U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ADGRF5 adhesion G protein-coupled receptor F5 [ Canis lupus familiaris (dog) ]

Gene ID: 474926, updated on 25-Jul-2026
Official Symbol
ADGRF5provided by VGNC
Official Full Name
adhesion G protein-coupled receptor F5provided by VGNC
Primary source
VGNC:VGNC:37642
See related
Ensembl:ENSCAFG00845013357 RGD:12102480
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
GPR116
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See ADGRF5 in Genome Data Viewer
Location:
chromosome: 12
Exon count:
25
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 12 NC_051816.1 (15510094..15612365, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 12 NC_006594.4 (15045001..15147394, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 12 NC_049233.1 (15263867..15336692, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 12 NC_049272.1 (15024852..15127029, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 12 NC_049753.1 (15117916..15219946, complement)

Chromosome 12 - NC_051816.1Genomic Context describing neighboring genes Neighboring gene phospholipase A2 group VII Neighboring gene ankyrin repeat domain 66 Neighboring gene uncharacterized LOC119874174 Neighboring gene meprin A subunit alpha Neighboring gene adhesion G protein-coupled receptor F1 Neighboring gene TNF receptor superfamily member 21

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
adhesion G protein-coupled receptor F5
Names
G protein-coupled receptor 116

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051816.1 Reference ROS_Cfam_1.0

    Range
    15510094..15612365 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038683712.1 → XP_038539640.1  adhesion G protein-coupled receptor F5 isoform X1

    UniProtKB/TrEMBL
    A0A8I3NZU4
    Conserved Domains (6) summary
    smart00409
    Location:286 → 362
    IG; Immunoglobulin
    cd15254
    Location:1051 → 1325
    7tmB2_GPR116_Ig-Hepta; The immunoglobulin-repeat-containing receptor Ig-hepta/GPR116, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:994 → 1038
    GPS; GPCR proteolysis site, GPS, motif
    pfam13927
    Location:514 → 587
    Ig_3; Immunoglobulin domain
    cd00096
    Location:514 → 517
    Ig; Ig strand A [structural motif]
    cl02507
    Location:179 → 265
    SEA; SEA domain

  2. XM_038683713.1 → XP_038539641.1  adhesion G protein-coupled receptor F5 isoform X1

    UniProtKB/TrEMBL
    A0A8I3NZU4
    Conserved Domains (6) summary
    smart00409
    Location:286 → 362
    IG; Immunoglobulin
    cd15254
    Location:1051 → 1325
    7tmB2_GPR116_Ig-Hepta; The immunoglobulin-repeat-containing receptor Ig-hepta/GPR116, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:994 → 1038
    GPS; GPCR proteolysis site, GPS, motif
    pfam13927
    Location:514 → 587
    Ig_3; Immunoglobulin domain
    cd00096
    Location:514 → 517
    Ig; Ig strand A [structural motif]
    cl02507
    Location:179 → 265
    SEA; SEA domain

  3. XM_038683715.1 → XP_038539643.1  adhesion G protein-coupled receptor F5 isoform X3

    UniProtKB/TrEMBL
    A0A8I3NZU4
    Related
    ENSCAFP00845018789.1, ENSCAFT00845023921.1
    Conserved Domains (6) summary
    smart00410
    Location:286 → 362
    IG_like; Immunoglobulin like
    cd15254
    Location:1051 → 1325
    7tmB2_GPR116_Ig-Hepta; The immunoglobulin-repeat-containing receptor Ig-hepta/GPR116, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:994 → 1038
    GPS; GPCR proteolysis site, GPS, motif
    pfam13927
    Location:514 → 587
    Ig_3; Immunoglobulin domain
    cd00096
    Location:514 → 517
    Ig; Ig strand A [structural motif]
    cl02507
    Location:179 → 265
    SEA; SEA domain

  4. XM_038683711.1 → XP_038539639.1  adhesion G protein-coupled receptor F5 isoform X1

    UniProtKB/TrEMBL
    A0A8I3NZU4
    Conserved Domains (6) summary
    smart00409
    Location:286 → 362
    IG; Immunoglobulin
    cd15254
    Location:1051 → 1325
    7tmB2_GPR116_Ig-Hepta; The immunoglobulin-repeat-containing receptor Ig-hepta/GPR116, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:994 → 1038
    GPS; GPCR proteolysis site, GPS, motif
    pfam13927
    Location:514 → 587
    Ig_3; Immunoglobulin domain
    cd00096
    Location:514 → 517
    Ig; Ig strand A [structural motif]
    cl02507
    Location:179 → 265
    SEA; SEA domain

  5. XM_038683714.1 → XP_038539642.1  adhesion G protein-coupled receptor F5 isoform X2

    UniProtKB/TrEMBL
    A0A8I3NZU4
    Conserved Domains (6) summary
    smart00410
    Location:285 → 361
    IG_like; Immunoglobulin like
    cd15254
    Location:1050 → 1324
    7tmB2_GPR116_Ig-Hepta; The immunoglobulin-repeat-containing receptor Ig-hepta/GPR116, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:993 → 1037
    GPS; GPCR proteolysis site, GPS, motif
    pfam13927
    Location:513 → 586
    Ig_3; Immunoglobulin domain
    cd00096
    Location:513 → 516
    Ig; Ig strand A [structural motif]
    cl02507
    Location:178 → 264
    SEA; SEA domain

  6. XM_038683717.1 → XP_038539645.1  adhesion G protein-coupled receptor F5 isoform X5

    UniProtKB/TrEMBL
    A0A8C0KI53, A0A8I3RXI2, A0A8I3S016
    Related
    ENSCAFP00845018683.1, ENSCAFT00845023799.1
    Conserved Domains (6) summary
    smart00409
    Location:285 → 361
    IG; Immunoglobulin
    cd15254
    Location:1010 → 1284
    7tmB2_GPR116_Ig-Hepta; The immunoglobulin-repeat-containing receptor Ig-hepta/GPR116, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:953 → 997
    GPS; GPCR proteolysis site, GPS, motif
    pfam13927
    Location:473 → 546
    Ig_3; Immunoglobulin domain
    cd00096
    Location:473 → 476
    Ig; Ig strand A [structural motif]
    cl02507
    Location:178 → 264
    SEA; SEA domain

  7. XM_038683716.1 → XP_038539644.1  adhesion G protein-coupled receptor F5 isoform X4

    UniProtKB/TrEMBL
    A0A8I3RXI2
    Conserved Domains (6) summary
    smart00409
    Location:286 → 362
    IG; Immunoglobulin
    cd15254
    Location:1011 → 1285
    7tmB2_GPR116_Ig-Hepta; The immunoglobulin-repeat-containing receptor Ig-hepta/GPR116, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:954 → 998
    GPS; GPCR proteolysis site, GPS, motif
    pfam13927
    Location:474 → 547
    Ig_3; Immunoglobulin domain
    cd00096
    Location:474 → 477
    Ig; Ig strand A [structural motif]
    cl02507
    Location:179 → 265
    SEA; SEA domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049272.1 Alternate UMICH_Zoey_3.1

    Range
    15024852..15127029 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038491996.1 → XP_038347924.1  

    Conserved Domains (6) summary
    smart00409
    Location:286 → 362
    IG; Immunoglobulin
    cd15254
    Location:1051 → 1325
    7tmB2_GPR116_Ig-Hepta; The immunoglobulin-repeat-containing receptor Ig-hepta/GPR116, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:994 → 1038
    GPS; GPCR proteolysis site, GPS, motif
    pfam13927
    Location:514 → 587
    Ig_3; Immunoglobulin domain
    cd00096
    Location:514 → 517
    Ig; Ig strand A [structural motif]
    cl02507
    Location:179 → 265
    SEA; SEA domain

  2. XM_038491997.1 → XP_038347925.1  

    Conserved Domains (6) summary
    smart00409
    Location:286 → 362
    IG; Immunoglobulin
    cd15254
    Location:1051 → 1325
    7tmB2_GPR116_Ig-Hepta; The immunoglobulin-repeat-containing receptor Ig-hepta/GPR116, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:994 → 1038
    GPS; GPCR proteolysis site, GPS, motif
    pfam13927
    Location:514 → 587
    Ig_3; Immunoglobulin domain
    cd00096
    Location:514 → 517
    Ig; Ig strand A [structural motif]
    cl02507
    Location:179 → 265
    SEA; SEA domain

  3. XM_038491999.1 → XP_038347927.1  

    Conserved Domains (6) summary
    smart00410
    Location:286 → 362
    IG_like; Immunoglobulin like
    cd15254
    Location:1051 → 1325
    7tmB2_GPR116_Ig-Hepta; The immunoglobulin-repeat-containing receptor Ig-hepta/GPR116, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:994 → 1038
    GPS; GPCR proteolysis site, GPS, motif
    pfam13927
    Location:514 → 587
    Ig_3; Immunoglobulin domain
    cd00096
    Location:514 → 517
    Ig; Ig strand A [structural motif]
    cl02507
    Location:179 → 265
    SEA; SEA domain

  4. XM_038491998.1 → XP_038347926.1  

    Conserved Domains (6) summary
    smart00410
    Location:285 → 361
    IG_like; Immunoglobulin like
    cd15254
    Location:1050 → 1324
    7tmB2_GPR116_Ig-Hepta; The immunoglobulin-repeat-containing receptor Ig-hepta/GPR116, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:993 → 1037
    GPS; GPCR proteolysis site, GPS, motif
    pfam13927
    Location:513 → 586
    Ig_3; Immunoglobulin domain
    cd00096
    Location:513 → 516
    Ig; Ig strand A [structural motif]
    cl02507
    Location:178 → 264
    SEA; SEA domain

  5. XM_038491994.1 → XP_038347922.1  

    Conserved Domains (6) summary
    smart00409
    Location:286 → 362
    IG; Immunoglobulin
    cd15254
    Location:1051 → 1325
    7tmB2_GPR116_Ig-Hepta; The immunoglobulin-repeat-containing receptor Ig-hepta/GPR116, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:994 → 1038
    GPS; GPCR proteolysis site, GPS, motif
    pfam13927
    Location:514 → 587
    Ig_3; Immunoglobulin domain
    cd00096
    Location:514 → 517
    Ig; Ig strand A [structural motif]
    cl02507
    Location:179 → 265
    SEA; SEA domain

  6. XM_038492001.1 → XP_038347929.1  

    Conserved Domains (6) summary
    smart00409
    Location:285 → 361
    IG; Immunoglobulin
    cd15254
    Location:1010 → 1284
    7tmB2_GPR116_Ig-Hepta; The immunoglobulin-repeat-containing receptor Ig-hepta/GPR116, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:953 → 997
    GPS; GPCR proteolysis site, GPS, motif
    pfam13927
    Location:473 → 546
    Ig_3; Immunoglobulin domain
    cd00096
    Location:473 → 476
    Ig; Ig strand A [structural motif]
    cl02507
    Location:178 → 264
    SEA; SEA domain

  7. XM_038492000.1 → XP_038347928.1  

    Conserved Domains (6) summary
    smart00409
    Location:286 → 362
    IG; Immunoglobulin
    cd15254
    Location:1011 → 1285
    7tmB2_GPR116_Ig-Hepta; The immunoglobulin-repeat-containing receptor Ig-hepta/GPR116, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:954 → 998
    GPS; GPCR proteolysis site, GPS, motif
    pfam13927
    Location:474 → 547
    Ig_3; Immunoglobulin domain
    cd00096
    Location:474 → 477
    Ig; Ig strand A [structural motif]
    cl02507
    Location:179 → 265
    SEA; SEA domain

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049753.1 Alternate UNSW_CanFamBas_1.0

    Range
    15117916..15219946 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038618122.1 → XP_038474050.1  

  2. XM_038618123.1 → XP_038474051.1  

  3. XM_038618126.1 → XP_038474054.1  

  4. XM_038618125.1 → XP_038474053.1  

  5. XM_038618121.1 → XP_038474049.1  

  6. XM_038618128.1 → XP_038474056.1  

  7. XM_038618127.1 → XP_038474055.1  

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049233.1 Alternate UU_Cfam_GSD_1.0

    Range
    15263867..15336692 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038554260.1 → XP_038410188.1  adhesion G protein-coupled receptor F5 isoform X5

    UniProtKB/TrEMBL
    A0A8C0KI53, A0A8I3RXI2, A0A8I3S016
    Conserved Domains (6) summary
    smart00409
    Location:285 → 361
    IG; Immunoglobulin
    cd15254
    Location:1010 → 1284
    7tmB2_GPR116_Ig-Hepta; The immunoglobulin-repeat-containing receptor Ig-hepta/GPR116, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:953 → 997
    GPS; GPCR proteolysis site, GPS, motif
    pfam13927
    Location:473 → 546
    Ig_3; Immunoglobulin domain
    cd00096
    Location:473 → 476
    Ig; Ig strand A [structural motif]
    cl02507
    Location:178 → 264
    SEA; SEA domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006594.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    15045001..15147394 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005627442.4 → XP_005627499.1  adhesion G protein-coupled receptor F5 isoform X1

    See identical proteins and their annotated locations for XP_005627499.1

    UniProtKB/TrEMBL
    A0A8I3NZU4
    Conserved Domains (6) summary
    smart00409
    Location:286 → 362
    IG; Immunoglobulin
    cd15254
    Location:1051 → 1325
    7tmB2_GPR116_Ig-Hepta; The immunoglobulin-repeat-containing receptor Ig-hepta/GPR116, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:994 → 1038
    GPS; GPCR proteolysis site, GPS, motif
    pfam13927
    Location:514 → 587
    Ig_3; Immunoglobulin domain
    cd00096
    Location:514 → 517
    Ig; Ig strand A [structural motif]
    cl02507
    Location:179 → 265
    SEA; SEA domain

  2. XM_022426127.2 → XP_022281835.1  adhesion G protein-coupled receptor F5 isoform X1

    UniProtKB/TrEMBL
    A0A8I3NZU4
    Conserved Domains (6) summary
    smart00409
    Location:286 → 362
    IG; Immunoglobulin
    cd15254
    Location:1051 → 1325
    7tmB2_GPR116_Ig-Hepta; The immunoglobulin-repeat-containing receptor Ig-hepta/GPR116, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:994 → 1038
    GPS; GPCR proteolysis site, GPS, motif
    pfam13927
    Location:514 → 587
    Ig_3; Immunoglobulin domain
    cd00096
    Location:514 → 517
    Ig; Ig strand A [structural motif]
    cl02507
    Location:179 → 265
    SEA; SEA domain

  3. XM_005627444.4 → XP_005627501.1  adhesion G protein-coupled receptor F5 isoform X3

    UniProtKB/TrEMBL
    A0A8I3NZU4
    Conserved Domains (6) summary
    smart00410
    Location:286 → 362
    IG_like; Immunoglobulin like
    cd15254
    Location:1051 → 1325
    7tmB2_GPR116_Ig-Hepta; The immunoglobulin-repeat-containing receptor Ig-hepta/GPR116, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:994 → 1038
    GPS; GPCR proteolysis site, GPS, motif
    pfam13927
    Location:514 → 587
    Ig_3; Immunoglobulin domain
    cd00096
    Location:514 → 517
    Ig; Ig strand A [structural motif]
    cl02507
    Location:179 → 265
    SEA; SEA domain

  4. XM_005627443.4 → XP_005627500.1  adhesion G protein-coupled receptor F5 isoform X2

    UniProtKB/TrEMBL
    A0A8I3NZU4
    Conserved Domains (6) summary
    smart00410
    Location:285 → 361
    IG_like; Immunoglobulin like
    cd15254
    Location:1050 → 1324
    7tmB2_GPR116_Ig-Hepta; The immunoglobulin-repeat-containing receptor Ig-hepta/GPR116, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:993 → 1037
    GPS; GPCR proteolysis site, GPS, motif
    pfam13927
    Location:513 → 586
    Ig_3; Immunoglobulin domain
    cd00096
    Location:513 → 516
    Ig; Ig strand A [structural motif]
    cl02507
    Location:178 → 264
    SEA; SEA domain

  5. XM_005627441.4 → XP_005627498.1  adhesion G protein-coupled receptor F5 isoform X1

    See identical proteins and their annotated locations for XP_005627498.1

    UniProtKB/TrEMBL
    A0A8I3NZU4
    Conserved Domains (6) summary
    smart00409
    Location:286 → 362
    IG; Immunoglobulin
    cd15254
    Location:1051 → 1325
    7tmB2_GPR116_Ig-Hepta; The immunoglobulin-repeat-containing receptor Ig-hepta/GPR116, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:994 → 1038
    GPS; GPCR proteolysis site, GPS, motif
    pfam13927
    Location:514 → 587
    Ig_3; Immunoglobulin domain
    cd00096
    Location:514 → 517
    Ig; Ig strand A [structural motif]
    cl02507
    Location:179 → 265
    SEA; SEA domain

  6. XM_005627445.4 → XP_005627502.1  adhesion G protein-coupled receptor F5 isoform X4

    UniProtKB/TrEMBL
    A0A8I3RXI2
    Conserved Domains (6) summary
    smart00409
    Location:286 → 362
    IG; Immunoglobulin
    cd15254
    Location:1011 → 1285
    7tmB2_GPR116_Ig-Hepta; The immunoglobulin-repeat-containing receptor Ig-hepta/GPR116, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:954 → 998
    GPS; GPCR proteolysis site, GPS, motif
    pfam13927
    Location:474 → 547
    Ig_3; Immunoglobulin domain
    cd00096
    Location:474 → 477
    Ig; Ig strand A [structural motif]
    cl02507
    Location:179 → 265
    SEA; SEA domain

  7. XM_532160.7 → XP_532160.3  adhesion G protein-coupled receptor F5 isoform X5

    UniProtKB/TrEMBL
    A0A8C0KI53, A0A8I3RXI2, A0A8I3S016
    Conserved Domains (6) summary
    smart00409
    Location:285 → 361
    IG; Immunoglobulin
    cd15254
    Location:1010 → 1284
    7tmB2_GPR116_Ig-Hepta; The immunoglobulin-repeat-containing receptor Ig-hepta/GPR116, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:953 → 997
    GPS; GPCR proteolysis site, GPS, motif
    pfam13927
    Location:473 → 546
    Ig_3; Immunoglobulin domain
    cd00096
    Location:473 → 476
    Ig; Ig strand A [structural motif]
    cl02507
    Location:178 → 264
    SEA; SEA domain
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials