase gamma
    cl00271
    Location:692 → 860
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...
    cl14603
    Location:1374 → 1483
    C2; C2 domain

  3. XM_038459861.1 → XP_038315789.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X4

    UniProtKB/TrEMBL
    A0A8C0PKN7
    Conserved Domains (4) summary
    cd04012
    Location:520 → 675
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cl00271
    Location:692 → 860
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...
    cl02484
    Location:285 → 367
    PI3K_rbd; PI3-kinase family, ras-binding domain
    cl21453
    Location:867 → 1197
    PKc_like; Protein Kinases, catalytic domain

  4. XM_038459860.1 → XP_038315788.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X3

    UniProtKB/TrEMBL
    A0A8C0PKN7
    Conserved Domains (3) summary
    cd04012
    Location:520 → 675
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cl00271
    Location:692 → 860
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...
    cl21453
    Location:867 → 1200
    PKc_like; Protein Kinases, catalytic domain

  5. XM_038459857.1 → XP_038315785.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X1

    UniProtKB/TrEMBL
    A0A8C0PKN7, A0A8C0TFH2
    Conserved Domains (5) summary
    cd06896
    Location:1248 → 1348
    PX_PI3K_C2_gamma; The phosphoinositide binding Phox Homology Domain of the Gamma Isoform of Class II Phosphoinositide 3-Kinases
    cd04012
    Location:520 → 675
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd05177
    Location:867 → 1219
    PI3Kc_C2_gamma; Catalytic domain of Class II Phosphoinositide 3-kinase gamma
    cl00271
    Location:692 → 860
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...
    cl14603
    Location:1374 → 1483
    C2; C2 domain

  6. XM_038459859.1 → XP_038315787.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X2

    UniProtKB/TrEMBL
    A0A8C0PKN7, A0A8P0PEB0
    Conserved Domains (5) summary
    cd06896
    Location:1248 → 1348
    PX_PI3K_C2_gamma; The phosphoinositide binding Phox Homology Domain of the Gamma Isoform of Class II Phosphoinositide 3-Kinases
    cd04012
    Location:520 → 675
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd05177
    Location:867 → 1219
    PI3Kc_C2_gamma; Catalytic domain of Class II Phosphoinositide 3-kinase gamma
    cl00271
    Location:692 → 860
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...
    cl14603
    Location:1373 → 1482
    C2; C2 domain

RNA

  1. XR_005315442.1 RNA Sequence

  2. XR_005315443.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version

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