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SULF2 sulfatase 2 [ Canis lupus familiaris (dog) ]

Gene ID: 477254, updated on 27-Jun-2026
Official Symbol
SULF2provided by VGNC
Official Full Name
sulfatase 2provided by VGNC
Primary source
VGNC:VGNC:46975
See related
Ensembl:ENSCAFG00845022596 RGD:12402277
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See SULF2 in Genome Data Viewer
Location:
chromosome: 24
Exon count:
26
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 24 NC_051828.1 (35439403..35557819, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 24 NC_006606.4 (34191687..34280428, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 24 NC_049245.1 (35355060..35443790, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 24 NC_049284.1 (34679921..34768517, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 24 NC_049765.1 (34814508..34903572, complement)

Chromosome 24 - NC_051828.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119865555 Neighboring gene nuclear receptor coactivator 3 Neighboring gene translation initiation factor IF-2-like Neighboring gene uncharacterized LOC119865556 Neighboring gene uncharacterized LOC119865680

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Sulfatases and sulfatase modifying factors: an exclusive and promiscuous relationship. Sardiello M, et al. Hum Mol Genet, 2005 Nov 1. PMID 16174644
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables N-acetylglucosamine-6-sulfatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables glycosaminoglycan binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
extracellular sulfatase Sulf-2
NP_001041555.1
XP_038288739.1
XP_038288740.1
XP_038288741.1
XP_038288742.1
XP_038288743.1
XP_038288744.1
XP_038288745.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001048090.1 → NP_001041555.1  extracellular sulfatase Sulf-2 precursor

    See identical proteins and their annotated locations for NP_001041555.1

    Status: PROVISIONAL

    Source sequence(s)
    BN000766
    UniProtKB/TrEMBL
    A0A8C0KRQ7, A0A8I3PCK3, A0A8I3PGR0, F1PX97, Q32KH1
    Conserved Domains (3) summary
    cd16147
    Location:43 → 385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:529 → 660
    DUF3740; Sulfatase protein
    cl23718
    Location:748 → 797
    ALP_like; alkaline phosphatases and sulfatases

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051828.1 Reference ROS_Cfam_1.0

    Range
    35439403..35557819 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038432817.1 → XP_038288745.1  extracellular sulfatase Sulf-2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KRQ7, A0A8I3PCK3, A0A8I3PGR0, F1PX97, Q32KH1
    Conserved Domains (3) summary
    cd16147
    Location:43 → 385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:529 → 660
    DUF3740; Sulfatase protein
    cl23718
    Location:748 → 797
    ALP_like; alkaline phosphatases and sulfatases

  2. XM_038432816.1 → XP_038288744.1  extracellular sulfatase Sulf-2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KRQ7, A0A8I3PCK3, A0A8I3PGR0, F1PX97, Q32KH1
    Conserved Domains (3) summary
    cd16147
    Location:43 → 385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:529 → 660
    DUF3740; Sulfatase protein
    cl23718
    Location:748 → 797
    ALP_like; alkaline phosphatases and sulfatases

  3. XM_038432814.1 → XP_038288742.1  extracellular sulfatase Sulf-2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KRQ7, A0A8I3PCK3, A0A8I3PGR0, F1PX97, Q32KH1
    Conserved Domains (3) summary
    cd16147
    Location:43 → 385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:529 → 660
    DUF3740; Sulfatase protein
    cl23718
    Location:748 → 797
    ALP_like; alkaline phosphatases and sulfatases

  4. XM_038432811.1 → XP_038288739.1  extracellular sulfatase Sulf-2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KRQ7, A0A8I3PCK3, A0A8I3PGR0, F1PX97, Q32KH1
    Related
    ENSCAFP00845031294.1, ENSCAFT00845039964.1
    Conserved Domains (3) summary
    cd16147
    Location:43 → 385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:529 → 660
    DUF3740; Sulfatase protein
    cl23718
    Location:748 → 797
    ALP_like; alkaline phosphatases and sulfatases

  5. XM_038432813.1 → XP_038288741.1  extracellular sulfatase Sulf-2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KRQ7, A0A8I3PCK3, A0A8I3PGR0, F1PX97, Q32KH1
    Conserved Domains (3) summary
    cd16147
    Location:43 → 385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:529 → 660
    DUF3740; Sulfatase protein
    cl23718
    Location:748 → 797
    ALP_like; alkaline phosphatases and sulfatases

  6. XM_038432812.1 → XP_038288740.1  extracellular sulfatase Sulf-2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KRQ7, A0A8I3PCK3, A0A8I3PGR0, F1PX97, Q32KH1
    Conserved Domains (3) summary
    cd16147
    Location:43 → 385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:529 → 660
    DUF3740; Sulfatase protein
    cl23718
    Location:748 → 797
    ALP_like; alkaline phosphatases and sulfatases

  7. XM_038432815.1 → XP_038288743.1  extracellular sulfatase Sulf-2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KRQ7, A0A8I3PCK3, A0A8I3PGR0, F1PX97, Q32KH1
    Conserved Domains (3) summary
    cd16147
    Location:43 → 385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:529 → 660
    DUF3740; Sulfatase protein
    cl23718
    Location:748 → 797
    ALP_like; alkaline phosphatases and sulfatases

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049284.1 Alternate UMICH_Zoey_3.1

    Range
    34679921..34768517 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049765.1 Alternate UNSW_CanFamBas_1.0

    Range
    34814508..34903572 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049245.1 Alternate UU_Cfam_GSD_1.0

    Range
    35355060..35443790 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006606.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    34191687..34280428 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
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