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TOP1 DNA topoisomerase I [ Canis lupus familiaris (dog) ]

Gene ID: 477229, updated on 26-Sep-2018

Summary

Official Symbol
TOP1provided by VGNC
Official Full Name
DNA topoisomerase Iprovided by VGNC
Primary source
VGNC:VGNC:49631
See related
Ensembl:ENSCAFG00000009058
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
TOP
Orthologs

Genomic context

See TOP1 in Genome Data Viewer
Location:
chromosome: 24
Exon count:
21
Annotation release Status Assembly Chr Location
105 current CanFam3.1 (GCF_000002285.3) 24 NC_006606.3 (29075267..29166733)

Chromosome 24 - NC_006606.3Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111092153 Neighboring gene uncharacterized LOC102152405 Neighboring gene SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 pseudogene Neighboring gene uncharacterized LOC102152517 Neighboring gene phospholipase C gamma 1 Neighboring gene zinc fingers and homeoboxes 3 Neighboring gene uncharacterized LOC111092095

Genomic regions, transcripts, and products

Genomic Sequence:
NC_006606.3 Chromosome 24 Reference CanFam3.1 Primary Assembly

Pathways from BioSystems

General gene information

Markers

Homology

  • Homologs of the TOP1 gene: The TOP1 gene is conserved in human, chimpanzee, Rhesus monkey, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
  • Orthologs from Annotation Pipeline: 228 organisms have orthologs with human gene TOP1
  • Orthologs

General protein information

Preferred Names
DNA topoisomerase 1
Names
topoisomerase (DNA) I
topoisomerase I
XP_534420.3

NCBI Reference Sequences (RefSeq)

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 105 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference CanFam3.1 Primary Assembly

Genomic

  1. NC_006606.3 Reference CanFam3.1 Primary Assembly

    Range
    29075267..29166733
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_534420.6XP_534420.3  DNA topoisomerase 1

    UniProtKB/TrEMBL
    F1PUE0
    Related
    ENSCAFP00000013314.3, ENSCAFT00000014397.3
    Conserved Domains (2) summary
    smart00435
    Location:365742
    TOPEUc; DNA Topoisomerase I (eukaryota)
    cd03488
    Location:221435
    Topoisomer_IB_N_htopoI_like; Topoisomer_IB_N_htopoI_like : N-terminal DNA binding fragment found in eukaryotic DNA topoisomerase (topo) IB proteins similar to the monomeric yeast and human topo I. Topo I enzymes are divided into: topo type IA (bacterial) and type IB (eukaryotic). ...
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