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UPF1 UPF1 RNA helicase and ATPase [ Canis lupus familiaris (dog) ]

Gene ID: 476664, updated on 25-Jul-2026
Official Symbol
UPF1provided by VGNC
Official Full Name
UPF1 RNA helicase and ATPaseprovided by VGNC
Primary source
VGNC:VGNC:48150
See related
Ensembl:ENSCAFG00845019866 RGD:12177802
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
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See UPF1 in Genome Data Viewer
Location:
chromosome: 20
Exon count:
24
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 20 NC_051824.1 (44720750..44757369, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 20 NC_006602.4 (44149222..44185842, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 20 NC_049241.1 (44643707..44680326, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 20 NC_049280.1 (43958032..43994646, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 20 NC_049761.1 (44368223..44404830, complement)

Chromosome 20 - NC_051824.1Genomic Context describing neighboring genes Neighboring gene ceramide synthase 1 Neighboring gene growth differentiation factor 1 Neighboring gene uncharacterized LOC111091353 Neighboring gene uncharacterized LOC119864710

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
regulator of nonsense transcripts 1
XP_005632737.1
XP_038284032.1
XP_038284033.1
XP_038359691.1
XP_038359692.1
XP_038422716.1
XP_038422717.1
XP_038486857.1
XP_038486858.1
XP_533868.2

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051824.1 Reference ROS_Cfam_1.0

    Range
    44720750..44757369 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038428104.1 → XP_038284032.1  regulator of nonsense transcripts 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I3S463
    Related
    ENSCAFP00845027421.1, ENSCAFT00845035018.1
    Conserved Domains (2) summary
    COG1112
    Location:146 → 921
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    cd18039
    Location:482 → 715
    DEXXQc_UPF1; DEXXQ-box helicase domain of UPF1

  2. XM_038428105.1 → XP_038284033.1  regulator of nonsense transcripts 1 isoform X2

    Conserved Domains (2) summary
    COG1112
    Location:146 → 910
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    cd18039
    Location:471 → 704
    DEXXQc_UPF1; DEXXQ-box helicase domain of UPF1

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049280.1 Alternate UMICH_Zoey_3.1

    Range
    43958032..43994646 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038503763.1 → XP_038359691.1  

    Conserved Domains (2) summary
    COG1112
    Location:146 → 921
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    cd18039
    Location:482 → 715
    DEXXQc_UPF1; DEXXQ-box helicase domain of UPF1

  2. XM_038503764.1 → XP_038359692.1  

    Conserved Domains (2) summary
    COG1112
    Location:146 → 910
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    cd18039
    Location:471 → 704
    DEXXQc_UPF1; DEXXQ-box helicase domain of UPF1

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049761.1 Alternate UNSW_CanFamBas_1.0

    Range
    44368223..44404830 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038630929.1 → XP_038486857.1  

    Conserved Domains (2) summary
    COG1112
    Location:146 → 921
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    cd18039
    Location:482 → 715
    DEXXQc_UPF1; DEXXQ-box helicase domain of UPF1

  2. XM_038630930.1 → XP_038486858.1  

    Conserved Domains (2) summary
    COG1112
    Location:146 → 910
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    cd18039
    Location:471 → 704
    DEXXQc_UPF1; DEXXQ-box helicase domain of UPF1

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049241.1 Alternate UU_Cfam_GSD_1.0

    Range
    44643707..44680326 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038566788.1 → XP_038422716.1  regulator of nonsense transcripts 1 isoform X1

    Conserved Domains (2) summary
    COG1112
    Location:146 → 921
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    cd18039
    Location:482 → 715
    DEXXQc_UPF1; DEXXQ-box helicase domain of UPF1

  2. XM_038566789.1 → XP_038422717.1  regulator of nonsense transcripts 1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0KEN6
    Conserved Domains (2) summary
    COG1112
    Location:146 → 910
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    cd18039
    Location:471 → 704
    DEXXQc_UPF1; DEXXQ-box helicase domain of UPF1

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006602.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    44149222..44185842 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005632680.4 → XP_005632737.1  regulator of nonsense transcripts 1 isoform X1

    See identical proteins and their annotated locations for XP_005632737.1

    Conserved Domains (2) summary
    COG1112
    Location:146 → 921
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    cd18039
    Location:482 → 715
    DEXXQc_UPF1; DEXXQ-box helicase domain of UPF1

  2. XM_533868.6 → XP_533868.2  regulator of nonsense transcripts 1 isoform X2

    See identical proteins and their annotated locations for XP_533868.2

    UniProtKB/TrEMBL
    A0A8C0KEN6
    Conserved Domains (2) summary
    COG1112
    Location:146 → 910
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    cd18039
    Location:471 → 704
    DEXXQc_UPF1; DEXXQ-box helicase domain of UPF1
Nucleotide Protein
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