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Hcst hematopoietic cell signal transducer [ Rattus norvegicus (Norway rat) ]

Gene ID: 474146, updated on 5-Sep-2025
Official Symbol
Hcstprovided by RGD
Official Full Name
hematopoietic cell signal transducerprovided by RGD
Primary source
RGD:1359238
See related
Ensembl:ENSRNOG00000020849 AllianceGenome:RGD:1359238
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Dap10
Summary
Predicted to enable phosphatidylinositol 3-kinase binding activity; protein-macromolecule adaptor activity; and signaling receptor binding activity. Predicted to be involved in natural killer cell mediated cytotoxicity; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and protein phosphorylation. Predicted to be located in cell surface. Predicted to be active in plasma membrane. Orthologous to human HCST (hematopoietic cell signal transducer). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Biased expression in Spleen (RPKM 41.5), Thymus (RPKM 34.6) and 7 other tissues See more
Orthologs
human mouse all
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See Hcst in Genome Data Viewer
Location:
1q21
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (94804429..94806661, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (85676976..85679083, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (88879425..88881653, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene actin, gamma 1, pseudogene 6 Neighboring gene transmembrane immune signaling adaptor Tyrobp Neighboring gene NFKB inhibitor delta Neighboring gene amyloid beta precursor like protein 1 Neighboring gene kirre like nephrin family adhesion molecule 2

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Cutting edge: KAP10, a novel transmembrane adapter protein genetically linked to DAP12 but with unique signaling properties. Chang C, et al. J Immunol, 1999 Nov 1. PMID 10528161
  2. Rat and mouse CD94 associate directly with the activating transmembrane adaptor proteins DAP12 and DAP10 and activate NK cell cytotoxicity. Saether PC, et al. J Immunol, 2011 Dec 15. PMID 22084441
  3. An activating immunoreceptor complex formed by NKG2D and DAP10. Wu J, et al. Science, 1999 Jul 30. PMID 10426994
  4. A Structural basis for the association of DAP12 with mouse, but not human, NKG2D. Rosen DB, et al. J Immunol, 2004 Aug 15. PMID 15294961
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Both adaptor proteins DAP12 and DAP10 can associate with rat CD94/NKG2C; rat CD94 coimmunoprecipitates with both DAP12 and DAP10.
    Title: Rat and mouse CD94 associate directly with the activating transmembrane adaptor proteins DAP12 and DAP10 and activate NK cell cytotoxicity.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables phosphatidylinositol 3-kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol 3-kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol 3-kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-macromolecule adaptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within natural killer cell mediated cytotoxicity IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within natural killer cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
  
involved_in natural killer cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of immune response IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell surface IEA
Inferred from Electronic Annotation
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
hematopoietic cell signal transducer
Names
DNAX-activation protein 10
membrane protein DAP10

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005900.1 → NP_001005900.1  hematopoietic cell signal transducer precursor

    See identical proteins and their annotated locations for NP_001005900.1

    Status: PROVISIONAL

    Source sequence(s)
    AY247020
    UniProtKB/Swiss-Prot
    Q6X9T8
    UniProtKB/TrEMBL
    A0A8I5Y9X6, A6J9X2
    Related
    ENSRNOP00000028287.4, ENSRNOT00000028287.6
    Conserved Domains (1) summary
    pfam07213
    Location:1 → 79
    DAP10; DAP10 membrane protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    94804429..94806661 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006228785.5 → XP_006228847.1  hematopoietic cell signal transducer isoform X1

    UniProtKB/TrEMBL
    A6J9X1
    Conserved Domains (1) summary
    pfam07213
    Location:1 → 78
    DAP10; DAP10 membrane protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6X9T8.1 GenPept UniProtKB/Swiss-Prot:Q6X9T8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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