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NEU2 neuraminidase 2 [ Homo sapiens (human) ]

Gene ID: 4759, updated on 9-Dec-2018

Summary

Official Symbol
NEU2provided by HGNC
Official Full Name
neuraminidase 2provided by HGNC
Primary source
HGNC:HGNC:7759
See related
Ensembl:ENSG00000115488 MIM:605528
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIAL2
Summary
This gene belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. Expression studies in COS7 cells confirmed that this gene encodes a functional sialidase. Its cytosolic localization was demonstrated by cell fractionation experiments. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See NEU2 in Genome Data Viewer
Location:
2q37.1
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (233032672..233035057)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (233897382..233899767)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene secondary ossification center associated regulator of chondrocyte maturation Neighboring gene neuronal guanine nucleotide exchange factor Neighboring gene uncharacterized LOC101928881 Neighboring gene inositol polyphosphate-5-phosphatase D Neighboring gene RNA, 7SL, cytoplasmic 32, pseudogene Neighboring gene autophagy related 16 like 1 Neighboring gene small Cajal body-specific RNA 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Variants in the 1q21 risk region are associated with a visual endophenotype of autism and schizophrenia.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The desialylation of HIV-1 gp120 with neuraminidase greatly augments the initial virus-cell interaction, leading to remarkably enhanced viral replication and cytopathogenicity PubMed
env Removal of sialic acids from HIV-1 gp120 with neuraminidase (NA) enhances mannose-binding lectin (MBL) binding PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC129579

Gene Ontology Provided by GOA

Function Evidence Code Pubs
exo-alpha-(2->3)-sialidase activity IDA
Inferred from Direct Assay
more info
PubMed 
exo-alpha-(2->6)-sialidase activity IEA
Inferred from Electronic Annotation
more info
 
exo-alpha-(2->8)-sialidase activity IEA
Inferred from Electronic Annotation
more info
 
exo-alpha-sialidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
exo-alpha-sialidase activity IDA
Inferred from Direct Assay
more info
PubMed 
exo-alpha-sialidase activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular oligosaccharide catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
ganglioside catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ganglioside catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
glycosphingolipid metabolic process TAS
Traceable Author Statement
more info
 
oligosaccharide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oligosaccharide catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
catalytic complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
sialidase-2
Names
N-acetyl-alpha-neuraminidase 2
cytosolic sialidase
sialidase 2 (cytosolic sialidase)
NP_005374.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005383.2NP_005374.2  sialidase-2

    See identical proteins and their annotated locations for NP_005374.2

    Status: REVIEWED

    Source sequence(s)
    BC069151
    Consensus CDS
    CCDS2501.1
    UniProtKB/Swiss-Prot
    Q9Y3R4
    Related
    ENSP00000233840.3, ENST00000233840.3
    Conserved Domains (2) summary
    cd15482
    Location:14368
    Sialidase_non-viral; Non-viral sialidases
    pfam13088
    Location:32343
    BNR_2; BNR repeat-like domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    233032672..233035057
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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