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NRDC nardilysin convertase [ Canis lupus familiaris (dog) ]

Gene ID: 475354, updated on 25-Jul-2026
Official Symbol
NRDCprovided by VGNC
Official Full Name
nardilysin convertaseprovided by VGNC
Primary source
VGNC:VGNC:43964
See related
Ensembl:ENSCAFG00845021372 RGD:12408462
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
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See NRDC in Genome Data Viewer
Location:
chromosome: 15
Exon count:
34
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 15 NC_051819.1 (9538552..9629226)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 15 NC_006597.4 (9565904..9656554)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 15 NC_049236.1 (9456202..9547376)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 15 NC_049275.1 (9348951..9440061)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 15 NC_049756.1 (9438324..9528835)

Chromosome 15 - NC_051819.1Genomic Context describing neighboring genes Neighboring gene thioredoxin domain containing 12 Neighboring gene uncharacterized LOC111098968 Neighboring gene KTI12 chromatin associated homolog Neighboring gene RAB3B, member RAS oncogene family Neighboring gene uncharacterized LOC102154126 Neighboring gene microRNA mir-761 Neighboring gene small nucleolar RNA U3 Neighboring gene oxysterol binding protein like 9 Neighboring gene epidermal growth factor receptor pathway substrate 15 Neighboring gene calmodulin-like

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
nardilysin
XP_038351603.1
XP_038413965.1
XP_038477834.1
XP_038543592.1
XP_038543593.1
XP_038543594.1
XP_859649.1

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051819.1 Reference ROS_Cfam_1.0

    Range
    9538552..9629226
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038687664.1 → XP_038543592.1  nardilysin isoform X2

    UniProtKB/TrEMBL
    A0A8C0KL37, A0A8I3P8J4
    Related
    ENSCAFP00845029812.1, ENSCAFT00845038050.1
    Conserved Domains (1) summary
    COG1025
    Location:288 → 1166
    Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]

  2. XM_038687666.1 → XP_038543594.1  nardilysin isoform X1

    UniProtKB/TrEMBL
    A0A8C0R0G1
    Related
    ENSCAFP00845029577.1, ENSCAFT00845037746.1
    Conserved Domains (1) summary
    COG1025
    Location:220 → 1098
    Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]

  3. XM_038687665.1 → XP_038543593.1  nardilysin isoform X3

    UniProtKB/TrEMBL
    A0A8C0KL37
    Conserved Domains (1) summary
    COG1025
    Location:155 → 1033
    Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049275.1 Alternate UMICH_Zoey_3.1

    Range
    9348951..9440061
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038495675.1 → XP_038351603.1  

    Conserved Domains (1) summary
    COG1025
    Location:220 → 1098
    Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049756.1 Alternate UNSW_CanFamBas_1.0

    Range
    9438324..9528835
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038621906.1 → XP_038477834.1  

    Conserved Domains (1) summary
    COG1025
    Location:220 → 1098
    Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049236.1 Alternate UU_Cfam_GSD_1.0

    Range
    9456202..9547376
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038558037.1 → XP_038413965.1  nardilysin isoform X1

    UniProtKB/TrEMBL
    A0A8C0R0G1
    Conserved Domains (1) summary
    COG1025
    Location:220 → 1098
    Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006597.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    9565904..9656554
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_854556.5 → XP_859649.1  nardilysin isoform X1

    UniProtKB/TrEMBL
    A0A8C0R0G1
    Conserved Domains (1) summary
    COG1025
    Location:220 → 1098
    Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
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