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LNX1 ligand of numb-protein X 1 [ Canis lupus familiaris (dog) ]

Gene ID: 475143, updated on 27-Jun-2026
Official Symbol
LNX1provided by VGNC
Official Full Name
ligand of numb-protein X 1provided by VGNC
Primary source
VGNC:VGNC:51774
See related
Ensembl:ENSCAFG00845011670 RGD:12054197
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See LNX1 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
15
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 13 NC_051817.1 (46693922..46868875, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 13 NC_006595.4 (46041719..46216603, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 13 NC_049234.1 (46772319..46947171, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 13 NC_049273.1 (46367360..46486577, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 13 NC_049754.1 (45899411..46074025, complement)

Chromosome 13 - NC_051817.1Genomic Context describing neighboring genes Neighboring gene sec1 family domain containing 2 Neighboring gene uncharacterized LOC111098615 Neighboring gene uncharacterized LOC111098616 Neighboring gene factor interacting with PAPOLA and CPSF1 Neighboring gene uncharacterized LOC119864431 Neighboring gene uncharacterized LOC111098618 Neighboring gene uncharacterized LOC111098617

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The E3 ubiquitin ligase LNX1p80 promotes the removal of claudins from tight junctions in MDCK cells. Takahashi S, et al. J Cell Sci, 2009 Apr 1. PMID 19295125
  2. Ligand-of-Numb protein X is an endocytic scaffold for junctional adhesion molecule 4. Kansaku A, et al. Oncogene, 2006 Aug 24. PMID 16832352
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
E3 ubiquitin-protein ligase LNX
XP_005628247.1
XP_038281477.1
XP_038281479.1
XP_038281485.1
XP_038349699.1

Length

  • 732
XP_038412019.1
XP_038412020.1
XP_038412021.1
XP_038412022.1
XP_038412023.1
XP_038412024.1
XP_038475951.1
XP_038475952.1
XP_038475953.1
XP_038475954.1
XP_038475955.1
XP_038475956.1
XP_038541559.1
XP_038541560.1
XP_038541561.1
XP_038541562.1
XP_038541563.1
XP_038541564.1
XP_532373.2
XP_849707.1

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051817.1 Reference ROS_Cfam_1.0

    Range
    46693922..46868875 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038685632.1 → XP_038541560.1  E3 ubiquitin-protein ligase LNX isoform X1

    UniProtKB/TrEMBL
    A0A8I3N8X9
    Related
    ENSCAFP00845016255.1, ENSCAFT00845020725.1
    Conserved Domains (3) summary
    COG5222
    Location:40 → 173
    COG5222; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    cd00992
    Location:641 → 725
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd16779
    Location:42 → 83
    mRING-HC-C3HC3D_LNX1; Modified RING finger, HC subclass (C3HC3D-type), found in ligand of numb protein X 1 (LNX1)

  2. XM_038685634.1 → XP_038541562.1  E3 ubiquitin-protein ligase LNX isoform X1

    UniProtKB/TrEMBL
    A0A8I3N8X9
    Conserved Domains (3) summary
    COG5222
    Location:40 → 173
    COG5222; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    cd00992
    Location:641 → 725
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd16779
    Location:42 → 83
    mRING-HC-C3HC3D_LNX1; Modified RING finger, HC subclass (C3HC3D-type), found in ligand of numb protein X 1 (LNX1)

  3. XM_038685633.1 → XP_038541561.1  E3 ubiquitin-protein ligase LNX isoform X1

    UniProtKB/TrEMBL
    A0A8I3N8X9
    Conserved Domains (3) summary
    COG5222
    Location:40 → 173
    COG5222; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    cd00992
    Location:641 → 725
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd16779
    Location:42 → 83
    mRING-HC-C3HC3D_LNX1; Modified RING finger, HC subclass (C3HC3D-type), found in ligand of numb protein X 1 (LNX1)

  4. XM_038685631.1 → XP_038541559.1  E3 ubiquitin-protein ligase LNX isoform X1

    UniProtKB/TrEMBL
    A0A8I3N8X9
    Conserved Domains (3) summary
    COG5222
    Location:40 → 173
    COG5222; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    cd00992
    Location:641 → 725
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd16779
    Location:42 → 83
    mRING-HC-C3HC3D_LNX1; Modified RING finger, HC subclass (C3HC3D-type), found in ligand of numb protein X 1 (LNX1)

  5. XM_038685636.1 → XP_038541564.1  E3 ubiquitin-protein ligase LNX isoform X3

    UniProtKB/TrEMBL
    A0A8I3NKG6
    Related
    ENSCAFP00845016230.1, ENSCAFT00845020696.1
    Conserved Domains (1) summary
    cd00992
    Location:541 → 625
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  6. XM_038685635.1 → XP_038541563.1  E3 ubiquitin-protein ligase LNX isoform X2

    Conserved Domains (3) summary
    COG5222
    Location:40 → 173
    COG5222; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    cd00992
    Location:509 → 592
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd16779
    Location:42 → 83
    mRING-HC-C3HC3D_LNX1; Modified RING finger, HC subclass (C3HC3D-type), found in ligand of numb protein X 1 (LNX1)

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049273.1 Alternate UMICH_Zoey_3.1

    Range
    46367360..46486577 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038493771.1 → XP_038349699.1  

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049754.1 Alternate UNSW_CanFamBas_1.0

    Range
    45899411..46074025 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038620024.1 → XP_038475952.1  

    Conserved Domains (3) summary
    COG5222
    Location:40 → 173
    COG5222; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    cd00992
    Location:641 → 725
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd16779
    Location:42 → 83
    mRING-HC-C3HC3D_LNX1; Modified RING finger, HC subclass (C3HC3D-type), found in ligand of numb protein X 1 (LNX1)

  2. XM_038620026.1 → XP_038475954.1  

    Conserved Domains (3) summary
    COG5222
    Location:40 → 173
    COG5222; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    cd00992
    Location:641 → 725
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd16779
    Location:42 → 83
    mRING-HC-C3HC3D_LNX1; Modified RING finger, HC subclass (C3HC3D-type), found in ligand of numb protein X 1 (LNX1)

  3. XM_038620025.1 → XP_038475953.1  

    Conserved Domains (3) summary
    COG5222
    Location:40 → 173
    COG5222; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    cd00992
    Location:641 → 725
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd16779
    Location:42 → 83
    mRING-HC-C3HC3D_LNX1; Modified RING finger, HC subclass (C3HC3D-type), found in ligand of numb protein X 1 (LNX1)

  4. XM_038620023.1 → XP_038475951.1  

    Conserved Domains (3) summary
    COG5222
    Location:40 → 173
    COG5222; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    cd00992
    Location:641 → 725
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd16779
    Location:42 → 83
    mRING-HC-C3HC3D_LNX1; Modified RING finger, HC subclass (C3HC3D-type), found in ligand of numb protein X 1 (LNX1)

  5. XM_038620028.1 → XP_038475956.1  

    Conserved Domains (1) summary
    cd00992
    Location:541 → 625
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  6. XM_038620027.1 → XP_038475955.1  

    Conserved Domains (3) summary
    COG5222
    Location:40 → 173
    COG5222; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    cd00992
    Location:509 → 592
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd16779
    Location:42 → 83
    mRING-HC-C3HC3D_LNX1; Modified RING finger, HC subclass (C3HC3D-type), found in ligand of numb protein X 1 (LNX1)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049234.1 Alternate UU_Cfam_GSD_1.0

    Range
    46772319..46947171 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038556092.1 → XP_038412020.1  E3 ubiquitin-protein ligase LNX isoform X1

    UniProtKB/TrEMBL
    A0A8I3N8X9
    Conserved Domains (3) summary
    COG5222
    Location:40 → 173
    COG5222; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    cd00992
    Location:641 → 725
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd16779
    Location:42 → 83
    mRING-HC-C3HC3D_LNX1; Modified RING finger, HC subclass (C3HC3D-type), found in ligand of numb protein X 1 (LNX1)

  2. XM_038556094.1 → XP_038412022.1  E3 ubiquitin-protein ligase LNX isoform X1

    UniProtKB/TrEMBL
    A0A8I3N8X9
    Conserved Domains (3) summary
    COG5222
    Location:40 → 173
    COG5222; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    cd00992
    Location:641 → 725
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd16779
    Location:42 → 83
    mRING-HC-C3HC3D_LNX1; Modified RING finger, HC subclass (C3HC3D-type), found in ligand of numb protein X 1 (LNX1)

  3. XM_038556093.1 → XP_038412021.1  E3 ubiquitin-protein ligase LNX isoform X1

    UniProtKB/TrEMBL
    A0A8I3N8X9
    Conserved Domains (3) summary
    COG5222
    Location:40 → 173
    COG5222; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    cd00992
    Location:641 → 725
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd16779
    Location:42 → 83
    mRING-HC-C3HC3D_LNX1; Modified RING finger, HC subclass (C3HC3D-type), found in ligand of numb protein X 1 (LNX1)

  4. XM_038556091.1 → XP_038412019.1  E3 ubiquitin-protein ligase LNX isoform X1

    UniProtKB/TrEMBL
    A0A8I3N8X9
    Conserved Domains (3) summary
    COG5222
    Location:40 → 173
    COG5222; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    cd00992
    Location:641 → 725
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd16779
    Location:42 → 83
    mRING-HC-C3HC3D_LNX1; Modified RING finger, HC subclass (C3HC3D-type), found in ligand of numb protein X 1 (LNX1)

  5. XM_038556096.1 → XP_038412024.1  E3 ubiquitin-protein ligase LNX isoform X3

    UniProtKB/TrEMBL
    A0A8I3NKG6
    Conserved Domains (1) summary
    cd00992
    Location:541 → 625
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  6. XM_038556095.1 → XP_038412023.1  E3 ubiquitin-protein ligase LNX isoform X2

    Conserved Domains (3) summary
    COG5222
    Location:40 → 173
    COG5222; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    cd00992
    Location:509 → 592
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd16779
    Location:42 → 83
    mRING-HC-C3HC3D_LNX1; Modified RING finger, HC subclass (C3HC3D-type), found in ligand of numb protein X 1 (LNX1)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006595.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    46041719..46216603 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_844614.6 → XP_849707.1  E3 ubiquitin-protein ligase LNX isoform X1

    See identical proteins and their annotated locations for XP_849707.1

    Conserved Domains (3) summary
    COG5432
    Location:39 → 171
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd00992
    Location:641 → 725
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd16779
    Location:42 → 83
    mRING-HC-C3HC3D_LNX1; Modified RING finger, HC subclass (C3HC3D-type), found in ligand of numb protein X 1 (LNX1)

  2. XM_038425551.1 → XP_038281479.1  E3 ubiquitin-protein ligase LNX isoform X1

    Conserved Domains (3) summary
    COG5432
    Location:39 → 171
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd00992
    Location:641 → 725
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd16779
    Location:42 → 83
    mRING-HC-C3HC3D_LNX1; Modified RING finger, HC subclass (C3HC3D-type), found in ligand of numb protein X 1 (LNX1)

  3. XM_038425549.1 → XP_038281477.1  E3 ubiquitin-protein ligase LNX isoform X1

    Conserved Domains (3) summary
    COG5432
    Location:39 → 171
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd00992
    Location:641 → 725
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd16779
    Location:42 → 83
    mRING-HC-C3HC3D_LNX1; Modified RING finger, HC subclass (C3HC3D-type), found in ligand of numb protein X 1 (LNX1)

  4. XM_005628190.4 → XP_005628247.1  E3 ubiquitin-protein ligase LNX isoform X1

    See identical proteins and their annotated locations for XP_005628247.1

    Conserved Domains (3) summary
    COG5432
    Location:39 → 171
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd00992
    Location:641 → 725
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd16779
    Location:42 → 83
    mRING-HC-C3HC3D_LNX1; Modified RING finger, HC subclass (C3HC3D-type), found in ligand of numb protein X 1 (LNX1)

  5. XM_532373.7 → XP_532373.2  E3 ubiquitin-protein ligase LNX isoform X3

    Conserved Domains (1) summary
    cd00992
    Location:541 → 625
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  6. XM_038425557.1 → XP_038281485.1  E3 ubiquitin-protein ligase LNX isoform X2

    Conserved Domains (3) summary
    COG5432
    Location:39 → 171
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd00992
    Location:509 → 592
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd16779
    Location:42 → 83
    mRING-HC-C3HC3D_LNX1; Modified RING finger, HC subclass (C3HC3D-type), found in ligand of numb protein X 1 (LNX1)
Nucleotide Protein
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