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NEUROG1 neurogenin 1 [ Homo sapiens (human) ]

Gene ID: 4762, updated on 8-Dec-2022

Summary

Official Symbol
NEUROG1provided by HGNC
Official Full Name
neurogenin 1provided by HGNC
Primary source
HGNC:HGNC:7764
See related
Ensembl:ENSG00000181965 MIM:601726; AllianceGenome:HGNC:7764
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AKA; ngn1; Math4C; bHLHa6; NEUROD3
Summary
Enables E-box binding activity and protein homodimerization activity. Involved in several processes, including animal organ morphogenesis; cranial nerve development; and hard palate morphogenesis. Predicted to be located in neuronal cell body. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See NEUROG1 in Genome Data Viewer
Location:
5q31.1
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (135534282..135535964, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (136061404..136063086, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (134869972..134871654, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901073 Neighboring gene TIFA inhibitor Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:134825332-134826188 Neighboring gene Sharpr-MPRA regulatory region 242 Neighboring gene solute carrier family 25 member 48 Neighboring gene C-X-C motif chemokine ligand 14 Neighboring gene SLC25A48 antisense RNA 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
enables E-box binding IDA
Inferred from Direct Assay
more info
PubMed 
enables E-box binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables chromatin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables nucleic acid binding EXP
Inferred from Experiment
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in auditory behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cell fate commitment IEA
Inferred from Electronic Annotation
more info
 
involved_in cochlea development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cochlea morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in craniofacial suture morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in exit from mitosis IEA
Inferred from Electronic Annotation
more info
 
involved_in genitalia development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in genitalia morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in hard palate morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in inner ear development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in inner ear morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in learned vocalization behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in mastication IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of relaxation of muscle IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of saliva secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in nervous system development TAS
Traceable Author Statement
more info
PubMed 
involved_in neuromuscular process controlling balance IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in peristalsis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of exit from mitosis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of muscle organ development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in thorax and anterior abdomen determination IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in trigeminal nerve development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in vestibulocochlear nerve formation IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
neurogenin-1
Names
NGN-1
class A basic helix-loop-helix protein 6
neurogenic basic-helix-loop-helix protein
neurogenic differentiation 3
neurogenic differentiation factor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006161.3NP_006152.2  neurogenin-1

    See identical proteins and their annotated locations for NP_006152.2

    Status: VALIDATED

    Source sequence(s)
    AC005738, BC028226
    Consensus CDS
    CCDS4187.1
    UniProtKB/Swiss-Prot
    Q92886, Q96HE1
    UniProtKB/TrEMBL
    F1T0H3
    Related
    ENSP00000317580.4, ENST00000314744.6
    Conserved Domains (1) summary
    cd00083
    Location:90149
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    135534282..135535964 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    136061404..136063086 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)