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SCN8A sodium voltage-gated channel alpha subunit 8 [ Canis lupus familiaris (dog) ]

Gene ID: 477604, updated on 1-Mar-2025
Official Symbol
SCN8Aprovided by VGNC
Official Full Name
sodium voltage-gated channel alpha subunit 8provided by VGNC
Primary source
VGNC:VGNC:45923
See related
Ensembl:ENSCAFG00845027770 RGD:12363807
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See SCN8A in Genome Data Viewer
Location:
chromosome: 27
Exon count:
30
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 27 NC_051831.1 (3170259..3346792, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 27 NC_006609.4 (42959130..43080423)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 27 NC_049248.1 (43304862..43478762)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 27 NC_049287.1 (3189615..3363479, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 27 NC_049768.1 (3173058..3350013, complement)

Chromosome 27 - NC_051831.1Genomic Context describing neighboring genes Neighboring gene fidgetin like 2 Neighboring gene transmembrane and death domain 1 Neighboring gene U2 spliceosomal RNA Neighboring gene U4 spliceosomal RNA Neighboring gene uncharacterized LOC111092889 Neighboring gene solute carrier family 4 member 8 Neighboring gene uncharacterized LOC111092862

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A Missense Variant in SCN8A in Alpine Dachsbracke Dogs Affected by Spinocerebellar Ataxia. Letko A, et al. Genes (Basel), 2019 May 10. PMID 31083464, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables voltage-gated sodium channel activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in membrane depolarization during action potential IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neuronal action potential IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of voltage-gated sodium channel complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
sodium channel protein type 8 subunit alpha
Names
sodium channel, voltage gated, type VIII, alpha subunit

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051831.1 Reference ROS_Cfam_1.0

    Range
    3170259..3346792 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038438135.1 → XP_038294063.1  sodium channel protein type 8 subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A8C0T780, A0A8I3PUQ1
    Conserved Domains (6) summary
    smart00015
    Location:1894 → 1915
    IQ; Calmodulin-binding motif
    cd13433
    Location:1465 → 1517
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1197 → 1473
    Ion_trans; Ion transport protein
    pfam06512
    Location:991 → 1192
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:504 → 702
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1788 → 1835
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  2. XM_038438134.1 → XP_038294062.1  sodium channel protein type 8 subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A8C0T780, A0A8I3PUQ1
    Related
    ENSCAFP00845038537.1, ENSCAFT00845049118.1
    Conserved Domains (6) summary
    smart00015
    Location:1894 → 1915
    IQ; Calmodulin-binding motif
    cd13433
    Location:1465 → 1517
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1197 → 1473
    Ion_trans; Ion transport protein
    pfam06512
    Location:991 → 1192
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:504 → 702
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1788 → 1835
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  3. XM_038438133.1 → XP_038294061.1  sodium channel protein type 8 subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A8C0T780, A0A8I3PUQ1
    Conserved Domains (6) summary
    smart00015
    Location:1894 → 1915
    IQ; Calmodulin-binding motif
    cd13433
    Location:1465 → 1517
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1197 → 1473
    Ion_trans; Ion transport protein
    pfam06512
    Location:991 → 1192
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:504 → 702
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1788 → 1835
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  4. XM_038438136.1 → XP_038294064.1  sodium channel protein type 8 subunit alpha isoform X2

    UniProtKB/TrEMBL
    A0A8I3PUQ1
    Related
    ENSCAFP00845038462.1, ENSCAFT00845049022.1
    Conserved Domains (6) summary
    smart00015
    Location:1894 → 1915
    IQ; Calmodulin-binding motif
    cd13433
    Location:1465 → 1517
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1197 → 1473
    Ion_trans; Ion transport protein
    pfam06512
    Location:991 → 1192
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:504 → 702
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1788 → 1835
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  5. XM_038438137.1 → XP_038294065.1  sodium channel protein type 8 subunit alpha isoform X3

    UniProtKB/TrEMBL
    A0A8C0PMB1, A0A8I3Q8Z2
    Conserved Domains (6) summary
    smart00015
    Location:1732 → 1753
    IQ; Calmodulin-binding motif
    cd13433
    Location:1303 → 1355
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1035 → 1311
    Ion_trans; Ion transport protein
    pfam06512
    Location:829 → 1030
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:342 → 540
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1626 → 1673
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049287.1 Alternate UMICH_Zoey_3.1

    Range
    3189615..3363479 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038512830.1 → XP_038368758.1  sodium channel protein type 8 subunit alpha isoform X1

    Conserved Domains (6) summary
    smart00015
    Location:1894 → 1915
    IQ; Calmodulin-binding motif
    cd13433
    Location:1465 → 1517
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1197 → 1473
    Ion_trans; Ion transport protein
    pfam06512
    Location:991 → 1192
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:504 → 702
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1788 → 1835
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  2. XM_038512829.1 → XP_038368757.1  sodium channel protein type 8 subunit alpha isoform X1

    Conserved Domains (6) summary
    smart00015
    Location:1894 → 1915
    IQ; Calmodulin-binding motif
    cd13433
    Location:1465 → 1517
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1197 → 1473
    Ion_trans; Ion transport protein
    pfam06512
    Location:991 → 1192
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:504 → 702
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1788 → 1835
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  3. XM_038512828.1 → XP_038368756.1  sodium channel protein type 8 subunit alpha isoform X1

    Conserved Domains (6) summary
    smart00015
    Location:1894 → 1915
    IQ; Calmodulin-binding motif
    cd13433
    Location:1465 → 1517
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1197 → 1473
    Ion_trans; Ion transport protein
    pfam06512
    Location:991 → 1192
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:504 → 702
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1788 → 1835
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  4. XM_038512831.1 → XP_038368759.1  sodium channel protein type 8 subunit alpha isoform X2

    Conserved Domains (6) summary
    smart00015
    Location:1894 → 1915
    IQ; Calmodulin-binding motif
    cd13433
    Location:1465 → 1517
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1197 → 1473
    Ion_trans; Ion transport protein
    pfam06512
    Location:991 → 1192
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:504 → 702
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1788 → 1835
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  5. XM_038512832.1 → XP_038368760.1  sodium channel protein type 8 subunit alpha isoform X3

    Conserved Domains (6) summary
    smart00015
    Location:1732 → 1753
    IQ; Calmodulin-binding motif
    cd13433
    Location:1303 → 1355
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1035 → 1311
    Ion_trans; Ion transport protein
    pfam06512
    Location:829 → 1030
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:342 → 540
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1626 → 1673
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049768.1 Alternate UNSW_CanFamBas_1.0

    Range
    3173058..3350013 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038640591.1 → XP_038496519.1  sodium channel protein type 8 subunit alpha isoform X1

  2. XM_038640590.1 → XP_038496518.1  sodium channel protein type 8 subunit alpha isoform X1

  3. XM_038640589.1 → XP_038496517.1  sodium channel protein type 8 subunit alpha isoform X1

  4. XM_038640592.1 → XP_038496520.1  sodium channel protein type 8 subunit alpha isoform X2

  5. XM_038640593.1 → XP_038496521.1  sodium channel protein type 8 subunit alpha isoform X3

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049248.1 Alternate UU_Cfam_GSD_1.0

    Range
    43304862..43478762
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038577714.1 → XP_038433642.1  sodium channel protein type 8 subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A8C0T780, A0A8I3PUQ1
    Conserved Domains (6) summary
    smart00015
    Location:1894 → 1915
    IQ; Calmodulin-binding motif
    cd13433
    Location:1465 → 1517
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1197 → 1473
    Ion_trans; Ion transport protein
    pfam06512
    Location:991 → 1192
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:504 → 702
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1788 → 1835
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  2. XM_038577713.1 → XP_038433641.1  sodium channel protein type 8 subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A8C0T780, A0A8I3PUQ1
    Conserved Domains (6) summary
    smart00015
    Location:1894 → 1915
    IQ; Calmodulin-binding motif
    cd13433
    Location:1465 → 1517
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1197 → 1473
    Ion_trans; Ion transport protein
    pfam06512
    Location:991 → 1192
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:504 → 702
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1788 → 1835
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  3. XM_038577712.1 → XP_038433640.1  sodium channel protein type 8 subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A8C0T780, A0A8I3PUQ1
    Conserved Domains (6) summary
    smart00015
    Location:1894 → 1915
    IQ; Calmodulin-binding motif
    cd13433
    Location:1465 → 1517
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1197 → 1473
    Ion_trans; Ion transport protein
    pfam06512
    Location:991 → 1192
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:504 → 702
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1788 → 1835
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  4. XM_038577715.1 → XP_038433643.1  sodium channel protein type 8 subunit alpha isoform X2

    UniProtKB/TrEMBL
    A0A8I3PUQ1
    Conserved Domains (6) summary
    smart00015
    Location:1894 → 1915
    IQ; Calmodulin-binding motif
    cd13433
    Location:1465 → 1517
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1197 → 1473
    Ion_trans; Ion transport protein
    pfam06512
    Location:991 → 1192
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:504 → 702
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1788 → 1835
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006609.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    42959130..43080423
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038459484.1 → XP_038315412.1  sodium channel protein type 8 subunit alpha isoform X4

    UniProtKB/TrEMBL
    A0A8I3PUQ1
    Conserved Domains (6) summary
    smart00015
    Location:1930 → 1951
    IQ; Calmodulin-binding motif
    cd13433
    Location:1501 → 1553
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1233 → 1509
    Ion_trans; Ion transport protein
    pfam06512
    Location:1027 → 1228
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:540 → 738
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1824 → 1871
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
Nucleotide Protein
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