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SPIN2B spindlin family member 2B [ Homo sapiens (human) ]

Gene ID: 474343, updated on 9-Aug-2026
Official Symbol
SPIN2Bprovided by HGNC
Official Full Name
spindlin family member 2Bprovided by HGNC
Primary source
HGNC:HGNC:33147
See related
Ensembl:ENSG00000186787 MIM:300517; AllianceGenome:HGNC:33147
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPIN-2; TDRD26; SPIN-2B; dJ323P24.2; SPIN2_duplicate
Summary
Enables methylated histone binding activity. Predicted to be involved in regulation of DNA-templated transcription. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]
Expression
Ubiquitous expression in prostate (RPKM 2.6), brain (RPKM 2.6) and 25 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See SPIN2B in Genome Data Viewer
Location:
Xp11.21
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (57119682..57121548, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (56418555..56420421, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (57146115..57147981, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29701 Neighboring gene spindlin family member 3 Neighboring gene SPIN2 family pseudogene 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chrX:57143727-57144926 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20870 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:57168413-57168642 Neighboring gene fatty acid amide hydrolase 2 Neighboring gene spindlin family member 2A Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:57203412-57203990 Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 11 pseudogene 2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Functional cloning of SPIN-2, a nuclear anti-apoptotic protein with roles in cell cycle progression. Fletcher BS, et al. Leukemia, 2002 Aug. PMID 12145692
  2. Blocking the Wnt pathway, a unifying mechanism for an angiogenic inhibitor in the serine proteinase inhibitor family. Zhang B, et al. Proc Natl Acad Sci U S A, 2010 Apr 13. PMID 20351274, Free PMC Article
  3. A transcriptional coregulator, SPIN·DOC, attenuates the coactivator activity of Spindlin1. Bae N, et al. J Biol Chem, 2017 Dec 22. PMID 29061846, Free PMC Article
  4. Gain-of-Function MN1 Truncation Variants Cause a Recognizable Syndrome with Craniofacial and Brain Abnormalities. Miyake N, et al. Am J Hum Genet, 2020 Jan 2. PMID 31839203, Free PMC Article
  5. Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. Adams MD, et al. Nature, 1995 Sep 28. PMID 7566098

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SERPINA3K is a high-affinity, endogenous antagonist of LRP6
    Title: Blocking the Wnt pathway, a unifying mechanism for an angiogenic inhibitor in the serine proteinase inhibitor family.
Submit: New GeneRIF Correction

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables histone H3K4me3 reader activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H3K4me3 reader activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H3K4me3 reader activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in gamete generation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
spindlin-2B
Names
spindlin family, member 2 duplicate
spindlin-like protein 2B
telomeric SPIN2 copy

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006681.2 → NP_001006682.1  spindlin-2B isoform 1

    See identical proteins and their annotated locations for NP_001006682.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AL022157, BC071974, BQ221120
    Consensus CDS
    CCDS35311.1
    UniProtKB/Swiss-Prot
    Q7Z2M0, Q9BPZ2
    UniProtKB/TrEMBL
    Q5JZB8
    Related
    ENSP00000404314.2, ENST00000434397.3
    Conserved Domains (1) summary
    pfam02513
    Location:50 → 98
    Spin-Ssty; Spin/Ssty Family

  2. NM_001006682.2 → NP_001006683.1  spindlin-2B isoform 1

    See identical proteins and their annotated locations for NP_001006683.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate internal segment in the 5' UTR, as compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AL022157, BC000044, BQ221120
    Consensus CDS
    CCDS35311.1
    UniProtKB/Swiss-Prot
    Q7Z2M0, Q9BPZ2
    UniProtKB/TrEMBL
    Q5JZB8
    Related
    ENSP00000275988.5, ENST00000275988.6
    Conserved Domains (1) summary
    pfam02513
    Location:50 → 98
    Spin-Ssty; Spin/Ssty Family

  3. NM_001006683.2 → NP_001006684.1  spindlin-2B isoform 1

    See identical proteins and their annotated locations for NP_001006684.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an internal segment in the 5' UTR, as compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AF356353, AL022157, BQ221120
    Consensus CDS
    CCDS35311.1
    UniProtKB/Swiss-Prot
    Q7Z2M0, Q9BPZ2
    UniProtKB/TrEMBL
    Q5JZB8
    Related
    ENSP00000537936.1, ENST00000867877.2
    Conserved Domains (1) summary
    pfam02513
    Location:50 → 98
    Spin-Ssty; Spin/Ssty Family

  4. NM_001282461.2 → NP_001269390.1  spindlin-2B isoform 2

    See identical proteins and their annotated locations for NP_001269390.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks a segment in the central coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 4 and 5 encode the same isoform (2).
    Source sequence(s)
    AA319190, AL022157
    Consensus CDS
    CCDS65274.1
    UniProtKB/TrEMBL
    Q5JZB7
    Related
    ENSP00000364045.3, ENST00000374910.4
    Conserved Domains (1) summary
    pfam02513
    Location:109 → 153
    Spin-Ssty; Spin/Ssty Family

  5. NM_001282462.2 → NP_001269391.1  spindlin-2B isoform 2

    See identical proteins and their annotated locations for NP_001269391.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and lacks a segment in the central coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 4 and 5 encode the same isoform (2).
    Source sequence(s)
    AL022157, BX953266
    Consensus CDS
    CCDS65274.1
    UniProtKB/TrEMBL
    Q5JZB7
    Conserved Domains (1) summary
    pfam02513
    Location:109 → 153
    Spin-Ssty; Spin/Ssty Family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    57119682..57121548 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047442139.1 → XP_047298095.1  spindlin-2B isoform X5

    UniProtKB/TrEMBL
    Q5JZB7

  2. XM_011530788.4 → XP_011529090.1  spindlin-2B isoform X3

    See identical proteins and their annotated locations for XP_011529090.1

    UniProtKB/Swiss-Prot
    Q7Z2M0, Q9BPZ2
    UniProtKB/TrEMBL
    Q5JZB8
    Related
    ENSP00000537934.1, ENST00000867875.2
    Conserved Domains (1) summary
    pfam02513
    Location:50 → 98
    Spin-Ssty; Spin/Ssty Family

  3. XM_017029552.3 → XP_016885041.1  spindlin-2B isoform X3

    UniProtKB/Swiss-Prot
    Q7Z2M0, Q9BPZ2
    UniProtKB/TrEMBL
    Q5JZB8
    Related
    ENSP00000537938.1, ENST00000867879.2
    Conserved Domains (1) summary
    pfam02513
    Location:50 → 98
    Spin-Ssty; Spin/Ssty Family

  4. XM_005262010.3 → XP_005262067.1  spindlin-2B isoform X3

    See identical proteins and their annotated locations for XP_005262067.1

    UniProtKB/Swiss-Prot
    Q7Z2M0, Q9BPZ2
    UniProtKB/TrEMBL
    Q5JZB8
    Conserved Domains (1) summary
    pfam02513
    Location:50 → 98
    Spin-Ssty; Spin/Ssty Family

  5. XM_005262009.6 → XP_005262066.3  spindlin-2B isoform X2

    UniProtKB/TrEMBL
    Q5JZB8

  6. XM_005262008.6 → XP_005262065.3  spindlin-2B isoform X1

    UniProtKB/TrEMBL
    Q5JZB8
    Conserved Domains (1) summary
    pfam02513
    Location:96 → 144
    Spin-Ssty; Spin/Ssty Family

  7. XM_047442138.1 → XP_047298094.1  spindlin-2B isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    56418555..56420421 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054327123.1 → XP_054183098.1  spindlin-2B isoform X2

    UniProtKB/TrEMBL
    Q5JZB8

  2. XM_054327125.1 → XP_054183100.1  spindlin-2B isoform X3

    UniProtKB/Swiss-Prot
    Q7Z2M0, Q9BPZ2
    UniProtKB/TrEMBL
    Q5JZB8

  3. XM_054327124.1 → XP_054183099.1  spindlin-2B isoform X3

    UniProtKB/Swiss-Prot
    Q7Z2M0, Q9BPZ2
    UniProtKB/TrEMBL
    Q5JZB8

  4. XM_054327128.1 → XP_054183103.1  spindlin-2B isoform X5

    UniProtKB/TrEMBL
    Q5JZB7

  5. XM_054327122.1 → XP_054183097.1  spindlin-2B isoform X1

    UniProtKB/TrEMBL
    Q5JZB8

  6. XM_054327126.1 → XP_054183101.1  spindlin-2B isoform X3

    UniProtKB/Swiss-Prot
    Q7Z2M0, Q9BPZ2
    UniProtKB/TrEMBL
    Q5JZB8

  7. XM_054327127.1 → XP_054183102.1  spindlin-2B isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BPZ2.1 GenPept UniProtKB/Swiss-Prot:Q9BPZ2

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