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ITIH1 inter-alpha-trypsin inhibitor heavy chain 1 [ Canis lupus familiaris (dog) ]

Gene ID: 476590, updated on 27-Jun-2026
Official Symbol
ITIH1provided by VGNC
Official Full Name
inter-alpha-trypsin inhibitor heavy chain 1provided by VGNC
Primary source
VGNC:VGNC:42145
See related
Ensembl:ENSCAFG00845029717 RGD:12067748
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
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See ITIH1 in Genome Data Viewer
Location:
chromosome: 20
Exon count:
22
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 20 NC_051824.1 (37389088..37402888, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 20 NC_006602.4 (37020310..37034103, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 20 NC_049241.1 (37438657..37452458, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 20 NC_049280.1 (36752703..36766470, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 20 NC_049761.1 (37160669..37174902, complement)

Chromosome 20 - NC_051824.1Genomic Context describing neighboring genes Neighboring gene inter-alpha-trypsin inhibitor heavy chain 4 Neighboring gene uncharacterized LOC119864681 Neighboring gene inter-alpha-trypsin inhibitor heavy chain 3 Neighboring gene uncharacterized LOC119864680 Neighboring gene NIMA related kinase 4 Neighboring gene ATP synthase subunit g, mitochondrial-like Neighboring gene signal peptidase complex subunit 1

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in hyaluronan metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
inter-alpha-trypsin inhibitor heavy chain H1
Names
inter-alpha (globulin) inhibitor H1
XP_038359146.1

Length

  • 910

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051824.1 Reference ROS_Cfam_1.0

    Range
    37389088..37402888 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038427516.1 → XP_038283444.1  inter-alpha-trypsin inhibitor heavy chain H1 isoform X2

    UniProtKB/TrEMBL
    A0A8I3Q8F5
    Conserved Domains (3) summary
    smart00609
    Location:39 → 165
    VIT; Vault protein Inter-alpha-Trypsin domain
    cd01461
    Location:288 → 469
    vWA_interalpha_trypsin_inhibitor; vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to ...
    pfam06668
    Location:697 → 884
    ITI_HC_C; Inter-alpha-trypsin inhibitor heavy chain C-terminus

  2. XM_038427515.1 → XP_038283443.1  inter-alpha-trypsin inhibitor heavy chain H1 isoform X1

    UniProtKB/TrEMBL
    A0A8I3Q1V1, A0A8I3Q8F5
    Related
    ENSCAFP00845041373.1, ENSCAFT00845052708.1
    Conserved Domains (3) summary
    smart00609
    Location:39 → 165
    VIT; Vault protein Inter-alpha-Trypsin domain
    cd01461
    Location:288 → 469
    vWA_interalpha_trypsin_inhibitor; vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to ...
    pfam06668
    Location:704 → 891
    ITI_HC_C; Inter-alpha-trypsin inhibitor heavy chain C-terminus

  3. XM_038427517.1 → XP_038283445.1  inter-alpha-trypsin inhibitor heavy chain H1 isoform X3

    UniProtKB/TrEMBL
    A0A8I3Q1W7
    Conserved Domains (3) summary
    cd01461
    Location:200 → 381
    vWA_interalpha_trypsin_inhibitor; vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to ...
    pfam06668
    Location:616 → 803
    ITI_HC_C; Inter-alpha-trypsin inhibitor heavy chain C-terminus
    cl02699
    Location:9 → 77
    VIT; Vault protein inter-alpha-trypsin domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049280.1 Alternate UMICH_Zoey_3.1

    Range
    36752703..36766470 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038503218.1 → XP_038359146.1  

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049761.1 Alternate UNSW_CanFamBas_1.0

    Range
    37160669..37174902 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038630341.1 → XP_038486269.1  

  2. XM_038630340.1 → XP_038486268.1  

  3. XM_038630342.1 → XP_038486270.1  

    Conserved Domains (3) summary
    cd01461
    Location:200 → 381
    vWA_interalpha_trypsin_inhibitor; vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to ...
    pfam06668
    Location:616 → 803
    ITI_HC_C; Inter-alpha-trypsin inhibitor heavy chain C-terminus
    cl02699
    Location:9 → 77
    VIT; Vault protein inter-alpha-trypsin domain

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049241.1 Alternate UU_Cfam_GSD_1.0

    Range
    37438657..37452458 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038566175.1 → XP_038422103.1  inter-alpha-trypsin inhibitor heavy chain H1 isoform X2

    UniProtKB/TrEMBL
    A0A8I3Q8F5

  2. XM_038566174.1 → XP_038422102.1  inter-alpha-trypsin inhibitor heavy chain H1 isoform X1

    UniProtKB/TrEMBL
    A0A8I3Q8F5

  3. XM_038566176.1 → XP_038422104.1  inter-alpha-trypsin inhibitor heavy chain H1 isoform X3

    UniProtKB/TrEMBL
    A0A8I3Q1W7

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006602.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    37020310..37034103 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_022406614.2 → XP_022262322.2  inter-alpha-trypsin inhibitor heavy chain H1 isoform X2

    UniProtKB/TrEMBL
    A0A8I3Q8F5
    Conserved Domains (3) summary
    smart00609
    Location:39 → 165
    VIT; Vault protein Inter-alpha-Trypsin domain
    cd01461
    Location:288 → 469
    vWA_interalpha_trypsin_inhibitor; vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to ...
    pfam06668
    Location:697 → 884
    ITI_HC_C; Inter-alpha-trypsin inhibitor heavy chain C-terminus

  2. XM_533794.7 → XP_533794.3  inter-alpha-trypsin inhibitor heavy chain H1 isoform X1

    UniProtKB/TrEMBL
    A0A8I3Q8F5
    Conserved Domains (3) summary
    smart00609
    Location:39 → 165
    VIT; Vault protein Inter-alpha-Trypsin domain
    cd01461
    Location:288 → 469
    vWA_interalpha_trypsin_inhibitor; vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to ...
    pfam06668
    Location:704 → 891
    ITI_HC_C; Inter-alpha-trypsin inhibitor heavy chain C-terminus

  3. XM_005632432.4 → XP_005632489.2  inter-alpha-trypsin inhibitor heavy chain H1 isoform X3

    UniProtKB/TrEMBL
    A0A8I3Q1W7
    Conserved Domains (3) summary
    cd01461
    Location:200 → 381
    vWA_interalpha_trypsin_inhibitor; vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to ...
    pfam06668
    Location:616 → 803
    ITI_HC_C; Inter-alpha-trypsin inhibitor heavy chain C-terminus
    cl02699
    Location:9 → 77
    VIT; Vault protein inter-alpha-trypsin domain
Nucleotide Protein
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