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LATS2 large tumor suppressor kinase 2 [ Canis lupus familiaris (dog) ]

Gene ID: 477343, updated on 25-Jul-2026
Official Symbol
LATS2provided by VGNC
Official Full Name
large tumor suppressor kinase 2provided by VGNC
Primary source
VGNC:VGNC:42599
See related
Ensembl:ENSCAFG00845021300 RGD:12074928
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
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Try the new Transcripts and proteins table
See LATS2 in Genome Data Viewer
Location:
chromosome: 25
Exon count:
8
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 25 NC_051829.1 (17237244..17308678)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 25 NC_006607.4 (17188801..17201953)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 25 NC_049246.1 (17176853..17248494)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 25 NC_049285.1 (17109498..17180871)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 25 NC_049766.1 (17120566..17191969)

Chromosome 25 - NC_051829.1Genomic Context describing neighboring genes Neighboring gene spindle and kinetochore associated complex subunit 3 Neighboring gene Sin3A associated protein 18 Neighboring gene uncharacterized LOC119865836 Neighboring gene uncharacterized LOC119865922 Neighboring gene exportin 4 Neighboring gene uncharacterized LOC102157198 Neighboring gene EEF1A lysine methyltransferase 1

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in hippo signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of organ growth IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
serine/threonine-protein kinase LATS2
Names
LATS, large tumor suppressor, homolog 2
XP_038291015.1
XP_038314497.1
XP_038365991.1
XP_038429424.1
XP_038493723.1

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051829.1 Reference ROS_Cfam_1.0

    Range
    17237244..17308678
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038435087.1 → XP_038291015.1  serine/threonine-protein kinase LATS2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LHT2, A0A8I3S2A9
    Related
    ENSCAFP00845029446.1, ENSCAFT00845037585.1
    Conserved Domains (3) summary
    cd05626
    Location:663 → 1043
    STKc_LATS2; Catalytic domain of the Protein Serine/Threonine Kinase, Large Tumor Suppressor 2
    cd14398
    Location:101 → 141
    UBA_LATS2; UBA domain found in vertebrate serine/threonine-protein kinase LATS2
    pfam03154
    Location:156 → 474
    Atrophin-1; Atrophin-1 family

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049285.1 Alternate UMICH_Zoey_3.1

    Range
    17109498..17180871
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038510063.1 → XP_038365991.1  

    Conserved Domains (3) summary
    cd05626
    Location:663 → 1043
    STKc_LATS2; Catalytic domain of the Protein Serine/Threonine Kinase, Large Tumor Suppressor 2
    cd14398
    Location:101 → 141
    UBA_LATS2; UBA domain found in vertebrate serine/threonine-protein kinase LATS2
    pfam03154
    Location:156 → 474
    Atrophin-1; Atrophin-1 family

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049766.1 Alternate UNSW_CanFamBas_1.0

    Range
    17120566..17191969
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038637795.1 → XP_038493723.1  

    Conserved Domains (3) summary
    cd05626
    Location:663 → 1043
    STKc_LATS2; Catalytic domain of the Protein Serine/Threonine Kinase, Large Tumor Suppressor 2
    cd14398
    Location:101 → 141
    UBA_LATS2; UBA domain found in vertebrate serine/threonine-protein kinase LATS2
    pfam03154
    Location:156 → 474
    Atrophin-1; Atrophin-1 family

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049246.1 Alternate UU_Cfam_GSD_1.0

    Range
    17176853..17248494
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038573496.1 → XP_038429424.1  serine/threonine-protein kinase LATS2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LHT2, A0A8I3S2A9
    Conserved Domains (3) summary
    cd05626
    Location:663 → 1043
    STKc_LATS2; Catalytic domain of the Protein Serine/Threonine Kinase, Large Tumor Suppressor 2
    cd14398
    Location:101 → 141
    UBA_LATS2; UBA domain found in vertebrate serine/threonine-protein kinase LATS2
    pfam03154
    Location:156 → 474
    Atrophin-1; Atrophin-1 family

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006607.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    17188801..17201953
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038458569.1 → XP_038314497.1  serine/threonine-protein kinase LATS2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0LHT2
    Conserved Domains (3) summary
    cd05626
    Location:548 → 928
    STKc_LATS2; Catalytic domain of the Protein Serine/Threonine Kinase, Large Tumor Suppressor 2
    pfam03154
    Location:41 → 359
    Atrophin-1; Atrophin-1 family
    cl21463
    Location:1 → 26
    UBA_like_SF; UBA domain-like superfamily
Nucleotide Protein
Heading Accession and Version

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