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H2AB1 H2A.B variant histone 1 [ Homo sapiens (human) ]

Gene ID: 474382, updated on 25-Nov-2021

Summary

Official Symbol
H2AB1provided by HGNC
Official Full Name
H2A.B variant histone 1provided by HGNC
Primary source
HGNC:HGNC:22516
See related
Ensembl:ENSG00000274183 MIM:301037
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H2A.B; H2AFB1; H2A.Bbd
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. This gene is part of a region that is repeated three times on chromosome X, once in intron 22 of the F8 gene and twice closer to the Xq telomere. This record represents the most centromeric copy which is in intron 22 of the F8 gene. [provided by RefSeq, Oct 2015]
Orthologs
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Genomic context

See H2AB1 in Genome Data Viewer
Location:
Xq28
Exon count:
1
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (154884972..154885558)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (154113247..154113833)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 37 Neighboring gene small integral membrane protein 9 Neighboring gene coagulation factor VIII Neighboring gene int22h-1 recombination region Neighboring gene microRNA 1184-1 Neighboring gene coagulation factor VIII associated 1 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 31

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in mRNA processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nucleosome assembly IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of nucleosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus HDA PubMed 
located_in transcriptionally active chromatin IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
histone H2A-Bbd type 1
Names
H2A Barr body-deficient
H2A histone family member B1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017990.2NP_001017990.1  histone H2A-Bbd type 1

    See identical proteins and their annotated locations for NP_001017990.1

    Status: REVIEWED

    Source sequence(s)
    BX842559
    Consensus CDS
    CCDS35458.1
    UniProtKB/Swiss-Prot
    P0C5Y9
    Related
    ENSP00000484261.2, ENST00000620016.2
    Conserved Domains (2) summary
    smart00414
    Location:21113
    H2A; Histone 2A
    cl23907
    Location:21112
    H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    154884972..154885558
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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