APOE apolipoprotein E [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: APOEprovided by VGNC
Official Full Name: apolipoprotein Eprovided by VGNC
Primary source: VGNC:VGNC:38002
See related: Ensembl:ENSCAFG00845006705
Gene type: protein coding
RefSeq status: MODEL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: Apo-E
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	1	NC_051805.1 (111055483..111058288, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	1	NC_006583.4 (110006660..110009463, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	1	NC_049222.1 (111234400..111237204, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	1	NC_049261.1 (110730139..110732942, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	1	NC_049742.1 (110365616..110368413, complement)
105	previous assembly	CanFam3.1 (GCF_000002285.3)	1	NC_006583.3 (110525717..110528534, complement)

Chromosome 1 - NC_051805.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dogs lacking Apolipoprotein E show advanced atherosclerosis leading to apparent clinical complications.
Title: Dogs lacking Apolipoprotein E show advanced atherosclerosis leading to apparent clinical complications.
we successfully generated ApoE gene knock-out dogs by 123 microinjection CRISPR/Cas9 system into dog zygotes, following by using fibroblasts 124 from the knock-out dogs as the donor cells for SCNT, we achieved and expanded dog 125 population of homozygous ApoE gene targeting dogs
Title: Generation of ApoE deficient dogs via combination of embryo injection of CRISPR/Cas9 with somatic cell nuclear transfer.

Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

PMC99927P2 (e-PCR)
- UniSTS:273705

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by GO

Function	Evidence Code	Pubs
enables amyloid-beta binding	ISS Inferred from Sequence or Structural Similarity more info
enables antioxidant activity	IEA Inferred from Electronic Annotation more info
enables cholesterol transfer activity	IEA Inferred from Electronic Annotation more info
enables enzyme binding	IEA Inferred from Electronic Annotation more info
enables heparan sulfate proteoglycan binding	ISS Inferred from Sequence or Structural Similarity more info
enables heparin binding	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables lipoprotein particle binding	IEA Inferred from Electronic Annotation more info
enables low-density lipoprotein particle receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal chelating activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylcholine-sterol O-acyltransferase activator activity	IEA Inferred from Electronic Annotation more info
enables phospholipid binding	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables tau protein binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in AMPA glutamate receptor clustering	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in NMDA glutamate receptor clustering	IEA Inferred from Electronic Annotation more info
involved_in amyloid precursor protein metabolic process	IEA Inferred from Electronic Annotation more info
involved_in artery morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in cGMP-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in cholesterol efflux	ISS Inferred from Sequence or Structural Similarity more info
involved_in cholesterol homeostasis	IEA Inferred from Electronic Annotation more info
involved_in chylomicron remnant clearance	ISS Inferred from Sequence or Structural Similarity more info
involved_in fatty acid homeostasis	IEA Inferred from Electronic Annotation more info
involved_in gene expression	IEA Inferred from Electronic Annotation more info
involved_in high-density lipoprotein particle assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in high-density lipoprotein particle clearance	IEA Inferred from Electronic Annotation more info
involved_in high-density lipoprotein particle remodeling	IEA Inferred from Electronic Annotation more info
involved_in intermediate-density lipoprotein particle clearance	ISS Inferred from Sequence or Structural Similarity more info
involved_in intermembrane lipid transfer	IEA Inferred from Electronic Annotation more info
involved_in intracellular calcium ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in lipid transport involved in lipid storage	IEA Inferred from Electronic Annotation more info
involved_in lipoprotein biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in locomotory exploration behavior	IEA Inferred from Electronic Annotation more info
involved_in long-chain fatty acid transport	IEA Inferred from Electronic Annotation more info
involved_in long-term memory	IEA Inferred from Electronic Annotation more info
involved_in low-density lipoprotein particle remodeling	IEA Inferred from Electronic Annotation more info
involved_in maintenance of location in cell	IEA Inferred from Electronic Annotation more info
involved_in melanosome organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of MAP kinase activity	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of amyloid fibril formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of amyloid-beta formation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of blood vessel endothelial cell migration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cholesterol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of endothelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of long-term synaptic potentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of platelet activation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein secretion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of triglyceride metabolic process	IEA Inferred from Electronic Annotation more info
involved_in neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in nitric oxide mediated signal transduction	IEA Inferred from Electronic Annotation more info
involved_in phospholipid efflux	IEA Inferred from Electronic Annotation more info
involved_in positive regulation by host of viral process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of CoA-transferase activity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of amyloid-beta clearance	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cholesterol efflux	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cholesterol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of dendritic spine development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of dendritic spine maintenance	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endocytosis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of heparan sulfate binding	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of heparan sulfate proteoglycan binding	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of lipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of lipid transport across blood-brain barrier	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of low-density lipoprotein particle receptor catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of membrane protein ectodomain proteolysis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phospholipid efflux	IEA Inferred from Electronic Annotation more info
involved_in protein import	IEA Inferred from Electronic Annotation more info
involved_in receptor-mediated endocytosis	IEA Inferred from Electronic Annotation more info
involved_in regulation of Cdc42 protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in regulation of behavioral fear response	IEA Inferred from Electronic Annotation more info
involved_in regulation of cellular response to very-low-density lipoprotein particle stimulus	IEA Inferred from Electronic Annotation more info
involved_in regulation of innate immune response	IEA Inferred from Electronic Annotation more info
involved_in regulation of proteasomal protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein-containing complex assembly	IEA Inferred from Electronic Annotation more info
involved_in response to caloric restriction	IEA Inferred from Electronic Annotation more info
involved_in response to dietary excess	IEA Inferred from Electronic Annotation more info
involved_in response to oxidative stress	IEA Inferred from Electronic Annotation more info
involved_in reverse cholesterol transport	IEA Inferred from Electronic Annotation more info
involved_in triglyceride homeostasis	IEA Inferred from Electronic Annotation more info
involved_in triglyceride metabolic process	IEA Inferred from Electronic Annotation more info
involved_in triglyceride-rich lipoprotein particle clearance	ISS Inferred from Sequence or Structural Similarity more info
involved_in vasodilation	IEA Inferred from Electronic Annotation more info
involved_in very-low-density lipoprotein particle clearance	ISS Inferred from Sequence or Structural Similarity more info
involved_in very-low-density lipoprotein particle remodeling	IEA Inferred from Electronic Annotation more info
involved_in virion assembly	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
part_of chylomicron	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular matrix	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
part_of high-density lipoprotein particle	ISS Inferred from Sequence or Structural Similarity more info
part_of intermediate-density lipoprotein particle	ISS Inferred from Sequence or Structural Similarity more info
part_of low-density lipoprotein particle	ISS Inferred from Sequence or Structural Similarity more info
located_in melanosome	IEA Inferred from Electronic Annotation more info
located_in multivesicular body, internal vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in synaptic cleft	IEA Inferred from Electronic Annotation more info
part_of very-low-density lipoprotein particle	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: apolipoprotein E

Names: apolipoprotein E4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051805.1 Reference ROS_Cfam_1.0

Range

111055483..111058288 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038656704.1 → XP_038512632.1 apolipoprotein E

UniProtKB/Swiss-Prot

F1PJ74

Conserved Domains (1) summary

pfam01442
Location:92 → 279

Apolipoprotein; Apolipoprotein A1/A4/E domain
XM_038656703.1 → XP_038512631.1 apolipoprotein E

UniProtKB/Swiss-Prot

F1PJ74

Conserved Domains (1) summary

pfam01442
Location:92 → 279

Apolipoprotein; Apolipoprotein A1/A4/E domain
XM_038656705.1 → XP_038512633.1 apolipoprotein E

UniProtKB/Swiss-Prot

F1PJ74

Related

ENSCAFP00845009282.1, ENSCAFT00845011898.1

Conserved Domains (1) summary

pfam01442
Location:92 → 279

Apolipoprotein; Apolipoprotein A1/A4/E domain
XM_038656706.1 → XP_038512634.1 apolipoprotein E

UniProtKB/Swiss-Prot

F1PJ74

Conserved Domains (1) summary

pfam01442
Location:92 → 279

Apolipoprotein; Apolipoprotein A1/A4/E domain

Alternate UMICH_Zoey_3.1

Genomic

NC_049261.1 Alternate UMICH_Zoey_3.1

Range

110730139..110732942 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038467900.1 → XP_038323828.1 apolipoprotein E

Conserved Domains (1) summary

pfam01442
Location:92 → 279

Apolipoprotein; Apolipoprotein A1/A4/E domain
XM_038467899.1 → XP_038323827.1 apolipoprotein E

Conserved Domains (1) summary

pfam01442
Location:92 → 279

Apolipoprotein; Apolipoprotein A1/A4/E domain
XM_038467901.1 → XP_038323829.1 apolipoprotein E

Conserved Domains (1) summary

pfam01442
Location:92 → 279

Apolipoprotein; Apolipoprotein A1/A4/E domain
XM_038467902.1 → XP_038323830.1 apolipoprotein E

Conserved Domains (1) summary

pfam01442
Location:92 → 279

Apolipoprotein; Apolipoprotein A1/A4/E domain

Alternate UNSW_CanFamBas_1.0

Genomic

NC_049742.1 Alternate UNSW_CanFamBas_1.0

Range

110365616..110368413 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038592898.1 → XP_038448826.1 apolipoprotein E

Conserved Domains (1) summary

pfam01442
Location:92 → 279

Apolipoprotein; Apolipoprotein A1/A4/E domain
XM_038592897.1 → XP_038448825.1 apolipoprotein E

Conserved Domains (1) summary

pfam01442
Location:92 → 279

Apolipoprotein; Apolipoprotein A1/A4/E domain
XM_038592899.1 → XP_038448827.1 apolipoprotein E

Conserved Domains (1) summary

pfam01442
Location:92 → 279

Apolipoprotein; Apolipoprotein A1/A4/E domain
XM_038592900.1 → XP_038448828.1 apolipoprotein E

Conserved Domains (1) summary

pfam01442
Location:92 → 279

Apolipoprotein; Apolipoprotein A1/A4/E domain

Alternate UU_Cfam_GSD_1.0

Genomic

NC_049222.1 Alternate UU_Cfam_GSD_1.0

Range

111234400..111237204 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038528614.1 → XP_038384542.1 apolipoprotein E

Conserved Domains (1) summary

pfam01442
Location:92 → 279

Apolipoprotein; Apolipoprotein A1/A4/E domain
XM_038528613.1 → XP_038384541.1 apolipoprotein E

Conserved Domains (1) summary

pfam01442
Location:92 → 279

Apolipoprotein; Apolipoprotein A1/A4/E domain
XM_038528615.1 → XP_038384543.1 apolipoprotein E

Conserved Domains (1) summary

pfam01442
Location:92 → 279

Apolipoprotein; Apolipoprotein A1/A4/E domain
XM_038528616.1 → XP_038384544.1 apolipoprotein E

Conserved Domains (1) summary

pfam01442
Location:92 → 279

Apolipoprotein; Apolipoprotein A1/A4/E domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

NC_006583.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

Range

110006660..110009463 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_533644.7 → XP_533644.1 apolipoprotein E

See identical proteins and their annotated locations for XP_533644.1

UniProtKB/Swiss-Prot

F1PJ74

UniProtKB/TrEMBL

F1PJ74

Conserved Domains (1) summary

pfam01442
Location:92 → 279

Apolipoprotein; Apolipoprotein A1/A4/E domain
XM_005616460.4 → XP_005616517.2 apolipoprotein E

UniProtKB/Swiss-Prot

F1PJ74

UniProtKB/TrEMBL

F1PJ74

Conserved Domains (1) summary

pfam01442
Location:92 → 279

Apolipoprotein; Apolipoprotein A1/A4/E domain
XM_860950.5 → XP_866043.1 apolipoprotein E

See identical proteins and their annotated locations for XP_866043.1

UniProtKB/Swiss-Prot

F1PJ74

UniProtKB/TrEMBL

F1PJ74

Conserved Domains (1) summary

pfam01442
Location:92 → 279

Apolipoprotein; Apolipoprotein A1/A4/E domain
XM_022425020.2 → XP_022280728.1 apolipoprotein E

UniProtKB/Swiss-Prot

F1PJ74

Conserved Domains (1) summary

pfam01442
Location:92 → 279

Apolipoprotein; Apolipoprotein A1/A4/E domain