U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

dpf2 double PHD fingers 2 [ Danio rerio (zebrafish) ]

Gene ID: 474324, updated on 9-Sep-2025
Official Symbol
dpf2provided by ZNC
Official Full Name
double PHD fingers 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-041024-2
See related
Ensembl:ENSDARG00000012219 AllianceGenome:ZFIN:ZDB-GENE-041024-2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
im:7146797; zgc:101789
Summary
Predicted to enable metal ion binding activity. Predicted to be involved in nervous system development. Predicted to be located in cytoplasm and nucleus. Predicted to be part of nBAF complex. Is expressed in brain; epiphysis; and spinal cord. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 7. Orthologous to human DPF2 (double PHD fingers 2). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table
See dpf2 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 5 NC_133180.1 (38647590..38662852)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 5 NC_007116.7 (37744635..37759853)

Chromosome 5 - NC_133180.1Genomic Context describing neighboring genes Neighboring gene spectrin, beta, non-erythrocytic 2 Neighboring gene CDC42 effector protein (Rho GTPase binding) 2 Neighboring gene uncharacterized LOC141385560 Neighboring gene cholinergic receptor, muscarinic 1b Neighboring gene myosin Ic, paralog a

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex. Lange M, et al. Genes Dev, 2008 Sep 1. PMID 18765789, Free PMC Article
  2. Comparative analysis of single-cell transcriptomics in human and Zebrafish oocytes. Can H, et al. BMC Genomics, 2020 Jul 8. PMID 32640983, Free PMC Article
  3. Genome-wide, whole mount in situ analysis of transcriptional regulators in zebrafish embryos. Armant O, et al. Dev Biol, 2013 Aug 15. PMID 23684812, Free PMC Article
  4. Rbfox-regulated alternative splicing is critical for zebrafish cardiac and skeletal muscle functions. Gallagher TL, et al. Dev Biol, 2011 Nov 15. PMID 21925157, Free PMC Article
  5. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of nBAF complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
zinc finger protein ubi-d4
Names
D4, zinc and double PHD fingers family 2

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007152.1 → NP_001007153.1  zinc finger protein ubi-d4

    See identical proteins and their annotated locations for NP_001007153.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083281
    UniProtKB/TrEMBL
    A0A8M2BCR7, Q5XJL8
    Related
    ENSDARP00000003264.9, ENSDART00000014031.11
    Conserved Domains (3) summary
    cd15530
    Location:336 → 381
    PHD2_d4; PHD finger 2 found in d4 gene family proteins
    cd15691
    Location:279 → 334
    PHD1_DPF2_like; PHD finger 1 found in D4, zinc and double PHD fingers family 2 (DPF2)
    pfam14051
    Location:13 → 77
    Requiem_N; N-terminal domain of DPF2/REQ

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133180.1 Reference GRCz12tu Primary Assembly

    Range
    38647590..38662852
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_073950255.1 → XP_073806356.1  zinc finger protein ubi-d4 isoform X4

  2. XM_073950256.1 → XP_073806357.1  zinc finger protein ubi-d4 isoform X5

  3. XM_005165302.6 → XP_005165359.2  zinc finger protein ubi-d4 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BCR7

  4. XM_073950254.1 → XP_073806355.1  zinc finger protein ubi-d4 isoform X4

  5. XM_073950257.1 → XP_073806358.1  zinc finger protein ubi-d4 isoform X5

  6. XM_009301640.5 → XP_009299915.2  zinc finger protein ubi-d4 isoform X2

    UniProtKB/TrEMBL
    A0A8M3B9T0

  7. XM_073950253.1 → XP_073806354.1  zinc finger protein ubi-d4 isoform X3

    UniProtKB/TrEMBL
    A0A8M3B9T0

  8. XM_073950258.1 → XP_073806359.1  zinc finger protein ubi-d4 isoform X6

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools