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CLCN3 chloride voltage-gated channel 3 [ Canis lupus familiaris (dog) ]

Gene ID: 477354, updated on 5-Mar-2024

Summary

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Official Symbol
CLCN3provided by VGNC
Official Full Name
chloride voltage-gated channel 3provided by VGNC
Primary source
VGNC:VGNC:39303
See related
Ensembl:ENSCAFG00845028065
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 25
Exon count:
16
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 25 NC_051829.1 (20704517..20792549)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 25 NC_006607.4 (21198852..21249735)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 25 NC_049246.1 (20659558..20710662)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 25 NC_049285.1 (20623955..20675230)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 25 NC_049766.1 (20560112..20611064)

Chromosome 25 - NC_051829.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111092453 Neighboring gene NIMA related kinase 1 Neighboring gene uncharacterized LOC111092476 Neighboring gene 39S ribosomal protein L30, mitochondrial-like Neighboring gene histone PARylation factor 1 Neighboring gene uncharacterized LOC111092419 Neighboring gene uncharacterized LOC111092425

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of the canine CLCN3 gene and evaluation as candidate for late-onset NCL. Wohlke A, et al. BMC Genet, 2006 Mar 3. PMID 16515703, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables voltage-gated chloride channel activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in chloride transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in early endosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in synaptic vesicle IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
H(+)/Cl(-) exchange transporter 3
Names
chloride channel 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025619.2 → NP_001020790.1  H(+)/Cl(-) exchange transporter 3 isoform 2

    See identical proteins and their annotated locations for NP_001020790.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, resulting in a frameshift and an early stop codon, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AM048629, DN393059
    UniProtKB/TrEMBL
    A0A8C0KET3, A0A8C0RPW3, Q4LAL7
    Related
    ENSCAFP00845039090.1, ENSCAFT00845049843.1
    Conserved Domains (2) summary
    cd03684
    Location:109 → 615
    ClC_3_like; ClC-3-like chloride channel proteins. This CD includes ClC-3, ClC-4, ClC-5 and ClC-Y1. ClC-3 was initially cloned from rat kidney. Expression of ClC-3 produces outwardly-rectifying Cl currents that are inhibited by protein kinase C activation. It has ...
    cd04591
    Location:626 → 776
    CBS_pair_voltage-gated_CLC_euk_bac; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the voltage gated CLC (chloride channel) in eukaryotes and bacteria

  2. NM_001308463.1 → NP_001295392.1  H(+)/Cl(-) exchange transporter 3 isoform 1

    See identical proteins and their annotated locations for NP_001295392.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1, also known as isoform e).
    Source sequence(s)
    AM048628, DN393059
    UniProtKB/TrEMBL
    A0A8C0KET3, A0A8C0NYF0, A0A8C0QZ64, Q4LAL8
    Conserved Domains (2) summary
    cd03684
    Location:109 → 615
    ClC_3_like; ClC-3-like chloride channel proteins. This CD includes ClC-3, ClC-4, ClC-5 and ClC-Y1. ClC-3 was initially cloned from rat kidney. Expression of ClC-3 produces outwardly-rectifying Cl currents that are inhibited by protein kinase C activation. It has ...
    cd04591
    Location:626 → 776
    CBS_pair_voltage-gated_CLC_euk_bac; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the voltage gated CLC (chloride channel) in eukaryotes and bacteria

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051829.1 Reference ROS_Cfam_1.0

    Range
    20704517..20792549
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038434545.1 → XP_038290473.1  H(+)/Cl(-) exchange transporter 3 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KD47, A0A8C0NYL4, A0A8C0QZE4, A0A8I3Q2Q1
    Related
    ENSCAFP00845038874.1, ENSCAFT00845049552.1
    Conserved Domains (2) summary
    cd03684
    Location:136 → 642
    ClC_3_like; ClC-3-like chloride channel proteins. This CD includes ClC-3, ClC-4, ClC-5 and ClC-Y1. ClC-3 was initially cloned from rat kidney. Expression of ClC-3 produces outwardly-rectifying Cl currents that are inhibited by protein kinase C activation. It has ...
    cd04591
    Location:653 → 803
    CBS_pair_voltage-gated_CLC_euk_bac; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the voltage gated CLC (chloride channel) in eukaryotes and bacteria

  2. XM_038434546.1 → XP_038290474.1  H(+)/Cl(-) exchange transporter 3 isoform X2

    UniProtKB/TrEMBL
    A0A8C0KE95, A0A8C0QZE4, A0A8C0T6S9, A0A8I3S6L7
    Related
    ENSCAFP00845038999.1, ENSCAFT00845049725.1
    Conserved Domains (2) summary
    cd03684
    Location:136 → 642
    ClC_3_like; ClC-3-like chloride channel proteins. This CD includes ClC-3, ClC-4, ClC-5 and ClC-Y1. ClC-3 was initially cloned from rat kidney. Expression of ClC-3 produces outwardly-rectifying Cl currents that are inhibited by protein kinase C activation. It has ...
    cd04591
    Location:653 → 803
    CBS_pair_voltage-gated_CLC_euk_bac; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the voltage gated CLC (chloride channel) in eukaryotes and bacteria

  3. XM_038434547.1 → XP_038290475.1  H(+)/Cl(-) exchange transporter 3 isoform X3

    UniProtKB/TrEMBL
    A0A8C0KGF8, A0A8C0TA49
    Conserved Domains (2) summary
    cd03684
    Location:78 → 584
    ClC_3_like; ClC-3-like chloride channel proteins. This CD includes ClC-3, ClC-4, ClC-5 and ClC-Y1. ClC-3 was initially cloned from rat kidney. Expression of ClC-3 produces outwardly-rectifying Cl currents that are inhibited by protein kinase C activation. It has ...
    cd04591
    Location:595 → 745
    CBS_pair_voltage-gated_CLC_euk_bac; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the voltage gated CLC (chloride channel) in eukaryotes and bacteria

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049285.1 Alternate UMICH_Zoey_3.1

    Range
    20623955..20675230
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049766.1 Alternate UNSW_CanFamBas_1.0

    Range
    20560112..20611064
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049246.1 Alternate UU_Cfam_GSD_1.0

    Range
    20659558..20710662
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006607.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    21198852..21249735
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
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