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NEU2 neuraminidase 2 [ Homo sapiens (human) ]

Gene ID: 4759, updated on 17-Jun-2024

Summary

Official Symbol
NEU2provided by HGNC
Official Full Name
neuraminidase 2provided by HGNC
Primary source
HGNC:HGNC:7759
See related
Ensembl:ENSG00000115488 MIM:605528; AllianceGenome:HGNC:7759
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIAL2
Summary
This gene belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. Expression studies in COS7 cells confirmed that this gene encodes a functional sialidase. Its cytosolic localization was demonstrated by cell fractionation experiments. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See NEU2 in Genome Data Viewer
Location:
2q37.1
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (233032672..233035057)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (233520063..233522448)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (233897382..233899767)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:233736904-233737669 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12464 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:233755984-233756593 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:233756594-233757202 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:233765119-233765744 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:233766250-233767449 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:233769412-233770057 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:233770058-233770702 Neighboring gene secondary ossification center associated regulator of chondrocyte maturation Neighboring gene neuronal guanine nucleotide exchange factor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17326 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17327 Neighboring gene uncharacterized LOC101928881 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12465 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17328 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12466 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17329 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:233926783-233927376 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:233927377-233927970 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17330 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12468 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:233937995-233938700 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17331 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17332 Neighboring gene Sharpr-MPRA regulatory region 10619 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17333 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:233953501-233954000 Neighboring gene inositol polyphosphate-5-phosphatase D Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:233972121-233972622 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:233972623-233973122 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17334 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:233982267-233982860 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:233987251-233987751 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:233988888-233989435 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:233989436-233989982 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:233993677-233994176 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:234072305-234072918 Neighboring gene NANOG hESC enhancer GRCh37_chr2:234125377-234125936 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:234131944-234132095 Neighboring gene RNA, 7SL, cytoplasmic 32, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr2:234151441-234151635 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:234155927-234157126 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17335 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17336 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17337 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12469 Neighboring gene autophagy related 16 like 1 Neighboring gene small Cajal body-specific RNA 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Variants in the 1q21 risk region are associated with a visual endophenotype of autism and schizophrenia.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The desialylation of HIV-1 gp120 with neuraminidase greatly augments the initial virus-cell interaction, leading to remarkably enhanced viral replication and cytopathogenicity PubMed
env Removal of sialic acids from HIV-1 gp120 with neuraminidase (NA) enhances mannose-binding lectin (MBL) binding PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC129579

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables exo-alpha-(2->3)-sialidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables exo-alpha-(2->6)-sialidase activity IEA
Inferred from Electronic Annotation
more info
 
enables exo-alpha-(2->8)-sialidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables exo-alpha-sialidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables exo-alpha-sialidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables exo-alpha-sialidase activity TAS
Traceable Author Statement
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in ganglioside catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in ganglioside catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glycoprotein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glycosphingolipid catabolic process TAS
Traceable Author Statement
more info
 
involved_in oligosaccharide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in oligosaccharide catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of catalytic complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
sialidase-2
Names
N-acetyl-alpha-neuraminidase 2
cytosolic sialidase
sialidase 2 (cytosolic sialidase)
NP_005374.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005383.2NP_005374.2  sialidase-2

    See identical proteins and their annotated locations for NP_005374.2

    Status: REVIEWED

    Source sequence(s)
    BC069151
    Consensus CDS
    CCDS2501.1
    UniProtKB/Swiss-Prot
    Q3KNW4, Q6NTB4, Q9Y3R4
    Related
    ENSP00000233840.3, ENST00000233840.3
    Conserved Domains (2) summary
    cd15482
    Location:14368
    Sialidase_non-viral; Non-viral sialidases
    pfam13088
    Location:32343
    BNR_2; BNR repeat-like domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    233032672..233035057
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    233520063..233522448
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)