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dolpp1 dolichyldiphosphatase 1 [ Danio rerio (zebrafish) ]

Gene ID: 474331, updated on 4-Jan-2025

Summary

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Official Symbol
dolpp1provided by ZNC
Official Full Name
dolichyldiphosphatase 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-041024-11
See related
Ensembl:ENSDARG00000036915 AllianceGenome:ZFIN:ZDB-GENE-041024-11
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:101585
Summary
Predicted to enable dolichyldiphosphatase activity. Predicted to be involved in protein N-linked glycosylation. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human DOLPP1 (dolichyldiphosphatase 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See dolpp1 in Genome Data Viewer
Location:
chromosome: 21
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (3897680..3918450)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (3733061..3753831)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 Neighboring gene mitoguardin 2 Neighboring gene senataxin Neighboring gene netrin g2b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. trappc11 is required for protein glycosylation in zebrafish and humans. DeRossi C, et al. Mol Biol Cell, 2016 Apr 15. PMID 26912795, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables dolichyldiphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dolichyldiphosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dolichyldiphosphatase 1
Names
dolichyl pyrophosphate phosphatase 1
NP_001007062.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007061.1 → NP_001007062.1  dolichyldiphosphatase 1

    See identical proteins and their annotated locations for NP_001007062.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083210
    UniProtKB/TrEMBL
    Q5XJT5
    Related
    ENSDARP00000133381.1, ENSDART00000170653.3
    Conserved Domains (2) summary
    COG0671
    Location:32 → 183
    PgpB; Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]
    cd03382
    Location:16 → 179
    PAP2_dolichyldiphosphatase; PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a membrane-associated protein located in the endoplasmic reticulum and hydrolyzes dolichyl pyrophosphate, as well as dolichylmonophosphate at a low rate. The enzyme is ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    3897680..3918450
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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