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SPIN2B spindlin family member 2B [ Homo sapiens (human) ]

Gene ID: 474343, updated on 23-Nov-2021

Summary

Official Symbol
SPIN2Bprovided by HGNC
Official Full Name
spindlin family member 2Bprovided by HGNC
Primary source
HGNC:HGNC:33147
See related
Ensembl:ENSG00000186787 MIM:300517
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPIN-2; TDRD26; SPIN-2B; dJ323P24.2; SPIN2_duplicate
Expression
Ubiquitous expression in prostate (RPKM 2.6), brain (RPKM 2.6) and 25 other tissues See more
Orthologs
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Genomic context

See SPIN2B in Genome Data Viewer
Location:
Xp11.21
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (57112142..57121905, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (57146115..57147981, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene spindlin family member 3 Neighboring gene SPIN2 family pseudogene 1 Neighboring gene fatty acid amide hydrolase 2 Neighboring gene spindlin family member 2A Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 11 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables methylated histone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in gamete generation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
spindlin-2B
Names
spindlin family, member 2 duplicate
spindlin-like protein 2B
telomeric SPIN2 copy

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006681.2NP_001006682.1  spindlin-2B isoform 1

    See identical proteins and their annotated locations for NP_001006682.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AL022157, BC071974, BQ221120
    Consensus CDS
    CCDS35311.1
    UniProtKB/Swiss-Prot
    Q9BPZ2
    UniProtKB/TrEMBL
    A0A024R9Y9
    Related
    ENSP00000404314.2, ENST00000434397.3
    Conserved Domains (1) summary
    pfam02513
    Location:5098
    Spin-Ssty; Spin/Ssty Family
  2. NM_001006682.2NP_001006683.1  spindlin-2B isoform 1

    See identical proteins and their annotated locations for NP_001006683.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate internal segment in the 5' UTR, as compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AL022157, BC000044, BQ221120
    Consensus CDS
    CCDS35311.1
    UniProtKB/Swiss-Prot
    Q9BPZ2
    UniProtKB/TrEMBL
    A0A024R9Y9
    Related
    ENSP00000275988.5, ENST00000275988.5
    Conserved Domains (1) summary
    pfam02513
    Location:5098
    Spin-Ssty; Spin/Ssty Family
  3. NM_001006683.2NP_001006684.1  spindlin-2B isoform 1

    See identical proteins and their annotated locations for NP_001006684.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an internal segment in the 5' UTR, as compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AF356353, AL022157, BQ221120
    Consensus CDS
    CCDS35311.1
    UniProtKB/Swiss-Prot
    Q9BPZ2
    UniProtKB/TrEMBL
    A0A024R9Y9
    Conserved Domains (1) summary
    pfam02513
    Location:5098
    Spin-Ssty; Spin/Ssty Family
  4. NM_001282461.2NP_001269390.1  spindlin-2B isoform 2

    See identical proteins and their annotated locations for NP_001269390.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks a segment in the central coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 4 and 5 encode the same isoform (2).
    Source sequence(s)
    AA319190, AL022157
    Consensus CDS
    CCDS65274.1
    UniProtKB/TrEMBL
    Q5JZB7
    Related
    ENSP00000364045.3, ENST00000374910.3
    Conserved Domains (1) summary
    pfam02513
    Location:109153
    Spin-Ssty; Spin/Ssty Family
  5. NM_001282462.2NP_001269391.1  spindlin-2B isoform 2

    See identical proteins and their annotated locations for NP_001269391.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and lacks a segment in the central coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 4 and 5 encode the same isoform (2).
    Source sequence(s)
    AL022157, BX953266
    Consensus CDS
    CCDS65274.1
    UniProtKB/TrEMBL
    Q5JZB7
    Conserved Domains (1) summary
    pfam02513
    Location:109153
    Spin-Ssty; Spin/Ssty Family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    57112142..57121905 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530789.2XP_011529091.1  spindlin-2B isoform X3

    See identical proteins and their annotated locations for XP_011529091.1

    UniProtKB/TrEMBL
    Q5JZB7
    Conserved Domains (1) summary
    pfam02513
    Location:109153
    Spin-Ssty; Spin/Ssty Family
  2. XM_011530788.3XP_011529090.1  spindlin-2B isoform X1

    See identical proteins and their annotated locations for XP_011529090.1

    UniProtKB/Swiss-Prot
    Q9BPZ2
    UniProtKB/TrEMBL
    A0A024R9Y9
    Conserved Domains (1) summary
    pfam02513
    Location:5098
    Spin-Ssty; Spin/Ssty Family
  3. XM_017029552.2XP_016885041.1  spindlin-2B isoform X1

    UniProtKB/Swiss-Prot
    Q9BPZ2
    UniProtKB/TrEMBL
    A0A024R9Y9
    Conserved Domains (1) summary
    pfam02513
    Location:5098
    Spin-Ssty; Spin/Ssty Family
  4. XM_005262010.2XP_005262067.1  spindlin-2B isoform X1

    See identical proteins and their annotated locations for XP_005262067.1

    UniProtKB/Swiss-Prot
    Q9BPZ2
    UniProtKB/TrEMBL
    A0A024R9Y9
    Conserved Domains (1) summary
    pfam02513
    Location:5098
    Spin-Ssty; Spin/Ssty Family
  5. XM_005262008.5XP_005262065.3  spindlin-2B isoform X2

    Conserved Domains (1) summary
    pfam02513
    Location:96144
    Spin-Ssty; Spin/Ssty Family
  6. XM_005262009.5XP_005262066.2  spindlin-2B isoform X1

    UniProtKB/Swiss-Prot
    Q9BPZ2
    UniProtKB/TrEMBL
    A0A024R9Y9
    Conserved Domains (1) summary
    pfam02513
    Location:5098
    Spin-Ssty; Spin/Ssty Family

RNA

  1. XR_001755692.1 RNA Sequence

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