KLKB1 kallikrein B1 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: KLKB1provided by VGNC
Official Full Name: kallikrein B1provided by VGNC
Primary source: VGNC:VGNC:42484
See related: Ensembl:ENSCAFG00845019450 RGD:12247405
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: PK
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Genomic context

Location:: chromosome: 16

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	16	NC_051820.1 (46683089..46736876, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	16	NC_006598.4 (44979694..45003202, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	16	NC_049237.1 (45418960..45442647, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	16	NC_049276.1 (44675226..44698533, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	16	NC_049757.1 (45288025..45311430, complement)

Chromosome 16 - NC_051820.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in proteolysis	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: plasma kallikrein

Names: prekallikrein

NP_001229646.1

EC 3.4.21.34

XP_038544795.1

EC 3.4.21.34

XP_038544796.1

EC 3.4.21.34

XP_038544797.1

EC 3.4.21.34

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001242717.1 → NP_001229646.1 plasma kallikrein

See identical proteins and their annotated locations for NP_001229646.1

Status: PROVISIONAL

Source sequence(s)

AB558589

UniProtKB/TrEMBL

A0A5K1VKB9, A0A8C0S4B7, A0A8P0SCP0

Related

ENSCAFP00845026905.1, ENSCAFT00845034365.1

Conserved Domains (2) summary

smart00223
Location:201 → 284

APPLE; APPLE domain

cd00190
Location:391 → 622

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051820.1 Reference ROS_Cfam_1.0

Range

46683089..46736876 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038688869.1 → XP_038544797.1 plasma kallikrein isoform X3

UniProtKB/TrEMBL

A0A8C0NKV2

Conserved Domains (2) summary

smart00223
Location:184 → 267

APPLE; APPLE domain

cd00190
Location:372 → 602

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_038688868.1 → XP_038544796.1 plasma kallikrein isoform X2

UniProtKB/TrEMBL

A0A8C0JGU3, A0A8C0NKV2

Conserved Domains (2) summary

smart00223
Location:200 → 283

APPLE; APPLE domain

cd00190
Location:388 → 618

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_038688867.1 → XP_038544795.1 plasma kallikrein isoform X1

UniProtKB/TrEMBL

A0A8C0S4B7

Conserved Domains (2) summary

smart00223
Location:255 → 338

APPLE; APPLE domain

cd00190
Location:445 → 676

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...