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SMOC2 SPARC related modular calcium binding 2 [ Canis lupus familiaris (dog) ]

Gene ID: 476270, updated on 25-Jul-2026
Official Symbol
SMOC2provided by VGNC
Official Full Name
SPARC related modular calcium binding 2provided by VGNC
Primary source
VGNC:VGNC:46567
See related
Ensembl:ENSCAFG00845005168 RGD:12228111
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Canis lupus familiaris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
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Try the new Transcripts and proteins table
See SMOC2 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
13
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 1 NC_051805.1 (56009740..56168234)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 1 NC_006583.4 (56617795..56777591)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 1 NC_049222.1 (56380993..56539474)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 1 NC_049261.1 (55906584..56065183)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 1 NC_049742.1 (55753833..55912398)

Chromosome 1 - NC_051805.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111090696 Neighboring gene uncharacterized LOC102153625 Neighboring gene dishevelled binding antagonist of beta catenin 2 Neighboring gene uncharacterized LOC102153755 Neighboring gene uncharacterized LOC119870669

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Localization of canine brachycephaly using an across breed mapping approach. Bannasch D, et al. PLoS One, 2010 Mar 10. PMID 20224736, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables extracellular matrix binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables heparin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in basement membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
SPARC-related modular calcium-binding protein 2

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177803.1 → NP_001171274.1  SPARC-related modular calcium-binding protein 2 precursor

    Status: VALIDATED

    Source sequence(s)
    CO620032, DN370033, DN402126, DN402972, DN865424, DN880995
    UniProtKB/TrEMBL
    A0A8I3RU03
    Related
    ENSCAFP00845007302.1, ENSCAFT00845009293.1
    Conserved Domains (5) summary
    cd00104
    Location:47 → 84
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd00191
    Location:215 → 281
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    cd16241
    Location:304 → 416
    EFh_SPARC_SMOC2; EF-hand, extracellular calcium-binding (EC) motif, found in secreted modular calcium-binding protein 2 (SMOC-2)
    pfam00086
    Location:90 → 153
    Thyroglobulin_1; Thyroglobulin type-1 repeat
    pfam16597
    Location:154 → 214
    Thyroglob_assoc; Thyroglobulin_1 repeat associated disordered domain

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051805.1 Reference ROS_Cfam_1.0

    Range
    56009740..56168234
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038653486.1 → XP_038509414.1  SPARC-related modular calcium-binding protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I3RU03
    Conserved Domains (5) summary
    cd00104
    Location:47 → 84
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd00191
    Location:226 → 292
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    cd16241
    Location:315 → 427
    EFh_SPARC_SMOC2; EF-hand, extracellular calcium-binding (EC) motif, found in secreted modular calcium-binding protein 2 (SMOC-2)
    pfam00086
    Location:90 → 153
    Thyroglobulin_1; Thyroglobulin type-1 repeat
    pfam16597
    Location:154 → 225
    Thyroglob_assoc; Thyroglobulin_1 repeat associated disordered domain

  2. XM_038653487.1 → XP_038509415.1  SPARC-related modular calcium-binding protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I3RU03
    Conserved Domains (5) summary
    cd00104
    Location:47 → 84
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd00191
    Location:226 → 292
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    cd16241
    Location:315 → 427
    EFh_SPARC_SMOC2; EF-hand, extracellular calcium-binding (EC) motif, found in secreted modular calcium-binding protein 2 (SMOC-2)
    pfam00086
    Location:90 → 153
    Thyroglobulin_1; Thyroglobulin type-1 repeat
    pfam16597
    Location:154 → 225
    Thyroglob_assoc; Thyroglobulin_1 repeat associated disordered domain

  3. XM_038653488.1 → XP_038509416.1  SPARC-related modular calcium-binding protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A8I3MSK1, A0A8I3RU03
    Related
    ENSCAFP00845007295.1, ENSCAFT00845009278.1
    Conserved Domains (5) summary
    cd00104
    Location:47 → 84
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd00191
    Location:215 → 281
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    cd16241
    Location:304 → 416
    EFh_SPARC_SMOC2; EF-hand, extracellular calcium-binding (EC) motif, found in secreted modular calcium-binding protein 2 (SMOC-2)
    pfam00086
    Location:90 → 153
    Thyroglobulin_1; Thyroglobulin type-1 repeat
    pfam16597
    Location:154 → 214
    Thyroglob_assoc; Thyroglobulin_1 repeat associated disordered domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049261.1 Alternate UMICH_Zoey_3.1

    Range
    55906584..56065183
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049742.1 Alternate UNSW_CanFamBas_1.0

    Range
    55753833..55912398
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049222.1 Alternate UU_Cfam_GSD_1.0

    Range
    56380993..56539474
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006583.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    56617795..56777591
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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