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GIMAP6 GTPase, IMAP family member 6 [ Homo sapiens (human) ]

Gene ID: 474344, updated on 1-Jun-2020

Summary

Official Symbol
GIMAP6provided by HGNC
Official Full Name
GTPase, IMAP family member 6provided by HGNC
Primary source
HGNC:HGNC:21918
See related
Ensembl:ENSG00000133561 MIM:616960
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IAN2; IAN6; IAN-2; IAN-6
Summary
This gene encodes a member of the GTPases of immunity-associated proteins (GIMAP) family. GIMAP proteins contain GTP-binding and coiled-coil motifs, and may play roles in the regulation of cell survival. Decreased expression of this gene may play a role in non-small cell lung cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, which is found in a cluster with seven additional GIMAP genes on the long arm of chromosome 7. [provided by RefSeq, Sep 2011]
Expression
Broad expression in spleen (RPKM 29.7), lymph node (RPKM 22.3) and 23 other tissues See more
Orthologs

Genomic context

See GIMAP6 in Genome Data Viewer
Location:
7q36.1
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (150625375..150632648, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (150322463..150329736, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 2A pseudogene 2 Neighboring gene transient receptor potential cation channel subfamily C member 6 pseudogene Neighboring gene eukaryotic translation initiation factor 2A pseudogene 3 Neighboring gene GTPase, IMAP family member 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif downregulates the expression of GTPase, IMAP family member 6 (GIMAP6) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22690, DKFZp686A01175

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
GTPase IMAP family member 6
Names
immune associated nucleotide 2
immune associated nucleotide 6
immune-associated nucleotide-binding protein 6

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001244071.2NP_001231000.1  GTPase IMAP family member 6 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC060760, DA582331
    Consensus CDS
    CCDS59087.1
    UniProtKB/Swiss-Prot
    Q6P9H5
    Related
    ENSP00000418304.1, ENST00000493969.2
  2. NM_001244072.1NP_001231001.1  GTPase IMAP family member 6 isoform 2

    See identical proteins and their annotated locations for NP_001231001.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is longer than isoform 1.
    Source sequence(s)
    AK294989, BC060760, DC384795
    Consensus CDS
    CCDS75676.1
    UniProtKB/Swiss-Prot
    Q6P9H5
    UniProtKB/TrEMBL
    B4DH95
    Related
    ENSP00000479580.1, ENST00000618759.4
    Conserved Domains (1) summary
    cd01852
    Location:111311
    AIG1; AvrRpt2-Induced Gene 1 (AIG1)
  3. NM_024711.6NP_078987.3  GTPase IMAP family member 6 isoform 1

    See identical proteins and their annotated locations for NP_078987.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    BC060760, CR749355
    Consensus CDS
    CCDS34778.1
    UniProtKB/Swiss-Prot
    Q6P9H5
    UniProtKB/TrEMBL
    A0A090N7V4
    Related
    ENSP00000330374.5, ENST00000328902.9
    Conserved Domains (1) summary
    cd01852
    Location:41241
    AIG1; AvrRpt2-Induced Gene 1 (AIG1)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    150625375..150632648 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001007224.1: Suppressed sequence

    Description
    NM_001007224.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
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