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SEMA4D semaphorin 4D [ Canis lupus familiaris (dog) ]

Gene ID: 476350, updated on 27-Jun-2026
Official Symbol
SEMA4Dprovided by VGNC
Official Full Name
semaphorin 4Dprovided by VGNC
Primary source
VGNC:VGNC:53974
See related
Ensembl:ENSCAFG00845018763 RGD:12352662
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
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Try the new Transcripts and proteins table
See SEMA4D in Genome Data Viewer
Location:
chromosome: 1
Exon count:
23
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 1 NC_051805.1 (97427590..97490619)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 1 NC_006583.4 (97278644..97342104)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 1 NC_049222.1 (97533063..97596441)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 1 NC_049261.1 (97055805..97118887)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 1 NC_049742.1 (96774870..96838078)

Chromosome 1 - NC_051805.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119870856 Neighboring gene growth arrest and DNA damage inducible gamma Neighboring gene SECIS binding protein 2 Neighboring gene uncharacterized LOC111097076 Neighboring gene CDC28 protein kinase regulatory subunit 2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables chemorepellent activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables semaphorin receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in axon guidance IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative chemotaxis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of axon extension involved in axon guidance IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neural crest cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in ossification involved in bone maturation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in semaphorin-plexin signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
semaphorin-4D

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051805.1 Reference ROS_Cfam_1.0

    Range
    97427590..97490619
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038655417.1 → XP_038511345.1  semaphorin-4D isoform X2

    UniProtKB/TrEMBL
    A0A8I3P3E0
    Conserved Domains (4) summary
    cd11259
    Location:146 → 616
    Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
    smart00423
    Location:618 → 669
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd00096
    Location:674 → 679
    Ig; Ig strand A [structural motif]
    cl11960
    Location:674 → 760
    Ig; Immunoglobulin domain

  2. XM_038655416.1 → XP_038511344.1  semaphorin-4D isoform X1

    UniProtKB/TrEMBL
    A0A8I3P379
    Related
    ENSCAFP00845026060.1, ENSCAFT00845033287.1
    Conserved Domains (4) summary
    cd11259
    Location:184 → 654
    Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
    smart00423
    Location:656 → 707
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd00096
    Location:712 → 717
    Ig; Ig strand A [structural motif]
    cl11960
    Location:712 → 798
    Ig; Immunoglobulin domain

  3. XM_038655418.1 → XP_038511346.1  semaphorin-4D isoform X3

    UniProtKB/TrEMBL
    A0A8I3P3E0
    Related
    ENSCAFP00845026217.1, ENSCAFT00845033490.1
    Conserved Domains (4) summary
    cd11259
    Location:140 → 610
    Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
    smart00423
    Location:612 → 663
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd00096
    Location:668 → 673
    Ig; Ig strand A [structural motif]
    cl11960
    Location:668 → 754
    Ig; Immunoglobulin domain

  4. XM_038655419.1 → XP_038511347.1  semaphorin-4D isoform X4

    UniProtKB/TrEMBL
    A0A8I3P3H8
    Related
    ENSCAFP00845026339.1, ENSCAFT00845033643.1
    Conserved Domains (4) summary
    cd11259
    Location:29 → 499
    Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
    smart00423
    Location:501 → 552
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd00096
    Location:557 → 562
    Ig; Ig strand A [structural motif]
    cl11960
    Location:557 → 643
    Ig; Immunoglobulin domain

RNA

  1. XR_005421861.1 RNA Sequence

    Related
    ENSCAFT00845033155.1

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049261.1 Alternate UMICH_Zoey_3.1

    Range
    97055805..97118887
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038466613.1 → XP_038322541.1  

    Conserved Domains (4) summary
    cd11259
    Location:146 → 616
    Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
    smart00423
    Location:618 → 669
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd00096
    Location:674 → 679
    Ig; Ig strand A [structural motif]
    cl11960
    Location:674 → 760
    Ig; Immunoglobulin domain

  2. XM_038466615.1 → XP_038322543.1  

  3. XM_038466612.1 → XP_038322540.1  

    Conserved Domains (4) summary
    cd11259
    Location:184 → 654
    Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
    smart00423
    Location:656 → 707
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd00096
    Location:712 → 717
    Ig; Ig strand A [structural motif]
    cl11960
    Location:712 → 798
    Ig; Immunoglobulin domain

  4. XM_038466614.1 → XP_038322542.1  

    Conserved Domains (4) summary
    cd11259
    Location:140 → 610
    Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
    smart00423
    Location:612 → 663
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd00096
    Location:668 → 673
    Ig; Ig strand A [structural motif]
    cl11960
    Location:668 → 754
    Ig; Immunoglobulin domain

  5. XM_038466616.1 → XP_038322544.1  

    Conserved Domains (4) summary
    cd11259
    Location:29 → 499
    Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
    smart00423
    Location:501 → 552
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd00096
    Location:557 → 562
    Ig; Ig strand A [structural motif]
    cl11960
    Location:557 → 643
    Ig; Immunoglobulin domain

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049742.1 Alternate UNSW_CanFamBas_1.0

    Range
    96774870..96838078
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038591617.1 → XP_038447545.1  

  2. XM_038591619.1 → XP_038447547.1  

  3. XM_038591616.1 → XP_038447544.1  

  4. XM_038591618.1 → XP_038447546.1  

  5. XM_038591620.1 → XP_038447548.1  

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049222.1 Alternate UU_Cfam_GSD_1.0

    Range
    97533063..97596441
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038527312.1 → XP_038383240.1  semaphorin-4D isoform X2

    UniProtKB/TrEMBL
    A0A8I3P3E0

  2. XM_038527314.1 → XP_038383242.1  semaphorin-4D isoform X7

    UniProtKB/TrEMBL
    A0A8I3NX99

  3. XM_038527311.1 → XP_038383239.1  semaphorin-4D isoform X1

    UniProtKB/TrEMBL
    A0A8I3P379

  4. XM_038527313.1 → XP_038383241.1  semaphorin-4D isoform X3

    UniProtKB/TrEMBL
    A0A8I3P3E0

  5. XM_038527315.1 → XP_038383243.1  semaphorin-4D isoform X4

    UniProtKB/TrEMBL
    A0A8I3P3H8

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006583.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    97278644..97342104
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_533551.7 → XP_533551.4  semaphorin-4D isoform X2

    UniProtKB/TrEMBL
    A0A8I3P3E0
    Conserved Domains (4) summary
    cd11259
    Location:146 → 616
    Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
    smart00410
    Location:683 → 738
    IG_like; Immunoglobulin like
    smart00423
    Location:618 → 669
    PSI; domain found in Plexins, Semaphorins and Integrins
    cl11960
    Location:674 → 760
    Ig; Immunoglobulin domain

  2. XM_005615960.4 → XP_005616017.2  semaphorin-4D isoform X8

    UniProtKB/TrEMBL
    A0A8I3NX99
    Conserved Domains (3) summary
    cd11259
    Location:184 → 654
    Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
    smart00409
    Location:767 → 843
    IG; Immunoglobulin
    smart00423
    Location:656 → 692
    PSI; domain found in Plexins, Semaphorins and Integrins

  3. XM_005615958.3 → XP_005616015.2  semaphorin-4D isoform X1

    UniProtKB/TrEMBL
    A0A8I3P379
    Conserved Domains (4) summary
    cd11259
    Location:184 → 654
    Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
    smart00423
    Location:656 → 707
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd00096
    Location:712 → 717
    Ig; Ig strand A [structural motif]
    cl11960
    Location:712 → 798
    Ig; Immunoglobulin domain

  4. XM_038606145.1 → XP_038462073.1  semaphorin-4D isoform X3

    UniProtKB/TrEMBL
    A0A8I3P3E0
    Conserved Domains (4) summary
    cd11259
    Location:140 → 610
    Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
    smart00423
    Location:612 → 663
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd00096
    Location:668 → 673
    Ig; Ig strand A [structural motif]
    cl11960
    Location:668 → 754
    Ig; Immunoglobulin domain

  5. XM_038606262.1 → XP_038462190.1  semaphorin-4D isoform X4

    UniProtKB/TrEMBL
    A0A8I3P3H8
    Conserved Domains (4) summary
    cd11259
    Location:29 → 499
    Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
    smart00423
    Location:501 → 552
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd00096
    Location:557 → 562
    Ig; Ig strand A [structural motif]
    cl11960
    Location:557 → 643
    Ig; Immunoglobulin domain
Nucleotide Protein
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