U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 [ Canis lupus familiaris (dog) ]

Gene ID: 475010, updated on 1-Mar-2025
Official Symbol
HACE1provided by VGNC
Official Full Name
HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1provided by VGNC
Primary source
VGNC:VGNC:41583
See related
Ensembl:ENSCAFG00845006967 RGD:12052666
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table
See HACE1 in Genome Data Viewer
Location:
chromosome: 12
Exon count:
26
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 12 NC_051816.1 (63079955..63187531, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 12 NC_006594.4 (62019271..62126625, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 12 NC_049233.1 (62555861..62663750, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 12 NC_049272.1 (62436034..62543942, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 12 NC_049753.1 (62277683..62385051, complement)

Chromosome 12 - NC_051816.1Genomic Context describing neighboring genes Neighboring gene piezo-type mechanosensitive ion channel component 1-like Neighboring gene cofilin-1-like Neighboring gene apolipoprotein C-I-like Neighboring gene uncharacterized LOC119874225

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A 1 bp deletion in HACE1 causes ataxia in Norwegian elkhound, black. Bellamy KKL, et al. PLoS One, 2022. PMID 35061740, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A 1 bp deletion in HACE1 causes ataxia in Norwegian elkhound, black.
    Title: A 1 bp deletion in HACE1 causes ataxia in Norwegian elkhound, black.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein polyubiquitination IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
E3 ubiquitin-protein ligase HACE1
XP_005627724.1
XP_022282107.1
XP_022282109.1
XP_022282111.1
XP_038348437.1
XP_038348438.1
XP_038348439.1
XP_038348440.1
XP_038348441.1
XP_038410741.1
XP_038410742.1
XP_038410743.1
XP_038410744.1
XP_038410745.1
XP_038474618.1
XP_038474619.1
XP_038474620.1
XP_038474621.1
XP_038474622.1
XP_038540179.1
XP_038540180.1
XP_038540181.1
XP_038540182.1
XP_038540183.1
XP_854232.1

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051816.1 Reference ROS_Cfam_1.0

    Range
    63079955..63187531 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038684251.1 → XP_038540179.1  E3 ubiquitin-protein ligase HACE1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KW65, A0A8C0R341, A0A8I3N5H0, A0A8P0T9I4
    Related
    ENSCAFP00845010078.1, ENSCAFT00845012929.1
    Conserved Domains (4) summary
    COG0666
    Location:83 → 220
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00078
    Location:554 → 903
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    sd00045
    Location:97 → 128
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:34 → 126
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_038684254.1 → XP_038540182.1  E3 ubiquitin-protein ligase HACE1 isoform X4

    UniProtKB/TrEMBL
    A0A8C0KYR5, A0A8I3RV94, A0A8P0NVC4
    Related
    ENSCAFP00845009990.1, ENSCAFT00845012812.1
    Conserved Domains (4) summary
    PLN03192
    Location:3 → 234
    PLN03192; Voltage-dependent potassium channel; Provisional
    cd00078
    Location:510 → 859
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    sd00045
    Location:66 → 95
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:69 → 179
    Ank_2; Ankyrin repeats (3 copies)

  3. XM_038684252.1 → XP_038540180.1  E3 ubiquitin-protein ligase HACE1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0R341
    Conserved Domains (4) summary
    COG0666
    Location:49 → 186
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00078
    Location:520 → 869
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    sd00045
    Location:63 → 94
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:4 → 92
    Ank_2; Ankyrin repeats (3 copies)

  4. XM_038684253.1 → XP_038540181.1  E3 ubiquitin-protein ligase HACE1 isoform X3

    UniProtKB/TrEMBL
    A0A8I3RV80
    Conserved Domains (4) summary
    cd00078
    Location:441 → 790
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    sd00045
    Location:17 → 48
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:4 → 38
    Ank_4; Ankyrin repeats (many copies)
    pfam12796
    Location:22 → 110
    Ank_2; Ankyrin repeats (3 copies)

  5. XM_038684255.1 → XP_038540183.1  E3 ubiquitin-protein ligase HACE1 isoform X5

    Conserved Domains (2) summary
    cd00078
    Location:386 → 735
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cl39094
    Location:38 → 83
    Ank_2; Ankyrin repeats (3 copies)

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049272.1 Alternate UMICH_Zoey_3.1

    Range
    62436034..62543942 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038492509.1 → XP_038348437.1  E3 ubiquitin-protein ligase HACE1 isoform X1

    Conserved Domains (4) summary
    COG0666
    Location:83 → 220
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00078
    Location:554 → 903
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    sd00045
    Location:97 → 128
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:34 → 126
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_038492512.1 → XP_038348440.1  E3 ubiquitin-protein ligase HACE1 isoform X4

    Conserved Domains (4) summary
    PLN03192
    Location:3 → 234
    PLN03192; Voltage-dependent potassium channel; Provisional
    cd00078
    Location:510 → 859
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    sd00045
    Location:66 → 95
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:69 → 179
    Ank_2; Ankyrin repeats (3 copies)

  3. XM_038492510.1 → XP_038348438.1  E3 ubiquitin-protein ligase HACE1 isoform X2

    Conserved Domains (4) summary
    COG0666
    Location:49 → 186
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00078
    Location:520 → 869
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    sd00045
    Location:63 → 94
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:4 → 92
    Ank_2; Ankyrin repeats (3 copies)

  4. XM_038492511.1 → XP_038348439.1  E3 ubiquitin-protein ligase HACE1 isoform X6

  5. XM_038492513.1 → XP_038348441.1  E3 ubiquitin-protein ligase HACE1 isoform X5

    Conserved Domains (2) summary
    cd00078
    Location:386 → 735
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cl39094
    Location:38 → 83
    Ank_2; Ankyrin repeats (3 copies)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049753.1 Alternate UNSW_CanFamBas_1.0

    Range
    62277683..62385051 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038618690.1 → XP_038474618.1  E3 ubiquitin-protein ligase HACE1 isoform X1

    Conserved Domains (4) summary
    COG0666
    Location:83 → 220
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00078
    Location:554 → 903
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    sd00045
    Location:97 → 128
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:34 → 126
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_038618693.1 → XP_038474621.1  E3 ubiquitin-protein ligase HACE1 isoform X4

    Conserved Domains (4) summary
    PLN03192
    Location:3 → 234
    PLN03192; Voltage-dependent potassium channel; Provisional
    cd00078
    Location:510 → 859
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    sd00045
    Location:66 → 95
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:69 → 179
    Ank_2; Ankyrin repeats (3 copies)

  3. XM_038618691.1 → XP_038474619.1  E3 ubiquitin-protein ligase HACE1 isoform X2

    Conserved Domains (4) summary
    COG0666
    Location:49 → 186
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00078
    Location:520 → 869
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    sd00045
    Location:63 → 94
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:4 → 92
    Ank_2; Ankyrin repeats (3 copies)

  4. XM_038618692.1 → XP_038474620.1  E3 ubiquitin-protein ligase HACE1 isoform X3

    Conserved Domains (4) summary
    cd00078
    Location:441 → 790
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    sd00045
    Location:17 → 48
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:4 → 38
    Ank_4; Ankyrin repeats (many copies)
    pfam12796
    Location:22 → 110
    Ank_2; Ankyrin repeats (3 copies)

  5. XM_038618694.1 → XP_038474622.1  E3 ubiquitin-protein ligase HACE1 isoform X5

    Conserved Domains (2) summary
    cd00078
    Location:386 → 735
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cl39094
    Location:38 → 83
    Ank_2; Ankyrin repeats (3 copies)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049233.1 Alternate UU_Cfam_GSD_1.0

    Range
    62555861..62663750 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038554813.1 → XP_038410741.1  E3 ubiquitin-protein ligase HACE1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KW65, A0A8C0R341, A0A8I3N5H0, A0A8P0T9I4
    Conserved Domains (4) summary
    COG0666
    Location:83 → 220
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00078
    Location:554 → 903
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    sd00045
    Location:97 → 128
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:34 → 126
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_038554816.1 → XP_038410744.1  E3 ubiquitin-protein ligase HACE1 isoform X4

    UniProtKB/TrEMBL
    A0A8C0KYR5, A0A8I3RV94, A0A8P0NVC4
    Conserved Domains (4) summary
    PLN03192
    Location:3 → 234
    PLN03192; Voltage-dependent potassium channel; Provisional
    cd00078
    Location:510 → 859
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    sd00045
    Location:66 → 95
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:69 → 179
    Ank_2; Ankyrin repeats (3 copies)

  3. XM_038554814.1 → XP_038410742.1  E3 ubiquitin-protein ligase HACE1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0R341
    Conserved Domains (4) summary
    COG0666
    Location:49 → 186
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00078
    Location:520 → 869
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    sd00045
    Location:63 → 94
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:4 → 92
    Ank_2; Ankyrin repeats (3 copies)

  4. XM_038554815.1 → XP_038410743.1  E3 ubiquitin-protein ligase HACE1 isoform X3

    UniProtKB/TrEMBL
    A0A8I3RV80
    Conserved Domains (4) summary
    cd00078
    Location:441 → 790
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    sd00045
    Location:17 → 48
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:4 → 38
    Ank_4; Ankyrin repeats (many copies)
    pfam12796
    Location:22 → 110
    Ank_2; Ankyrin repeats (3 copies)

  5. XM_038554817.1 → XP_038410745.1  E3 ubiquitin-protein ligase HACE1 isoform X5

    Conserved Domains (2) summary
    cd00078
    Location:386 → 735
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cl39094
    Location:38 → 83
    Ank_2; Ankyrin repeats (3 copies)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006594.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    62019271..62126625 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_849139.6 → XP_854232.1  E3 ubiquitin-protein ligase HACE1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KW65, A0A8C0R341, A0A8I3N5H0, A0A8P0T9I4
    Conserved Domains (4) summary
    COG0666
    Location:83 → 220
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00078
    Location:554 → 903
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    sd00045
    Location:97 → 128
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:34 → 126
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_005627667.4 → XP_005627724.1  E3 ubiquitin-protein ligase HACE1 isoform X4

    UniProtKB/TrEMBL
    A0A8C0KYR5, A0A8I3RV94, A0A8P0NVC4
    Conserved Domains (4) summary
    PLN03192
    Location:3 → 234
    PLN03192; Voltage-dependent potassium channel; Provisional
    cd00078
    Location:510 → 859
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    sd00045
    Location:66 → 95
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:69 → 179
    Ank_2; Ankyrin repeats (3 copies)

  3. XM_022426399.2 → XP_022282107.1  E3 ubiquitin-protein ligase HACE1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0R341
    Conserved Domains (4) summary
    COG0666
    Location:49 → 186
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00078
    Location:520 → 869
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    sd00045
    Location:63 → 94
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:4 → 92
    Ank_2; Ankyrin repeats (3 copies)

  4. XM_022426401.2 → XP_022282109.1  E3 ubiquitin-protein ligase HACE1 isoform X3

    UniProtKB/TrEMBL
    A0A8I3RV80
    Conserved Domains (4) summary
    cd00078
    Location:441 → 790
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    sd00045
    Location:17 → 48
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:4 → 38
    Ank_4; Ankyrin repeats (many copies)
    pfam12796
    Location:22 → 110
    Ank_2; Ankyrin repeats (3 copies)

  5. XM_022426403.2 → XP_022282111.1  E3 ubiquitin-protein ligase HACE1 isoform X5

    Conserved Domains (2) summary
    cd00078
    Location:386 → 735
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cl39094
    Location:38 → 83
    Ank_2; Ankyrin repeats (3 copies)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials