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ADAM9 ADAM metallopeptidase domain 9 [ Canis lupus familiaris (dog) ]

Gene ID: 475579, updated on 1-Mar-2025
Official Symbol
ADAM9provided by VGNC
Official Full Name
ADAM metallopeptidase domain 9provided by VGNC
Primary source
VGNC:VGNC:37588
See related
Ensembl:ENSCAFG00845010921 RGD:12354473
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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See ADAM9 in Genome Data Viewer
Location:
chromosome: 16
Exon count:
22
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 16 NC_051820.1 (28245576..28382674, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 16 NC_006598.4 (26936243..27072615, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 16 NC_049237.1 (27154835..27291400, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 16 NC_049276.1 (26539869..26676393, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 16 NC_049757.1 (27116645..27253104, complement)

Chromosome 16 - NC_051820.1Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase domain 32 Neighboring gene ER membrane protein complex subunit 3-like Neighboring gene microRNA mir-8799d Neighboring gene TM2 domain containing 2 Neighboring gene HtrA serine peptidase 4 Neighboring gene pleckstrin homology domain containing A2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. An ADAM9 mutation in canine cone-rod dystrophy 3 establishes homology with human cone-rod dystrophy 9. Goldstein O, et al. Mol Vis, 2010 Aug 11. PMID 20806078, Free PMC Article
  2. Generalized progressive retinal atrophy in the Irish Glen of Imaal Terrier is associated with a deletion in the ADAM9 gene. Kropatsch R, et al. Mol Cell Probes, 2010 Dec. PMID 20691256
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sequence analysis of ADAM9 in affected and carrier Glen of Imaal Terrier revealed a deletion of exons 15 and 16 which alters the reading frame leading to a premature stop codon.
    Title: Generalized progressive retinal atrophy in the Irish Glen of Imaal Terrier is associated with a deletion in the ADAM9 gene.
  2. Identification of ADAM9 deletion in crd3-affected dogs establishes this canine disease as orthologous to CORD9 in humans.
    Title: An ADAM9 mutation in canine cone-rod dystrophy 3 establishes homology with human cone-rod dystrophy 9.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables integrin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell-cell adhesion mediated by integrin IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in membrane protein ectodomain proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
disintegrin and metalloproteinase domain-containing protein 9
Names
disintegrin and metalloproteinase domain 9
meltrin gamma

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195402.1 → NP_001182331.1  disintegrin and metalloproteinase domain-containing protein 9 precursor

    See identical proteins and their annotated locations for NP_001182331.1

    Status: PROVISIONAL

    Source sequence(s)
    HM590630
    UniProtKB/TrEMBL
    A0A8C0JMG7, A0A8C0N948, A0A8C0S078, E1ACC5
    Related
    ENSCAFP00845015401.1, ENSCAFT00845019685.1
    Conserved Domains (4) summary
    smart00050
    Location:423 → 498
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:500 → 636
    ACR; ADAM Cysteine-Rich Domain
    pfam01421
    Location:212 → 406
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:44 → 163
    Pep_M12B_propep; Reprolysin family propeptide

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051820.1 Reference ROS_Cfam_1.0

    Range
    28245576..28382674 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049276.1 Alternate UMICH_Zoey_3.1

    Range
    26539869..26676393 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049757.1 Alternate UNSW_CanFamBas_1.0

    Range
    27116645..27253104 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049237.1 Alternate UU_Cfam_GSD_1.0

    Range
    27154835..27291400 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006598.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    26936243..27072615 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases
Research Materials