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PREPL prolyl endopeptidase like [ Canis lupus familiaris (dog) ]

Gene ID: 474574, updated on 25-Jul-2026
Official Symbol
PREPLprovided by VGNC
Official Full Name
prolyl endopeptidase likeprovided by VGNC
Primary source
VGNC:VGNC:44961
See related
Ensembl:ENSCAFG00845026670 RGD:12435585
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
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See PREPL in Genome Data Viewer
Location:
chromosome: 10
Exon count:
16
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 10 NC_051814.1 (47613473..47672368, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 10 NC_006592.4 (46595349..46654047, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 10 NC_049231.1 (47794300..47853142, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 10 NC_049270.1 (47320610..47379420, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 10 NC_049751.1 (47611662..47670468, complement)

Chromosome 10 - NC_051814.1Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S19-like Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent 1B Neighboring gene solute carrier family 3 member 1 Neighboring gene calmodulin-lysine N-methyltransferase Neighboring gene uncharacterized LOC111097845

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
prolyl endopeptidase-like

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051814.1 Reference ROS_Cfam_1.0

    Range
    47613473..47672368 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038680459.1 → XP_038536387.1  prolyl endopeptidase-like isoform X3

    UniProtKB/TrEMBL
    A0A8I3PT30
    Conserved Domains (1) summary
    COG1770
    Location:93 → 644
    PtrB; Protease II [Amino acid transport and metabolism]

  2. XM_038680460.1 → XP_038536388.1  prolyl endopeptidase-like isoform X4

    UniProtKB/TrEMBL
    A0A8I3PQA0, A0A8I3PT30
    Related
    ENSCAFP00845036899.1, ENSCAFT00845047021.1
    Conserved Domains (1) summary
    COG1770
    Location:26 → 578
    PtrB; Protease II [Amino acid transport and metabolism]

  3. XM_038680458.1 → XP_038536386.1  prolyl endopeptidase-like isoform X2

    UniProtKB/TrEMBL
    A0A8I3PT30
    Conserved Domains (1) summary
    COG1770
    Location:93 → 645
    PtrB; Protease II [Amino acid transport and metabolism]

  4. XM_038680461.1 → XP_038536389.1  prolyl endopeptidase-like isoform X4

    UniProtKB/TrEMBL
    A0A8I3PQA0, A0A8I3PT30
    Conserved Domains (1) summary
    COG1770
    Location:26 → 578
    PtrB; Protease II [Amino acid transport and metabolism]

  5. XM_038680457.1 → XP_038536385.1  prolyl endopeptidase-like isoform X1

    UniProtKB/TrEMBL
    A0A8C0LKI7, A0A8I3PT30, A0A8I3PTZ6
    Related
    ENSCAFP00845037005.1, ENSCAFT00845047157.1
    Conserved Domains (1) summary
    COG1770
    Location:115 → 667
    PtrB; Protease II [Amino acid transport and metabolism]

RNA

  1. XR_005433624.1 RNA Sequence

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049270.1 Alternate UMICH_Zoey_3.1

    Range
    47320610..47379420 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038489173.1 → XP_038345101.1  

    Conserved Domains (1) summary
    COG1770
    Location:93 → 644
    PtrB; Protease II [Amino acid transport and metabolism]

  2. XM_038489174.1 → XP_038345102.1  

    Conserved Domains (1) summary
    COG1770
    Location:26 → 578
    PtrB; Protease II [Amino acid transport and metabolism]

  3. XM_038489172.1 → XP_038345100.1  

    Conserved Domains (1) summary
    COG1770
    Location:93 → 645
    PtrB; Protease II [Amino acid transport and metabolism]

  4. XM_038489175.1 → XP_038345103.1  

    Conserved Domains (1) summary
    COG1770
    Location:26 → 578
    PtrB; Protease II [Amino acid transport and metabolism]

  5. XM_038489170.1 → XP_038345098.1  

    Conserved Domains (1) summary
    COG1770
    Location:115 → 667
    PtrB; Protease II [Amino acid transport and metabolism]

RNA

  1. XR_005332169.1 RNA Sequence

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049751.1 Alternate UNSW_CanFamBas_1.0

    Range
    47611662..47670468 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038615074.1 → XP_038471002.1  

    Conserved Domains (1) summary
    COG1770
    Location:93 → 644
    PtrB; Protease II [Amino acid transport and metabolism]

  2. XM_038615075.1 → XP_038471003.1  

    Conserved Domains (1) summary
    COG1770
    Location:26 → 578
    PtrB; Protease II [Amino acid transport and metabolism]

  3. XM_038615073.1 → XP_038471001.1  

    Conserved Domains (1) summary
    COG1770
    Location:93 → 645
    PtrB; Protease II [Amino acid transport and metabolism]

  4. XM_038615076.1 → XP_038471004.1  

    Conserved Domains (1) summary
    COG1770
    Location:26 → 578
    PtrB; Protease II [Amino acid transport and metabolism]

  5. XM_038615072.1 → XP_038471000.1  

    Conserved Domains (1) summary
    COG1770
    Location:115 → 667
    PtrB; Protease II [Amino acid transport and metabolism]

RNA

  1. XR_005400260.1 RNA Sequence

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049231.1 Alternate UU_Cfam_GSD_1.0

    Range
    47794300..47853142 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038551174.1 → XP_038407102.1  prolyl endopeptidase-like isoform X3

    UniProtKB/TrEMBL
    A0A8I3PT30
    Conserved Domains (1) summary
    COG1770
    Location:93 → 644
    PtrB; Protease II [Amino acid transport and metabolism]

  2. XM_038551175.1 → XP_038407103.1  prolyl endopeptidase-like isoform X4

    UniProtKB/TrEMBL
    A0A8I3PQA0, A0A8I3PT30
    Conserved Domains (1) summary
    COG1770
    Location:26 → 578
    PtrB; Protease II [Amino acid transport and metabolism]

  3. XM_038551173.1 → XP_038407101.1  prolyl endopeptidase-like isoform X2

    UniProtKB/TrEMBL
    A0A8I3PT30
    Conserved Domains (1) summary
    COG1770
    Location:93 → 645
    PtrB; Protease II [Amino acid transport and metabolism]

  4. XM_038551176.1 → XP_038407104.1  prolyl endopeptidase-like isoform X4

    UniProtKB/TrEMBL
    A0A8I3PQA0, A0A8I3PT30
    Conserved Domains (1) summary
    COG1770
    Location:26 → 578
    PtrB; Protease II [Amino acid transport and metabolism]

  5. XM_038551170.1 → XP_038407098.1  prolyl endopeptidase-like isoform X1

    UniProtKB/TrEMBL
    A0A8C0LKI7, A0A8I3PT30, A0A8I3PTZ6
    Conserved Domains (1) summary
    COG1770
    Location:115 → 667
    PtrB; Protease II [Amino acid transport and metabolism]

RNA

  1. XR_005365819.1 RNA Sequence

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006592.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    46595349..46654047 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_014117507.3 → XP_013972982.1  prolyl endopeptidase-like isoform X3

    UniProtKB/TrEMBL
    A0A8I3PT30
    Conserved Domains (1) summary
    COG1770
    Location:93 → 644
    PtrB; Protease II [Amino acid transport and metabolism]

  2. XM_005626076.4 → XP_005626133.1  prolyl endopeptidase-like isoform X4

    UniProtKB/TrEMBL
    A0A8I3PQA0, A0A8I3PT30
    Conserved Domains (1) summary
    COG1770
    Location:26 → 578
    PtrB; Protease II [Amino acid transport and metabolism]

  3. XM_859349.6 → XP_864442.3  prolyl endopeptidase-like isoform X2

    UniProtKB/TrEMBL
    A0A8I3PT30
    Conserved Domains (1) summary
    COG1770
    Location:93 → 645
    PtrB; Protease II [Amino acid transport and metabolism]

  4. XM_038646275.1 → XP_038502203.1  prolyl endopeptidase-like isoform X4

    UniProtKB/TrEMBL
    A0A8I3PQA0, A0A8I3PT30
    Conserved Domains (1) summary
    COG1770
    Location:26 → 578
    PtrB; Protease II [Amino acid transport and metabolism]

  5. XM_014117506.3 → XP_013972981.1  prolyl endopeptidase-like isoform X1

    UniProtKB/TrEMBL
    A0A8C0LKI7, A0A8I3PT30, A0A8I3PTZ6
    Conserved Domains (1) summary
    COG1770
    Location:115 → 667
    PtrB; Protease II [Amino acid transport and metabolism]

RNA

  1. XR_001317130.3 RNA Sequence

Nucleotide Protein
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