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XRN1 5'-3' exoribonuclease 1 [ Canis lupus familiaris (dog) ]

Gene ID: 477100, updated on 25-Jul-2026
Official Symbol
XRN1provided by VGNC
Official Full Name
5'-3' exoribonuclease 1provided by VGNC
Primary source
VGNC:VGNC:48471
See related
Ensembl:ENSCAFG00845028618 RGD:12161732
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See XRN1 in Genome Data Viewer
Location:
chromosome: 23
Exon count:
44
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 23 NC_051827.1 (38560332..38663551, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 23 NC_006605.4 (38020211..38058721, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 23 NC_049244.1 (38563654..38666694, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 23 NC_049283.1 (38242400..38345593, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 23 NC_049764.1 (38319385..38422540, complement)

Chromosome 23 - NC_051827.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119865407 Neighboring gene transcription factor Dp-2 Neighboring gene glycerol kinase 5 Neighboring gene transfer RNA glutamic acid (anticodon CUC) Neighboring gene ATR serine/threonine kinase Neighboring gene 60S ribosomal protein L36-like

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 5'-3' RNA exonuclease activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in nuclear-transcribed mRNA catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in rRNA catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
5'-3' exoribonuclease 1
XP_038288486.1
XP_038288487.1
XP_038288488.1
XP_038312964.1
XP_038363791.1
XP_038363792.1
XP_038363793.1
XP_038427031.1
XP_038427032.1
XP_038427033.1
XP_038491222.1
XP_038491223.1
XP_038491224.1

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051827.1 Reference ROS_Cfam_1.0

    Range
    38560332..38663551 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038432559.1 → XP_038288487.1  5'-3' exoribonuclease 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I3S6T5
    Related
    ENSCAFP00845039675.1, ENSCAFT00845050608.1
    Conserved Domains (4) summary
    COG5049
    Location:1 → 735
    XRN1; 5'-3' exonuclease [Replication, recombination and repair]
    pfam18129
    Location:1101 → 1171
    SH3_12; Xrn1 SH3-like domain
    pfam18332
    Location:658 → 843
    XRN1_D1; Exoribonuclease Xrn1 D1 domain
    pfam18334
    Location:853 → 934
    XRN1_D2_D3; Exoribonuclease Xrn1 D2/D3 domain

  2. XM_038432558.1 → XP_038288486.1  5'-3' exoribonuclease 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I3S6T5
    Related
    ENSCAFP00845039635.1, ENSCAFT00845050556.1
    Conserved Domains (4) summary
    COG5049
    Location:1 → 735
    XRN1; 5'-3' exonuclease [Replication, recombination and repair]
    pfam18129
    Location:1101 → 1171
    SH3_12; Xrn1 SH3-like domain
    pfam18332
    Location:658 → 843
    XRN1_D1; Exoribonuclease Xrn1 D1 domain
    pfam18334
    Location:853 → 934
    XRN1_D2_D3; Exoribonuclease Xrn1 D2/D3 domain

  3. XM_038432560.1 → XP_038288488.1  5'-3' exoribonuclease 1 isoform X3

    UniProtKB/TrEMBL
    A0A8C0K5M7
    Conserved Domains (2) summary
    COG5049
    Location:1 → 735
    XRN1; 5'-3' exonuclease [Replication, recombination and repair]
    pfam18332
    Location:658 → 843
    XRN1_D1; Exoribonuclease Xrn1 D1 domain

RNA

  1. XR_005300232.1 RNA Sequence

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049283.1 Alternate UMICH_Zoey_3.1

    Range
    38242400..38345593 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038507864.1 → XP_038363792.1  

    Conserved Domains (4) summary
    COG5049
    Location:1 → 735
    XRN1; 5'-3' exonuclease [Replication, recombination and repair]
    pfam18129
    Location:1101 → 1171
    SH3_12; Xrn1 SH3-like domain
    pfam18332
    Location:658 → 843
    XRN1_D1; Exoribonuclease Xrn1 D1 domain
    pfam18334
    Location:853 → 934
    XRN1_D2_D3; Exoribonuclease Xrn1 D2/D3 domain

  2. XM_038507863.1 → XP_038363791.1  

    Conserved Domains (4) summary
    COG5049
    Location:1 → 735
    XRN1; 5'-3' exonuclease [Replication, recombination and repair]
    pfam18129
    Location:1101 → 1171
    SH3_12; Xrn1 SH3-like domain
    pfam18332
    Location:658 → 843
    XRN1_D1; Exoribonuclease Xrn1 D1 domain
    pfam18334
    Location:853 → 934
    XRN1_D2_D3; Exoribonuclease Xrn1 D2/D3 domain

  3. XM_038507865.1 → XP_038363793.1  

    Conserved Domains (2) summary
    COG5049
    Location:1 → 735
    XRN1; 5'-3' exonuclease [Replication, recombination and repair]
    pfam18332
    Location:658 → 843
    XRN1_D1; Exoribonuclease Xrn1 D1 domain

RNA

  1. XR_005343322.1 RNA Sequence

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049764.1 Alternate UNSW_CanFamBas_1.0

    Range
    38319385..38422540 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038635295.1 → XP_038491223.1  

  2. XM_038635294.1 → XP_038491222.1  

  3. XM_038635296.1 → XP_038491224.1  

RNA

  1. XR_005411035.1 RNA Sequence

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049244.1 Alternate UU_Cfam_GSD_1.0

    Range
    38563654..38666694 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038571104.1 → XP_038427032.1  5'-3' exoribonuclease 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I3S6T5
    Conserved Domains (4) summary
    COG5049
    Location:1 → 735
    XRN1; 5'-3' exonuclease [Replication, recombination and repair]
    pfam18129
    Location:1101 → 1171
    SH3_12; Xrn1 SH3-like domain
    pfam18332
    Location:658 → 843
    XRN1_D1; Exoribonuclease Xrn1 D1 domain
    pfam18334
    Location:853 → 934
    XRN1_D2_D3; Exoribonuclease Xrn1 D2/D3 domain

  2. XM_038571103.1 → XP_038427031.1  5'-3' exoribonuclease 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I3S6T5
    Conserved Domains (4) summary
    COG5049
    Location:1 → 735
    XRN1; 5'-3' exonuclease [Replication, recombination and repair]
    pfam18129
    Location:1101 → 1171
    SH3_12; Xrn1 SH3-like domain
    pfam18332
    Location:658 → 843
    XRN1_D1; Exoribonuclease Xrn1 D1 domain
    pfam18334
    Location:853 → 934
    XRN1_D2_D3; Exoribonuclease Xrn1 D2/D3 domain

  3. XM_038571105.1 → XP_038427033.1  5'-3' exoribonuclease 1 isoform X3

    UniProtKB/TrEMBL
    A0A8C0K5M7
    Conserved Domains (2) summary
    COG5049
    Location:1 → 735
    XRN1; 5'-3' exonuclease [Replication, recombination and repair]
    pfam18332
    Location:658 → 843
    XRN1_D1; Exoribonuclease Xrn1 D1 domain

RNA

  1. XR_005377104.1 RNA Sequence

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006605.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    38020211..38058721 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038457036.1 → XP_038312964.1  5'-3' exoribonuclease 1 isoform X4

    Conserved Domains (1) summary
    COG5049
    Location:1 → 554
    XRN1; 5'-3' exonuclease [Replication, recombination and repair]
Nucleotide Protein
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