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SLC8A1 solute carrier family 8 member A1 [ Canis lupus familiaris (dog) ]

Gene ID: 475738, updated on 17-Aug-2024

Summary

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Official Symbol
SLC8A1provided by VGNC
Official Full Name
solute carrier family 8 member A1provided by VGNC
Primary source
VGNC:VGNC:46480
See related
Ensembl:ENSCAFG00845024998
Gene type
protein coding
RefSeq status
INFERRED
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
NCX1
Orthologs
human mouse all
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Genomic context

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See SLC8A1 in Genome Data Viewer
Location:
chromosome: 17
Exon count:
16
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 17 NC_051821.1 (32669189..33057808, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 17 NC_006599.4 (31772774..32072461, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 17 NC_049238.1 (32171264..32471231, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 17 NC_049277.1 (31887301..32186904, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 17 NC_049758.1 (31956496..32256674, complement)

Chromosome 17 - NC_051821.1Genomic Context describing neighboring genes Neighboring gene THUMP domain containing 2 Neighboring gene uncharacterized LOC111090432 Neighboring gene uncharacterized LOC111090587 Neighboring gene uncharacterized LOC111090586 Neighboring gene uncharacterized LOC111090585 Neighboring gene uncharacterized LOC102157060 Neighboring gene uncharacterized LOC119880481 Neighboring gene uncharacterized LOC119874749 Neighboring gene uncharacterized LOC119874750

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The cardiac biomarker sodium-calcium exchanger (NCX-1) can differentiate between heart failure and renal failure: a comparative study of NCX-1 expression in dogs with chronic mitral valvular insufficiency and azotemia. Nam SJ, et al. J Vet Intern Med, 2010 Nov-Dec. PMID 21054542
  2. The crystal structure of the primary Ca2+ sensor of the Na+/Ca2+ exchanger reveals a novel Ca2+ binding motif. Nicoll DA, et al. J Biol Chem, 2006 Aug 4. PMID 16774926
  3. Helix packing of the cardiac Na+-Ca2+ exchanger: proximity of transmembrane segments 1, 2, and 6. Ren X, et al. J Biol Chem, 2006 Aug 11. PMID 16785232
  4. Fluorescent Na+-Ca+ exchangers: electrophysiological and optical characterization. Ottolia M, et al. J Biol Chem, 2007 Feb 9. PMID 17158867
  5. Structure and dynamics of Ca2+-binding domain 1 of the Na+/Ca2+ exchanger in the presence and in the absence of Ca2+. Johnson E, et al. J Mol Biol, 2008 Mar 28. PMID 18280495, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Model results demonstrate that a reduction in the local NCX1- and NaK-mediated regulation of dyadic [Ca(2+)] and [Na(+)] results in an increase in Ca(2+) spark activity during isoproterenol stimulation, which in turn stochastically activates NCX1 in the dyad.
    Title: Na(+) microdomains and sparks: Role in cardiac excitation-contraction coupling and arrhythmias in ankyrin-B deficiency.
  2. knockdown of NCX1 in Madin-Darby canine kidney cells alters epithelial morphology and characteristics by destabilization of E-cadherin and induction of beta-catenin signaling.
    Title: Knockdown of sodium-calcium exchanger 1 induces epithelial-to-mesenchymal transition in kidney epithelial cells.
  3. NCX1 palmitoylation is governed by a distal secondary structure element rather than by local primary sequence.
    Title: An amphipathic α-helix directs palmitoylation of the large intracellular loop of the sodium/calcium exchanger.
  4. Palmitoylation of NCX1 occurs in the Golgi and anchors the NCX1 large regulatory intracellular loop to membranes.
    Title: Palmitoylation of the Na/Ca exchanger cytoplasmic loop controls its inactivation and internalization during stress signaling.
  5. These data confirm the role of NCX1 activity in regulating renal epithelial cell migration.
    Title: Sodium-calcium exchanger 1 regulates epithelial cell migration via calcium-dependent extracellular signal-regulated kinase signaling.
  6. f-loop residues 562-679 may contain the regulatory site for endogenous exchanger inhibitor peptide XIP, but this site is distinct from the Ca2+-regulatory domains of the NCX.
    Title: Cardiac sodium-calcium exchanger is regulated by allosteric calcium and exchanger inhibitory peptide at distinct sites.
  7. NCX1 is a novel regulatory target for calcineurin; depressed NCX activity might contribute to the etiology of in vivo cardiac hypertrophy and dysfunction occurring under conditions in which both calcineurin and protein kinase C are chronically activated
    Title: Calcineurin inhibits Na+/Ca2+ exchange in phenylephrine-treated hypertrophic cardiomyocytes.
  8. Population shift underlies Ca2+-induced regulatory transitions in the sodium-calcium exchanger (NCX).
    Title: Population shift underlies Ca2+-induced regulatory transitions in the sodium-calcium exchanger (NCX).
  9. The Ca(2+)-driven interdomain switch described here represents a general mechanism for initial conduction of regulatory signals in NCX variants.
    Title: A common Ca2+-driven interdomain module governs eukaryotic NCX regulation.
  10. mu-Calpain-mediated deregulation of cardiac, brain, and kidney NCX1 splice variants.
    Title: μ-Calpain-mediated deregulation of cardiac, brain, and kidney NCX1 splice variants.
Submit: New GeneRIF Correction See all GeneRIFs (25)

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium:sodium antiporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium ion import across plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell communication IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in sarcolemma IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
sodium/calcium exchanger 1
Names
Na(+)/Ca(2+)-exchange protein 1
Na+/Ca2+ exchanger
cardiac sarcolemmal sodium-calcium exchanger
solute carrier family 8 member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304962.1 → NP_001291891.1  sodium/calcium exchanger 1 precursor

    See identical proteins and their annotated locations for NP_001291891.1

    Status: INFERRED

    Source sequence(s)
    JAAUVH010000359
    UniProtKB/Swiss-Prot
    P23685
    UniProtKB/TrEMBL
    A0A8C0TYC5
    Related
    ENSCAFP00845034837.1, ENSCAFT00845044459.1
    Conserved Domains (1) summary
    TIGR00845
    Location:1 → 970
    caca; sodium/calcium exchanger 1

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051821.1 Reference ROS_Cfam_1.0

    Range
    32669189..33057808 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038690483.1 → XP_038546411.1  sodium/calcium exchanger 1 isoform X11

    UniProtKB/Swiss-Prot
    P23685
    UniProtKB/TrEMBL
    A0A8C0TYC5
    Conserved Domains (1) summary
    TIGR00845
    Location:1 → 970
    caca; sodium/calcium exchanger 1

  2. XM_038690484.1 → XP_038546412.1  sodium/calcium exchanger 1 isoform X11

    UniProtKB/Swiss-Prot
    P23685
    UniProtKB/TrEMBL
    A0A8C0TYC5
    Conserved Domains (1) summary
    TIGR00845
    Location:1 → 970
    caca; sodium/calcium exchanger 1

  3. XM_038690489.1 → XP_038546417.1  sodium/calcium exchanger 1 isoform X11

    UniProtKB/Swiss-Prot
    P23685
    UniProtKB/TrEMBL
    A0A8C0TYC5
    Conserved Domains (1) summary
    TIGR00845
    Location:1 → 970
    caca; sodium/calcium exchanger 1

  4. XM_038690491.1 → XP_038546419.1  sodium/calcium exchanger 1 isoform X11

    UniProtKB/Swiss-Prot
    P23685
    UniProtKB/TrEMBL
    A0A8C0TYC5
    Conserved Domains (1) summary
    TIGR00845
    Location:1 → 970
    caca; sodium/calcium exchanger 1

  5. XM_038690485.1 → XP_038546413.1  sodium/calcium exchanger 1 isoform X11

    UniProtKB/Swiss-Prot
    P23685
    UniProtKB/TrEMBL
    A0A8C0TYC5
    Conserved Domains (1) summary
    TIGR00845
    Location:1 → 970
    caca; sodium/calcium exchanger 1

  6. XM_038690487.1 → XP_038546415.1  sodium/calcium exchanger 1 isoform X11

    UniProtKB/Swiss-Prot
    P23685
    UniProtKB/TrEMBL
    A0A8C0TYC5
    Conserved Domains (1) summary
    TIGR00845
    Location:1 → 970
    caca; sodium/calcium exchanger 1

  7. XM_038690486.1 → XP_038546414.1  sodium/calcium exchanger 1 isoform X11

    UniProtKB/Swiss-Prot
    P23685
    UniProtKB/TrEMBL
    A0A8C0TYC5
    Conserved Domains (1) summary
    TIGR00845
    Location:1 → 970
    caca; sodium/calcium exchanger 1

  8. XM_038690488.1 → XP_038546416.1  sodium/calcium exchanger 1 isoform X11

    UniProtKB/Swiss-Prot
    P23685
    UniProtKB/TrEMBL
    A0A8C0TYC5
    Conserved Domains (1) summary
    TIGR00845
    Location:1 → 970
    caca; sodium/calcium exchanger 1

  9. XM_038690476.1 → XP_038546404.1  sodium/calcium exchanger 1 isoform X4

    UniProtKB/TrEMBL
    A0A8C0TY97
    Conserved Domains (1) summary
    TIGR00845
    Location:35 → 998
    caca; sodium/calcium exchanger 1

  10. XM_038690493.1 → XP_038546421.1  sodium/calcium exchanger 1 isoform X13

    UniProtKB/TrEMBL
    A0A8C0TUM3, A0A8I3PPN4
    Related
    ENSCAFP00845034698.1, ENSCAFT00845044277.1
    Conserved Domains (1) summary
    TIGR00845
    Location:35 → 968
    caca; sodium/calcium exchanger 1

  11. XM_038690480.1 → XP_038546408.1  sodium/calcium exchanger 1 isoform X8

    UniProtKB/TrEMBL
    A0A8C0TY97
    Conserved Domains (1) summary
    TIGR00845
    Location:35 → 991
    caca; sodium/calcium exchanger 1

  12. XM_038690478.1 → XP_038546406.1  sodium/calcium exchanger 1 isoform X6

    UniProtKB/TrEMBL
    A0A8C0TY97
    Conserved Domains (1) summary
    TIGR00845
    Location:35 → 996
    caca; sodium/calcium exchanger 1

  13. XM_038690482.1 → XP_038546410.1  sodium/calcium exchanger 1 isoform X10

    UniProtKB/TrEMBL
    A0A8C0TUM3, A0A8I3PPN4
    Conserved Domains (1) summary
    TIGR00845
    Location:35 → 975
    caca; sodium/calcium exchanger 1

  14. XM_038690474.1 → XP_038546402.1  sodium/calcium exchanger 1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0TY97
    Conserved Domains (1) summary
    TIGR00845
    Location:35 → 1003
    caca; sodium/calcium exchanger 1

  15. XM_038690479.1 → XP_038546407.1  sodium/calcium exchanger 1 isoform X7

    UniProtKB/TrEMBL
    A0A8C0Z749
    Conserved Domains (1) summary
    TIGR00845
    Location:35 → 992
    caca; sodium/calcium exchanger 1

  16. XM_038690477.1 → XP_038546405.1  sodium/calcium exchanger 1 isoform X5

    UniProtKB/TrEMBL
    A0A8C0TYC5
    Conserved Domains (1) summary
    TIGR00845
    Location:35 → 997
    caca; sodium/calcium exchanger 1

  17. XM_038690481.1 → XP_038546409.1  sodium/calcium exchanger 1 isoform X9

    UniProtKB/TrEMBL
    A0A8C0Z749
    Conserved Domains (1) summary
    TIGR00845
    Location:35 → 976
    caca; sodium/calcium exchanger 1

  18. XM_038690475.1 → XP_038546403.1  sodium/calcium exchanger 1 isoform X3

    UniProtKB/TrEMBL
    A0A8C0Z749
    Related
    ENSCAFP00845034894.1, ENSCAFT00845044535.1
    Conserved Domains (1) summary
    TIGR00845
    Location:35 → 999
    caca; sodium/calcium exchanger 1

  19. XM_038690492.1 → XP_038546420.1  sodium/calcium exchanger 1 isoform X12

    UniProtKB/TrEMBL
    A0A8C0TUM3, A0A8I3PPN4
    Conserved Domains (1) summary
    TIGR00845
    Location:35 → 969
    caca; sodium/calcium exchanger 1

  20. XM_038690473.1 → XP_038546401.1  sodium/calcium exchanger 1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0TYC5
    Conserved Domains (1) summary
    TIGR00845
    Location:35 → 1004
    caca; sodium/calcium exchanger 1

  21. XM_038690490.1 → XP_038546418.1  sodium/calcium exchanger 1 isoform X11

    UniProtKB/Swiss-Prot
    P23685
    UniProtKB/TrEMBL
    A0A8C0TYC5
    Conserved Domains (1) summary
    TIGR00845
    Location:1 → 970
    caca; sodium/calcium exchanger 1

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049277.1 Alternate UMICH_Zoey_3.1

    Range
    31887301..32186904 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049758.1 Alternate UNSW_CanFamBas_1.0

    Range
    31956496..32256674 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049238.1 Alternate UU_Cfam_GSD_1.0

    Range
    32171264..32471231 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006599.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    31772774..32072461 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P23685.1 GenPept UniProtKB/Swiss-Prot:P23685

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